{"text_format":"1","workbook":"xlsx","n_sheets":10,"sheets":["Title page","Version Control","Irish Population Estimates","Patient Population","Drug Acquisition Costs","Drug Acquisition Costs (PAS)","Additional Costs","Results","Results (PAS)","References"],"not_rendered":{"charts":0,"images":2,"macros":1,"external_links":0,"defined_names":71,"comments":0,"pivot_tables":0},"unopened":[],"bounds":{"document_bytes":16777216,"sheet_cells":100000,"rows_first":2000,"rows_last":500,"rows_between":2000,"halvings":0,"cell_chars":16384,"cell_head_chars":4096},"cells_cut":0,"cells_raw":0,"read":"whole","date_system":"1900"}

{"sheet":"Title page","index":0,"n_rows":63,"n_cols":7,"rows_kept":63,"cut":false,"hidden":false,"merged":[[50,3,50,5],[50,6,50,14],[51,3,51,5],[51,6,51,14],[52,3,52,5],[52,6,52,14],[47,3,47,5],[47,6,47,14],[48,3,48,5],[48,6,48,14],[49,3,49,5],[49,6,49,14],[18,0,20,14],[29,0,29,2],[30,0,30,2],[31,0,31,2],[29,3,29,14],[30,3,30,14],[31,3,33,14],[22,0,22,14],[46,6,46,14],[41,0,41,2],[42,0,42,2],[43,0,43,2],[44,0,44,2],[45,0,45,2],[38,3,38,8],[35,0,36,14],[46,0,46,2],[40,3,40,5],[40,6,40,14],[41,3,41,5],[42,3,42,5],[43,3,43,5],[44,3,44,5],[45,3,45,5],[46,3,46,5],[41,6,41,14],[42,6,42,14],[43,6,43,14],[44,6,44,14],[45,6,45,14]]}
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["Please reference this model as \"Lamrock F, O'Donnell H, Varley A,Eames H, Leahy J, Maguire O, Trela-Larsen L, Tilson L. National Centre for Pharmacoeconomics Budget Impact Model Template Version 2.3. Dublin: NCPE April 2026\" in any adaptions or publications."]
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["General instructions: Please fill in all worksheets where there are blue or orange cells.  \nPlease consult the NCPE Budget Impact Model Guidelines when completing this template. "]
[null,null,null,null,"Cells highlighted in ORANGE are input cells for the Applicant in the form of a drop down menu"]
[null,null,null,null,"Cells highlighted in BLUE are input cells for the Applicant"]
[null,null,null,null,"Cells highlighted in YELLOW contain confidential information"]
[null,null,null,null,"Cells highlighted in PINK indicate missing information below from Applicant."]
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["INN:"]
["Brand name:"]
["Indication under assessment:"]
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["Up to 12 comparators can be used in this model. If more comparators exist, please contact bim@ncpe.ie \nNote: For HTA submissions, comparators with the highest market share should align with the chosen comparators in the cost-effectiveness model."]
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[null,null,null,"How many comparators will be used in this model?"]
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[null,null,null,"Name",null,null,"Description"]
["Comparator 1:"]
["Comparator 2:"]
["Comparator 3:"]
["Comparator 4:"]
["Comparator 5:"]
["Comparator 6:"]
[null,"Comparator 7:"]
[null,"Comparator 8:"]
[null,"Comparator 9:"]
[null,"Comparator 10:"]
[null,"Comparator 11:"]
[null,"Comparator 12:"]
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["Next review date: October 2027"]

{"sheet":"Version Control","index":1,"n_rows":7,"n_cols":4,"rows_kept":7,"cut":false,"hidden":false,"merged":[]}
["Version","Date","Worksheet","Description of key changes"]
[2.2999999999999998,"2026-04-13","Irish Population Estimates","Updated to 2026-2030 and based on 2022 census"]
[null,null,"Wording of the eligible and treated population","Clarification to the eligible and treated populations on the 'Patient Population' and 'Results' sheet"]
[null,null,"Inclusion of 5% FASPM Scenario","Inclusion of functionality to apply a scenario which applies a 5% framework rebate to all applicable \"new medicines\", as per the FASPM."]
[null,null,"Updated Framework Agreement Rebates","Functionality added to change the rebate applied to medicinal products, based on whether these are considered as new medicines under the FASPM. "]
[null,null,"CDS Fee","Updated to reflect PCRS CDS dispensing claims in 2026."]
[null,"Abbrevations: FASPM: Framework Agreement of the Supply and Pricing of Medicines 2026 to 2029; PAS Patient Access Scheme"]

{"sheet":"Irish Population Estimates","index":2,"n_rows":133,"n_cols":22,"rows_kept":133,"cut":false,"hidden":false,"merged":[[16,1,20,10],[132,0,132,21]]}
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[null,"This worksheet provides the background demographic estimates of the Irish population, to aid in identifying the population subject to the indication under assessment. If using these estimates, it is important to show what cells and population was used. This worksheet should not be changed, but provides the most up to date estimates which are encouraged to be referenced on the Patient Population worksheet."]
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[null,"Males",null,null,null,null,null,null,null,"Females",null,null,null,null,null,null,null,"Total"]
["Age",2026,2027,2028,2029,2030,null,null,null,2026,2027,2028,2029,2030,null,null,null,2026,2027,2028,2029,2030]
[0,28420,28109,27841,27678,27605,null,null,null,26970,26677,26420,26267,26196,null,null,null,55390,54786,54261,53945,53801]
[1,28879,28670,28353,28085,27922,null,null,null,27419,27220,26920,26663,26511,null,null,null,56298,55890,55273,54748,54433]
[2,29362,29141,28926,28609,28341,null,null,null,27872,27665,27459,27160,26903,null,null,null,57234,56806,56385,55769,55244]
[3,30741,29595,29369,29154,28837,null,null,null,29164,28081,27870,27664,27365,null,null,null,59905,57676,57239,56818,56202]
[4,30839,30969,29819,29593,29378,null,null,null,29369,29395,28307,28096,27890,null,null,null,60208,60364,58126,57689,57268]
[5,30285,31094,31219,30069,29843,null,null,null,28829,29570,29594,28507,28296,null,null,null,59114,60664,60813,58576,58139]
[6,31539,30521,31326,31451,30301,null,null,null,30147,29051,29788,29812,28725,null,null,null,61686,59572,61114,61263,59026]
[7,32328,31768,30748,31552,31677,null,null,null,30712,30356,29258,29995,30019,null,null,null,63040,62124,60006,61547,61696]
[8,33010,32539,31977,30957,31761,null,null,null,31079,30922,30563,29465,30202,null,null,null,64089,63461,62540,60422,61963]
[9,34010,33227,32754,32192,31172,null,null,null,32596,31279,31119,30760,29662,null,null,null,66606,64506,63873,62952,60834]
[10,35378,34232,33446,32973,32411,null,null,null,33880,32812,31492,31332,30973,null,null,null,69258,67044,64938,64305,63384]
[11,36740,35607,34457,33671,33198,null,null,null,34796,34086,33016,31696,31536,null,null,null,71536,69693,67473,65367,64734]
[12,37598,36966,35830,34680,33895,null,null,null,35692,35010,34298,33228,31908,null,null,null,73290,71976,70128,67908,65803]
[13,38285,37822,37187,36051,34901,null,null,null,36464,35914,35228,34516,33446,null,null,null,74749,73736,72415,70567,68347]
[14,39350,38442,37978,37343,36207,null,null,null,37275,36614,36063,35377,34665,null,null,null,76625,75056,74041,72720,70872]
[15,39530,39537,38651,38187,37552,null,null,null,38218,37654,37003,36452,35767,null,null,null,77748,77191,75654,74639,73319]
[16,40260,39725,39753,38868,38404,null,null,null,38992,38606,38054,37403,36852,null,null,null,79252,78331,77807,76271,75256]
[17,39869,40491,39975,40003,39119,null,null,null,38763,39317,38947,38395,37744,null,null,null,78632,79808,78922,78398,76863]
[18,39020,40020,40667,40151,40179,null,null,null,38397,39077,39649,39280,38727,null,null,null,77417,79097,80316,79431,78906]
[19,37484,39137,40164,40811,40296,null,null,null,36639,38709,39407,39979,39610,null,null,null,74123,77846,79571,80790,79906]
[20,36176,37583,39263,40290,40937,null,null,null,35387,36925,39015,39713,40285,null,null,null,71563,74508,78278,80003,81222]
[21,36263,36255,37692,39372,40398,null,null,null,34967,35616,37178,39268,39966,null,null,null,71230,71871,74870,78640,80364]
[22,35102,36328,36351,37788,39468,null,null,null,34759,35176,35850,37412,39502,null,null,null,69861,71504,72201,75200,78970]
[23,34192,35155,36412,36435,37872,null,null,null,33895,34972,35415,36089,37651,null,null,null,68087,70127,71827,72524,75523]
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[26,34331,33900,34966,35632,36625,null,null,null,34253,33765,35209,35662,36768,null,null,null,68584,67665,70175,71294,73393]
[27,34495,34967,34531,35597,36263,null,null,null,34074,35030,34524,35969,36421,null,null,null,68569,69997,69055,71566,72684]
[28,34394,35118,35585,35150,36216,null,null,null,33964,34814,35755,35249,36694,null,null,null,68358,69932,71340,70399,72910]
[29,34039,35002,35723,36190,35756,null,null,null,33789,34655,35493,36434,35928,null,null,null,67828,69657,71216,72624,71684]
[30,33168,34609,35572,36293,36761,null,null,null,33091,34465,35321,36158,37100,null,null,null,66259,69074,70893,72451,73861]
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["99+",426,467,496,529,587,null,null,null,1157,1211,1285,1341,1453,null,null,null,1583,1678,1781,1870,2040]
["All ages",2722565,2750944,2778866,2806261,2833219,null,null,"All ages",2798195,2830893,2862904,2894455,2925612,null,null,"All ages",5520760,5581837,5641770,5700716,5758831]
["12+ ",{"$f":"SUM(B37:B124)","v":2341034},{"$f":"SUM(C37:C124)","v":2375472},2408631,2440277,2470773,null,null,"12+ ",2435362,2473779,2511098,2547038,2581334,null,null,"12+ ",4776396,4849251,4919729,4987315,5052107]
["18+ ",{"$f":"SUM(B43:B124)","v":2106142},{"$f":"SUM(C43:C124)","v":2142489},2179257,2215145,2250695,null,null,"18+ ",2209958,2250664,2291505,2331667,2370952,null,null,"18+ ",4316100,4393153,4470762,4546812,4621647]
["Applicant input ",null,null,null,null,null,null,null,"Applicant input ",null,null,null,null,null,null,null,"Applicant input "]
[]
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[]
["Note: If using CSO estimates, it is important to show what population was used by highlighting the appropriate cells. The sum of the total population, 12+ population and 18+ population are provided in Rows 125 to 127. Where an alternative age range is required, please input this in Row 128."]

{"sheet":"Patient Population","index":3,"n_rows":138,"n_cols":14,"rows_kept":138,"cut":false,"hidden":false,"merged":[[15,1,15,10],[20,1,21,3],[20,4,21,11],[25,13,27,22],[28,13,29,22],[130,1,130,3],[131,1,131,3],[104,13,105,22],[67,13,68,22],[87,13,88,22],[24,1,24,6],[64,1,64,6],[84,1,84,6],[122,1,122,6],[30,9,30,11],[66,9,66,11],[67,1,67,3],[34,13,34,22],[30,13,30,22],[32,13,32,22],[68,9,68,11],[32,1,32,3],[32,9,32,11],[34,1,34,3],[34,9,34,11],[69,1,69,3],[69,9,69,11],[70,1,70,3],[91,1,91,3],[91,9,91,11],[86,9,86,11],[70,9,70,11],[71,1,71,3],[35,1,35,3],[35,9,35,11],[71,9,71,11],[72,1,72,3],[73,1,73,3],[72,9,72,11],[73,9,73,11],[74,1,74,3],[74,9,74,11],[75,1,75,3],[75,9,75,11],[76,1,76,3],[76,9,76,11],[77,1,77,3],[77,9,77,11],[26,9,26,11],[27,9,27,11],[28,9,28,11],[29,1,29,3],[29,9,29,11],[27,1,27,3],[28,1,28,3],[31,1,31,3],[31,9,31,11],[30,1,30,3],[103,1,103,8],[33,1,33,3],[33,9,33,11],[45,1,45,6],[40,1,40,6],[67,9,67,11],[68,1,68,3],[47,9,47,11],[53,9,53,11],[51,1,51,3],[51,9,51,11],[57,1,57,3],[57,9,57,11],[58,1,58,3],[61,9,61,11],[58,9,58,11],[59,1,59,3],[59,9,59,11],[54,1,54,3],[54,9,54,11],[55,1,55,3],[55,9,55,11],[56,1,56,3],[56,9,56,11],[96,9,96,11],[97,1,97,3],[97,9,97,11],[98,1,98,3],[98,9,98,11],[99,1,99,3],[99,9,99,11],[95,1,95,3],[95,9,95,11],[96,1,96,3],[48,13,49,22],[52,1,52,3],[53,1,53,3],[52,9,52,11],[48,1,48,3],[48,9,48,11],[49,1,49,3],[49,9,49,11],[50,1,50,3],[50,9,50,11],[78,1,78,3],[78,9,78,11],[136,1,136,3],[137,1,137,3],[115,1,115,3],[116,1,116,3],[117,1,117,3],[132,1,132,3],[133,1,133,3],[128,1,128,3],[129,1,129,3],[125,1,125,3],[126,1,126,3],[127,1,127,3],[111,1,111,3],[92,1,92,3],[93,1,93,3],[92,9,92,11],[93,9,93,11],[107,1,107,3],[108,1,108,3],[109,1,109,3],[106,1,106,3],[110,1,110,3],[16,1,16,10],[19,13,19,22],[24,9,24,11],[45,9,45,11],[64,9,64,11],[84,9,84,11],[81,9,81,11],[134,1,134,3],[135,1,135,3],[79,1,79,3],[79,9,79,11],[112,1,112,3],[113,1,113,3],[114,1,114,3],[87,1,87,3],[87,9,87,11],[88,1,88,3],[88,9,88,11],[89,1,89,3],[89,9,89,11],[90,1,90,3],[90,9,90,11],[94,1,94,3],[94,9,94,11]]}
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,"In this worksheet, the patient population eligible to receive the new intervention is estimated by the Applicant. The market share estimates are used to calculate the expected number of patients to receive the new intervention over the next 5 years."]
[null,"Applicants should adhere to the BIM template, to increase transparency in patient number estimates and to allow scenario analysis by the Review Group. Extra worksheets may be added for any additional explanations or calculations required to estimate parameter inputs. These should adhere to the flow of the BIM template, ensuring that each individual component of the calculation is modifiable by the Review Group, to enable validation and scenario analysis by the Review Group. Estimates from the BIM should be copied and pasted directly into the Applicant template."]
[null,"Note: Please ensure that all cells highlighted in blue are completed. Fields in white will be automatically populated. "]
[]
[]
[]
[]
[]
[]
[null,"Table 1: Eligible patient population",null,null,null,null,null,null,null,{"$f":"IF(OR(ISBLANK(J28),ISBLANK(J29),ISBLANK(J31),ISBLANK(J33),ISBLANK(J35)),\"Please fill in source in table below\",\"Sources complete\")","v":"Please fill in source in table below"}]
[null,null,null,null,null,null,null,null,null,null,null,null,null,"Insert the number of Irish prevalent and incident patients by using the \"Irish Population Estimates\" tab. If additional rows are needed for calculations, please add them to an additional worksheet but place the aggregated numbers here.  Please describe the reference source cells used and any calculations. The prevalent and incident cells can be manually inserted or linked to each other where the applicant deems appropriate for the calculations. Absolute numbers should be used."]
[null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5","Reference/Calculations"]
[null,"Prevalent patients"]
[null,"Incident patients",null,null,null,null,null,null,null,null,null,null,null,"Please note that prevalent and incidence calculations should not include mortality and sub-population calculation. Mortality will be calculated next, and the sub-population is an optional specific sub-population of patients narrower than that covered by the licence. "]
[null,"Total number of patients",null,null,{"$f":"(E28+E29)","v":0},{"$f":"(F28+F29)","v":0},{"$f":"(G28+G29)","v":0},{"$f":"(H28+H29)","v":0},{"$f":"(I28+I29)","v":0},"Calculation"]
[null,"Mortality rate ",null,null,null,null,null,null,null,null,null,null,null,"Insert the mortality rate as a percent per annum of the patient cohort with the condition.  If the mortality rate is not known or is not significant, please set to 0. Please describe the reference source and any calculations."]
[null,"Net total number of patients",null,null,{"$f":"(E30*(1-(E31)))","v":0},{"$f":"(F30*(1-(F31)))","v":0},{"$f":"(G30*(1-(G31)))","v":0},{"$f":"(H30*(1-(H31)))","v":0},{"$f":"(I30*(1-(I31)))","v":0},"Calculation"]
[null,"Patients eligible for the new intervention under the full licensed therapeutic indication (%)",null,null,null,null,null,null,null,null,null,null,null,"Insert the percentage of patients eligible for the new intervention under the license. Please describe the reference source and any calculations."]
[null,"Number of patients eligible for treatment under the full licensed therapeutic indication (i.e. eligible population)",null,null,{"$f":"E30*E33","v":0},{"$f":"F30*F33","v":0},0,0,0,"Calculation"]
[null,"Proportion of the eligible population expected to receive (any) treatment",null,null,null,null,null,null,null,null,null,null,null,"This proportion should account for any cases in which the eligible population is reduced as a result of patient factors, capacity constraints etc. In the absence of an appropriate justification for this reduction, this proportion should be set to 100%.\nIn exceptional circumstances, wherein a subpopulation of the full licensed therapeutic indication is deemed appropriate, this may be accounted for in this proportion, as a scenario analysis."]
[null,"Number of patients expected to receive treatment (i.e. treated population)",null,null,{"$f":"E35*E34","v":0},{"$f":"F35*F34","v":0},{"$f":"G35*G34","v":0},{"$f":"H35*H34","v":0},{"$f":"I35*I34","v":0},"Calculation"]
[]
[]
[]
[]
[null,"Market shares"]
[]
[]
[]
[]
[null,"Table 2: Market share without intervention",null,null,null,null,null,null,null,{"$f":"IF(OR(COUNTA(J49:L60)<NumberofComparators,ISBLANK('Title page'!K39)),\"Please fill in source in table below\",\"Sources complete\")","v":"Please fill in source in table below"}]
[]
[null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5","Reference/Justification"]
[null,{"$f":"CONCATENATE(\"Comparator 1: \",NameComparator1)","v":"Comparator 1: "},null,null,null,null,null,null,null,null,null,null,null,"Estimated market shares should sum to 100% each year. Where appropriate, outline if the market share estimates represent mid-year or end-of-year projections and the justification for taking this approach. Additional information regarding how market shares were obtained, e.g. market research can be submitted as a separate document/tab/excel file. For HTA submissions, comparators with the highest market share should align with the chosen comparators in the cost-effectiveness model."]
[null,{"$f":"CONCATENATE(\"Comparator 2: \",NameComparator2)","v":"Comparator 2: "}]
[null,{"$f":"CONCATENATE(\"Comparator 3: \",NameComparator3)","v":"Comparator 3: "}]
[null,{"$f":"CONCATENATE(\"Comparator 4: \",NameComparator4)","v":"Comparator 4: "}]
[null,{"$f":"CONCATENATE(\"Comparator 5: \",NameComparator5)","v":"Comparator 5: "}]
[null,{"$f":"CONCATENATE(\"Comparator 6: \",NameComparator6)","v":"Comparator 6: "}]
[null,{"$f":"CONCATENATE(\"Comparator 7: \",NameComparator7)","v":"Comparator 7: "}]
[null,{"$f":"CONCATENATE(\"Comparator 8: \",NameComparator8)","v":"Comparator 8: "}]
[null,{"$f":"CONCATENATE(\"Comparator 9: \",NameComparator9)","v":"Comparator 9: "}]
[null,{"$f":"CONCATENATE(\"Comparator 10: \",NameComparator10)","v":"Comparator 10: "}]
[null,{"$f":"CONCATENATE(\"Comparator 11: \",NameComparator11)","v":"Comparator 11: "}]
[null,{"$f":"CONCATENATE(\"Comparator 12: \",NameComparator12)","v":"Comparator 12: "}]
[]
[null,null,null,null,{"$f":"SUM(E49:E60)","v":0},{"$f":"SUM(F49:F60)","v":0},{"$f":"SUM(G49:G60)","v":0},{"$f":"SUM(H49:H60)","v":0},{"$f":"SUM(I49:I60)","v":0},{"$f":"IF(OR(E62<>100%,F62<>100%,G62<>100%,H62<>100%,I62<>100%),\"Check market shares above sum to 100%\",\"Market shares sum to 100%\")","v":"Check market shares above sum to 100%"}]
[]
[]
[null,"Table 3: Market share with intervention",null,null,null,null,null,null,null,{"$f":"IF(COUNTA(J68:L79)>NumberofComparators,\"Sources complete\",\"Please fill in source in table below\")","v":"Please fill in source in table below"}]
[]
[null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5","Reference/Justification"]
[null,{"$f":"CONCATENATE(\"Intervention: \",InterventionINN)","v":"Intervention: "},null,null,null,null,null,null,null,null,null,null,null,"Estimated market shares should sum to 100% each year. Additional information regarding how market shares were obtained, e.g. market research can be submitted as a separate worksheet. For HTA submissions, comparators with the highest market share should align with the chosen comparators in the cost-effectiveness model."]
[null,{"$f":"CONCATENATE(\"Comparator 1: \",NameComparator1)","v":"Comparator 1: "}]
[null,{"$f":"CONCATENATE(\"Comparator 2: \",NameComparator2)","v":"Comparator 2: "}]
[null,{"$f":"CONCATENATE(\"Comparator 3: \",NameComparator3)","v":"Comparator 3: "}]
[null,{"$f":"CONCATENATE(\"Comparator 4: \",NameComparator4)","v":"Comparator 4: "}]
[null,{"$f":"CONCATENATE(\"Comparator 5: \",NameComparator5)","v":"Comparator 5: "}]
[null,{"$f":"CONCATENATE(\"Comparator 6: \",NameComparator6)","v":"Comparator 6: "}]
[null,{"$f":"CONCATENATE(\"Comparator 7: \",NameComparator7)","v":"Comparator 7: "}]
[null,{"$f":"CONCATENATE(\"Comparator 8: \",NameComparator8)","v":"Comparator 8: "}]
[null,{"$f":"CONCATENATE(\"Comparator 9: \",NameComparator9)","v":"Comparator 9: "}]
[null,{"$f":"CONCATENATE(\"Comparator 10: \",NameComparator10)","v":"Comparator 10: "}]
[null,{"$f":"CONCATENATE(\"Comparator 11: \",NameComparator11)","v":"Comparator 11: "}]
[null,{"$f":"CONCATENATE(\"Comparator 12: \",NameComparator12)","v":"Comparator 12: "}]
[]
[null,null,null,null,{"$f":"SUM(E68:E80)","v":0},{"$f":"SUM(F68:F80)","v":0},0,0,{"$f":"SUM(I68:I80)","v":0},{"$f":"IF(OR(E82<>100%,F82<>100%,G82<>100%,H82<>100%,I82<>100%),\"Check market shares above sum to 100%\",\"Market shares sum to 100%\")","v":"Check market shares above sum to 100%"}]
[]
[]
[null,"Table 4: Discontinuation rates",null,null,null,null,null,null,null,{"$f":"IF(COUNTA(J88:L99)>NumberofComparators,\"Sources complete\",\"Please fill in source in table below\")","v":"Please fill in source in table below"}]
[]
[null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5","Reference/Justification"]
[null,{"$f":"CONCATENATE(\"Intervention: \",InterventionINN)","v":"Intervention: "},null,null,null,null,null,null,null,null,null,null,null,"Optional: The proportion of patients discontinuing either the invertention or a comparator should be placed here. Discontinuation can also include adherence rates. For drugs calculated based on mean number of cycles, this will already take into account discontinuation rates."]
[null,{"$f":"CONCATENATE(\"Comparator 1: \",NameComparator1)","v":"Comparator 1: "}]
[null,{"$f":"CONCATENATE(\"Comparator 2: \",NameComparator2)","v":"Comparator 2: "}]
[null,{"$f":"CONCATENATE(\"Comparator 3: \",NameComparator3)","v":"Comparator 3: "}]
[null,{"$f":"CONCATENATE(\"Comparator 4: \",NameComparator4)","v":"Comparator 4: "}]
[null,{"$f":"CONCATENATE(\"Comparator 5: \",NameComparator5)","v":"Comparator 5: "}]
[null,{"$f":"CONCATENATE(\"Comparator 6: \",NameComparator6)","v":"Comparator 6: "}]
[null,{"$f":"CONCATENATE(\"Comparator 7: \",NameComparator7)","v":"Comparator 7: "}]
[null,{"$f":"CONCATENATE(\"Comparator 8: \",NameComparator8)","v":"Comparator 8: "}]
[null,{"$f":"CONCATENATE(\"Comparator 9: \",NameComparator9)","v":"Comparator 9: "}]
[null,{"$f":"CONCATENATE(\"Comparator 10: \",NameComparator10)","v":"Comparator 10: "}]
[null,{"$f":"CONCATENATE(\"Comparator 11: \",NameComparator11)","v":"Comparator 11: "}]
[null,{"$f":"CONCATENATE(\"Comparator 12: \",NameComparator12)","v":"Comparator 12: "}]
[]
[]
[]
[null,"Table 5: Summary of population without new intervention"]
[null,null,null,null,null,null,null,null,null,null,null,null,null,"These are the population estimates of the intervention and comparator drugs for five years used in the budget impact calculations"]
[null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5"]
[null,{"$f":"CONCATENATE(\"Comparator 1: \",NameComparator1)","v":"Comparator 1: "},null,null,{"$f":"(E49*$E$36)","v":0},{"$f":"(F49*F$36)","v":0},{"$f":"(G49*G$36)","v":0},0,0]
[null,{"$f":"CONCATENATE(\"Comparator 2: \",NameComparator2)","v":"Comparator 2: "},null,null,{"$f":"(E50*$E$36)","v":0},{"$f":"(F50*F$36)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 3: \",NameComparator3)","v":"Comparator 3: "},null,null,0,0,0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 4: \",NameComparator4)","v":"Comparator 4: "},null,null,0,0,0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 5: \",NameComparator5)","v":"Comparator 5: "},null,null,0,0,0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 6: \",NameComparator6)","v":"Comparator 6: "},null,null,0,0,0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 7: \",NameComparator7)","v":"Comparator 7: "},null,null,0,0,0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 8: \",NameComparator8)","v":"Comparator 8: "},null,null,0,0,0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 9: \",NameComparator9)","v":"Comparator 9: "},null,null,0,0,0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 10: \",NameComparator10)","v":"Comparator 10: "},null,null,0,0,0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 11: \",NameComparator11)","v":"Comparator 11: "},null,null,0,0,0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 12: \",NameComparator12)","v":"Comparator 12: "},null,null,0,0,0,0,0]
[]
[]
[]
[]
[null,"Table 6: Summary of population with new intervention"]
[]
[null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5"]
[null,{"$f":"CONCATENATE(\"Intervention: \",InterventionINN)","v":"Intervention: "},null,null,{"$f":"(E68*$E$36)","v":0},{"$f":"(F68*F$36)","v":0},{"$f":"(G68*G$36)","v":0},0,0]
[null,{"$f":"CONCATENATE(\"Comparator 1: \",NameComparator1)","v":"Comparator 1: "},null,null,{"$f":"(E69*$E$36)","v":0},{"$f":"(F69*F$36)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 2: \",NameComparator2)","v":"Comparator 2: "},null,null,0,0,0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 3: \",NameComparator3)","v":"Comparator 3: "},null,null,0,0,0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 4: \",NameComparator4)","v":"Comparator 4: "},null,null,0,0,0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 5: \",NameComparator5)","v":"Comparator 5: "},null,null,0,0,0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 6: \",NameComparator6)","v":"Comparator 6: "},null,null,0,0,0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 7: \",NameComparator7)","v":"Comparator 7: "},null,null,0,0,0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 8: \",NameComparator8)","v":"Comparator 8: "},null,null,0,0,0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 9: \",NameComparator9)","v":"Comparator 9: "},null,null,0,0,0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 10: \",NameComparator10)","v":"Comparator 10: "},null,null,0,0,0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 11: \",NameComparator11)","v":"Comparator 11: "},null,null,0,0,0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 12: \",NameComparator12)","v":"Comparator 12: "},null,null,0,0,0,0,0]

{"sheet":"Drug Acquisition 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[null,"\n\n• Following the instructions beside each table, use the drug cost calculators to calculate the cost per patient per year or per treatment course for the intervention and comparator(s). Orange cells represent drop down menus.\n• Please use Table G to select the most appropriate cost for inclusion in Tables 1a and 1b for each intervention and comparator(s)\n• Figures will automatically populate in Tables 1a and 1b based on selections in Table G unless selected as \"Calculated elsewhere by Applicant\" in Table G. The corresponding cells will then be coloured blue in Tables 1a and 1b. Please manually overwrite the formula with the appropriate figure if using the manual option.\n• Please include additional calculations in the notes box if required. \n• The calculator applies the patient care fee and dispensing fees across time periods pro-rata. This may not always be appropriate depending on the data underlying how the average treatment duration was calculated where rounding may be more appropriate. Please add additional rows to the calculator in Table F if it is more appropriate to adopt the rounding approach and highlight the change. \n• It is not possible to program the calculator for every form of dosing regimen. Please refer to the NCPE Drug Cost Guidelines for further detail on the calculation of drug costs. \n• If a Patient Access Scheme (PAS) is planned, please include the drug acquisitions costs as a separate worksheet (Drug Acquisition Costs (PAS))\n• Please note that the calculator assumes 1 month = 30.4375 days =365.25/12\n"]
[]
[null,null,null,null,null,null,null,null,null,null,"NCPE Drug Cost Guidelines"]
[]
[]
[]
[]
[null,"Scenario: ",null,"Apply scenario of 5% rebate?",null,"No","• Please select 'Yes' in Cell F24 if running the scenario analysis of a 5% Framework Agreement rebate across each Year of the BIM."]
[]
[null,"Table 1a: Price including VAT",null,null,null,null,null,null,null,null,"Table 1b: Price excluding VAT"]
[null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5",null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5"]
[null,{"$f":"CONCATENATE(\"Intervention: \",InterventionINN)","v":"Intervention: "},null,null,{"$f":"IFERROR(INDIRECT($F114),0)","v":0},{"$f":"IFERROR(INDIRECT($F114),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Intervention: \",InterventionINN)","v":"Intervention: "},null,null,{"$f":"IFERROR(INDIRECT($H114),0)","v":0},{"$f":"IFERROR(INDIRECT($H114),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 1: \",NameComparator1)","v":"Comparator 1: "},null,null,{"$f":"IFERROR(INDIRECT($F202),0)","v":0},{"$f":"IFERROR(INDIRECT($F202),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 1: \",NameComparator1)","v":"Comparator 1: "},null,null,{"$f":"IFERROR(INDIRECT($H202),0)","v":0},{"$f":"IFERROR(INDIRECT($H202),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 2: \",NameComparator2)","v":"Comparator 2: "},null,null,{"$f":"IFERROR(INDIRECT($F290),)","v":0},{"$f":"IFERROR(INDIRECT($F290),)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 2: \",NameComparator2)","v":"Comparator 2: "},null,null,{"$f":"IFERROR(INDIRECT($H290),0)","v":0},{"$f":"IFERROR(INDIRECT($H290),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 3: \",NameComparator3)","v":"Comparator 3: "},null,null,{"$f":"IFERROR(INDIRECT($F379),0)","v":0},{"$f":"IFERROR(INDIRECT($F379),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 3: \",NameComparator3)","v":"Comparator 3: "},null,null,{"$f":"IFERROR(INDIRECT($H379),0)","v":0},{"$f":"IFERROR(INDIRECT($H379),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 4: \",NameComparator4)","v":"Comparator 4: "},null,null,{"$f":"IFERROR(INDIRECT($F467),0)","v":0},{"$f":"IFERROR(INDIRECT($F467),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 4: \",NameComparator4)","v":"Comparator 4: "},null,null,{"$f":"IFERROR(INDIRECT($H467),0)","v":0},{"$f":"IFERROR(INDIRECT($H467),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 5: \",NameComparator5)","v":"Comparator 5: "},null,null,{"$f":"IFERROR(INDIRECT($F556),0)","v":0},{"$f":"IFERROR(INDIRECT($F556),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 5: \",NameComparator5)","v":"Comparator 5: "},null,null,{"$f":"IFERROR(INDIRECT($H556),0)","v":0},{"$f":"IFERROR(INDIRECT($H556),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 6: \",NameComparator6)","v":"Comparator 6: "},null,null,{"$f":"IFERROR(INDIRECT($F644),0)","v":0},{"$f":"IFERROR(INDIRECT($F644),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 6: \",NameComparator6)","v":"Comparator 6: "},null,null,{"$f":"IFERROR(INDIRECT($H644),0)","v":0},{"$f":"IFERROR(INDIRECT($H644),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 7: \",NameComparator7)","v":"Comparator 7: "},null,null,{"$f":"IFERROR(INDIRECT($F732),0)","v":0},{"$f":"IFERROR(INDIRECT($F732),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 7: \",NameComparator7)","v":"Comparator 7: "},null,null,{"$f":"IFERROR(INDIRECT($H732),0)","v":0},{"$f":"IFERROR(INDIRECT($H732),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 8: \",NameComparator8)","v":"Comparator 8: "},null,null,{"$f":"IFERROR(INDIRECT($F820),0)","v":0},{"$f":"IFERROR(INDIRECT($F820),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 8: \",NameComparator8)","v":"Comparator 8: "},null,null,{"$f":"IFERROR(INDIRECT($H820),0)","v":0},{"$f":"IFERROR(INDIRECT($H820),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 9: \",NameComparator9)","v":"Comparator 9: "},null,null,{"$f":"IFERROR(INDIRECT($F908),0)","v":0},{"$f":"IFERROR(INDIRECT($F908),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 9: \",NameComparator9)","v":"Comparator 9: "},null,null,{"$f":"IFERROR(INDIRECT($H908),0)","v":0},{"$f":"IFERROR(INDIRECT($H908),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 10: \",NameComparator10)","v":"Comparator 10: "},null,null,{"$f":"IFERROR(INDIRECT($F996),0)","v":0},{"$f":"IFERROR(INDIRECT($F996),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 10: \",NameComparator10)","v":"Comparator 10: "},null,null,{"$f":"IFERROR(INDIRECT($H996),0)","v":0},{"$f":"IFERROR(INDIRECT($H996),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 11: \",NameComparator11)","v":"Comparator 11: "},null,null,{"$f":"IFERROR(INDIRECT($F1084),0)","v":0},{"$f":"IFERROR(INDIRECT($F1084),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 11: \",NameComparator11)","v":"Comparator 11: "},null,null,{"$f":"IFERROR(INDIRECT($H1084),0)","v":0},{"$f":"IFERROR(INDIRECT($H1084),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 12: \",NameComparator12)","v":"Comparator 12: "},null,null,{"$f":"IFERROR(INDIRECT($F1172),0)","v":0},{"$f":"IFERROR(INDIRECT($F1172),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 12: \",NameComparator12)","v":"Comparator 12: "},null,null,{"$f":"IFERROR(INDIRECT($H1172),0)","v":0},{"$f":"IFERROR(INDIRECT($H1172),0)","v":0},0,0,0]
[]
[]
[null,{"$f":"CONCATENATE(\"Intervention: \",InterventionINN)","v":"Intervention: "}]
[]
[]
[null,"Table A: Applicant Input Selection Table to calculate the cost per pack",null,null,null,null,null,null,null,null," - Please input all information requested in this table to automatically calculate the cost per pack in Table C. Up to four type of packs  can be accomodated in this table across columns F to I. If there are less than four packs, please leave the extra columns blank. If there are more than four products, please contact bim@ncpe.ie. "]
[null,"Details required to calculate the cost per pack and pharmacy fee information"]
[null,null,null,null,null,"Strength/Pack Size"]
[null,"Pack Identification",null,null,null,null,null,null,null,null," - Enter identifying information (e.g. strength, pack size) for each pack. For example, column F: 40mgx28; column G: 20mgx28. "]
[null,"Calculation Starting Point",null,null,null,null,null,null,null,"\u0080"," - Enter whether the calculation starting point is the Price to Wholesaler (PTW) or Reimbursement Price. PTW is listed on the pricing application form (PAF) submitted to the HSE. Reimbursement price is listed on the PCRS website. "]
[null,"Price per Pack",null,null,null,null,null,null,null,null," - Enter the relevant pack price here.  "]
[null,"Drug Funding Arrangement",null,null,null,null,null,null,null,"\u0080"," - Choose the funding arrangements. CDS = Community Drug Schemes, HT = High Tech Drug Arrangements, Hosp = Hospital. "]
[null,"Fridge",null,null,null,null,null,null,null,"\u0080"," - Optional: fridge item status only required for the CDS as wholesale mark-up varies here. May leave blank for other schemes."]
[null,"Oral product (including inhalers)",null,null,null,null,null,null,null,"\u0080"," - Required for VAT. Oral products including inhalers are exempt from VAT."]
[null,"Biologic",null,null,null,null,null,null,null,"\u0080"," - Required for Framework Agreement rebate calculation."]
[null,"If Biologic =Yes: Select  Biologic and Patent Exclusivity Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =Yes, select the biologic and patent exclusivity status, pre- or post- 2026,  from the drop down list. If Biologic =No, select N/A. Required for Framework Agreement rebate calculation."]
[null,"If Biologic =No,  select Non Biologic Patent Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =No, select the non-biologic patent status, pre- or post- 2026.  If Biologic =Yes, select N/A. Required for Framework Agreement rebate calculation."]
[]
[null,"Table B: Applicant Input Table to calculate the cost per treatment cycle",null,null,null,null,null,null,null,null," - Treatment cycle is the length of time between product dispensings. For example, many oral tablet products have a treatment cycle of 28 days. If a drug is administered every six months, the treatment cycle is six months."]
[null,"Details required to calculate  the cost per treatment cycle"]
[null,"Length of Treatment Cycle",null,null,null,null,null,null,null,null," - Enter treatment cycle length in column F and select unit of measurement (Days/Months) in column H.  For treatment cycles measured in weeks, convert the number of weeks to days (e.g. 4 weeks = 28 days). One month is not equivalent to four weeks. If there is confusion over whether a dose is administered every four weeks or every month, refer to the SPC. "]
[null,{"$f":"B49","v":"Pack Identification"},null,null,null,{"$f":"IF(ISBLANK(F49),\"\",F49)","v":""},{"$f":"IF(ISBLANK(G49),\"\",G49)","v":""},{"$f":"IF(ISBLANK(H49),\"\",H49)","v":""},{"$f":"IF(ISBLANK(I49),\"\",I49)","v":""}]
[null,"Number of packs required per treatment cycle",null,null,null,null,null,null,null,null," - Enter the number of packs of each pack presentation required per treatment cycle. For example if the treatment cycle is 28 days, and there are 14 days supply in one pack, enter \"2\" into column F.  Where each patient requires multiple products every treatment cycle, enter the number of packs of each pack type into the relevant column. For example,  where a patient requires 2 x Pack (F) and 1 x Pack (G) every 28 day treatment cycle, please enter 2 in column F and 1 in column G. Alternatively, where only a single pack is required by a patient each cycle but multiple strengths are available, a weighted average can be calculated by entering the relevant weight for each pack in every column. Ensure weights sum to 1. Add details of how weights are derived in notes section. "]
[]
[]
[]
[null,"Table C. Total Cost to the HSE per pack"]
["This table will fill automatically based on the information inserted above. This information in this table is used to calculate the costs in Table F."]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF(F49=\"\",\"\",F49)","v":""},{"$f":"IF(G49=\"\",\"\",G49)","v":""},{"$f":"IF(H49=\"\",\"\",H49)","v":""},{"$f":"IF(I49=\"\",\"\",I49)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR(F50=\"\",F51=\"\",F52=\"\"),\"\",IF(F50=\"Price to Wholesaler\",F51,IF(F50=\"Reimbursement Price\",(F73/(1+E72)*1),\"Error\")))","v":""},{"$f":"IF(OR(G50=\"\",G51=\"\",F52=\"\"),\"\",IF(G50=\"Price to Wholesaler\",G51,IF(G50=\"Reimbursement Price\",(G73/(1+E72)*1),\"Error\")))","v":""},{"$f":"IF(OR(H50=\"\",H51=\"\",F52=\"\"),\"\",IF(H50=\"Price to Wholesaler\",H51,IF(H50=\"Reimbursement Price\",(H73/(1+E72)*1),\"Error\")))","v":""},{"$f":"IF(OR(I50=\"\",I51=\"\",F52=\"\"),\"\",IF(I50=\"Price to Wholesaler\",I51,IF(I50=\"Reimbursement Price\",(I73/(1+E72)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR(F52=\"\"),\"\",IF(AND(F52=\"CDS\",F53=\"Yes\"),CYF,IF(AND(F52=\"CDS\",F53=\"No\"),CNF,IF(F52=\"HT\",CHT,IF(F52=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR(F52=\"\",F51=\"\",F50=\"\"),\"\",F71*E72)","v":""},{"$f":"IF(OR(F52=\"\",G51=\"\",G50=\"\"),\"\",G71*E72)","v":""},{"$f":"IF(OR(F52=\"\",H51=\"\",H50=\"\"),\"\",H71*E72)","v":""},{"$f":"IF(OR(F52=\"\",I51=\"\",I50=\"\"),\"\",I71*E72)","v":""}]
["C",{"$f":"IF(F52=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF(F50=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF(F50=\"Reimbursement Price\",F51,IF(ISBLANK(E72),\"\",IF(F50=\"Price to Wholesaler\",(F71+F72),IF(F50=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(G50=\"Reimbursement Price\",G51,IF(ISBLANK(E72),\"\",IF(G50=\"Price to Wholesaler\",(G71+G72),IF(G50=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(H50=\"Reimbursement Price\",H51,IF(ISBLANK(E72),\"\",IF(H50=\"Price to Wholesaler\",(H71+H72),IF(H50=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(I50=\"Reimbursement Price\",I51,IF(ISBLANK(E72),\"\",IF(I50=\"Price to Wholesaler\",(I71+I72),IF(I50=\"\",\"\",\"Error\"))))","v":""}]
["D","Framework Agreement Rebate",null,null,{"$f":"IF(OR(F55=\"\",AND(F55=\"Yes\",F56=\"\"),AND(F55=\"No\",F57=\"\")),\"\",IF(AND(F55=\"No\",F57=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (pre-2026)\"),MRpre2026,IF(AND(F55=\"No\",F57=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F55=\"No\",F57=\"Off Patent Non-Exclusive or Generic\"),\"None\",IF(AND(F55=\"Yes\",F56=\"Biosimilar\"),\"None\",IF(AND(F55=\"Yes\",F56=\"Patented or Off Patent Exclusive (pre-2026)\"),MRpre2026,IF(AND(F55=\"Yes\",F56=\"Patented or Off Patent Exclusive (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F55=\"Yes\",F56=\"Off Patent Non-Exclusive 12.5% Rebate incorporated into Price to Wholesaler\"),\"None\",IF(AND(F55=\"Yes\",F56=\"Off Patent Non-Exclusive 12.5% Rebate\"),MRB,\"Error\")))))))))","v":""},{"$f":"IF(OR(F55=\"\",AND(F55=\"Yes\",F56=\"\"),AND(F55=\"No\",F57=\"\"),F50=\"\",ISBLANK(F51)),\"\",IF(E74=\"None\",0,(E74*F71)))","v":""},{"$f":"IF(OR(F55=\"\",AND(F55=\"Yes\",F56=\"\"),AND(F55=\"No\",F57=\"\"),G50=\"\",ISBLANK(G51)),\"\",IF(E74=\"None\",0,(E74*G71)))","v":""},{"$f":"IF(OR(F55=\"\",AND(F55=\"Yes\",F56=\"\"),AND(F55=\"No\",F57=\"\"),H50=\"\",ISBLANK(H51)),\"\",IF(E74=\"None\",0,(E74*H71)))","v":""},{"$f":"IF(OR(F55=\"\",AND(F55=\"Yes\",F56=\"\"),AND(F55=\"No\",F57=\"\"),I50=\"\",ISBLANK(I51)),\"\",IF(E74=\"None\",0,(E74*I71)))","v":""}]
["E","VAT on Drug Cost ",null,null,{"$f":"IF(F54=\"\",\"\",IF(F54=\"Yes\",0,VT))","v":""},{"$f":"IF(OR(F51=\"\",ISBLANK(F51)),\"\",($E75*F73))","v":""},{"$f":"IF(OR(G51=\"\",ISBLANK(G51)),\"\",($E75*G73))","v":""},"",""]
["F(i)","Total Drug Cost to the HSE per pack including VAT",null,null,null,{"$f":"IF(OR(F50=\"\",$F52=\"\",$F54=\"\",$F55=\"\"),\"\",SUM(F73:F75))","v":""},{"$f":"IF(OR(G50=\"\",$F52=\"\",$F54=\"\",$F55=\"\"),\"\",SUM(G73:G75))","v":""},{"$f":"IF(OR(H50=\"\",$F52=\"\",$F54=\"\",$F55=\"\"),\"\",SUM(H73:H75))","v":""},{"$f":"IF(OR(I50=\"\",$F52=\"\",$F54=\"\",$F55=\"\"),\"\",SUM(I73:I75))","v":""}]
["F(ii)","Total Drug Cost to the HSE per pack excluding VAT",null,null,null,{"$f":"IF(OR(F50=\"\",$F52=\"\",$F54=\"\",$F55=\"\"),\"\",SUM(F73:F74))","v":""},{"$f":"IF(OR(G50=\"\",$F52=\"\",$F54=\"\",$F55=\"\"),\"\",SUM(G73:G74))","v":""},{"$f":"IF(OR(H50=\"\",$F52=\"\",$F54=\"\",$F55=\"\"),\"\",SUM(H73:H74))","v":""},{"$f":"IF(OR(I50=\"\",$F52=\"\",$F54=\"\",$F55=\"\"),\"\",SUM(I73:I74))","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table D. Pharmacy Fees payable based on the type of product and reimbursement arrangements"]
[null,"For hospital drugs this table may be ignored."]
[null,"This table fills  automatically based on scheme and product information inputted above in Table A. "]
[]
[null,null,null,null,null,null,"Calculation ","Value"]
[null,"Pharmacy Fees excluding VAT",null,null,null,null,{"$f":"IF(F52=\"\",\"\",IF(F52=\"CDS\",\"per dispensing\",IF(F52=\"HT\",\"per month\",IF(F52=\"Hosp\",\"No Fee\", ERROR))))","v":""},{"$f":"IF(F52=\"\",\"\",IF(F52=\"CDS\",DF,IF(F52=\"HT\",PC,IF(F52=\"Hosp\",\"No Fee\",ERROR))))","v":""},"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         "]
[null,"VAT on Pharmacy Fees",null,null,null,null,{"$f":"IF(OR(F52=\"\",F54=\"\"),\"\",IF(F52=\"Hosp\",\"No Fee\",IF(F52=\"HT\",\"No VAT\",IF(AND(F52=\"CDS\",F54=\"No\"),VT,\"No VAT\"))))","v":""},{"$f":"IF(OR(F54=\"\",F52=\"Hosp\"),\"\",IF(OR(F54=\"Yes\",F52=\"HT\"),0,H84*G85))","v":""}]
[]
[]
["Table E Pharmacy Fees per product treatment cycle. \n",null,null,null,null,null,null,null,null,null," - Based on the drug's dispensing regimen and the NCPE drug cost guidelines, please input the pharmacy fees per treatment cycle. Use data presented in Table D to generate an appropriate formula for Column H of Table E. Notes may be added in column G. "]
["This section may be ommited for hospital drugs",null,null,null,null,null,"Notes","Value",null,null,{"$f":"IF(F52=\"HT\",\"For High tech, if a treatment cycle =28 days the corresponding pharmacy fee is =62.03*12/365.25*28.  The pharmacy fee remains the same regardless of the number of products dispensed that month.\",IF(F52=\"CDS\",\"For CDS, if 2 packets of the same pack presentation are required per treatment cycle, one dispensing fee applies (€5.48). If multiple pack presentations are required, multiple dispensing fees apply\",\"\"))","v":""}]
["G","Pharmacy Fees per treatment cycle excluding VAT"]
["H","Non dispensed patient care fee per treatment cycle (High Tech only)",null,null,null,null,null,null,null,null," - Enter here if relevant. See NCPE drug cost guidelines for more information on non-dispensed patient care fees (High Tech only). "]
["I","VAT on pharmacy Fees",null,null,null,null,null,null,null,null," - Please input VAT payable on pharmacy fees if applicable based on the information presented in Table D. "]
["J (i)","Total pharmacy Fees per treatment cycle including VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H90),\"\",SUM(H90:H92))","v":""}]
["J (ii)","Total pharmacy Fees per treatment cycle excluding VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H90),\"\",SUM(H90:H91))","v":""}]
[]
[]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per treatment Cycle","Total Cost per Year","Total Cost per unit time",null," - Calculate the cost for the budget impact model using  cost per number of cycles, per year or per unit time. Input the length of time required  into the blue boxes where applicable. Irrelevant columns may be left blank. Use the drop down boxes to select days or months when calculating the cost per unit time."]
[]
[null,null,null,null,null,null,"number of cycles"]
["A",{"$f":"B71","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F71:I71,F63:I63)","v":0},{"$f":"F102*G100","v":0},{"$f":"IF(H61=\"Days\",F102/F61*365.25,IF(H61=\"Months\",F102/F61*12,\"\"))","v":""},{"$f":"IF(AND(H61=\"Days\",I101=\"Days\"),F102/F61*I100,IF(AND(H61=\"Months\",I101=\"Months\"),F102/F61*I100,IF(AND(H61=\"Days\",I101=\"Months\"),F102/F61*30.4375*I100,IF(AND(H61=\"Months\",I101=\"Days\"),F102/F61/30.4375*I100,\"\"))))","v":""}]
["B",{"$f":"B72","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F72:I72,F63:I63)","v":0},{"$f":"F103*G100","v":0},{"$f":"IF(H61=\"Days\",F103/F61*365.25,IF(H61=\"Months\",F103/F61*12,\"\"))","v":""},{"$f":"IF(AND(H61=\"Days\",I101=\"Days\"),F103/F61*I100,IF(AND(H61=\"Months\",I101=\"Months\"),F103/F61*I100,IF(AND(H61=\"Days\",I101=\"Months\"),F103/F61*30.4375*I100,IF(AND(H61=\"Months\",I101=\"Days\"),F103/F61/30.4375*I100,\"\"))))","v":""}]
["C",{"$f":"B73","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F73:I73,F63:I63)","v":0},{"$f":"F104*G100","v":0},{"$f":"IF(H61=\"Days\",F104/F61*365.25,IF(H61=\"Months\",F104/F61*12,\"\"))","v":""},{"$f":"IF(AND(H61=\"Days\",I101=\"Days\"),F104/F61*I100,IF(AND(H61=\"Months\",I101=\"Months\"),F104/F61*I100,IF(AND(H61=\"Days\",I101=\"Months\"),F104/F61*30.4375*I100,IF(AND(H61=\"Months\",I101=\"Days\"),F104/F61/30.4375*I100,\"\"))))","v":""}]
["D",{"$f":"B74","v":"Framework Agreement Rebate"},null,null,null,{"$f":"SUMPRODUCT(F74:I74,F63:I63)","v":0},{"$f":"F105*G100","v":0},{"$f":"IF(H61=\"Days\",F105/F61*365.25,IF(H61=\"Months\",F105/F61*12,\"\"))","v":""},{"$f":"IF(AND(H61=\"Days\",I101=\"Days\"),F105/F61*I100,IF(AND(H61=\"Months\",I101=\"Months\"),F105/F61*I100,IF(AND(H61=\"Days\",I101=\"Months\"),F105/F61*30.4375*I100,IF(AND(H61=\"Months\",I101=\"Days\"),F105/F61/30.4375*I100,\"\"))))","v":""}]
["E",{"$f":"B75","v":"VAT on Drug Cost "},null,null,null,{"$f":"SUMPRODUCT(F75:I75,F63:I63)","v":0},{"$f":"F106*G100","v":0},{"$f":"IF(H61=\"Days\",F106/F61*365.25,IF(H61=\"Months\",F106/F61*12,\"\"))","v":""},{"$f":"IF(AND(H61=\"Days\",I101=\"Days\"),F106/F61*I100,IF(AND(H61=\"Months\",I101=\"Months\"),F106/F61*I100,IF(AND(H61=\"Days\",I101=\"Months\"),F106/F61*30.4375*I100,IF(AND(H61=\"Months\",I101=\"Days\"),F106/F61/30.4375*I100,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF(H93=\"\",\"\",H93)","v":""},{"$f":"IF(F107=\"\",\"\",F107*G100)","v":""},{"$f":"IF(F107=\"\",\"\",MIN(IF(H61=\"Days\",F107/F61*365.25,IF(H61=\"Months\",F107/F61*12,\"\")), 744.36))","v":""},{"$f":"IF(F107=\"\",\"\",IF(AND(H61=\"Days\",I101=\"Days\"),F107/F61*I100,IF(AND(H61=\"Months\",I101=\"Months\"),F107/F61*I100,IF(AND(H61=\"Days\",I101=\"Months\"),F107/F61*30.4375*I100,IF(AND(H61=\"Months\",I101=\"Days\"),F107/F61/30.4375*I100,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF(H94=\"\",\"\",H94)","v":""},{"$f":"IF(F108=\"\",\"\",F108*G100)","v":""},{"$f":"IF(F108=\"\",\"\",MIN(IF(H61=\"Days\",F108/F61*365.25,IF(H61=\"Months\",F108/F61*12,\"\")), 744.36))","v":""},{"$f":"IF(F108=\"\",\"\",IF(AND(H61=\"Days\",I101=\"Days\"),F108/F61*I100,IF(AND(H61=\"Months\",I101=\"Months\"),F108/F61*I100,IF(AND(H61=\"Days\",I101=\"Months\"),F108/F61*30.4375*I100,IF(AND(H61=\"Months\",I101=\"Days\"),F108/F61/30.4375*I100,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Intervention",null,null,null,{"$f":"SUM(F104:F107)","v":0},{"$f":"SUM(G104:G107)","v":0},{"$f":"SUM(H104:H107)","v":0},{"$f":"SUM(I104:I107)","v":0},null,"It is important to complete Table F as figures will automatically populate in Tables 1a and 1b based on selections in Table G"]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Intervention",null,null,null,{"$f":"IF(F108=\"\",SUM(F104+F105),F104+F105+F108)","v":0},{"$f":"IF(G108=\"\",SUM(G104+G105),G104+G105+G108)","v":0},{"$f":"IF(H108=\"\",SUM(H104:H105),H104+H105+H108)","v":0},{"$f":"IF(I108=\"\",SUM(I104:I105),I104+I105+I108)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"CONCATENATE(\"Intervention: \",InterventionINN)","v":"Intervention: "},null,null,null,{"$f":"IF($E114=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E114,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$113&\" Intervention\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E114=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E114,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$113&\" Intervention\"),$B:$B,0))","v":{"$error":"#N/A"}},null,null," - Figures will automatically populate in Tables 1a and 1b based on selections in Table G unless selected as \"Calculated elsewhere by Applicant\" in Table G. The corresponding cells will then be coloured blue in Tables 1a and 1b. Please manually overwrite the formula in the blue cells with the appropriate figure if using the manual option."]
[]
[null,"Notes"]
[]
[null,"Source used to inform the duration of treatment (e.g pivotal trial publication/ reference cell in CEM):",null,null,null,null,null,null,null,null,"•\tThe Applicant should provide any additional detail necessary to permit validation of drug cost calculations by the Review Group. \n•\tPlease note that where drug cost calculations are insufficiently described, this will lead to delays in the appraisal process. "]
[null,"Please specify whether the above refers to a particular subpopulation (if applicable):"]
[null,"Source for dosing regimen applied in BIM (e.g product SmPC): "]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 1: \",NameComparator1)","v":"Comparator 1: "}]
[]
[]
[null,"Table A: Applicant Input Selection Table to calculate the cost per pack",null,null,null,null,null,null,null,null," - Please input all information requested in this table to automatically calculate the cost per pack in Table C. Up to four type of packs  can be accomodated in this table across columns F to I. If there are less than four packs, please leave extra columns blank. If there are more than four products, please contact bim@ncpe.ie. "]
[null,"Details required to calculate the cost per pack and pharmacy fee information"]
[null,null,null,null,null,"Strength/Pack Size"]
[null,"Pack Identification",null,null,null,null,null,null,null,null," - Enter identifying information (e.g. strength, pack size) for each pack. For example, column F: 40mgx28; column G: 20mgx28. "]
[null,"Calculation Starting Point",null,null,null,null,null,null,null,"\u0080"," - Enter whether the calculation starting point is the Price to Wholesaler (PTW) or Reimbursement Price. PTW is listed on the pricing application form (PAF) submitted to the HSE. Reimbursement price is listed on the PCRS website. "]
[null,"Price per Pack",null,null,null,null,null,null,null,null," - Enter the relevant pack price here.  "]
[null,"Drug Funding Arrangement",null,null,null,null,null,null,null,"\u0080"," - Choose the funding arrangements. CDS = Community Drug Schemes, HT = High Tech Drug Arrangements, Hosp = Hospital. "]
[null,"Fridge",null,null,null,null,null,null,null,"\u0080"," - Optional: fridge item status only required for the CDS as wholesale mark-up varies here. May leave blank for other schemes."]
[null,"Oral product (including inhalers)",null,null,null,null,null,null,null,"\u0080"," - Required for VAT. Oral products including inhalers are exempt from VAT."]
[null,"Biologic",null,null,null,null,null,null,null,"\u0080"," - Required for Frameowrk Agreement rebate calculation."]
[null,"If Biologic =Yes: Select  Biologic and Patent Exclusivity Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =Yes, select the biologic and patent exclusivity status, pre- or post- 2026,  from the drop down list. If Biologic =No, select N/A. Required for Framework Agreement rebate calculation."]
[null,"If Biologic =No,  select Non Biologic Patent Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =No, select the non-biologic patent status, pre- or post- 2026.  If Biologic =Yes, select N/A. Required for Framework Agreement rebate calculation."]
[]
[null,"Table B: Applicant Input Table to calculate the cost per treatment cycle",null,null,null,null,null,null,null,null," - Treatment cycle is the length of time between product dispensings. For example, many oral tablet products have a treatment cycle of 28 days. If a drug is administered every six months, the treatment cycle is six months."]
[null,"Details required to calculate  the cost per treatment cycle"]
[null,"Length of Treatment Cycle",null,null,null,null,null,null,null,null," - Enter treatment cycle length in column F and select unit of measurement (Days/Months) in column H.  For treatment cycles measured in weeks, convert the number of weeks to days (e.g. 4 weeks = 28 days). One month is not equivalent to four weeks. If there is confusion over whether a dose is administered every four weeks or every month, refer to the SPC. "]
[null,{"$f":"B137","v":"Pack Identification"},null,null,null,{"$f":"IF(ISBLANK(F137),\"\",F137)","v":""},{"$f":"IF(ISBLANK(G137),\"\",G137)","v":""},{"$f":"IF(ISBLANK(H137),\"\",H137)","v":""},{"$f":"IF(ISBLANK(I137),\"\",I137)","v":""}]
[null,"Number of packs required per treatment cycle",null,null,null,null,null,null,null,null," - Enter the number of packs of each pack presentation required per treatment cycle. For example if the treatment cycle is 28 days, and there are 14 days supply in one pack, enter \"2\" into column F.  Where each patient requires multiple products every treatment cycle, enter the number of packs of each pack type into the relevant column. For example,  where a patient requires 2 x Pack (F) and 1 x Pack (G) every 28 day treatment cycle, please enter 2 in column F and 1 in column G. Alternatively, where only a single pack is required by a patient each cycle but multiple strengths are available, a weighted average can be calculated by entering the relevant weight for each pack in every column. Ensure weights sum to 1. Add details of how weights are derived in notes section. "]
[]
[]
[]
[null,"Table C. Total Cost to the HSE per pack"]
["This table will fill automatically based on the information inserted above. This information in this table is used to calculate the costs in Table F."]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF(F137=\"\",\"\",F137)","v":""},{"$f":"IF(G137=\"\",\"\",G137)","v":""},{"$f":"IF(H137=\"\",\"\",H137)","v":""},{"$f":"IF(I137=\"\",\"\",I137)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR(F138=\"\",F139=\"\",F140=\"\"),\"\",IF(F138=\"Price to Wholesaler\",F139,IF(F138=\"Reimbursement Price\",(F161/(1+E160)*1),\"Error\")))","v":""},{"$f":"IF(OR(G138=\"\",G139=\"\",F140=\"\"),\"\",IF(G138=\"Price to Wholesaler\",G139,IF(G138=\"Reimbursement Price\",(G161/(1+E160)*1),\"Error\")))","v":""},{"$f":"IF(OR(H138=\"\",H139=\"\",F140=\"\"),\"\",IF(H138=\"Price to Wholesaler\",H139,IF(H138=\"Reimbursement Price\",(H161/(1+E160)*1),\"Error\")))","v":""},{"$f":"IF(OR(I138=\"\",I139=\"\",F140=\"\"),\"\",IF(I138=\"Price to Wholesaler\",I139,IF(I138=\"Reimbursement Price\",(I161/(1+E160)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR(F140=\"\"),\"\",IF(AND(F140=\"CDS\",F141=\"Yes\"),CYF,IF(AND(F140=\"CDS\",F141=\"No\"),CNF,IF(F140=\"HT\",CHT,IF(F140=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR(F140=\"\",F139=\"\",F138=\"\"),\"\",F159*E160)","v":""},{"$f":"IF(OR(F140=\"\",G139=\"\",G138=\"\"),\"\",G159*E160)","v":""},{"$f":"IF(OR(F140=\"\",H139=\"\",H138=\"\"),\"\",H159*E160)","v":""},{"$f":"IF(OR(F140=\"\",I139=\"\",I138=\"\"),\"\",I159*E160)","v":""}]
["C",{"$f":"IF(F140=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF(F138=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF(F138=\"Reimbursement Price\",F139,IF(ISBLANK(E160),\"\",IF(F138=\"Price to Wholesaler\",(F159+F160),IF(F138=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(G138=\"Reimbursement Price\",G139,IF(ISBLANK(E160),\"\",IF(G138=\"Price to Wholesaler\",(G159+G160),IF(G138=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(H138=\"Reimbursement Price\",H139,IF(ISBLANK(E160),\"\",IF(H138=\"Price to Wholesaler\",(H159+H160),IF(H138=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(I138=\"Reimbursement Price\",I139,IF(ISBLANK(E160),\"\",IF(I138=\"Price to Wholesaler\",(I159+I160),IF(I138=\"\",\"\",\"Error\"))))","v":""}]
["D","Framework Agreement Rebate",null,null,{"$f":"IF(OR(F143=\"\",AND(F143=\"Yes\",F144=\"\"),AND(F143=\"No\",F145=\"\")),\"\",IF(AND(F143=\"No\",F145=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (pre-2026)\"),MRpre2026,IF(AND(F143=\"No\",F145=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F143=\"No\",F145=\"Off Patent Non-Exclusive or Generic\"),\"None\",IF(AND(F143=\"Yes\",F144=\"Biosimilar\"),\"None\",IF(AND(F143=\"Yes\",F144=\"Patented or Off Patent Exclusive (pre-2026)\"),MRpre2026,IF(AND(F143=\"Yes\",F144=\"Patented or Off Patent Exclusive (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F143=\"Yes\",F144=\"Off Patent Non-Exclusive 12.5% Rebate incorporated into Price to Wholesaler\"),\"None\",IF(AND(F143=\"Yes\",F144=\"Off Patent Non-Exclusive 12.5% Rebate\"),MRB,\"Error\")))))))))","v":""},{"$f":"IF(OR(F143=\"\",AND(F143=\"Yes\",F144=\"\"),AND(F143=\"No\",F145=\"\"),F138=\"\",ISBLANK(F139)),\"\",IF(E162=\"None\",0,(E162*F159)))","v":""},{"$f":"IF(OR(F143=\"\",AND(F143=\"Yes\",F144=\"\"),AND(F143=\"No\",F145=\"\"),G138=\"\",ISBLANK(G139)),\"\",IF(E162=\"None\",0,(E162*G159)))","v":""},{"$f":"IF(OR(F143=\"\",AND(F143=\"Yes\",F144=\"\"),AND(F143=\"No\",F145=\"\"),H138=\"\",ISBLANK(H139)),\"\",IF(E162=\"None\",0,(E162*H159)))","v":""},{"$f":"IF(OR(F143=\"\",AND(F143=\"Yes\",F144=\"\"),AND(F143=\"No\",F145=\"\"),I138=\"\",ISBLANK(I139)),\"\",IF(E162=\"None\",0,(E162*I159)))","v":""}]
["E","VAT on Drug Cost ",null,null,{"$f":"IF(F142=\"\",\"\",IF(F142=\"Yes\",0,VT))","v":""},{"$f":"IF(OR(F139=\"\",ISBLANK(F139)),\"\",($E163*F161))","v":""},{"$f":"IF(OR(G139=\"\",ISBLANK(G139)),\"\",($E163*G161))","v":""},"",""]
["F(i)","Total Drug Cost to the HSE per pack including VAT",null,null,null,{"$f":"IF(OR(F138=\"\",$F140=\"\",$F142=\"\",$F143=\"\"),\"\",SUM(F161:F163))","v":""},{"$f":"IF(OR(G138=\"\",$F140=\"\",$F142=\"\",$F143=\"\"),\"\",SUM(G161:G163))","v":""},{"$f":"IF(OR(H138=\"\",$F140=\"\",$F142=\"\",$F143=\"\"),\"\",SUM(H161:H163))","v":""},{"$f":"IF(OR(I138=\"\",$F140=\"\",$F142=\"\",$F143=\"\"),\"\",SUM(I161:I163))","v":""}]
["F(ii)","Total Drug Cost to the HSE per pack excluding VAT",null,null,null,{"$f":"IF(OR(F138=\"\",$F140=\"\",$F142=\"\",$F143=\"\"),\"\",SUM(F161:F162))","v":""},{"$f":"IF(OR(G138=\"\",$F140=\"\",$F142=\"\",$F143=\"\"),\"\",SUM(G161:G162))","v":""},{"$f":"IF(OR(H138=\"\",$F140=\"\",$F142=\"\",$F143=\"\"),\"\",SUM(H161:H162))","v":""},{"$f":"IF(OR(I138=\"\",$F140=\"\",$F142=\"\",$F143=\"\"),\"\",SUM(I161:I162))","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table D. Pharmacy Fees payable based on the type of product and reimbursement arrangements"]
[null,"For hospital drugs this table may be ignored."]
[null,"This table fills  automatically based on scheme and product information inputted above in Table A. "]
[]
[null,null,null,null,null,null,"Calculation ","Value"]
[null,"Pharmacy Fees excluding VAT",null,null,null,null,{"$f":"IF(F140=\"\",\"\",IF(F140=\"CDS\",\"per dispensing\",IF(F140=\"HT\",\"per month\",IF(F140=\"Hosp\",\"No Fee\", ERROR))))","v":""},{"$f":"IF(F140=\"\",\"\",IF(F140=\"CDS\",DF,IF(F140=\"HT\",PC,IF(F140=\"Hosp\",\"No Fee\",ERROR))))","v":""},"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         "]
[null,"VAT on Pharmacy Fees",null,null,null,null,{"$f":"IF(OR(F140=\"\",F142=\"\"),\"\",IF(F140=\"Hosp\",\"No Fee\",IF(F140=\"HT\",\"No VAT\",IF(AND(F140=\"CDS\",F142=\"No\"),VT,\"No VAT\"))))","v":""},{"$f":"IF(OR(F142=\"\",F140=\"Hosp\"),\"\",IF(OR(F142=\"Yes\",F140=\"HT\"),0,H172*G173))","v":""}]
[]
[]
["Table E Pharmacy Fees per product treatment cycle. \n",null,null,null,null,null,null,null,null,null," - Based on the drug's dispensing regimen and the NCPE drug cost guidelines, please input the pharmacy fees per treatment cycle. Use data presented in Table D to generate an appropriate formula for Column H of Table E. Notes may be added in column G. "]
["This section may be ommited for hospital drugs",null,null,null,null,null,"Notes","Value",null,null,{"$f":"IF(F140=\"HT\",\"For High tech, if a treatment cycle =28 days the corresponding pharmacy fee is =62.03*12/365.25*28.  The pharmacy fee remains the same regardless of the number of products dispensed that month.\",IF(F140=\"CDS\",\"For CDS, if 2 packets of the same pack presentation are required per treatment cycle, one dispensing fee applies (€5.48). If multiple pack presentations are required, multiple dispensing fees apply\",\"\"))","v":""}]
["G","Pharmacy Fees per treatment cycle excluding VAT"]
["H","Non dispensed patient care fee per treatment cycle (High Tech only)",null,null,null,null,null,null,null,null," - Enter here if relevant. See NCPE drug cost guidelines for more information on non-dispensed patient care fees (High Tech only). "]
["I","VAT on pharmacy Fees",null,null,null,null,null,null,null,null," - Please input VAT payable on pharmacy fees if applicable based on the information presented in Table D. "]
["J (i)","Total pharmacy Fees per treatment cycle including VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H178),\"\",SUM(H178:H180))","v":""}]
["J (ii)","Total pharmacy Fees per treatment cycle excluding VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H178),\"\",SUM(H178:H179))","v":""}]
[]
[]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time",null," - Calculate the cost for the budget impact model using  cost per number of cycles, per year or per unit time. Input the length of time required  into the blue boxes where applicable. Irrelevant columns may be left blank. Use the drop down boxes to select days or months when calculating the cost per unit time."]
[]
[null,null,null,null,null,null,"number of cycles"]
["A",{"$f":"B159","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F159:I159,F151:I151)","v":0},{"$f":"F190*G188","v":0},{"$f":"IF(H149=\"Days\",F190/F149*365.25,IF(H149=\"Months\",F190/F149*12,\"\"))","v":""},{"$f":"IF(AND(H149=\"Days\",I189=\"Days\"),F190/F149*I188,IF(AND(H149=\"Months\",I189=\"Months\"),F190/F149*I188,IF(AND(H149=\"Days\",I189=\"Months\"),F190/F149*30.4375*I188,IF(AND(H149=\"Months\",I189=\"Days\"),F190/F149/30.4375*I188,\"\"))))","v":""}]
["B",{"$f":"B160","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F160:I160,F151:I151)","v":0},{"$f":"F191*G188","v":0},{"$f":"IF(H149=\"Days\",F191/F149*365.25,IF(H149=\"Months\",F191/F149*12,\"\"))","v":""},{"$f":"IF(AND(H149=\"Days\",I189=\"Days\"),F191/F149*I188,IF(AND(H149=\"Months\",I189=\"Months\"),F191/F149*I188,IF(AND(H149=\"Days\",I189=\"Months\"),F191/F149*30.4375*I188,IF(AND(H149=\"Months\",I189=\"Days\"),F191/F149/30.4375*I188,\"\"))))","v":""}]
["C",{"$f":"B161","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F161:I161,F151:I151)","v":0},{"$f":"F192*G188","v":0},{"$f":"IF(H149=\"Days\",F192/F149*365.25,IF(H149=\"Months\",F192/F149*12,\"\"))","v":""},{"$f":"IF(AND(H149=\"Days\",I189=\"Days\"),F192/F149*I188,IF(AND(H149=\"Months\",I189=\"Months\"),F192/F149*I188,IF(AND(H149=\"Days\",I189=\"Months\"),F192/F149*30.4375*I188,IF(AND(H149=\"Months\",I189=\"Days\"),F192/F149/30.4375*I188,\"\"))))","v":""}]
["D",{"$f":"B162","v":"Framework Agreement Rebate"},null,null,null,{"$f":"SUMPRODUCT(F162:I162,F151:I151)","v":0},{"$f":"F193*G188","v":0},{"$f":"IF(H149=\"Days\",F193/F149*365.25,IF(H149=\"Months\",F193/F149*12,\"\"))","v":""},{"$f":"IF(AND(H149=\"Days\",I189=\"Days\"),F193/F149*I188,IF(AND(H149=\"Months\",I189=\"Months\"),F193/F149*I188,IF(AND(H149=\"Days\",I189=\"Months\"),F193/F149*30.4375*I188,IF(AND(H149=\"Months\",I189=\"Days\"),F193/F149/30.4375*I188,\"\"))))","v":""}]
["E",{"$f":"B163","v":"VAT on Drug Cost "},null,null,null,{"$f":"SUMPRODUCT(F163:I163,F151:I151)","v":0},{"$f":"F194*G188","v":0},{"$f":"IF(H149=\"Days\",F194/F149*365.25,IF(H149=\"Months\",F194/F149*12,\"\"))","v":""},{"$f":"IF(AND(H149=\"Days\",I189=\"Days\"),F194/F149*I188,IF(AND(H149=\"Months\",I189=\"Months\"),F194/F149*I188,IF(AND(H149=\"Days\",I189=\"Months\"),F194/F149*30.4375*I188,IF(AND(H149=\"Months\",I189=\"Days\"),F194/F149/30.4375*I188,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF(H181=\"\",\"\",H181)","v":""},{"$f":"IF(F195=\"\",\"\",F195*G188)","v":""},{"$f":"IF(F195=\"\",\"\",MIN(IF(H149=\"Days\",F195/F149*365.25,IF(H149=\"Months\",F195/F149*12,\"\")), 744.36))","v":""},{"$f":"IF(F195=\"\",\"\",IF(AND(H149=\"Days\",I189=\"Days\"),F195/F149*I188,IF(AND(H149=\"Months\",I189=\"Months\"),F195/F149*I188,IF(AND(H149=\"Days\",I189=\"Months\"),F195/F149*30.4375*I188,IF(AND(H149=\"Months\",I189=\"Days\"),F195/F149/30.4375*I188,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF(H182=\"\",\"\",H182)","v":""},{"$f":"IF(F196=\"\",\"\",F196*G188)","v":""},{"$f":"IF(F196=\"\",\"\",MIN(IF(H149=\"Days\",F196/F149*365.25,IF(H149=\"Months\",F196/F149*12,\"\")), 744.36))","v":""},{"$f":"IF(F196=\"\",\"\",IF(AND(H149=\"Days\",I189=\"Days\"),F196/F149*I188,IF(AND(H149=\"Months\",I189=\"Months\"),F196/F149*I188,IF(AND(H149=\"Days\",I189=\"Months\"),F196/F149*30.4375*I188,IF(AND(H149=\"Months\",I189=\"Days\"),F196/F149/30.4375*I188,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 1",null,null,null,{"$f":"SUM(F192:F195)","v":0},{"$f":"SUM(G192:G195)","v":0},{"$f":"SUM(H192:H195)","v":0},{"$f":"SUM(I192:I195)","v":0},null,"It is important to complete Table F as figures will automatically populate in Tables 1a and 1b based on selections in Table G"]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 1",null,null,null,{"$f":"IF(F196=\"\",SUM(F192+F193),F192+F193+F196)","v":0},{"$f":"IF(G196=\"\",SUM(G192+G193),G192+G193+G196)","v":0},{"$f":"IF(H196=\"\",SUM(H192:H193),H192+H193+H196)","v":0},{"$f":"IF(I196=\"\",SUM(I192:I193),I192+I193+I196)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"CONCATENATE(\"Comparator 1: \",NameComparator1)","v":"Comparator 1: "},null,null,null,{"$f":"IF($E202=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E202,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$113&\" Comparator 1\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E202=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E202,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$113&\" Comparator 1\"),$B:$B,0))","v":{"$error":"#N/A"}},null,null," - Figures will automatically populate in Tables 1a and 1b based on selections in Table G unless selected as \"Calculated elsewhere by Applicant\" in Table G. The corresponding cells will then be coloured blue in Tables 1a and 1b. Please manually overwrite the formula in the blue cells with the appropriate figure if using the manual option."]
[]
[null,"Notes"]
[]
[null,"Source used to inform the duration of treatment (e.g pivotal trial publication/ reference cell in CEM):",null,null,null,null,null,null,null,null,"•\tThe Applicant should provide any additional detail necessary to permit validation of drug cost calculations by the Review Group. \n•\tPlease note that where drug cost calculations are insufficiently described, this will lead to delays in the appraisal process. "]
[null,"Please specify whether the above refers to a particular subpopulation (if applicable):"]
[null,"Source for dosing regimen applied in BIM (e.g product SmPC): "]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 2: \",NameComparator2)","v":"Comparator 2: "}]
[]
[]
[null,"Table A: Applicant Input Selection Table to calculate the cost per pack",null,null,null,null,null,null,null,null," - Please input all information requested in this table to automatically calculate the cost per pack in Table C. Up to four type of packs  can be accomodated in this table across columns F to I. If there are less than four packs, please leave extra columns blank. If there are more than four products, please contact bim@ncpe.ie. "]
[null,"Details required to calculate the cost per pack and pharmacy fee information"]
[null,null,null,null,null,"Strength/Pack Size"]
[null,"Pack Identification",null,null,null,null,null,null,null,null," - Enter identifying information (e.g. strength, pack size) for each pack. For example, column F: 40mgx28; column G: 20mgx28. "]
[null,"Calculation Starting Point",null,null,null,null,null,null,null,"\u0080"," - Enter whether the calculation starting point is the Price to Wholesaler (PTW) or Reimbursement Price. PTW is listed on the pricing application form (PAF) submitted to the HSE. Reimbursement price is listed on the PCRS website. "]
[null,"Price per Pack",null,null,null,null,null,null,null,null," - Enter the relevant pack price here.  "]
[null,"Drug Funding Arrangement",null,null,null,null,null,null,null,"\u0080"," - Choose the funding arrangements. CDS = Community Drug Schemes, HT = High Tech Drug Arrangements, Hosp = Hospital. "]
[null,"Fridge",null,null,null,null,null,null,null,"\u0080"," - Optional: fridge item status only required for the CDS as wholesale mark-up varies here. May leave blank for other schemes."]
[null,"Oral product (including inhalers)",null,null,null,null,null,null,null,"\u0080"," - Required for VAT. Oral products including inhalers are exempt from VAT."]
[null,"Biologic",null,null,null,null,null,null,null,"\u0080"," - Required for Framework Agreement rebate calculation."]
[null,"If Biologic =Yes: Select  Biologic and Patent Exclusivity Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =Yes, select the biologic and patent exclusivity status, pre- or post- 2026,  from the drop down list. If Biologic =No, select N/A. Required for Framework Agreement rebate calculation."]
[null,"If Biologic =No,  select Non Biologic Patent Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =No, select the non-biologic patent status, pre- or post- 2026.  If Biologic =Yes, select N/A. Required for Framework Agreement rebate calculation."]
[]
[null,"Table B: Applicant Input Table to calculate the cost per treatment cycle",null,null,null,null,null,null,null,null," - Treatment cycle is the length of time between product dispensings. For example, many oral tablet products have a treatment cycle of 28 days. If a drug is administered every six months, the treatment cycle is six months."]
[null,"Details required to calculate  the cost per treatment cycle"]
[null,"Length of Treatment Cycle",null,null,null,null,null,null,null,null," - Enter treatment cycle length in column F and select unit of measurement (Days/Months) in column H.  For treatment cycles measured in weeks, convert the number of weeks to days (e.g. 4 weeks = 28 days). One month is not equivalent to four weeks. If there is confusion over whether a dose is administered every four weeks or every month, refer to the SPC. "]
[null,{"$f":"B225","v":"Pack Identification"},null,null,null,{"$f":"IF(ISBLANK(F225),\"\",F225)","v":""},{"$f":"IF(ISBLANK(G225),\"\",G225)","v":""},{"$f":"IF(ISBLANK(H225),\"\",H225)","v":""},{"$f":"IF(ISBLANK(I225),\"\",I225)","v":""}]
[null,"Number of packs required per treatment cycle",null,null,null,null,null,null,null,null," - Enter the number of packs of each pack presentation required per treatment cycle. For example if the treatment cycle is 28 days, and there are 14 days supply in one pack, enter \"2\" into column F.  Where each patient requires multiple products every treatment cycle, enter the number of packs of each pack type into the relevant column. For example,  where a patient requires 2 x Pack (F) and 1 x Pack (G) every 28 day treatment cycle, please enter 2 in column F and 1 in column G. Alternatively, where only a single pack is required by a patient each cycle but multiple strengths are available, a weighted average can be calculated by entering the relevant weight for each pack in every column. Ensure weights sum to 1. Add details of how weights are derived in notes section. "]
[]
[]
[]
[null,"Table C. Total Cost to the HSE per pack"]
["This table will fill automatically based on the information inserted above. This information in this table is used to calculate the costs in Table F."]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF(F225=\"\",\"\",F225)","v":""},{"$f":"IF(G225=\"\",\"\",G225)","v":""},{"$f":"IF(H225=\"\",\"\",H225)","v":""},{"$f":"IF(I225=\"\",\"\",I225)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR(F226=\"\",F227=\"\",F228=\"\"),\"\",IF(F226=\"Price to Wholesaler\",F227,IF(F226=\"Reimbursement Price\",(F249/(1+E248)*1),\"Error\")))","v":""},{"$f":"IF(OR(G226=\"\",G227=\"\",F228=\"\"),\"\",IF(G226=\"Price to Wholesaler\",G227,IF(G226=\"Reimbursement Price\",(G249/(1+E248)*1),\"Error\")))","v":""},{"$f":"IF(OR(H226=\"\",H227=\"\",F228=\"\"),\"\",IF(H226=\"Price to Wholesaler\",H227,IF(H226=\"Reimbursement Price\",(H249/(1+E248)*1),\"Error\")))","v":""},{"$f":"IF(OR(I226=\"\",I227=\"\",F228=\"\"),\"\",IF(I226=\"Price to Wholesaler\",I227,IF(I226=\"Reimbursement Price\",(I249/(1+E248)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR(F228=\"\"),\"\",IF(AND(F228=\"CDS\",F229=\"Yes\"),CYF,IF(AND(F228=\"CDS\",F229=\"No\"),CNF,IF(F228=\"HT\",CHT,IF(F228=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR(F228=\"\",F227=\"\",F226=\"\"),\"\",F247*E248)","v":""},{"$f":"IF(OR(F228=\"\",G227=\"\",G226=\"\"),\"\",G247*E248)","v":""},{"$f":"IF(OR(F228=\"\",H227=\"\",H226=\"\"),\"\",H247*E248)","v":""},{"$f":"IF(OR(F228=\"\",I227=\"\",I226=\"\"),\"\",I247*E248)","v":""}]
["C",{"$f":"IF(F228=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF(F226=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF(F226=\"Reimbursement Price\",F227,IF(ISBLANK(E248),\"\",IF(F226=\"Price to Wholesaler\",(F247+F248),IF(F226=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(G226=\"Reimbursement Price\",G227,IF(ISBLANK(E248),\"\",IF(G226=\"Price to Wholesaler\",(G247+G248),IF(G226=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(H226=\"Reimbursement Price\",H227,IF(ISBLANK(E248),\"\",IF(H226=\"Price to Wholesaler\",(H247+H248),IF(H226=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(I226=\"Reimbursement Price\",I227,IF(ISBLANK(E248),\"\",IF(I226=\"Price to Wholesaler\",(I247+I248),IF(I226=\"\",\"\",\"Error\"))))","v":""}]
["D","Framework Agreement Rebate",null,null,{"$f":"IF(OR(F231=\"\",AND(F231=\"Yes\",F232=\"\"),AND(F231=\"No\",F233=\"\")),\"\",IF(AND(F231=\"No\",F233=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (pre-2026)\"),MRpre2026,IF(AND(F231=\"No\",F233=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F231=\"No\",F233=\"Off Patent Non-Exclusive or Generic\"),\"None\",IF(AND(F231=\"Yes\",F232=\"Biosimilar\"),\"None\",IF(AND(F231=\"Yes\",F232=\"Patented or Off Patent Exclusive (pre-2026)\"),MRpre2026,IF(AND(F231=\"Yes\",F232=\"Patented or Off Patent Exclusive (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F231=\"Yes\",F232=\"Off Patent Non-Exclusive 12.5% Rebate incorporated into Price to Wholesaler\"),\"None\",IF(AND(F231=\"Yes\",F232=\"Off Patent Non-Exclusive 12.5% Rebate\"),MRB,\"Error\")))))))))","v":""},{"$f":"IF(OR(F231=\"\",AND(F231=\"Yes\",F232=\"\"),AND(F231=\"No\",F233=\"\"),F226=\"\",ISBLANK(F227)),\"\",IF(E250=\"None\",0,(E250*F247)))","v":""},{"$f":"IF(OR(F231=\"\",AND(F231=\"Yes\",F232=\"\"),AND(F231=\"No\",F233=\"\"),G226=\"\",ISBLANK(G227)),\"\",IF(E250=\"None\",0,(E250*G247)))","v":""},{"$f":"IF(OR(F231=\"\",AND(F231=\"Yes\",F232=\"\"),AND(F231=\"No\",F233=\"\"),H226=\"\",ISBLANK(H227)),\"\",IF(E250=\"None\",0,(E250*H247)))","v":""},{"$f":"IF(OR(F231=\"\",AND(F231=\"Yes\",F232=\"\"),AND(F231=\"No\",F233=\"\"),I226=\"\",ISBLANK(I227)),\"\",IF(E250=\"None\",0,(E250*I247)))","v":""}]
["E","VAT on Drug Cost ",null,null,{"$f":"IF(F230=\"\",\"\",IF(F230=\"Yes\",0,VT))","v":""},{"$f":"IF(OR(F227=\"\",ISBLANK(F227)),\"\",($E251*F249))","v":""},{"$f":"IF(OR(G227=\"\",ISBLANK(G227)),\"\",($E251*G249))","v":""},"",""]
["F(i)","Total Drug Cost to the HSE per pack including VAT",null,null,null,{"$f":"IF(OR(F226=\"\",$F228=\"\",$F230=\"\",$F231=\"\"),\"\",SUM(F249:F251))","v":""},{"$f":"IF(OR(G226=\"\",$F228=\"\",$F230=\"\",$F231=\"\"),\"\",SUM(G249:G251))","v":""},{"$f":"IF(OR(H226=\"\",$F228=\"\",$F230=\"\",$F231=\"\"),\"\",SUM(H249:H251))","v":""},{"$f":"IF(OR(I226=\"\",$F228=\"\",$F230=\"\",$F231=\"\"),\"\",SUM(I249:I251))","v":""}]
["F(ii)","Total Drug Cost to the HSE per pack excluding VAT",null,null,null,{"$f":"IF(OR(F226=\"\",$F228=\"\",$F230=\"\",$F231=\"\"),\"\",SUM(F249:F250))","v":""},{"$f":"IF(OR(G226=\"\",$F228=\"\",$F230=\"\",$F231=\"\"),\"\",SUM(G249:G250))","v":""},{"$f":"IF(OR(H226=\"\",$F228=\"\",$F230=\"\",$F231=\"\"),\"\",SUM(H249:H250))","v":""},{"$f":"IF(OR(I226=\"\",$F228=\"\",$F230=\"\",$F231=\"\"),\"\",SUM(I249:I250))","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table D. Pharmacy Fees payable based on the type of product and reimbursement arrangements"]
[null,"For hospital drugs this table may be ignored."]
[null,"This table fills  automatically based on scheme and product information inputted above in Table A. "]
[]
[null,null,null,null,null,null,"Calculation ","Value"]
[null,"Pharmacy Fees excluding VAT",null,null,null,null,{"$f":"IF(F228=\"\",\"\",IF(F228=\"CDS\",\"per dispensing\",IF(F228=\"HT\",\"per month\",IF(F228=\"Hosp\",\"No Fee\", ERROR))))","v":""},{"$f":"IF(F228=\"\",\"\",IF(F228=\"CDS\",DF,IF(F228=\"HT\",PC,IF(F228=\"Hosp\",\"No Fee\",ERROR))))","v":""},"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         "]
[null,"VAT on Pharmacy Fees",null,null,null,null,{"$f":"IF(OR(F228=\"\",F230=\"\"),\"\",IF(F228=\"Hosp\",\"No Fee\",IF(F228=\"HT\",\"No VAT\",IF(AND(F228=\"CDS\",F230=\"No\"),VT,\"No VAT\"))))","v":""},{"$f":"IF(OR(F230=\"\",F228=\"Hosp\"),\"\",IF(OR(F230=\"Yes\",F228=\"HT\"),0,H260*G261))","v":""}]
[]
[]
["Table E Pharmacy Fees per product treatment cycle. \n",null,null,null,null,null,null,null,null,null," - Based on the drug's dispensing regimen and the NCPE drug cost guidelines, please input the pharmacy fees per treatment cycle. Use data presented in Table D to generate an appropriate formula for Column H of Table E. Notes may be added in column G. "]
["This section may be ommited for hospital drugs",null,null,null,null,null,"Notes","Value",null,null,{"$f":"IF(F228=\"HT\",\"For High tech, if a treatment cycle =28 days the corresponding pharmacy fee is =62.03*12/365.25*28.  The pharmacy fee remains the same regardless of the number of products dispensed that month.\",IF(F228=\"CDS\",\"For CDS, if 2 packets of the same pack presentation are required per treatment cycle, one dispensing fee applies (€5.48). If multiple pack presentations are required, multiple dispensing fees apply\",\"\"))","v":""}]
["G","Pharmacy Fees per treatment cycle excluding VAT"]
["H","Non dispensed patient care fee per treatment cycle (High Tech only)",null,null,null,null,null,null,null,null," - Enter here if relevant. See NCPE drug cost guidelines for more information on non-dispensed patient care fees (High Tech only). "]
["I","VAT on pharmacy Fees",null,null,null,null,null,null,null,null," - Please input VAT payable on pharmacy fees if applicable based on the information presented in Table D. "]
["J (i)","Total pharmacy Fees per treatment cycle including VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H266),\"\",SUM(H266:H268))","v":""}]
["J (ii)","Total pharmacy Fees per treatment cycle excluding VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H266),\"\",SUM(H266:H267))","v":""}]
[]
[]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time",null," - Calculate the cost for the budget impact model using  cost per number of cycles, per year or per unit time. Input the length of time required  into the blue boxes where applicable. Irrelevant columns may be left blank. Use the drop down boxes to select days or months when calculating the cost per unit time."]
[]
[null,null,null,null,null,null,"number of cycles"]
["A",{"$f":"B247","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F247:I247,F239:I239)","v":0},{"$f":"F278*G276","v":0},{"$f":"IF(H237=\"Days\",F278/F237*365.25,IF(H237=\"Months\",F278/F237*12,\"\"))","v":""},{"$f":"IF(AND(H237=\"Days\",I277=\"Days\"),F278/F237*I276,IF(AND(H237=\"Months\",I277=\"Months\"),F278/F237*I276,IF(AND(H237=\"Days\",I277=\"Months\"),F278/F237*30.4375*I276,IF(AND(H237=\"Months\",I277=\"Days\"),F278/F237/30.4375*I276,\"\"))))","v":""}]
["B",{"$f":"B248","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F248:I248,F239:I239)","v":0},{"$f":"F279*G276","v":0},{"$f":"IF(H237=\"Days\",F279/F237*365.25,IF(H237=\"Months\",F279/F237*12,\"\"))","v":""},{"$f":"IF(AND(H237=\"Days\",I277=\"Days\"),F279/F237*I276,IF(AND(H237=\"Months\",I277=\"Months\"),F279/F237*I276,IF(AND(H237=\"Days\",I277=\"Months\"),F279/F237*30.4375*I276,IF(AND(H237=\"Months\",I277=\"Days\"),F279/F237/30.4375*I276,\"\"))))","v":""}]
["C",{"$f":"B249","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F249:I249,F239:I239)","v":0},{"$f":"F280*G276","v":0},{"$f":"IF(H237=\"Days\",F280/F237*365.25,IF(H237=\"Months\",F280/F237*12,\"\"))","v":""},{"$f":"IF(AND(H237=\"Days\",I277=\"Days\"),F280/F237*I276,IF(AND(H237=\"Months\",I277=\"Months\"),F280/F237*I276,IF(AND(H237=\"Days\",I277=\"Months\"),F280/F237*30.4375*I276,IF(AND(H237=\"Months\",I277=\"Days\"),F280/F237/30.4375*I276,\"\"))))","v":""}]
["D",{"$f":"B250","v":"Framework Agreement Rebate"},null,null,null,{"$f":"SUMPRODUCT(F250:I250,F239:I239)","v":0},{"$f":"F281*G276","v":0},{"$f":"IF(H237=\"Days\",F281/F237*365.25,IF(H237=\"Months\",F281/F237*12,\"\"))","v":""},{"$f":"IF(AND(H237=\"Days\",I277=\"Days\"),F281/F237*I276,IF(AND(H237=\"Months\",I277=\"Months\"),F281/F237*I276,IF(AND(H237=\"Days\",I277=\"Months\"),F281/F237*30.4375*I276,IF(AND(H237=\"Months\",I277=\"Days\"),F281/F237/30.4375*I276,\"\"))))","v":""}]
["E",{"$f":"B251","v":"VAT on Drug Cost "},null,null,null,{"$f":"SUMPRODUCT(F251:I251,F239:I239)","v":0},{"$f":"F282*G276","v":0},{"$f":"IF(H237=\"Days\",F282/F237*365.25,IF(H237=\"Months\",F282/F237*12,\"\"))","v":""},{"$f":"IF(AND(H237=\"Days\",I277=\"Days\"),F282/F237*I276,IF(AND(H237=\"Months\",I277=\"Months\"),F282/F237*I276,IF(AND(H237=\"Days\",I277=\"Months\"),F282/F237*30.4375*I276,IF(AND(H237=\"Months\",I277=\"Days\"),F282/F237/30.4375*I276,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF(H269=\"\",\"\",H269)","v":""},{"$f":"IF(F283=\"\",\"\",F283*G276)","v":""},{"$f":"IF(F283=\"\",\"\",MIN(IF(H237=\"Days\",F283/F237*365.25,IF(H237=\"Months\",F283/F237*12,\"\")), 744.36))","v":""},{"$f":"IF(F283=\"\",\"\",IF(AND(H237=\"Days\",I277=\"Days\"),F283/F237*I276,IF(AND(H237=\"Months\",I277=\"Months\"),F283/F237*I276,IF(AND(H237=\"Days\",I277=\"Months\"),F283/F237*30.4375*I276,IF(AND(H237=\"Months\",I277=\"Days\"),F283/F237/30.4375*I276,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF(H270=\"\",\"\",H270)","v":""},{"$f":"IF(F284=\"\",\"\",F284*G276)","v":""},{"$f":"IF(F284=\"\",\"\",MIN(IF(H237=\"Days\",F284/F237*365.25,IF(H237=\"Months\",F284/F237*12,\"\")), 744.36))","v":""},{"$f":"IF(F284=\"\",\"\",IF(AND(H237=\"Days\",I277=\"Days\"),F284/F237*I276,IF(AND(H237=\"Months\",I277=\"Months\"),F284/F237*I276,IF(AND(H237=\"Days\",I277=\"Months\"),F284/F237*30.4375*I276,IF(AND(H237=\"Months\",I277=\"Days\"),F284/F237/30.4375*I276,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 2",null,null,null,{"$f":"SUM(F280:F283)","v":0},{"$f":"SUM(G280:G283)","v":0},{"$f":"SUM(H280:H283)","v":0},{"$f":"SUM(I280:I283)","v":0},null,"It is important to complete Table F as figures will automatically populate in Tables 1a and 1b based on selections in Table G"]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 2",null,null,null,{"$f":"IF(F284=\"\",SUM(F280+F281),F280+F281+F284)","v":0},{"$f":"IF(G284=\"\",SUM(G280+G281),G280+G281+G284)","v":0},{"$f":"IF(H284=\"\",SUM(H280:H281),H280+H281+H284)","v":0},{"$f":"IF(I284=\"\",SUM(I280:I281),I280+I281+I284)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"CONCATENATE(\"Comparator 2: \",NameComparator2)","v":"Comparator 2: "},null,null,null,{"$f":"IF($E290=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E290,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$113&\" Comparator 2\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E290=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E290,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$113&\" Comparator 2\"),$B:$B,0))","v":{"$error":"#N/A"}},null,null," - Figures will automatically populate in Tables 1a and 1b based on selections in Table G unless selected as \"Calculated elsewhere by Applicant\" in Table G. The corresponding cells will then be coloured blue in Tables 1a and 1b. Please manually overwrite the formula in the blue cells with the appropriate figure if using the manual option."]
[]
[null,"Notes"]
[]
[null,"Source used to inform the duration of treatment (e.g pivotal trial publication/ reference cell in CEM):",null,null,null,null,null,null,null,null,"•\tThe Applicant should provide any additional detail necessary to permit validation of drug cost calculations by the Review Group. \n•\tPlease note that where drug cost calculations are insufficiently described, this will lead to delays in the appraisal process. "]
[null,"Please specify whether the above refers to a particular subpopulation (if applicable):"]
[null,"Source for dosing regimen applied in BIM (e.g product SmPC): "]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 3: \",NameComparator3)","v":"Comparator 3: "}]
[]
[]
[null,"Table A: Applicant Input Selection Table to calculate the cost per pack",null,null,null,null,null,null,null,null," - Please input all information requested in this table to automatically calculate the cost per pack in Table C. Up to four type of packs  can be accomodated in this table across columns F to I. If there are less than four packs, please leave extra columns blank. If there are more than four products, please contact bim@ncpe.ie. "]
[null,"Details required to calculate the cost per pack and pharmacy fee information"]
[null,null,null,null,null,"Strength/Pack Size"]
[null,"Pack Identification",null,null,null,null,null,null,null,null," - Enter identifying information (e.g. strength, pack size) for each pack. For example, column F: 40mgx28; column G: 20mgx28. "]
[null,"Calculation Starting Point",null,null,null,null,null,null,null,"\u0080"," - Enter whether the calculation starting point is the Price to Wholesaler (PTW) or Reimbursement Price. PTW is listed on the pricing application form (PAF) submitted to the HSE. Reimbursement price is listed on the PCRS website. "]
[null,"Price per Pack",null,null,null,null,null,null,null,null," - Enter the relevant pack price here.  "]
[null,"Drug Funding Arrangement",null,null,null,null,null,null,null,"\u0080"," - Choose the funding arrangements. CDS = Community Drug Schemes, HT = High Tech Drug Arrangements, Hosp = Hospital. "]
[null,"Fridge",null,null,null,null,null,null,null,"\u0080"," - Optional: fridge item status only required for the CDS as wholesale mark-up varies here. May leave blank for other schemes."]
[null,"Oral product (including inhalers)",null,null,null,null,null,null,null,"\u0080"," - Required for VAT. Oral products including inhalers are exempt from VAT."]
[null,"Biologic",null,null,null,null,null,null,null,"\u0080"," - Required for Framework Agreement rebate calculation."]
[null,"If Biologic =Yes: Select  Biologic and Patent Exclusivity Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =Yes, select the biologic and patent exclusivity status, pre- or post- 2026,  from the drop down list. If Biologic =No, select N/A. Required for Framework Agreement rebate calculation."]
[null,"If Biologic =No,  select Non Biologic Patent Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =No, select the non-biologic patent status, pre- or post- 2026.  If Biologic =Yes, select N/A. Required for Framework Agreement rebate calculation."]
[]
[null,"Table B: Applicant Input Table to calculate the cost per treatment cycle",null,null,null,null,null,null,null,null," - Treatment cycle is the length of time between product dispensings. For example, many oral tablet products have a treatment cycle of 28 days. If a drug is administered every six months, the treatment cycle is six months."]
[null,"Details required to calculate  the cost per treatment cycle"]
[null,"Length of Treatment Cycle",null,null,null,null,null,null,null,null," - Enter treatment cycle length in column F and select unit of measurement (Days/Months) in column H.  For treatment cycles measured in weeks, convert the number of weeks to days (e.g. 4 weeks = 28 days). One month is not equivalent to four weeks. If there is confusion over whether a dose is administered every four weeks or every month, refer to the SPC. "]
[null,{"$f":"B314","v":"Pack Identification"},null,null,null,{"$f":"IF(ISBLANK(F314),\"\",F314)","v":""},{"$f":"IF(ISBLANK(G314),\"\",G314)","v":""},{"$f":"IF(ISBLANK(H314),\"\",H314)","v":""},{"$f":"IF(ISBLANK(I314),\"\",I314)","v":""}]
[null,"Number of packs required per treatment cycle",null,null,null,null,null,null,null,null," - Enter the number of packs of each pack presentation required per treatment cycle. For example if the treatment cycle is 28 days, and there are 14 days supply in one pack, enter \"2\" into column F.  Where each patient requires multiple products every treatment cycle, enter the number of packs of each pack type into the relevant column. For example,  where a patient requires 2 x Pack (F) and 1 x Pack (G) every 28 day treatment cycle, please enter 2 in column F and 1 in column G. Alternatively, where only a single pack is required by a patient each cycle but multiple strengths are available, a weighted average can be calculated by entering the relevant weight for each pack in every column. Ensure weights sum to 1. Add details of how weights are derived in notes section. "]
[]
[]
[]
[null,"Table C. Total Cost to the HSE per pack"]
["This table will fill automatically based on the information inserted above. This information in this table is used to calculate the costs in Table F."]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF(F314=\"\",\"\",F314)","v":""},{"$f":"IF(G314=\"\",\"\",G314)","v":""},{"$f":"IF(H314=\"\",\"\",H314)","v":""},{"$f":"IF(I314=\"\",\"\",I314)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR(F315=\"\",F316=\"\",F317=\"\"),\"\",IF(F315=\"Price to Wholesaler\",F316,IF(F315=\"Reimbursement Price\",(F338/(1+E337)*1),\"Error\")))","v":""},{"$f":"IF(OR(G315=\"\",G316=\"\",F317=\"\"),\"\",IF(G315=\"Price to Wholesaler\",G316,IF(G315=\"Reimbursement Price\",(G338/(1+E337)*1),\"Error\")))","v":""},{"$f":"IF(OR(H315=\"\",H316=\"\",F317=\"\"),\"\",IF(H315=\"Price to Wholesaler\",H316,IF(H315=\"Reimbursement Price\",(H338/(1+E337)*1),\"Error\")))","v":""},{"$f":"IF(OR(I315=\"\",I316=\"\",F317=\"\"),\"\",IF(I315=\"Price to Wholesaler\",I316,IF(I315=\"Reimbursement Price\",(I338/(1+E337)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR(F317=\"\"),\"\",IF(AND(F317=\"CDS\",F318=\"Yes\"),CYF,IF(AND(F317=\"CDS\",F318=\"No\"),CNF,IF(F317=\"HT\",CHT,IF(F317=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR(F317=\"\",F316=\"\",F315=\"\"),\"\",F336*E337)","v":""},{"$f":"IF(OR(F317=\"\",G316=\"\",G315=\"\"),\"\",G336*E337)","v":""},{"$f":"IF(OR(F317=\"\",H316=\"\",H315=\"\"),\"\",H336*E337)","v":""},{"$f":"IF(OR(F317=\"\",I316=\"\",I315=\"\"),\"\",I336*E337)","v":""}]
["C",{"$f":"IF(F317=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF(F315=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF(F315=\"Reimbursement Price\",F316,IF(ISBLANK(E337),\"\",IF(F315=\"Price to Wholesaler\",(F336+F337),IF(F315=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(G315=\"Reimbursement Price\",G316,IF(ISBLANK(E337),\"\",IF(G315=\"Price to Wholesaler\",(G336+G337),IF(G315=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(H315=\"Reimbursement Price\",H316,IF(ISBLANK(E337),\"\",IF(H315=\"Price to Wholesaler\",(H336+H337),IF(H315=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(I315=\"Reimbursement Price\",I316,IF(ISBLANK(E337),\"\",IF(I315=\"Price to Wholesaler\",(I336+I337),IF(I315=\"\",\"\",\"Error\"))))","v":""}]
["D","Framework Agreement Rebate",null,null,{"$f":"IF(OR(F320=\"\",AND(F320=\"Yes\",F321=\"\"),AND(F320=\"No\",F322=\"\")),\"\",IF(AND(F320=\"No\",F322=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (pre-2026)\"),MRpre2026,IF(AND(F320=\"No\",F322=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F320=\"No\",F322=\"Off Patent Non-Exclusive or Generic\"),\"None\",IF(AND(F320=\"Yes\",F321=\"Biosimilar\"),\"None\",IF(AND(F320=\"Yes\",F321=\"Patented or Off Patent Exclusive (pre-2026)\"),MRpre2026,IF(AND(F320=\"Yes\",F321=\"Patented or Off Patent Exclusive (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F320=\"Yes\",F321=\"Off Patent Non-Exclusive 12.5% Rebate incorporated into Price to Wholesaler\"),\"None\",IF(AND(F320=\"Yes\",F321=\"Off Patent Non-Exclusive 12.5% Rebate\"),MRB,\"Error\")))))))))","v":""},{"$f":"IF(OR(F320=\"\",AND(F320=\"Yes\",F321=\"\"),AND(F320=\"No\",F322=\"\"),F315=\"\",ISBLANK(F316)),\"\",IF(E339=\"None\",0,(E339*F336)))","v":""},{"$f":"IF(OR(F320=\"\",AND(F320=\"Yes\",F321=\"\"),AND(F320=\"No\",F322=\"\"),G315=\"\",ISBLANK(G316)),\"\",IF(E339=\"None\",0,(E339*G336)))","v":""},{"$f":"IF(OR(F320=\"\",AND(F320=\"Yes\",F321=\"\"),AND(F320=\"No\",F322=\"\"),H315=\"\",ISBLANK(H316)),\"\",IF(E339=\"None\",0,(E339*H336)))","v":""},{"$f":"IF(OR(F320=\"\",AND(F320=\"Yes\",F321=\"\"),AND(F320=\"No\",F322=\"\"),I315=\"\",ISBLANK(I316)),\"\",IF(E339=\"None\",0,(E339*I336)))","v":""}]
["E","VAT on Drug Cost ",null,null,{"$f":"IF(F319=\"\",\"\",IF(F319=\"Yes\",0,VT))","v":""},{"$f":"IF(OR(F316=\"\",ISBLANK(F316)),\"\",($E340*F338))","v":""},{"$f":"IF(OR(G316=\"\",ISBLANK(G316)),\"\",($E340*G338))","v":""},"",""]
["F(i)","Total Drug Cost to the HSE per pack including VAT",null,null,null,{"$f":"IF(OR(F315=\"\",$F317=\"\",$F319=\"\",$F320=\"\"),\"\",SUM(F338:F340))","v":""},{"$f":"IF(OR(G315=\"\",$F317=\"\",$F319=\"\",$F320=\"\"),\"\",SUM(G338:G340))","v":""},{"$f":"IF(OR(H315=\"\",$F317=\"\",$F319=\"\",$F320=\"\"),\"\",SUM(H338:H340))","v":""},{"$f":"IF(OR(I315=\"\",$F317=\"\",$F319=\"\",$F320=\"\"),\"\",SUM(I338:I340))","v":""}]
["F(ii)","Total Drug Cost to the HSE per pack excluding VAT",null,null,null,{"$f":"IF(OR(F315=\"\",$F317=\"\",$F319=\"\",$F320=\"\"),\"\",SUM(F338:F339))","v":""},{"$f":"IF(OR(G315=\"\",$F317=\"\",$F319=\"\",$F320=\"\"),\"\",SUM(G338:G339))","v":""},{"$f":"IF(OR(H315=\"\",$F317=\"\",$F319=\"\",$F320=\"\"),\"\",SUM(H338:H339))","v":""},{"$f":"IF(OR(I315=\"\",$F317=\"\",$F319=\"\",$F320=\"\"),\"\",SUM(I338:I339))","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table D. Pharmacy Fees payable based on the type of product and reimbursement arrangements"]
[null,"For hospital drugs this table may be ignored."]
[null,"This table fills  automatically based on scheme and product information inputted above in Table A. "]
[]
[null,null,null,null,null,null,"Calculation ","Value"]
[null,"Pharmacy Fees excluding VAT",null,null,null,null,{"$f":"IF(F317=\"\",\"\",IF(F317=\"CDS\",\"per dispensing\",IF(F317=\"HT\",\"per month\",IF(F317=\"Hosp\",\"No Fee\", ERROR))))","v":""},{"$f":"IF(F317=\"\",\"\",IF(F317=\"CDS\",DF,IF(F317=\"HT\",PC,IF(F317=\"Hosp\",\"No Fee\",ERROR))))","v":""},"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         "]
[null,"VAT on Pharmacy Fees",null,null,null,null,{"$f":"IF(OR(F317=\"\",F319=\"\"),\"\",IF(F317=\"Hosp\",\"No Fee\",IF(F317=\"HT\",\"No VAT\",IF(AND(F317=\"CDS\",F319=\"No\"),VT,\"No VAT\"))))","v":""},{"$f":"IF(OR(F319=\"\",F317=\"Hosp\"),\"\",IF(OR(F319=\"Yes\",F317=\"HT\"),0,H349*G350))","v":""}]
[]
[]
["Table E Pharmacy Fees per product treatment cycle. \n",null,null,null,null,null,null,null,null,null," - Based on the drug's dispensing regimen and the NCPE drug cost guidelines, please input the pharmacy fees per treatment cycle. Use data presented in Table D to generate an appropriate formula for Column H of Table E. Notes may be added in column G. "]
["This section may be ommited for hospital drugs",null,null,null,null,null,"Notes","Value",null,null,{"$f":"IF(F317=\"HT\",\"For High tech, if a treatment cycle =28 days the corresponding pharmacy fee is =62.03*12/365.25*28.  The pharmacy fee remains the same regardless of the number of products dispensed that month.\",IF(F317=\"CDS\",\"For CDS, if 2 packets of the same pack presentation are required per treatment cycle, one dispensing fee applies (€5.48). If multiple pack presentations are required, multiple dispensing fees apply\",\"\"))","v":""}]
["G","Pharmacy Fees per treatment cycle excluding VAT"]
["H","Non dispensed patient care fee per treatment cycle (High Tech only)",null,null,null,null,null,null,null,null," - Enter here if relevant. See NCPE drug cost guidelines for more information on non-dispensed patient care fees (High Tech only). "]
["I","VAT on pharmacy Fees",null,null,null,null,null,null,null,null," - Please input VAT payable on pharmacy fees if applicable based on the information presented in Table D. "]
["J (i)","Total pharmacy Fees per treatment cycle including VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H355),\"\",SUM(H355:H357))","v":""}]
["J (ii)","Total pharmacy Fees per treatment cycle excluding VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H355),\"\",SUM(H355:H356))","v":""}]
[]
[]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time",null," - Calculate the cost for the budget impact model using  cost per number of cycles, per year or per unit time. Input the length of time required  into the blue boxes where applicable. Irrelevant columns may be left blank. Use the drop down boxes to select days or months when calculating the cost per unit time."]
[]
[null,null,null,null,null,null,"number of cycles"]
["A",{"$f":"B336","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F336:I336,F328:I328)","v":0},{"$f":"F367*G365","v":0},{"$f":"IF(H326=\"Days\",F367/F326*365.25,IF(H326=\"Months\",F367/F326*12,\"\"))","v":""},{"$f":"IF(AND(H326=\"Days\",I366=\"Days\"),F367/F326*I365,IF(AND(H326=\"Months\",I366=\"Months\"),F367/F326*I365,IF(AND(H326=\"Days\",I366=\"Months\"),F367/F326*30.4375*I365,IF(AND(H326=\"Months\",I366=\"Days\"),F367/F326/30.4375*I365,\"\"))))","v":""}]
["B",{"$f":"B337","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F337:I337,F328:I328)","v":0},{"$f":"F368*G365","v":0},{"$f":"IF(H326=\"Days\",F368/F326*365.25,IF(H326=\"Months\",F368/F326*12,\"\"))","v":""},{"$f":"IF(AND(H326=\"Days\",I366=\"Days\"),F368/F326*I365,IF(AND(H326=\"Months\",I366=\"Months\"),F368/F326*I365,IF(AND(H326=\"Days\",I366=\"Months\"),F368/F326*30.4375*I365,IF(AND(H326=\"Months\",I366=\"Days\"),F368/F326/30.4375*I365,\"\"))))","v":""}]
["C",{"$f":"B338","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F338:I338,F328:I328)","v":0},{"$f":"F369*G365","v":0},{"$f":"IF(H326=\"Days\",F369/F326*365.25,IF(H326=\"Months\",F369/F326*12,\"\"))","v":""},{"$f":"IF(AND(H326=\"Days\",I366=\"Days\"),F369/F326*I365,IF(AND(H326=\"Months\",I366=\"Months\"),F369/F326*I365,IF(AND(H326=\"Days\",I366=\"Months\"),F369/F326*30.4375*I365,IF(AND(H326=\"Months\",I366=\"Days\"),F369/F326/30.4375*I365,\"\"))))","v":""}]
["D",{"$f":"B339","v":"Framework Agreement Rebate"},null,null,null,{"$f":"SUMPRODUCT(F339:I339,F328:I328)","v":0},{"$f":"F370*G365","v":0},{"$f":"IF(H326=\"Days\",F370/F326*365.25,IF(H326=\"Months\",F370/F326*12,\"\"))","v":""},{"$f":"IF(AND(H326=\"Days\",I366=\"Days\"),F370/F326*I365,IF(AND(H326=\"Months\",I366=\"Months\"),F370/F326*I365,IF(AND(H326=\"Days\",I366=\"Months\"),F370/F326*30.4375*I365,IF(AND(H326=\"Months\",I366=\"Days\"),F370/F326/30.4375*I365,\"\"))))","v":""}]
["E",{"$f":"B340","v":"VAT on Drug Cost "},null,null,null,{"$f":"SUMPRODUCT(F340:I340,F328:I328)","v":0},{"$f":"F371*G365","v":0},{"$f":"IF(H326=\"Days\",F371/F326*365.25,IF(H326=\"Months\",F371/F326*12,\"\"))","v":""},{"$f":"IF(AND(H326=\"Days\",I366=\"Days\"),F371/F326*I365,IF(AND(H326=\"Months\",I366=\"Months\"),F371/F326*I365,IF(AND(H326=\"Days\",I366=\"Months\"),F371/F326*30.4375*I365,IF(AND(H326=\"Months\",I366=\"Days\"),F371/F326/30.4375*I365,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF(H358=\"\",\"\",H358)","v":""},{"$f":"IF(F372=\"\",\"\",F372*G365)","v":""},{"$f":"IF(F372=\"\",\"\",MIN(IF(H326=\"Days\",F372/F326*365.25,IF(H326=\"Months\",F372/F326*12,\"\")), 744.36))","v":""},{"$f":"IF(F372=\"\",\"\",IF(AND(H326=\"Days\",I366=\"Days\"),F372/F326*I365,IF(AND(H326=\"Months\",I366=\"Months\"),F372/F326*I365,IF(AND(H326=\"Days\",I366=\"Months\"),F372/F326*30.4375*I365,IF(AND(H326=\"Months\",I366=\"Days\"),F372/F326/30.4375*I365,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF(H359=\"\",\"\",H359)","v":""},{"$f":"IF(F373=\"\",\"\",F373*G365)","v":""},{"$f":"IF(F373=\"\",\"\",MIN(IF(H326=\"Days\",F373/F326*365.25,IF(H326=\"Months\",F373/F326*12,\"\")), 744.36))","v":""},{"$f":"IF(F373=\"\",\"\",IF(AND(H326=\"Days\",I366=\"Days\"),F373/F326*I365,IF(AND(H326=\"Months\",I366=\"Months\"),F373/F326*I365,IF(AND(H326=\"Days\",I366=\"Months\"),F373/F326*30.4375*I365,IF(AND(H326=\"Months\",I366=\"Days\"),F373/F326/30.4375*I365,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 3",null,null,null,{"$f":"SUM(F369:F372)","v":0},{"$f":"SUM(G369:G372)","v":0},{"$f":"SUM(H369:H372)","v":0},{"$f":"SUM(I369:I372)","v":0},null,"It is important to complete Table F as figures will automatically populate in Tables 1a and 1b based on selections in Table G"]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 3",null,null,null,{"$f":"IF(F373=\"\",SUM(F369+F370),F369+F370+F373)","v":0},{"$f":"IF(G373=\"\",SUM(G369+G370),G369+G370+G373)","v":0},{"$f":"IF(H373=\"\",SUM(H369:H370),H369+H370+H373)","v":0},{"$f":"IF(I373=\"\",SUM(I369:I370),I369+I370+I373)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"CONCATENATE(\"Comparator 3: \",NameComparator3)","v":"Comparator 3: "},null,null,null,{"$f":"IF($E379=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E379,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$113&\" Comparator 3\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E379=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E379,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$113&\" Comparator 3\"),$B:$B,0))","v":{"$error":"#N/A"}},null,null," - Figures will automatically populate in Tables 1a and 1b based on selections in Table G unless selected as \"Calculated elsewhere by Applicant\" in Table G. The corresponding cells will then be coloured blue in Tables 1a and 1b. Please manually overwrite the formula in the blue cells with the appropriate figure if using the manual option."]
[]
[null,"Notes"]
[]
[null,"Source used to inform the duration of treatment (e.g pivotal trial publication/ reference cell in CEM):",null,null,null,null,null,null,null,null,"•\tThe Applicant should provide any additional detail necessary to permit validation of drug cost calculations by the Review Group. \n•\tPlease note that where drug cost calculations are insufficiently described, this will lead to delays in the appraisal process. "]
[null,"Please specify whether the above refers to a particular subpopulation (if applicable):"]
[null,"Source for dosing regimen applied in BIM (e.g product SmPC): "]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 4: \",NameComparator4)","v":"Comparator 4: "}]
[]
[]
[null,"Table A: Applicant Input Selection Table to calculate the cost per pack",null,null,null,null,null,null,null,null," - Please input all information requested in this table to automatically calculate the cost per pack in Table C. Up to four type of packs  can be accomodated in this table across columns F to I. If there are less than four packs, please leave extra columns blank. If there are more than four products, please contact bim@ncpe.ie. "]
[null,"Details required to calculate the cost per pack and pharmacy fee information"]
[null,null,null,null,null,"Strength/Pack Size"]
[null,"Pack Identification",null,null,null,null,null,null,null,null," - Enter identifying information (e.g. strength, pack size) for each pack. For example, column F: 40mgx28; column G: 20mgx28. "]
[null,"Calculation Starting Point",null,null,null,null,null,null,null,"\u0080"," - Enter whether the calculation starting point is the Price to Wholesaler (PTW) or Reimbursement Price. PTW is listed on the pricing application form (PAF) submitted to the HSE. Reimbursement price is listed on the PCRS website. "]
[null,"Price per Pack",null,null,null,null,null,null,null,null," - Enter the relevant pack price here.  "]
[null,"Drug Funding Arrangement",null,null,null,null,null,null,null,"\u0080"," - Choose the funding arrangements. CDS = Community Drug Schemes, HT = High Tech Drug Arrangements, Hosp = Hospital. "]
[null,"Fridge",null,null,null,null,null,null,null,"\u0080"," - Optional: fridge item status only required for the CDS as wholesale mark-up varies here. May leave blank for other schemes."]
[null,"Oral product (including inhalers)",null,null,null,null,null,null,null,"\u0080"," - Required for VAT. Oral products including inhalers are exempt from VAT."]
[null,"Biologic",null,null,null,null,null,null,null,"\u0080"," - Required for Framework Agreement rebate calculation."]
[null,"If Biologic =Yes: Select  Biologic and Patent Exclusivity Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =Yes, select the biologic and patent exclusivity status, pre- or post- 2026,  from the drop down list. If Biologic =No, select N/A. Required for Framework Agreement rebate calculation."]
[null,"If Biologic =No,  select Non Biologic Patent Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =No, select the non-biologic patent status, pre- or post- 2026.  If Biologic =Yes, select N/A. Required for Framework Agreement rebate calculation."]
[]
[null,"Table B: Applicant Input Table to calculate the cost per treatment cycle",null,null,null,null,null,null,null,null," - Treatment cycle is the length of time between product dispensings. For example, many oral tablet products have a treatment cycle of 28 days. If a drug is administered every six months, the treatment cycle is six months."]
[null,"Details required to calculate  the cost per treatment cycle"]
[null,"Length of Treatment Cycle",null,null,null,null,null,null,null,null," - Enter treatment cycle length in column F and select unit of measurement (Days/Months) in column H.  For treatment cycles measured in weeks, convert the number of weeks to days (e.g. 4 weeks = 28 days). One month is not equivalent to four weeks. If there is confusion over whether a dose is administered every four weeks or every month, refer to the SPC. "]
[null,{"$f":"B402","v":"Pack Identification"},null,null,null,{"$f":"IF(ISBLANK(F402),\"\",F402)","v":""},{"$f":"IF(ISBLANK(G402),\"\",G402)","v":""},{"$f":"IF(ISBLANK(H402),\"\",H402)","v":""},{"$f":"IF(ISBLANK(I402),\"\",I402)","v":""}]
[null,"Number of packs required per treatment cycle",null,null,null,null,null,null,null,null," - Enter the number of packs of each pack presentation required per treatment cycle. For example if the treatment cycle is 28 days, and there are 14 days supply in one pack, enter \"2\" into column F.  Where each patient requires multiple products every treatment cycle, enter the number of packs of each pack type into the relevant column. For example,  where a patient requires 2 x Pack (F) and 1 x Pack (G) every 28 day treatment cycle, please enter 2 in column F and 1 in column G. Alternatively, where only a single pack is required by a patient each cycle but multiple strengths are available, a weighted average can be calculated by entering the relevant weight for each pack in every column. Ensure weights sum to 1. Add details of how weights are derived in notes section. "]
[]
[]
[]
[null,"Table C. Total Cost to the HSE per pack"]
["This table will fill automatically based on the information inserted above. This information in this table is used to calculate the costs in Table F."]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF(F402=\"\",\"\",F402)","v":""},{"$f":"IF(G402=\"\",\"\",G402)","v":""},{"$f":"IF(H402=\"\",\"\",H402)","v":""},{"$f":"IF(I402=\"\",\"\",I402)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR(F403=\"\",F404=\"\",F405=\"\"),\"\",IF(F403=\"Price to Wholesaler\",F404,IF(F403=\"Reimbursement Price\",(F426/(1+E425)*1),\"Error\")))","v":""},{"$f":"IF(OR(G403=\"\",G404=\"\",F405=\"\"),\"\",IF(G403=\"Price to Wholesaler\",G404,IF(G403=\"Reimbursement Price\",(G426/(1+E425)*1),\"Error\")))","v":""},{"$f":"IF(OR(H403=\"\",H404=\"\",F405=\"\"),\"\",IF(H403=\"Price to Wholesaler\",H404,IF(H403=\"Reimbursement Price\",(H426/(1+E425)*1),\"Error\")))","v":""},{"$f":"IF(OR(I403=\"\",I404=\"\",F405=\"\"),\"\",IF(I403=\"Price to Wholesaler\",I404,IF(I403=\"Reimbursement Price\",(I426/(1+E425)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR(F405=\"\"),\"\",IF(AND(F405=\"CDS\",F406=\"Yes\"),CYF,IF(AND(F405=\"CDS\",F406=\"No\"),CNF,IF(F405=\"HT\",CHT,IF(F405=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR(F405=\"\",F404=\"\",F403=\"\"),\"\",F424*E425)","v":""},{"$f":"IF(OR(F405=\"\",G404=\"\",G403=\"\"),\"\",G424*E425)","v":""},{"$f":"IF(OR(F405=\"\",H404=\"\",H403=\"\"),\"\",H424*E425)","v":""},{"$f":"IF(OR(F405=\"\",I404=\"\",I403=\"\"),\"\",I424*E425)","v":""}]
["C",{"$f":"IF(F405=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF(F403=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF(F403=\"Reimbursement Price\",F404,IF(ISBLANK(E425),\"\",IF(F403=\"Price to Wholesaler\",(F424+F425),IF(F403=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(G403=\"Reimbursement Price\",G404,IF(ISBLANK(E425),\"\",IF(G403=\"Price to Wholesaler\",(G424+G425),IF(G403=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(H403=\"Reimbursement Price\",H404,IF(ISBLANK(E425),\"\",IF(H403=\"Price to Wholesaler\",(H424+H425),IF(H403=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(I403=\"Reimbursement Price\",I404,IF(ISBLANK(E425),\"\",IF(I403=\"Price to Wholesaler\",(I424+I425),IF(I403=\"\",\"\",\"Error\"))))","v":""}]
["D","Framework Agreement Rebate",null,null,{"$f":"IF(OR(F408=\"\",AND(F408=\"Yes\",F409=\"\"),AND(F408=\"No\",F410=\"\")),\"\",IF(AND(F408=\"No\",F410=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (pre-2026)\"),MRpre2026,IF(AND(F408=\"No\",F410=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F408=\"No\",F410=\"Off Patent Non-Exclusive or Generic\"),\"None\",IF(AND(F408=\"Yes\",F409=\"Biosimilar\"),\"None\",IF(AND(F408=\"Yes\",F409=\"Patented or Off Patent Exclusive (pre-2026)\"),MRpre2026,IF(AND(F408=\"Yes\",F409=\"Patented or Off Patent Exclusive (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F408=\"Yes\",F409=\"Off Patent Non-Exclusive 12.5% Rebate incorporated into Price to Wholesaler\"),\"None\",IF(AND(F408=\"Yes\",F409=\"Off Patent Non-Exclusive 12.5% Rebate\"),MRB,\"Error\")))))))))","v":""},{"$f":"IF(OR(F408=\"\",AND(F408=\"Yes\",F409=\"\"),AND(F408=\"No\",F410=\"\"),F403=\"\",ISBLANK(F404)),\"\",IF(E427=\"None\",0,(E427*F424)))","v":""},{"$f":"IF(OR(F408=\"\",AND(F408=\"Yes\",F409=\"\"),AND(F408=\"No\",F410=\"\"),G403=\"\",ISBLANK(G404)),\"\",IF(E427=\"None\",0,(E427*G424)))","v":""},{"$f":"IF(OR(F408=\"\",AND(F408=\"Yes\",F409=\"\"),AND(F408=\"No\",F410=\"\"),H403=\"\",ISBLANK(H404)),\"\",IF(E427=\"None\",0,(E427*H424)))","v":""},{"$f":"IF(OR(F408=\"\",AND(F408=\"Yes\",F409=\"\"),AND(F408=\"No\",F410=\"\"),I403=\"\",ISBLANK(I404)),\"\",IF(E427=\"None\",0,(E427*I424)))","v":""}]
["E","VAT on Drug Cost ",null,null,{"$f":"IF(F407=\"\",\"\",IF(F407=\"Yes\",0,VT))","v":""},{"$f":"IF(OR(F404=\"\",ISBLANK(F404)),\"\",($E428*F426))","v":""},{"$f":"IF(OR(G404=\"\",ISBLANK(G404)),\"\",($E428*G426))","v":""},"",""]
["F(i)","Total Drug Cost to the HSE per pack including VAT",null,null,null,{"$f":"IF(OR(F403=\"\",$F405=\"\",$F407=\"\",$F408=\"\"),\"\",SUM(F426:F428))","v":""},{"$f":"IF(OR(G403=\"\",$F405=\"\",$F407=\"\",$F408=\"\"),\"\",SUM(G426:G428))","v":""},{"$f":"IF(OR(H403=\"\",$F405=\"\",$F407=\"\",$F408=\"\"),\"\",SUM(H426:H428))","v":""},{"$f":"IF(OR(I403=\"\",$F405=\"\",$F407=\"\",$F408=\"\"),\"\",SUM(I426:I428))","v":""}]
["F(ii)","Total Drug Cost to the HSE per pack excluding VAT",null,null,null,{"$f":"IF(OR(F403=\"\",$F405=\"\",$F407=\"\",$F408=\"\"),\"\",SUM(F426:F427))","v":""},{"$f":"IF(OR(G403=\"\",$F405=\"\",$F407=\"\",$F408=\"\"),\"\",SUM(G426:G427))","v":""},{"$f":"IF(OR(H403=\"\",$F405=\"\",$F407=\"\",$F408=\"\"),\"\",SUM(H426:H427))","v":""},{"$f":"IF(OR(I403=\"\",$F405=\"\",$F407=\"\",$F408=\"\"),\"\",SUM(I426:I427))","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table D. Pharmacy Fees payable based on the type of product and reimbursement arrangements"]
[null,"For hospital drugs this table may be ignored."]
[null,"This table fills  automatically based on scheme and product information inputted above in Table A. "]
[]
[null,null,null,null,null,null,"Calculation ","Value"]
[null,"Pharmacy Fees excluding VAT",null,null,null,null,{"$f":"IF(F405=\"\",\"\",IF(F405=\"CDS\",\"per dispensing\",IF(F405=\"HT\",\"per month\",IF(F405=\"Hosp\",\"No Fee\", ERROR))))","v":""},{"$f":"IF(F405=\"\",\"\",IF(F405=\"CDS\",DF,IF(F405=\"HT\",PC,IF(F405=\"Hosp\",\"No Fee\",ERROR))))","v":""},"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         "]
[null,"VAT on Pharmacy Fees",null,null,null,null,{"$f":"IF(OR(F405=\"\",F407=\"\"),\"\",IF(F405=\"Hosp\",\"No Fee\",IF(F405=\"HT\",\"No VAT\",IF(AND(F405=\"CDS\",F407=\"No\"),VT,\"No VAT\"))))","v":""},{"$f":"IF(OR(F407=\"\",F405=\"Hosp\"),\"\",IF(OR(F407=\"Yes\",F405=\"HT\"),0,H437*G438))","v":""}]
[]
[]
["Table E Pharmacy Fees per product treatment cycle. \n",null,null,null,null,null,null,null,null,null," - Based on the drug's dispensing regimen and the NCPE drug cost guidelines, please input the pharmacy fees per treatment cycle. Use data presented in Table D to generate an appropriate formula for Column H of Table E. Notes may be added in column G. "]
["This section may be ommited for hospital drugs",null,null,null,null,null,"Notes","Value",null,null,{"$f":"IF(F405=\"HT\",\"For High tech, if a treatment cycle =28 days the corresponding pharmacy fee is =62.03*12/365.25*28.  The pharmacy fee remains the same regardless of the number of products dispensed that month.\",IF(F405=\"CDS\",\"For CDS, if 2 packets of the same pack presentation are required per treatment cycle, one dispensing fee applies (€5.48). If multiple pack presentations are required, multiple dispensing fees apply\",\"\"))","v":""}]
["G","Pharmacy Fees per treatment cycle excluding VAT"]
["H","Non dispensed patient care fee per treatment cycle (High Tech only)",null,null,null,null,null,null,null,null," - Enter here if relevant. See NCPE drug cost guidelines for more information on non-dispensed patient care fees (High Tech only). "]
["I","VAT on pharmacy Fees",null,null,null,null,null,null,null,null," - Please input VAT payable on pharmacy fees if applicable based on the information presented in Table D. "]
["J (i)","Total pharmacy Fees per treatment cycle including VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H443),\"\",SUM(H443:H445))","v":""}]
["J (ii)","Total pharmacy Fees per treatment cycle excluding VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H443),\"\",SUM(H443:H444))","v":""}]
[]
[]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time",null," - Calculate the cost for the budget impact model using  cost per number of cycles, per year or per unit time. Input the length of time required  into the blue boxes where applicable. Irrelevant columns may be left blank. Use the drop down boxes to select days or months when calculating the cost per unit time."]
[]
[null,null,null,null,null,null,"number of cycles"]
["A",{"$f":"B424","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F424:I424,F416:I416)","v":0},{"$f":"F455*G453","v":0},{"$f":"IF(H414=\"Days\",F455/F414*365.25,IF(H414=\"Months\",F455/F414*12,\"\"))","v":""},{"$f":"IF(AND(H414=\"Days\",I454=\"Days\"),F455/F414*I453,IF(AND(H414=\"Months\",I454=\"Months\"),F455/F414*I453,IF(AND(H414=\"Days\",I454=\"Months\"),F455/F414*30.4375*I453,IF(AND(H414=\"Months\",I454=\"Days\"),F455/F414/30.4375*I453,\"\"))))","v":""}]
["B",{"$f":"B425","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F425:I425,F416:I416)","v":0},{"$f":"F456*G453","v":0},{"$f":"IF(H414=\"Days\",F456/F414*365.25,IF(H414=\"Months\",F456/F414*12,\"\"))","v":""},{"$f":"IF(AND(H414=\"Days\",I454=\"Days\"),F456/F414*I453,IF(AND(H414=\"Months\",I454=\"Months\"),F456/F414*I453,IF(AND(H414=\"Days\",I454=\"Months\"),F456/F414*30.4375*I453,IF(AND(H414=\"Months\",I454=\"Days\"),F456/F414/30.4375*I453,\"\"))))","v":""}]
["C",{"$f":"B426","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F426:I426,F416:I416)","v":0},{"$f":"F457*G453","v":0},{"$f":"IF(H414=\"Days\",F457/F414*365.25,IF(H414=\"Months\",F457/F414*12,\"\"))","v":""},{"$f":"IF(AND(H414=\"Days\",I454=\"Days\"),F457/F414*I453,IF(AND(H414=\"Months\",I454=\"Months\"),F457/F414*I453,IF(AND(H414=\"Days\",I454=\"Months\"),F457/F414*30.4375*I453,IF(AND(H414=\"Months\",I454=\"Days\"),F457/F414/30.4375*I453,\"\"))))","v":""}]
["D",{"$f":"B427","v":"Framework Agreement Rebate"},null,null,null,{"$f":"SUMPRODUCT(F427:I427,F416:I416)","v":0},{"$f":"F458*G453","v":0},{"$f":"IF(H414=\"Days\",F458/F414*365.25,IF(H414=\"Months\",F458/F414*12,\"\"))","v":""},{"$f":"IF(AND(H414=\"Days\",I454=\"Days\"),F458/F414*I453,IF(AND(H414=\"Months\",I454=\"Months\"),F458/F414*I453,IF(AND(H414=\"Days\",I454=\"Months\"),F458/F414*30.4375*I453,IF(AND(H414=\"Months\",I454=\"Days\"),F458/F414/30.4375*I453,\"\"))))","v":""}]
["E",{"$f":"B428","v":"VAT on Drug Cost "},null,null,null,{"$f":"SUMPRODUCT(F428:I428,F416:I416)","v":0},{"$f":"F459*G453","v":0},{"$f":"IF(H414=\"Days\",F459/F414*365.25,IF(H414=\"Months\",F459/F414*12,\"\"))","v":""},{"$f":"IF(AND(H414=\"Days\",I454=\"Days\"),F459/F414*I453,IF(AND(H414=\"Months\",I454=\"Months\"),F459/F414*I453,IF(AND(H414=\"Days\",I454=\"Months\"),F459/F414*30.4375*I453,IF(AND(H414=\"Months\",I454=\"Days\"),F459/F414/30.4375*I453,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF(H446=\"\",\"\",H446)","v":""},{"$f":"IF(F460=\"\",\"\",F460*G453)","v":""},{"$f":"IF(F460=\"\",\"\",MIN(IF(H414=\"Days\",F460/F414*365.25,IF(H414=\"Months\",F460/F414*12,\"\")), 744.36))","v":""},{"$f":"IF(F460=\"\",\"\",IF(AND(H414=\"Days\",I454=\"Days\"),F460/F414*I453,IF(AND(H414=\"Months\",I454=\"Months\"),F460/F414*I453,IF(AND(H414=\"Days\",I454=\"Months\"),F460/F414*30.4375*I453,IF(AND(H414=\"Months\",I454=\"Days\"),F460/F414/30.4375*I453,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF(H447=\"\",\"\",H447)","v":""},{"$f":"IF(F461=\"\",\"\",F461*G453)","v":""},{"$f":"IF(F461=\"\",\"\",MIN(IF(H414=\"Days\",F461/F414*365.25,IF(H414=\"Months\",F461/F414*12,\"\")), 744.36))","v":""},{"$f":"IF(F461=\"\",\"\",IF(AND(H414=\"Days\",I454=\"Days\"),F461/F414*I453,IF(AND(H414=\"Months\",I454=\"Months\"),F461/F414*I453,IF(AND(H414=\"Days\",I454=\"Months\"),F461/F414*30.4375*I453,IF(AND(H414=\"Months\",I454=\"Days\"),F461/F414/30.4375*I453,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 4",null,null,null,{"$f":"SUM(F457:F460)","v":0},{"$f":"SUM(G457:G460)","v":0},{"$f":"SUM(H457:H460)","v":0},{"$f":"SUM(I457:I460)","v":0},null,"It is important to complete Table F as figures will automatically populate in Tables 1a and 1b based on selections in Table G"]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 4",null,null,null,{"$f":"IF(F461=\"\",SUM(F457+F458),F457+F458+F461)","v":0},{"$f":"IF(G461=\"\",SUM(G457+G458),G457+G458+G461)","v":0},{"$f":"IF(H461=\"\",SUM(H457:H458),H457+H458+H461)","v":0},{"$f":"IF(I461=\"\",SUM(I457:I458),I457+I458+I461)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"CONCATENATE(\"Comparator 4: \",NameComparator4)","v":"Comparator 4: "},null,null,null,{"$f":"IF($E467=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E467,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$113&\" Comparator 4\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E467=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E467,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$113&\" Comparator 4\"),$B:$B,0))","v":{"$error":"#N/A"}},null,null," - Figures will automatically populate in Tables 1a and 1b based on selections in Table G unless selected as \"Calculated elsewhere by Applicant\" in Table G. The corresponding cells will then be coloured blue in Tables 1a and 1b. Please manually overwrite the formula in the blue cells with the appropriate figure if using the manual option."]
[]
[null,"Notes"]
[]
[null,"Source used to inform the duration of treatment (e.g pivotal trial publication/ reference cell in CEM):",null,null,null,null,null,null,null,null,"•\tThe Applicant should provide any additional detail necessary to permit validation of drug cost calculations by the Review Group. \n•\tPlease note that where drug cost calculations are insufficiently described, this will lead to delays in the appraisal process. "]
[null,"Please specify whether the above refers to a particular subpopulation (if applicable):"]
[null,"Source for dosing regimen applied in BIM (e.g product SmPC): "]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 5: \",NameComparator5)","v":"Comparator 5: "}]
[]
[]
[null,"Table A: Applicant Input Selection Table to calculate the cost per pack",null,null,null,null,null,null,null,null," - Please input all information requested in this table to automatically calculate the cost per pack in Table C. Up to four type of packs  can be accomodated in this table across columns F to I. If there are less than four packs, please leave extra columns blank. If there are more than four products, please contact bim@ncpe.ie. "]
[null,"Details required to calculate the cost per pack and pharmacy fee information"]
[null,null,null,null,null,"Strength/Pack Size"]
[null,"Pack Identification",null,null,null,null,null,null,null,null," - Enter identifying information (e.g. strength, pack size) for each pack. For example, column F: 40mgx28; column G: 20mgx28. "]
[null,"Calculation Starting Point",null,null,null,null,null,null,null,"\u0080"," - Enter whether the calculation starting point is the Price to Wholesaler (PTW) or Reimbursement Price. PTW is listed on the pricing application form (PAF) submitted to the HSE. Reimbursement price is listed on the PCRS website. "]
[null,"Price per Pack",null,null,null,null,null,null,null,null," - Enter the relevant pack price here.  "]
[null,"Drug Funding Arrangement",null,null,null,null,null,null,null,"\u0080"," - Choose the funding arrangements. CDS = Community Drug Schemes, HT = High Tech Drug Arrangements, Hosp = Hospital. "]
[null,"Fridge",null,null,null,null,null,null,null,"\u0080"," - Optional: fridge item status only required for the CDS as wholesale mark-up varies here. May leave blank for other schemes."]
[null,"Oral product (including inhalers)",null,null,null,null,null,null,null,"\u0080"," - Required for VAT. Oral products including inhalers are exempt from VAT."]
[null,"Biologic",null,null,null,null,null,null,null,"\u0080"," - Required for Framework Agreement rebate calculation."]
[null,"If Biologic =Yes: Select  Biologic and Patent Exclusivity Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =Yes, select the biologic and patent exclusivity status, pre- or post- 2026,  from the drop down list. If Biologic =No, select N/A. Required for Framework Agreement rebate calculation."]
[null,"If Biologic =No,  select Non Biologic Patent Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =No, select the non-biologic patent status, pre- or post- 2026.  If Biologic =Yes, select N/A. Required for Framework Agreement rebate calculation."]
[]
[null,"Table B: Applicant Input Table to calculate the cost per treatment cycle",null,null,null,null,null,null,null,null," - Treatment cycle is the length of time between product dispensings. For example, many oral tablet products have a treatment cycle of 28 days. If a drug is administered every six months, the treatment cycle is six months."]
[null,"Details required to calculate  the cost per treatment cycle"]
[null,"Length of Treatment Cycle",null,null,null,null,null,null,null,null," - Enter treatment cycle length in column F and select unit of measurement (Days/Months) in column H.  For treatment cycles measured in weeks, convert the number of weeks to days (e.g. 4 weeks = 28 days). One month is not equivalent to four weeks. If there is confusion over whether a dose is administered every four weeks or every month, refer to the SPC. "]
[null,{"$f":"B491","v":"Pack Identification"},null,null,null,{"$f":"IF(ISBLANK(F491),\"\",F491)","v":""},{"$f":"IF(ISBLANK(G491),\"\",G491)","v":""},{"$f":"IF(ISBLANK(H491),\"\",H491)","v":""},{"$f":"IF(ISBLANK(I491),\"\",I491)","v":""}]
[null,"Number of packs required per treatment cycle",null,null,null,null,null,null,null,null," - Enter the number of packs of each pack presentation required per treatment cycle. For example if the treatment cycle is 28 days, and there are 14 days supply in one pack, enter \"2\" into column F.  Where each patient requires multiple products every treatment cycle, enter the number of packs of each pack type into the relevant column. For example,  where a patient requires 2 x Pack (F) and 1 x Pack (G) every 28 day treatment cycle, please enter 2 in column F and 1 in column G. Alternatively, where only a single pack is required by a patient each cycle but multiple strengths are available, a weighted average can be calculated by entering the relevant weight for each pack in every column. Ensure weights sum to 1. Add details of how weights are derived in notes section. "]
[]
[]
[]
[null,"Table C. Total Cost to the HSE per pack"]
["This table will fill automatically based on the information inserted above. This information in this table is used to calculate the costs in Table F."]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF(F491=\"\",\"\",F491)","v":""},{"$f":"IF(G491=\"\",\"\",G491)","v":""},{"$f":"IF(H491=\"\",\"\",H491)","v":""},{"$f":"IF(I491=\"\",\"\",I491)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR(F492=\"\",F493=\"\",F494=\"\"),\"\",IF(F492=\"Price to Wholesaler\",F493,IF(F492=\"Reimbursement Price\",(F515/(1+E514)*1),\"Error\")))","v":""},{"$f":"IF(OR(G492=\"\",G493=\"\",F494=\"\"),\"\",IF(G492=\"Price to Wholesaler\",G493,IF(G492=\"Reimbursement Price\",(G515/(1+E514)*1),\"Error\")))","v":""},{"$f":"IF(OR(H492=\"\",H493=\"\",F494=\"\"),\"\",IF(H492=\"Price to Wholesaler\",H493,IF(H492=\"Reimbursement Price\",(H515/(1+E514)*1),\"Error\")))","v":""},{"$f":"IF(OR(I492=\"\",I493=\"\",F494=\"\"),\"\",IF(I492=\"Price to Wholesaler\",I493,IF(I492=\"Reimbursement Price\",(I515/(1+E514)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR(F494=\"\"),\"\",IF(AND(F494=\"CDS\",F495=\"Yes\"),CYF,IF(AND(F494=\"CDS\",F495=\"No\"),CNF,IF(F494=\"HT\",CHT,IF(F494=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR(F494=\"\",F493=\"\",F492=\"\"),\"\",F513*E514)","v":""},{"$f":"IF(OR(F494=\"\",G493=\"\",G492=\"\"),\"\",G513*E514)","v":""},{"$f":"IF(OR(F494=\"\",H493=\"\",H492=\"\"),\"\",H513*E514)","v":""},{"$f":"IF(OR(F494=\"\",I493=\"\",I492=\"\"),\"\",I513*E514)","v":""}]
["C",{"$f":"IF(F494=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF(F492=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF(F492=\"Reimbursement Price\",F493,IF(ISBLANK(E514),\"\",IF(F492=\"Price to Wholesaler\",(F513+F514),IF(F492=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(G492=\"Reimbursement Price\",G493,IF(ISBLANK(E514),\"\",IF(G492=\"Price to Wholesaler\",(G513+G514),IF(G492=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(H492=\"Reimbursement Price\",H493,IF(ISBLANK(E514),\"\",IF(H492=\"Price to Wholesaler\",(H513+H514),IF(H492=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(I492=\"Reimbursement Price\",I493,IF(ISBLANK(E514),\"\",IF(I492=\"Price to Wholesaler\",(I513+I514),IF(I492=\"\",\"\",\"Error\"))))","v":""}]
["D","Framework Agreement Rebate",null,null,{"$f":"IF(OR(F497=\"\",AND(F497=\"Yes\",F498=\"\"),AND(F497=\"No\",F499=\"\")),\"\",IF(AND(F497=\"No\",F499=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (pre-2026)\"),MRpre2026,IF(AND(F497=\"No\",F499=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F497=\"No\",F499=\"Off Patent Non-Exclusive or Generic\"),\"None\",IF(AND(F497=\"Yes\",F498=\"Biosimilar\"),\"None\",IF(AND(F497=\"Yes\",F498=\"Patented or Off Patent Exclusive (pre-2026)\"),MRpre2026,IF(AND(F497=\"Yes\",F498=\"Patented or Off Patent Exclusive (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F497=\"Yes\",F498=\"Off Patent Non-Exclusive 12.5% Rebate incorporated into Price to Wholesaler\"),\"None\",IF(AND(F497=\"Yes\",F498=\"Off Patent Non-Exclusive 12.5% Rebate\"),MRB,\"Error\")))))))))","v":""},{"$f":"IF(OR(F497=\"\",AND(F497=\"Yes\",F498=\"\"),AND(F497=\"No\",F499=\"\"),F492=\"\",ISBLANK(F493)),\"\",IF(E516=\"None\",0,(E516*F513)))","v":""},{"$f":"IF(OR(F497=\"\",AND(F497=\"Yes\",F498=\"\"),AND(F497=\"No\",F499=\"\"),G492=\"\",ISBLANK(G493)),\"\",IF(E516=\"None\",0,(E516*G513)))","v":""},{"$f":"IF(OR(F497=\"\",AND(F497=\"Yes\",F498=\"\"),AND(F497=\"No\",F499=\"\"),H492=\"\",ISBLANK(H493)),\"\",IF(E516=\"None\",0,(E516*H513)))","v":""},{"$f":"IF(OR(F497=\"\",AND(F497=\"Yes\",F498=\"\"),AND(F497=\"No\",F499=\"\"),I492=\"\",ISBLANK(I493)),\"\",IF(E516=\"None\",0,(E516*I513)))","v":""}]
["E","VAT on Drug Cost ",null,null,{"$f":"IF(F496=\"\",\"\",IF(F496=\"Yes\",0,VT))","v":""},{"$f":"IF(OR(F493=\"\",ISBLANK(F493)),\"\",($E517*F515))","v":""},{"$f":"IF(OR(G493=\"\",ISBLANK(G493)),\"\",($E517*G515))","v":""},"",""]
["F(i)","Total Drug Cost to the HSE per pack including VAT",null,null,null,{"$f":"IF(OR(F492=\"\",$F494=\"\",$F496=\"\",$F497=\"\"),\"\",SUM(F515:F517))","v":""},{"$f":"IF(OR(G492=\"\",$F494=\"\",$F496=\"\",$F497=\"\"),\"\",SUM(G515:G517))","v":""},{"$f":"IF(OR(H492=\"\",$F494=\"\",$F496=\"\",$F497=\"\"),\"\",SUM(H515:H517))","v":""},{"$f":"IF(OR(I492=\"\",$F494=\"\",$F496=\"\",$F497=\"\"),\"\",SUM(I515:I517))","v":""}]
["F(ii)","Total Drug Cost to the HSE per pack excluding VAT",null,null,null,{"$f":"IF(OR(F492=\"\",$F494=\"\",$F496=\"\",$F497=\"\"),\"\",SUM(F515:F516))","v":""},{"$f":"IF(OR(G492=\"\",$F494=\"\",$F496=\"\",$F497=\"\"),\"\",SUM(G515:G516))","v":""},{"$f":"IF(OR(H492=\"\",$F494=\"\",$F496=\"\",$F497=\"\"),\"\",SUM(H515:H516))","v":""},{"$f":"IF(OR(I492=\"\",$F494=\"\",$F496=\"\",$F497=\"\"),\"\",SUM(I515:I516))","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table D. Pharmacy Fees payable based on the type of product and reimbursement arrangements"]
[null,"For hospital drugs this table may be ignored."]
[null,"This table fills  automatically based on scheme and product information inputted above in Table A. "]
[]
[null,null,null,null,null,null,"Calculation ","Value"]
[null,"Pharmacy Fees excluding VAT",null,null,null,null,{"$f":"IF(F494=\"\",\"\",IF(F494=\"CDS\",\"per dispensing\",IF(F494=\"HT\",\"per month\",IF(F494=\"Hosp\",\"No Fee\", ERROR))))","v":""},{"$f":"IF(F494=\"\",\"\",IF(F494=\"CDS\",DF,IF(F494=\"HT\",PC,IF(F494=\"Hosp\",\"No Fee\",ERROR))))","v":""},"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         "]
[null,"VAT on Pharmacy Fees",null,null,null,null,{"$f":"IF(OR(F494=\"\",F496=\"\"),\"\",IF(F494=\"Hosp\",\"No Fee\",IF(F494=\"HT\",\"No VAT\",IF(AND(F494=\"CDS\",F496=\"No\"),VT,\"No VAT\"))))","v":""},{"$f":"IF(OR(F496=\"\",F494=\"Hosp\"),\"\",IF(OR(F496=\"Yes\",F494=\"HT\"),0,H526*G527))","v":""}]
[]
[]
["Table E Pharmacy Fees per product treatment cycle. \n",null,null,null,null,null,null,null,null,null," - Based on the drug's dispensing regimen and the NCPE drug cost guidelines, please input the pharmacy fees per treatment cycle. Use data presented in Table D to generate an appropriate formula for Column H of Table E. Notes may be added in column G. "]
["This section may be ommited for hospital drugs",null,null,null,null,null,"Notes","Value",null,null,{"$f":"IF(F494=\"HT\",\"For High tech, if a treatment cycle =28 days the corresponding pharmacy fee is =62.03*12/365.25*28.  The pharmacy fee remains the same regardless of the number of products dispensed that month.\",IF(F494=\"CDS\",\"For CDS, if 2 packets of the same pack presentation are required per treatment cycle, one dispensing fee applies (€5.48). If multiple pack presentations are required, multiple dispensing fees apply\",\"\"))","v":""}]
["G","Pharmacy Fees per treatment cycle excluding VAT"]
["H","Non dispensed patient care fee per treatment cycle (High Tech only)",null,null,null,null,null,null,null,null," - Enter here if relevant. See NCPE drug cost guidelines for more information on non-dispensed patient care fees (High Tech only). "]
["I","VAT on pharmacy Fees",null,null,null,null,null,null,null,null," - Please input VAT payable on pharmacy fees if applicable based on the information presented in Table D. "]
["J (i)","Total pharmacy Fees per treatment cycle including VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H532),\"\",SUM(H532:H534))","v":""}]
["J (ii)","Total pharmacy Fees per treatment cycle excluding VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H532),\"\",SUM(H532:H533))","v":""}]
[]
[]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time",null," - Calculate the cost for the budget impact model using  cost per number of cycles, per year or per unit time. Input the length of time required  into the blue boxes where applicable. Irrelevant columns may be left blank. Use the drop down boxes to select days or months when calculating the cost per unit time."]
[]
[null,null,null,null,null,null,"number of cycles"]
["A",{"$f":"B513","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F513:I513,F505:I505)","v":0},{"$f":"F544*G542","v":0},{"$f":"IF(H503=\"Days\",F544/F503*365.25,IF(H503=\"Months\",F544/F503*12,\"\"))","v":""},{"$f":"IF(AND(H503=\"Days\",I543=\"Days\"),F544/F503*I542,IF(AND(H503=\"Months\",I543=\"Months\"),F544/F503*I542,IF(AND(H503=\"Days\",I543=\"Months\"),F544/F503*30.4375*I542,IF(AND(H503=\"Months\",I543=\"Days\"),F544/F503/30.4375*I542,\"\"))))","v":""}]
["B",{"$f":"B514","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F514:I514,F505:I505)","v":0},{"$f":"F545*G542","v":0},{"$f":"IF(H503=\"Days\",F545/F503*365.25,IF(H503=\"Months\",F545/F503*12,\"\"))","v":""},{"$f":"IF(AND(H503=\"Days\",I543=\"Days\"),F545/F503*I542,IF(AND(H503=\"Months\",I543=\"Months\"),F545/F503*I542,IF(AND(H503=\"Days\",I543=\"Months\"),F545/F503*30.4375*I542,IF(AND(H503=\"Months\",I543=\"Days\"),F545/F503/30.4375*I542,\"\"))))","v":""}]
["C",{"$f":"B515","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F515:I515,F505:I505)","v":0},{"$f":"F546*G542","v":0},{"$f":"IF(H503=\"Days\",F546/F503*365.25,IF(H503=\"Months\",F546/F503*12,\"\"))","v":""},{"$f":"IF(AND(H503=\"Days\",I543=\"Days\"),F546/F503*I542,IF(AND(H503=\"Months\",I543=\"Months\"),F546/F503*I542,IF(AND(H503=\"Days\",I543=\"Months\"),F546/F503*30.4375*I542,IF(AND(H503=\"Months\",I543=\"Days\"),F546/F503/30.4375*I542,\"\"))))","v":""}]
["D",{"$f":"B516","v":"Framework Agreement Rebate"},null,null,null,{"$f":"SUMPRODUCT(F516:I516,F505:I505)","v":0},{"$f":"F547*G542","v":0},{"$f":"IF(H503=\"Days\",F547/F503*365.25,IF(H503=\"Months\",F547/F503*12,\"\"))","v":""},{"$f":"IF(AND(H503=\"Days\",I543=\"Days\"),F547/F503*I542,IF(AND(H503=\"Months\",I543=\"Months\"),F547/F503*I542,IF(AND(H503=\"Days\",I543=\"Months\"),F547/F503*30.4375*I542,IF(AND(H503=\"Months\",I543=\"Days\"),F547/F503/30.4375*I542,\"\"))))","v":""}]
["E",{"$f":"B517","v":"VAT on Drug Cost "},null,null,null,{"$f":"SUMPRODUCT(F517:I517,F505:I505)","v":0},{"$f":"F548*G542","v":0},{"$f":"IF(H503=\"Days\",F548/F503*365.25,IF(H503=\"Months\",F548/F503*12,\"\"))","v":""},{"$f":"IF(AND(H503=\"Days\",I543=\"Days\"),F548/F503*I542,IF(AND(H503=\"Months\",I543=\"Months\"),F548/F503*I542,IF(AND(H503=\"Days\",I543=\"Months\"),F548/F503*30.4375*I542,IF(AND(H503=\"Months\",I543=\"Days\"),F548/F503/30.4375*I542,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF(H535=\"\",\"\",H535)","v":""},{"$f":"IF(F549=\"\",\"\",F549*G542)","v":""},{"$f":"IF(F549=\"\",\"\",MIN(IF(H503=\"Days\",F549/F503*365.25,IF(H503=\"Months\",F549/F503*12,\"\")), 744.36))","v":""},{"$f":"IF(F549=\"\",\"\",IF(AND(H503=\"Days\",I543=\"Days\"),F549/F503*I542,IF(AND(H503=\"Months\",I543=\"Months\"),F549/F503*I542,IF(AND(H503=\"Days\",I543=\"Months\"),F549/F503*30.4375*I542,IF(AND(H503=\"Months\",I543=\"Days\"),F549/F503/30.4375*I542,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF(H536=\"\",\"\",H536)","v":""},{"$f":"IF(F550=\"\",\"\",F550*G542)","v":""},{"$f":"IF(F550=\"\",\"\",MIN(IF(H503=\"Days\",F550/F503*365.25,IF(H503=\"Months\",F550/F503*12,\"\")), 744.36))","v":""},{"$f":"IF(F550=\"\",\"\",IF(AND(H503=\"Days\",I543=\"Days\"),F550/F503*I542,IF(AND(H503=\"Months\",I543=\"Months\"),F550/F503*I542,IF(AND(H503=\"Days\",I543=\"Months\"),F550/F503*30.4375*I542,IF(AND(H503=\"Months\",I543=\"Days\"),F550/F503/30.4375*I542,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 5",null,null,null,{"$f":"SUM(F546:F549)","v":0},{"$f":"SUM(G546:G549)","v":0},{"$f":"SUM(H546:H549)","v":0},{"$f":"SUM(I546:I549)","v":0},null,"It is important to complete Table F as figures will automatically populate in Tables 1a and 1b based on selections in Table G"]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 5",null,null,null,{"$f":"IF(F550=\"\",SUM(F546+F547),F546+F547+F550)","v":0},{"$f":"IF(G550=\"\",SUM(G546+G547),G546+G547+G550)","v":0},{"$f":"IF(H550=\"\",SUM(H546:H547),H546+H547+H550)","v":0},{"$f":"IF(I550=\"\",SUM(I546:I547),I546+I547+I550)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"CONCATENATE(\"Comparator 5: \",NameComparator5)","v":"Comparator 5: "},null,null,null,{"$f":"IF($E556=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E556,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$113&\" Comparator 5\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E556=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E556,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$113&\" Comparator 5\"),$B:$B,0))","v":{"$error":"#N/A"}},null,null," - Figures will automatically populate in Tables 1a and 1b based on selections in Table G unless selected as \"Calculated elsewhere by Applicant\" in Table G. The corresponding cells will then be coloured blue in Tables 1a and 1b. Please manually overwrite the formula in the blue cells with the appropriate figure if using the manual option."]
[]
[null,"Notes"]
[]
[null,"Source used to inform the duration of treatment (e.g pivotal trial publication/ reference cell in CEM):",null,null,null,null,null,null,null,null,"•\tThe Applicant should provide any additional detail necessary to permit validation of drug cost calculations by the Review Group. \n•\tPlease note that where drug cost calculations are insufficiently described, this will lead to delays in the appraisal process. "]
[null,"Please specify whether the above refers to a particular subpopulation (if applicable):"]
[null,"Source for dosing regimen applied in BIM (e.g product SmPC): "]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 6: \",NameComparator6)","v":"Comparator 6: "}]
[]
[]
[null,"Table A: Applicant Input Selection Table to calculate the cost per pack",null,null,null,null,null,null,null,null," - Please input all information requested in this table to automatically calculate the cost per pack in Table C. Up to four type of packs  can be accomodated in this table across columns F to I. If there are less than four packs, please leave extra columns blank. If there are more than four products, please contact bim@ncpe.ie. "]
[null,"Details required to calculate the cost per pack and pharmacy fee information"]
[null,null,null,null,null,"Strength/Pack Size"]
[null,"Pack Identification",null,null,null,null,null,null,null,null," - Enter identifying information (e.g. strength, pack size) for each pack. For example, column F: 40mgx28; column G: 20mgx28. "]
[null,"Calculation Starting Point",null,null,null,null,null,null,null,"\u0080"," - Enter whether the calculation starting point is the Price to Wholesaler (PTW) or Reimbursement Price. PTW is listed on the pricing application form (PAF) submitted to the HSE. Reimbursement price is listed on the PCRS website. "]
[null,"Price per Pack",null,null,null,null,null,null,null,null," - Enter the relevant pack price here.  "]
[null,"Drug Funding Arrangement",null,null,null,null,null,null,null,"\u0080"," - Choose the funding arrangements. CDS = Community Drug Schemes, HT = High Tech Drug Arrangements, Hosp = Hospital. "]
[null,"Fridge",null,null,null,null,null,null,null,"\u0080"," - Optional: fridge item status only required for the CDS as wholesale mark-up varies here. May leave blank for other schemes."]
[null,"Oral product (including inhalers)",null,null,null,null,null,null,null,"\u0080"," - Required for VAT. Oral products including inhalers are exempt from VAT."]
[null,"Biologic",null,null,null,null,null,null,null,"\u0080"," - Required for Framework Agreement rebate calculation."]
[null,"If Biologic =Yes: Select  Biologic and Patent Exclusivity Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =Yes, select the biologic and patent exclusivity status, pre- or post- 2026,  from the drop down list. If Biologic =No, select N/A. Required for Framework Agreement rebate calculation."]
[null,"If Biologic =No,  select Non Biologic Patent Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =No, select the non-biologic patent status, pre- or post- 2026.  If Biologic =Yes, select N/A. Required for Framework Agreement rebate calculation."]
[]
[null,"Table B: Applicant Input Table to calculate the cost per treatment cycle",null,null,null,null,null,null,null,null," - Treatment cycle is the length of time between product dispensings. For example, many oral tablet products have a treatment cycle of 28 days. If a drug is administered every six months, the treatment cycle is six months."]
[null,"Details required to calculate  the cost per treatment cycle"]
[null,"Length of Treatment Cycle",null,null,null,null,null,null,null,null," - Enter treatment cycle length in column F and select unit of measurement (Days/Months) in column H.  For treatment cycles measured in weeks, convert the number of weeks to days (e.g. 4 weeks = 28 days). One month is not equivalent to four weeks. If there is confusion over whether a dose is administered every four weeks or every month, refer to the SPC. "]
[null,{"$f":"B579","v":"Pack Identification"},null,null,null,{"$f":"IF(ISBLANK(F579),\"\",F579)","v":""},{"$f":"IF(ISBLANK(G579),\"\",G579)","v":""},{"$f":"IF(ISBLANK(H579),\"\",H579)","v":""},{"$f":"IF(ISBLANK(I579),\"\",I579)","v":""}]
[null,"Number of packs required per treatment cycle",null,null,null,null,null,null,null,null," - Enter the number of packs of each pack presentation required per treatment cycle. For example if the treatment cycle is 28 days, and there are 14 days supply in one pack, enter \"2\" into column F.  Where each patient requires multiple products every treatment cycle, enter the number of packs of each pack type into the relevant column. For example,  where a patient requires 2 x Pack (F) and 1 x Pack (G) every 28 day treatment cycle, please enter 2 in column F and 1 in column G. Alternatively, where only a single pack is required by a patient each cycle but multiple strengths are available, a weighted average can be calculated by entering the relevant weight for each pack in every column. Ensure weights sum to 1. Add details of how weights are derived in notes section. "]
[]
[]
[]
[null,"Table C. Total Cost to the HSE per pack"]
["This table will fill automatically based on the information inserted above. This information in this table is used to calculate the costs in Table F."]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF(F579=\"\",\"\",F579)","v":""},{"$f":"IF(G579=\"\",\"\",G579)","v":""},{"$f":"IF(H579=\"\",\"\",H579)","v":""},{"$f":"IF(I579=\"\",\"\",I579)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR(F580=\"\",F581=\"\",F582=\"\"),\"\",IF(F580=\"Price to Wholesaler\",F581,IF(F580=\"Reimbursement Price\",(F603/(1+E602)*1),\"Error\")))","v":""},{"$f":"IF(OR(G580=\"\",G581=\"\",F582=\"\"),\"\",IF(G580=\"Price to Wholesaler\",G581,IF(G580=\"Reimbursement Price\",(G603/(1+E602)*1),\"Error\")))","v":""},{"$f":"IF(OR(H580=\"\",H581=\"\",F582=\"\"),\"\",IF(H580=\"Price to Wholesaler\",H581,IF(H580=\"Reimbursement Price\",(H603/(1+E602)*1),\"Error\")))","v":""},{"$f":"IF(OR(I580=\"\",I581=\"\",F582=\"\"),\"\",IF(I580=\"Price to Wholesaler\",I581,IF(I580=\"Reimbursement Price\",(I603/(1+E602)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR(F582=\"\"),\"\",IF(AND(F582=\"CDS\",F583=\"Yes\"),CYF,IF(AND(F582=\"CDS\",F583=\"No\"),CNF,IF(F582=\"HT\",CHT,IF(F582=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR(F582=\"\",F581=\"\",F580=\"\"),\"\",F601*E602)","v":""},{"$f":"IF(OR(F582=\"\",G581=\"\",G580=\"\"),\"\",G601*E602)","v":""},{"$f":"IF(OR(F582=\"\",H581=\"\",H580=\"\"),\"\",H601*E602)","v":""},{"$f":"IF(OR(F582=\"\",I581=\"\",I580=\"\"),\"\",I601*E602)","v":""}]
["C",{"$f":"IF(F582=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF(F580=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF(F580=\"Reimbursement Price\",F581,IF(ISBLANK(E602),\"\",IF(F580=\"Price to Wholesaler\",(F601+F602),IF(F580=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(G580=\"Reimbursement Price\",G581,IF(ISBLANK(E602),\"\",IF(G580=\"Price to Wholesaler\",(G601+G602),IF(G580=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(H580=\"Reimbursement Price\",H581,IF(ISBLANK(E602),\"\",IF(H580=\"Price to Wholesaler\",(H601+H602),IF(H580=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(I580=\"Reimbursement Price\",I581,IF(ISBLANK(E602),\"\",IF(I580=\"Price to Wholesaler\",(I601+I602),IF(I580=\"\",\"\",\"Error\"))))","v":""}]
["D","Framework Agreement Rebate",null,null,{"$f":"IF(OR(F585=\"\",AND(F585=\"Yes\",F586=\"\"),AND(F585=\"No\",F587=\"\")),\"\",IF(AND(F585=\"No\",F587=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (pre-2026)\"),MRpre2026,IF(AND(F585=\"No\",F587=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F585=\"No\",F587=\"Off Patent Non-Exclusive or Generic\"),\"None\",IF(AND(F585=\"Yes\",F586=\"Biosimilar\"),\"None\",IF(AND(F585=\"Yes\",F586=\"Patented or Off Patent Exclusive (pre-2026)\"),MRpre2026,IF(AND(F585=\"Yes\",F586=\"Patented or Off Patent Exclusive (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F585=\"Yes\",F586=\"Off Patent Non-Exclusive 12.5% Rebate incorporated into Price to Wholesaler\"),\"None\",IF(AND(F585=\"Yes\",F586=\"Off Patent Non-Exclusive 12.5% Rebate\"),MRB,\"Error\")))))))))","v":""},{"$f":"IF(OR(F585=\"\",AND(F585=\"Yes\",F586=\"\"),AND(F585=\"No\",F587=\"\"),F580=\"\",ISBLANK(F581)),\"\",IF(E604=\"None\",0,(E604*F601)))","v":""},{"$f":"IF(OR(F585=\"\",AND(F585=\"Yes\",F586=\"\"),AND(F585=\"No\",F587=\"\"),G580=\"\",ISBLANK(G581)),\"\",IF(E604=\"None\",0,(E604*G601)))","v":""},{"$f":"IF(OR(F585=\"\",AND(F585=\"Yes\",F586=\"\"),AND(F585=\"No\",F587=\"\"),H580=\"\",ISBLANK(H581)),\"\",IF(E604=\"None\",0,(E604*H601)))","v":""},{"$f":"IF(OR(F585=\"\",AND(F585=\"Yes\",F586=\"\"),AND(F585=\"No\",F587=\"\"),I580=\"\",ISBLANK(I581)),\"\",IF(E604=\"None\",0,(E604*I601)))","v":""}]
["E","VAT on Drug Cost ",null,null,{"$f":"IF(F584=\"\",\"\",IF(F584=\"Yes\",0,VT))","v":""},{"$f":"IF(OR(F581=\"\",ISBLANK(F581)),\"\",($E605*F603))","v":""},{"$f":"IF(OR(G581=\"\",ISBLANK(G581)),\"\",($E605*G603))","v":""},"",""]
["F(i)","Total Drug Cost to the HSE per pack including VAT",null,null,null,{"$f":"IF(OR(F580=\"\",$F582=\"\",$F584=\"\",$F585=\"\"),\"\",SUM(F603:F605))","v":""},{"$f":"IF(OR(G580=\"\",$F582=\"\",$F584=\"\",$F585=\"\"),\"\",SUM(G603:G605))","v":""},{"$f":"IF(OR(H580=\"\",$F582=\"\",$F584=\"\",$F585=\"\"),\"\",SUM(H603:H605))","v":""},{"$f":"IF(OR(I580=\"\",$F582=\"\",$F584=\"\",$F585=\"\"),\"\",SUM(I603:I605))","v":""}]
["F(ii)","Total Drug Cost to the HSE per pack excluding VAT",null,null,null,{"$f":"IF(OR(F580=\"\",$F582=\"\",$F584=\"\",$F585=\"\"),\"\",SUM(F603:F604))","v":""},{"$f":"IF(OR(G580=\"\",$F582=\"\",$F584=\"\",$F585=\"\"),\"\",SUM(G603:G604))","v":""},{"$f":"IF(OR(H580=\"\",$F582=\"\",$F584=\"\",$F585=\"\"),\"\",SUM(H603:H604))","v":""},{"$f":"IF(OR(I580=\"\",$F582=\"\",$F584=\"\",$F585=\"\"),\"\",SUM(I603:I604))","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table D. Pharmacy Fees payable based on the type of product and reimbursement arrangements"]
[null,"For hospital drugs this table may be ignored."]
[null,"This table fills  automatically based on scheme and product information inputted above in Table A. "]
[]
[null,null,null,null,null,null,"Calculation ","Value"]
[null,"Pharmacy Fees excluding VAT",null,null,null,null,{"$f":"IF(F582=\"\",\"\",IF(F582=\"CDS\",\"per dispensing\",IF(F582=\"HT\",\"per month\",IF(F582=\"Hosp\",\"No Fee\", ERROR))))","v":""},{"$f":"IF(F582=\"\",\"\",IF(F582=\"CDS\",DF,IF(F582=\"HT\",PC,IF(F582=\"Hosp\",\"No Fee\",ERROR))))","v":""},"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         "]
[null,"VAT on Pharmacy Fees",null,null,null,null,{"$f":"IF(OR(F582=\"\",F584=\"\"),\"\",IF(F582=\"Hosp\",\"No Fee\",IF(F582=\"HT\",\"No VAT\",IF(AND(F582=\"CDS\",F584=\"No\"),VT,\"No VAT\"))))","v":""},{"$f":"IF(OR(F584=\"\",F582=\"Hosp\"),\"\",IF(OR(F584=\"Yes\",F582=\"HT\"),0,H614*G615))","v":""}]
[]
[]
["Table E Pharmacy Fees per product treatment cycle. \n",null,null,null,null,null,null,null,null,null," - Based on the drug's dispensing regimen and the NCPE drug cost guidelines, please input the pharmacy fees per treatment cycle. Use data presented in Table D to generate an appropriate formula for Column H of Table E. Notes may be added in column G. "]
["This section may be ommited for hospital drugs",null,null,null,null,null,"Notes","Value",null,null,{"$f":"IF(F582=\"HT\",\"For High tech, if a treatment cycle =28 days the corresponding pharmacy fee is =62.03*12/365.25*28.  The pharmacy fee remains the same regardless of the number of products dispensed that month.\",IF(F582=\"CDS\",\"For CDS, if 2 packets of the same pack presentation are required per treatment cycle, one dispensing fee applies (€5.48). If multiple pack presentations are required, multiple dispensing fees apply\",\"\"))","v":""}]
["G","Pharmacy Fees per treatment cycle excluding VAT"]
["H","Non dispensed patient care fee per treatment cycle (High Tech only)",null,null,null,null,null,null,null,null," - Enter here if relevant. See NCPE drug cost guidelines for more information on non-dispensed patient care fees (High Tech only). "]
["I","VAT on pharmacy Fees",null,null,null,null,null,null,null,null," - Please input VAT payable on pharmacy fees if applicable based on the information presented in Table D. "]
["J (i)","Total pharmacy Fees per treatment cycle including VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H620),\"\",SUM(H620:H622))","v":""}]
["J (ii)","Total pharmacy Fees per treatment cycle excluding VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H620),\"\",SUM(H620:H621))","v":""}]
[]
[]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time",null," - Calculate the cost for the budget impact model using  cost per number of cycles, per year or per unit time. Input the length of time required  into the blue boxes where applicable. Irrelevant columns may be left blank. Use the drop down boxes to select days or months when calculating the cost per unit time."]
[]
[null,null,null,null,null,null,"number of cycles"]
["A",{"$f":"B601","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F601:I601,F593:I593)","v":0},{"$f":"F632*G630","v":0},{"$f":"IF(H591=\"Days\",F632/F591*365.25,IF(H591=\"Months\",F632/F591*12,\"\"))","v":""},{"$f":"IF(AND(H591=\"Days\",I631=\"Days\"),F632/F591*I630,IF(AND(H591=\"Months\",I631=\"Months\"),F632/F591*I630,IF(AND(H591=\"Days\",I631=\"Months\"),F632/F591*30.4375*I630,IF(AND(H591=\"Months\",I631=\"Days\"),F632/F591/30.4375*I630,\"\"))))","v":""}]
["B",{"$f":"B602","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F602:I602,F593:I593)","v":0},{"$f":"F633*G630","v":0},{"$f":"IF(H591=\"Days\",F633/F591*365.25,IF(H591=\"Months\",F633/F591*12,\"\"))","v":""},{"$f":"IF(AND(H591=\"Days\",I631=\"Days\"),F633/F591*I630,IF(AND(H591=\"Months\",I631=\"Months\"),F633/F591*I630,IF(AND(H591=\"Days\",I631=\"Months\"),F633/F591*30.4375*I630,IF(AND(H591=\"Months\",I631=\"Days\"),F633/F591/30.4375*I630,\"\"))))","v":""}]
["C",{"$f":"B603","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F603:I603,F593:I593)","v":0},{"$f":"F634*G630","v":0},{"$f":"IF(H591=\"Days\",F634/F591*365.25,IF(H591=\"Months\",F634/F591*12,\"\"))","v":""},{"$f":"IF(AND(H591=\"Days\",I631=\"Days\"),F634/F591*I630,IF(AND(H591=\"Months\",I631=\"Months\"),F634/F591*I630,IF(AND(H591=\"Days\",I631=\"Months\"),F634/F591*30.4375*I630,IF(AND(H591=\"Months\",I631=\"Days\"),F634/F591/30.4375*I630,\"\"))))","v":""}]
["D",{"$f":"B604","v":"Framework Agreement Rebate"},null,null,null,{"$f":"SUMPRODUCT(F604:I604,F593:I593)","v":0},{"$f":"F635*G630","v":0},{"$f":"IF(H591=\"Days\",F635/F591*365.25,IF(H591=\"Months\",F635/F591*12,\"\"))","v":""},{"$f":"IF(AND(H591=\"Days\",I631=\"Days\"),F635/F591*I630,IF(AND(H591=\"Months\",I631=\"Months\"),F635/F591*I630,IF(AND(H591=\"Days\",I631=\"Months\"),F635/F591*30.4375*I630,IF(AND(H591=\"Months\",I631=\"Days\"),F635/F591/30.4375*I630,\"\"))))","v":""}]
["E",{"$f":"B605","v":"VAT on Drug Cost "},null,null,null,{"$f":"SUMPRODUCT(F605:I605,F593:I593)","v":0},{"$f":"F636*G630","v":0},{"$f":"IF(H591=\"Days\",F636/F591*365.25,IF(H591=\"Months\",F636/F591*12,\"\"))","v":""},{"$f":"IF(AND(H591=\"Days\",I631=\"Days\"),F636/F591*I630,IF(AND(H591=\"Months\",I631=\"Months\"),F636/F591*I630,IF(AND(H591=\"Days\",I631=\"Months\"),F636/F591*30.4375*I630,IF(AND(H591=\"Months\",I631=\"Days\"),F636/F591/30.4375*I630,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF(H623=\"\",\"\",H623)","v":""},{"$f":"IF(F637=\"\",\"\",F637*G630)","v":""},{"$f":"IF(F637=\"\",\"\",MIN(IF(H591=\"Days\",F637/F591*365.25,IF(H591=\"Months\",F637/F591*12,\"\")), 744.36))","v":""},{"$f":"IF(F637=\"\",\"\",IF(AND(H591=\"Days\",I631=\"Days\"),F637/F591*I630,IF(AND(H591=\"Months\",I631=\"Months\"),F637/F591*I630,IF(AND(H591=\"Days\",I631=\"Months\"),F637/F591*30.4375*I630,IF(AND(H591=\"Months\",I631=\"Days\"),F637/F591/30.4375*I630,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF(H624=\"\",\"\",H624)","v":""},{"$f":"IF(F638=\"\",\"\",F638*G630)","v":""},{"$f":"IF(F638=\"\",\"\",MIN(IF(H591=\"Days\",F638/F591*365.25,IF(H591=\"Months\",F638/F591*12,\"\")), 744.36))","v":""},{"$f":"IF(F638=\"\",\"\",IF(AND(H591=\"Days\",I631=\"Days\"),F638/F591*I630,IF(AND(H591=\"Months\",I631=\"Months\"),F638/F591*I630,IF(AND(H591=\"Days\",I631=\"Months\"),F638/F591*30.4375*I630,IF(AND(H591=\"Months\",I631=\"Days\"),F638/F591/30.4375*I630,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 6",null,null,null,{"$f":"SUM(F634:F637)","v":0},{"$f":"SUM(G634:G637)","v":0},{"$f":"SUM(H634:H637)","v":0},{"$f":"SUM(I634:I637)","v":0},null,"It is important to complete Table F as figures will automatically populate in Tables 1a and 1b based on selections in Table G"]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 6",null,null,null,{"$f":"IF(F638=\"\",SUM(F634+F635),F634+F635+F638)","v":0},{"$f":"IF(G638=\"\",SUM(G634+G635),G634+G635+G638)","v":0},{"$f":"IF(H638=\"\",SUM(H634:H635),H634+H635+H638)","v":0},{"$f":"IF(I638=\"\",SUM(I634:I635),I634+I635+I638)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"CONCATENATE(\"Comparator 6: \",NameComparator6)","v":"Comparator 6: "},null,null,null,{"$f":"IF($E644=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E644,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$113&\" Comparator 6\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E644=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E644,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$113&\" Comparator 6\"),$B:$B,0))","v":{"$error":"#N/A"}},null,null," - Figures will automatically populate in Tables 1a and 1b based on selections in Table G unless selected as \"Calculated elsewhere by Applicant\" in Table G. The corresponding cells will then be coloured blue in Tables 1a and 1b. Please manually overwrite the formula in the blue cells with the appropriate figure if using the manual option."]
[]
[null,"Notes"]
[]
[null,"Source used to inform the duration of treatment (e.g pivotal trial publication/ reference cell in CEM):",null,null,null,null,null,null,null,null,"•\tThe Applicant should provide any additional detail necessary to permit validation of drug cost calculations by the Review Group. \n•\tPlease note that where drug cost calculations are insufficiently described, this will lead to delays in the appraisal process. "]
[null,"Please specify whether the above refers to a particular subpopulation (if applicable):"]
[null,"Source for dosing regimen applied in BIM (e.g product SmPC): "]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 7: \",NameComparator7)","v":"Comparator 7: "}]
[]
[]
[null,"Table A: Applicant Input Selection Table to calculate the cost per pack",null,null,null,null,null,null,null,null," - Please input all information requested in this table to automatically calculate the cost per pack in Table C. Up to four type of packs  can be accomodated in this table across columns F to I. If there are less than four packs, please leave extra columns blank. If there are more than four products, please contact bim@ncpe.ie. "]
[null,"Details required to calculate the cost per pack and pharmacy fee information"]
[null,null,null,null,null,"Strength/Pack Size"]
[null,"Pack Identification",null,null,null,null,null,null,null,null," - Enter identifying information (e.g. strength, pack size) for each pack. For example, column F: 40mgx28; column G: 20mgx28. "]
[null,"Calculation Starting Point",null,null,null,null,null,null,null,"\u0080"," - Enter whether the calculation starting point is the Price to Wholesaler (PTW) or Reimbursement Price. PTW is listed on the pricing application form (PAF) submitted to the HSE. Reimbursement price is listed on the PCRS website. "]
[null,"Price per Pack",null,null,null,null,null,null,null,null," - Enter the relevant pack price here.  "]
[null,"Drug Funding Arrangement",null,null,null,null,null,null,null,"\u0080"," - Choose the funding arrangements. CDS = Community Drug Schemes, HT = High Tech Drug Arrangements, Hosp = Hospital. "]
[null,"Fridge",null,null,null,null,null,null,null,"\u0080"," - Optional: fridge item status only required for the CDS as wholesale mark-up varies here. May leave blank for other schemes."]
[null,"Oral product (including inhalers)",null,null,null,null,null,null,null,"\u0080"," - Required for VAT. Oral products including inhalers are exempt from VAT."]
[null,"Biologic",null,null,null,null,null,null,null,"\u0080"," - Required for Frameowrk Agreement rebate calculation."]
[null,"If Biologic =Yes: Select  Biologic and Patent Exclusivity Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =Yes, select the biologic and patent exclusivity status, pre- or post- 2026,  from the drop down list. If Biologic =No, select N/A. Required for Framework Agreement rebate calculation."]
[null,"If Biologic =No,  select Non Biologic Patent Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =No, select the non-biologic patent status, pre- or post- 2026.  If Biologic =Yes, select N/A. Required for Framework Agreement rebate calculation."]
[]
[null,"Table B: Applicant Input Table to calculate the cost per treatment cycle",null,null,null,null,null,null,null,null," - Treatment cycle is the length of time between product dispensings. For example, many oral tablet products have a treatment cycle of 28 days. If a drug is administered every six months, the treatment cycle is six months."]
[null,"Details required to calculate  the cost per treatment cycle"]
[null,"Length of Treatment Cycle",null,null,null,null,null,null,null,null," - Enter treatment cycle length in column F and select unit of measurement (Days/Months) in column H.  For treatment cycles measured in weeks, convert the number of weeks to days (e.g. 4 weeks = 28 days). One month is not equivalent to four weeks. If there is confusion over whether a dose is administered every four weeks or every month, refer to the SPC. "]
[null,{"$f":"B667","v":"Pack Identification"},null,null,null,{"$f":"IF(ISBLANK(F667),\"\",F667)","v":""},{"$f":"IF(ISBLANK(G667),\"\",G667)","v":""},{"$f":"IF(ISBLANK(H667),\"\",H667)","v":""},{"$f":"IF(ISBLANK(I667),\"\",I667)","v":""}]
[null,"Number of packs required per treatment cycle",null,null,null,null,null,null,null,null," - Enter the number of packs of each pack presentation required per treatment cycle. For example if the treatment cycle is 28 days, and there are 14 days supply in one pack, enter \"2\" into column F.  Where each patient requires multiple products every treatment cycle, enter the number of packs of each pack type into the relevant column. For example,  where a patient requires 2 x Pack (F) and 1 x Pack (G) every 28 day treatment cycle, please enter 2 in column F and 1 in column G. Alternatively, where only a single pack is required by a patient each cycle but multiple strengths are available, a weighted average can be calculated by entering the relevant weight for each pack in every column. Ensure weights sum to 1. Add details of how weights are derived in notes section. "]
[]
[]
[]
[null,"Table C. Total Cost to the HSE per pack"]
["This table will fill automatically based on the information inserted above. This information in this table is used to calculate the costs in Table F."]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF(F667=\"\",\"\",F667)","v":""},{"$f":"IF(G667=\"\",\"\",G667)","v":""},{"$f":"IF(H667=\"\",\"\",H667)","v":""},{"$f":"IF(I667=\"\",\"\",I667)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR(F668=\"\",F669=\"\",F670=\"\"),\"\",IF(F668=\"Price to Wholesaler\",F669,IF(F668=\"Reimbursement Price\",(F691/(1+E690)*1),\"Error\")))","v":""},{"$f":"IF(OR(G668=\"\",G669=\"\",F670=\"\"),\"\",IF(G668=\"Price to Wholesaler\",G669,IF(G668=\"Reimbursement Price\",(G691/(1+E690)*1),\"Error\")))","v":""},{"$f":"IF(OR(H668=\"\",H669=\"\",F670=\"\"),\"\",IF(H668=\"Price to Wholesaler\",H669,IF(H668=\"Reimbursement Price\",(H691/(1+E690)*1),\"Error\")))","v":""},{"$f":"IF(OR(I668=\"\",I669=\"\",F670=\"\"),\"\",IF(I668=\"Price to Wholesaler\",I669,IF(I668=\"Reimbursement Price\",(I691/(1+E690)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR(F670=\"\"),\"\",IF(AND(F670=\"CDS\",F671=\"Yes\"),CYF,IF(AND(F670=\"CDS\",F671=\"No\"),CNF,IF(F670=\"HT\",CHT,IF(F670=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR(F670=\"\",F669=\"\",F668=\"\"),\"\",F689*E690)","v":""},{"$f":"IF(OR(F670=\"\",G669=\"\",G668=\"\"),\"\",G689*E690)","v":""},{"$f":"IF(OR(F670=\"\",H669=\"\",H668=\"\"),\"\",H689*E690)","v":""},{"$f":"IF(OR(F670=\"\",I669=\"\",I668=\"\"),\"\",I689*E690)","v":""}]
["C",{"$f":"IF(F670=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF(F668=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF(F668=\"Reimbursement Price\",F669,IF(ISBLANK(E690),\"\",IF(F668=\"Price to Wholesaler\",(F689+F690),IF(F668=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(G668=\"Reimbursement Price\",G669,IF(ISBLANK(E690),\"\",IF(G668=\"Price to Wholesaler\",(G689+G690),IF(G668=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(H668=\"Reimbursement Price\",H669,IF(ISBLANK(E690),\"\",IF(H668=\"Price to Wholesaler\",(H689+H690),IF(H668=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(I668=\"Reimbursement Price\",I669,IF(ISBLANK(E690),\"\",IF(I668=\"Price to Wholesaler\",(I689+I690),IF(I668=\"\",\"\",\"Error\"))))","v":""}]
["D","Framework Agreement Rebate",null,null,{"$f":"IF(OR(F673=\"\",AND(F673=\"Yes\",F674=\"\"),AND(F673=\"No\",F675=\"\")),\"\",IF(AND(F673=\"No\",F675=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (pre-2026)\"),MRpre2026,IF(AND(F673=\"No\",F675=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F673=\"No\",F675=\"Off Patent Non-Exclusive or Generic\"),\"None\",IF(AND(F673=\"Yes\",F674=\"Biosimilar\"),\"None\",IF(AND(F673=\"Yes\",F674=\"Patented or Off Patent Exclusive (pre-2026)\"),MRpre2026,IF(AND(F673=\"Yes\",F674=\"Patented or Off Patent Exclusive (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F673=\"Yes\",F674=\"Off Patent Non-Exclusive 12.5% Rebate incorporated into Price to Wholesaler\"),\"None\",IF(AND(F673=\"Yes\",F674=\"Off Patent Non-Exclusive 12.5% Rebate\"),MRB,\"Error\")))))))))","v":""},{"$f":"IF(OR(F673=\"\",AND(F673=\"Yes\",F674=\"\"),AND(F673=\"No\",F675=\"\"),F668=\"\",ISBLANK(F669)),\"\",IF(E692=\"None\",0,(E692*F689)))","v":""},{"$f":"IF(OR(F673=\"\",AND(F673=\"Yes\",F674=\"\"),AND(F673=\"No\",F675=\"\"),G668=\"\",ISBLANK(G669)),\"\",IF(E692=\"None\",0,(E692*G689)))","v":""},{"$f":"IF(OR(F673=\"\",AND(F673=\"Yes\",F674=\"\"),AND(F673=\"No\",F675=\"\"),H668=\"\",ISBLANK(H669)),\"\",IF(E692=\"None\",0,(E692*H689)))","v":""},{"$f":"IF(OR(F673=\"\",AND(F673=\"Yes\",F674=\"\"),AND(F673=\"No\",F675=\"\"),I668=\"\",ISBLANK(I669)),\"\",IF(E692=\"None\",0,(E692*I689)))","v":""}]
["E","VAT on Drug Cost ",null,null,{"$f":"IF(F672=\"\",\"\",IF(F672=\"Yes\",0,VT))","v":""},{"$f":"IF(OR(F669=\"\",ISBLANK(F669)),\"\",($E693*F691))","v":""},{"$f":"IF(OR(G669=\"\",ISBLANK(G669)),\"\",($E693*G691))","v":""},"",""]
["F(i)","Total Drug Cost to the HSE per pack including VAT",null,null,null,{"$f":"IF(OR(F668=\"\",$F670=\"\",$F672=\"\",$F673=\"\"),\"\",SUM(F691:F693))","v":""},{"$f":"IF(OR(G668=\"\",$F670=\"\",$F672=\"\",$F673=\"\"),\"\",SUM(G691:G693))","v":""},{"$f":"IF(OR(H668=\"\",$F670=\"\",$F672=\"\",$F673=\"\"),\"\",SUM(H691:H693))","v":""},{"$f":"IF(OR(I668=\"\",$F670=\"\",$F672=\"\",$F673=\"\"),\"\",SUM(I691:I693))","v":""}]
["F(ii)","Total Drug Cost to the HSE per pack excluding VAT",null,null,null,{"$f":"IF(OR(F668=\"\",$F670=\"\",$F672=\"\",$F673=\"\"),\"\",SUM(F691:F692))","v":""},{"$f":"IF(OR(G668=\"\",$F670=\"\",$F672=\"\",$F673=\"\"),\"\",SUM(G691:G692))","v":""},{"$f":"IF(OR(H668=\"\",$F670=\"\",$F672=\"\",$F673=\"\"),\"\",SUM(H691:H692))","v":""},{"$f":"IF(OR(I668=\"\",$F670=\"\",$F672=\"\",$F673=\"\"),\"\",SUM(I691:I692))","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table D. Pharmacy Fees payable based on the type of product and reimbursement arrangements"]
[null,"For hospital drugs this table may be ignored."]
[null,"This table fills  automatically based on scheme and product information inputted above in Table A. "]
[]
[null,null,null,null,null,null,"Calculation ","Value"]
[null,"Pharmacy Fees excluding VAT",null,null,null,null,{"$f":"IF(F670=\"\",\"\",IF(F670=\"CDS\",\"per dispensing\",IF(F670=\"HT\",\"per month\",IF(F670=\"Hosp\",\"No Fee\", ERROR))))","v":""},{"$f":"IF(F670=\"\",\"\",IF(F670=\"CDS\",DF,IF(F670=\"HT\",PC,IF(F670=\"Hosp\",\"No Fee\",ERROR))))","v":""},"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         "]
[null,"VAT on Pharmacy Fees",null,null,null,null,{"$f":"IF(OR(F670=\"\",F672=\"\"),\"\",IF(F670=\"Hosp\",\"No Fee\",IF(F670=\"HT\",\"No VAT\",IF(AND(F670=\"CDS\",F672=\"No\"),VT,\"No VAT\"))))","v":""},{"$f":"IF(OR(F672=\"\",F670=\"Hosp\"),\"\",IF(OR(F672=\"Yes\",F670=\"HT\"),0,H702*G703))","v":""}]
[]
[]
["Table E Pharmacy Fees per product treatment cycle. \n",null,null,null,null,null,null,null,null,null," - Based on the drug's dispensing regimen and the NCPE drug cost guidelines, please input the pharmacy fees per treatment cycle. Use data presented in Table D to generate an appropriate formula for Column H of Table E. Notes may be added in column G. "]
["This section may be ommited for hospital drugs",null,null,null,null,null,"Notes","Value",null,null,{"$f":"IF(F670=\"HT\",\"For High tech, if a treatment cycle =28 days the corresponding pharmacy fee is =62.03*12/365.25*28.  The pharmacy fee remains the same regardless of the number of products dispensed that month.\",IF(F670=\"CDS\",\"For CDS, if 2 packets of the same pack presentation are required per treatment cycle, one dispensing fee applies (€5.48). If multiple pack presentations are required, multiple dispensing fees apply\",\"\"))","v":""}]
["G","Pharmacy Fees per treatment cycle excluding VAT"]
["H","Non dispensed patient care fee per treatment cycle (High Tech only)",null,null,null,null,null,null,null,null," - Enter here if relevant. See NCPE drug cost guidelines for more information on non-dispensed patient care fees (High Tech only). "]
["I","VAT on pharmacy Fees",null,null,null,null,null,null,null,null," - Please input VAT payable on pharmacy fees if applicable based on the information presented in Table D. "]
["J (i)","Total pharmacy Fees per treatment cycle including VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H708),\"\",SUM(H708:H710))","v":""}]
["J (ii)","Total pharmacy Fees per treatment cycle excluding VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H708),\"\",SUM(H708:H709))","v":""}]
[]
[]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time",null," - Calculate the cost for the budget impact model using  cost per number of cycles, per year or per unit time. Input the length of time required  into the blue boxes where applicable. Irrelevant columns may be left blank. Use the drop down boxes to select days or months when calculating the cost per unit time."]
[]
[null,null,null,null,null,null,"number of cycles"]
["A",{"$f":"B689","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F689:I689,F681:I681)","v":0},{"$f":"F720*G718","v":0},{"$f":"IF(H679=\"Days\",F720/F679*365.25,IF(H679=\"Months\",F720/F679*12,\"\"))","v":""},{"$f":"IF(AND(H679=\"Days\",I719=\"Days\"),F720/F679*I718,IF(AND(H679=\"Months\",I719=\"Months\"),F720/F679*I718,IF(AND(H679=\"Days\",I719=\"Months\"),F720/F679*30.4375*I718,IF(AND(H679=\"Months\",I719=\"Days\"),F720/F679/30.4375*I718,\"\"))))","v":""}]
["B",{"$f":"B690","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F690:I690,F681:I681)","v":0},{"$f":"F721*G718","v":0},{"$f":"IF(H679=\"Days\",F721/F679*365.25,IF(H679=\"Months\",F721/F679*12,\"\"))","v":""},{"$f":"IF(AND(H679=\"Days\",I719=\"Days\"),F721/F679*I718,IF(AND(H679=\"Months\",I719=\"Months\"),F721/F679*I718,IF(AND(H679=\"Days\",I719=\"Months\"),F721/F679*30.4375*I718,IF(AND(H679=\"Months\",I719=\"Days\"),F721/F679/30.4375*I718,\"\"))))","v":""}]
["C",{"$f":"B691","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F691:I691,F681:I681)","v":0},{"$f":"F722*G718","v":0},{"$f":"IF(H679=\"Days\",F722/F679*365.25,IF(H679=\"Months\",F722/F679*12,\"\"))","v":""},{"$f":"IF(AND(H679=\"Days\",I719=\"Days\"),F722/F679*I718,IF(AND(H679=\"Months\",I719=\"Months\"),F722/F679*I718,IF(AND(H679=\"Days\",I719=\"Months\"),F722/F679*30.4375*I718,IF(AND(H679=\"Months\",I719=\"Days\"),F722/F679/30.4375*I718,\"\"))))","v":""}]
["D",{"$f":"B692","v":"Framework Agreement Rebate"},null,null,null,{"$f":"SUMPRODUCT(F692:I692,F681:I681)","v":0},{"$f":"F723*G718","v":0},{"$f":"IF(H679=\"Days\",F723/F679*365.25,IF(H679=\"Months\",F723/F679*12,\"\"))","v":""},{"$f":"IF(AND(H679=\"Days\",I719=\"Days\"),F723/F679*I718,IF(AND(H679=\"Months\",I719=\"Months\"),F723/F679*I718,IF(AND(H679=\"Days\",I719=\"Months\"),F723/F679*30.4375*I718,IF(AND(H679=\"Months\",I719=\"Days\"),F723/F679/30.4375*I718,\"\"))))","v":""}]
["E",{"$f":"B693","v":"VAT on Drug Cost "},null,null,null,{"$f":"SUMPRODUCT(F693:I693,F681:I681)","v":0},{"$f":"F724*G718","v":0},{"$f":"IF(H679=\"Days\",F724/F679*365.25,IF(H679=\"Months\",F724/F679*12,\"\"))","v":""},{"$f":"IF(AND(H679=\"Days\",I719=\"Days\"),F724/F679*I718,IF(AND(H679=\"Months\",I719=\"Months\"),F724/F679*I718,IF(AND(H679=\"Days\",I719=\"Months\"),F724/F679*30.4375*I718,IF(AND(H679=\"Months\",I719=\"Days\"),F724/F679/30.4375*I718,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF(H711=\"\",\"\",H711)","v":""},{"$f":"IF(F725=\"\",\"\",F725*G718)","v":""},{"$f":"IF(F725=\"\",\"\",MIN(IF(H679=\"Days\",F725/F679*365.25,IF(H679=\"Months\",F725/F679*12,\"\")), 744.36))","v":""},{"$f":"IF(F725=\"\",\"\",IF(AND(H679=\"Days\",I719=\"Days\"),F725/F679*I718,IF(AND(H679=\"Months\",I719=\"Months\"),F725/F679*I718,IF(AND(H679=\"Days\",I719=\"Months\"),F725/F679*30.4375*I718,IF(AND(H679=\"Months\",I719=\"Days\"),F725/F679/30.4375*I718,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF(H712=\"\",\"\",H712)","v":""},{"$f":"IF(F726=\"\",\"\",F726*G718)","v":""},{"$f":"IF(F726=\"\",\"\",MIN(IF(H679=\"Days\",F726/F679*365.25,IF(H679=\"Months\",F726/F679*12,\"\")), 744.36))","v":""},{"$f":"IF(F726=\"\",\"\",IF(AND(H679=\"Days\",I719=\"Days\"),F726/F679*I718,IF(AND(H679=\"Months\",I719=\"Months\"),F726/F679*I718,IF(AND(H679=\"Days\",I719=\"Months\"),F726/F679*30.4375*I718,IF(AND(H679=\"Months\",I719=\"Days\"),F726/F679/30.4375*I718,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 7",null,null,null,{"$f":"SUM(F722:F725)","v":0},{"$f":"SUM(G722:G725)","v":0},{"$f":"SUM(H722:H725)","v":0},{"$f":"SUM(I722:I725)","v":0},null,"It is important to complete Table F as figures will automatically populate in Tables 1a and 1b based on selections in Table G"]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 7",null,null,null,{"$f":"IF(F726=\"\",SUM(F722+F723),F722+F723+F726)","v":0},{"$f":"IF(G726=\"\",SUM(G722+G723),G722+G723+G726)","v":0},{"$f":"IF(H726=\"\",SUM(H722:H723),H722+H723+H726)","v":0},{"$f":"IF(I726=\"\",SUM(I722:I723),I722+I723+I726)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"CONCATENATE(\"Comparator 7: \",NameComparator7)","v":"Comparator 7: "},null,null,null,{"$f":"IF($E732=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E732,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$113&\" Comparator 7\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E732=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E732,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$113&\" Comparator 7\"),$B:$B,0))","v":{"$error":"#N/A"}},null,null," - Figures will automatically populate in Tables 1a and 1b based on selections in Table G unless selected as \"Calculated elsewhere by Applicant\" in Table G. The corresponding cells will then be coloured blue in Tables 1a and 1b. Please manually overwrite the formula in the blue cells with the appropriate figure if using the manual option."]
[]
[null,"Notes"]
[]
[null,"Source used to inform the duration of treatment (e.g pivotal trial publication/ reference cell in CEM):",null,null,null,null,null,null,null,null,"•\tThe Applicant should provide any additional detail necessary to permit validation of drug cost calculations by the Review Group. \n•\tPlease note that where drug cost calculations are insufficiently described, this will lead to delays in the appraisal process. "]
[null,"Please specify whether the above refers to a particular subpopulation (if applicable):"]
[null,"Source for dosing regimen applied in BIM (e.g product SmPC): "]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 8: \",NameComparator8)","v":"Comparator 8: "}]
[]
[]
[null,"Table A: Applicant Input Selection Table to calculate the cost per pack",null,null,null,null,null,null,null,null," - Please input all information requested in this table to automatically calculate the cost per pack in Table C. Up to four type of packs  can be accomodated in this table across columns F to I. If there are less than four packs, please leave extra columns blank. If there are more than four products, please contact bim@ncpe.ie. "]
[null,"Details required to calculate the cost per pack and pharmacy fee information"]
[null,null,null,null,null,"Strength/Pack Size"]
[null,"Pack Identification",null,null,null,null,null,null,null,null," - Enter identifying information (e.g. strength, pack size) for each pack. For example, column F: 40mgx28; column G: 20mgx28. "]
[null,"Calculation Starting Point",null,null,null,null,null,null,null,"\u0080"," - Enter whether the calculation starting point is the Price to Wholesaler (PTW) or Reimbursement Price. PTW is listed on the pricing application form (PAF) submitted to the HSE. Reimbursement price is listed on the PCRS website. "]
[null,"Price per Pack",null,null,null,null,null,null,null,null," - Enter the relevant pack price here.  "]
[null,"Drug Funding Arrangement",null,null,null,null,null,null,null,"\u0080"," - Choose the funding arrangements. CDS = Community Drug Schemes, HT = High Tech Drug Arrangements, Hosp = Hospital. "]
[null,"Fridge",null,null,null,null,null,null,null,"\u0080"," - Optional: fridge item status only required for the CDS as wholesale mark-up varies here. May leave blank for other schemes."]
[null,"Oral product (including inhalers)",null,null,null,null,null,null,null,"\u0080"," - Required for VAT. Oral products including inhalers are exempt from VAT."]
[null,"Biologic",null,null,null,null,null,null,null,"\u0080"," - Required for Frameowrk Agreement rebate calculation."]
[null,"If Biologic =Yes: Select  Biologic and Patent Exclusivity Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =Yes, select the biologic and patent exclusivity status, pre- or post- 2026,  from the drop down list. If Biologic =No, select N/A. Required for Framework Agreement rebate calculation."]
[null,"If Biologic =No,  select Non Biologic Patent Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =No, select the non-biologic patent status, pre- or post- 2026.  If Biologic =Yes, select N/A. Required for Framework Agreement rebate calculation."]
[]
[null,"Table B: Applicant Input Table to calculate the cost per treatment cycle",null,null,null,null,null,null,null,null," - Treatment cycle is the length of time between product dispensings. For example, many oral tablet products have a treatment cycle of 28 days. If a drug is administered every six months, the treatment cycle is six months."]
[null,"Details required to calculate  the cost per treatment cycle"]
[null,"Length of Treatment Cycle",null,null,null,null,null,null,null,null," - Enter treatment cycle length in column F and select unit of measurement (Days/Months) in column H.  For treatment cycles measured in weeks, convert the number of weeks to days (e.g. 4 weeks = 28 days). One month is not equivalent to four weeks. If there is confusion over whether a dose is administered every four weeks or every month, refer to the SPC. "]
[null,{"$f":"B755","v":"Pack Identification"},null,null,null,{"$f":"IF(ISBLANK(F755),\"\",F755)","v":""},{"$f":"IF(ISBLANK(G755),\"\",G755)","v":""},{"$f":"IF(ISBLANK(H755),\"\",H755)","v":""},{"$f":"IF(ISBLANK(I755),\"\",I755)","v":""}]
[null,"Number of packs required per treatment cycle",null,null,null,null,null,null,null,null," - Enter the number of packs of each pack presentation required per treatment cycle. For example if the treatment cycle is 28 days, and there are 14 days supply in one pack, enter \"2\" into column F.  Where each patient requires multiple products every treatment cycle, enter the number of packs of each pack type into the relevant column. For example,  where a patient requires 2 x Pack (F) and 1 x Pack (G) every 28 day treatment cycle, please enter 2 in column F and 1 in column G. Alternatively, where only a single pack is required by a patient each cycle but multiple strengths are available, a weighted average can be calculated by entering the relevant weight for each pack in every column. Ensure weights sum to 1. Add details of how weights are derived in notes section. "]
[]
[]
[]
[null,"Table C. Total Cost to the HSE per pack"]
["This table will fill automatically based on the information inserted above. This information in this table is used to calculate the costs in Table F."]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF(F755=\"\",\"\",F755)","v":""},{"$f":"IF(G755=\"\",\"\",G755)","v":""},{"$f":"IF(H755=\"\",\"\",H755)","v":""},{"$f":"IF(I755=\"\",\"\",I755)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR(F756=\"\",F757=\"\",F758=\"\"),\"\",IF(F756=\"Price to Wholesaler\",F757,IF(F756=\"Reimbursement Price\",(F779/(1+E778)*1),\"Error\")))","v":""},{"$f":"IF(OR(G756=\"\",G757=\"\",F758=\"\"),\"\",IF(G756=\"Price to Wholesaler\",G757,IF(G756=\"Reimbursement Price\",(G779/(1+E778)*1),\"Error\")))","v":""},{"$f":"IF(OR(H756=\"\",H757=\"\",F758=\"\"),\"\",IF(H756=\"Price to Wholesaler\",H757,IF(H756=\"Reimbursement Price\",(H779/(1+E778)*1),\"Error\")))","v":""},{"$f":"IF(OR(I756=\"\",I757=\"\",F758=\"\"),\"\",IF(I756=\"Price to Wholesaler\",I757,IF(I756=\"Reimbursement Price\",(I779/(1+E778)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR(F758=\"\"),\"\",IF(AND(F758=\"CDS\",F759=\"Yes\"),CYF,IF(AND(F758=\"CDS\",F759=\"No\"),CNF,IF(F758=\"HT\",CHT,IF(F758=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR(F758=\"\",F757=\"\",F756=\"\"),\"\",F777*E778)","v":""},{"$f":"IF(OR(F758=\"\",G757=\"\",G756=\"\"),\"\",G777*E778)","v":""},{"$f":"IF(OR(F758=\"\",H757=\"\",H756=\"\"),\"\",H777*E778)","v":""},{"$f":"IF(OR(F758=\"\",I757=\"\",I756=\"\"),\"\",I777*E778)","v":""}]
["C",{"$f":"IF(F758=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF(F756=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF(F756=\"Reimbursement Price\",F757,IF(ISBLANK(E778),\"\",IF(F756=\"Price to Wholesaler\",(F777+F778),IF(F756=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(G756=\"Reimbursement Price\",G757,IF(ISBLANK(E778),\"\",IF(G756=\"Price to Wholesaler\",(G777+G778),IF(G756=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(H756=\"Reimbursement Price\",H757,IF(ISBLANK(E778),\"\",IF(H756=\"Price to Wholesaler\",(H777+H778),IF(H756=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(I756=\"Reimbursement Price\",I757,IF(ISBLANK(E778),\"\",IF(I756=\"Price to Wholesaler\",(I777+I778),IF(I756=\"\",\"\",\"Error\"))))","v":""}]
["D","Framework Agreement Rebate",null,null,{"$f":"IF(OR(F761=\"\",AND(F761=\"Yes\",F762=\"\"),AND(F761=\"No\",F763=\"\")),\"\",IF(AND(F761=\"No\",F763=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (pre-2026)\"),MRpre2026,IF(AND(F761=\"No\",F763=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F761=\"No\",F763=\"Off Patent Non-Exclusive or Generic\"),\"None\",IF(AND(F761=\"Yes\",F762=\"Biosimilar\"),\"None\",IF(AND(F761=\"Yes\",F762=\"Patented or Off Patent Exclusive (pre-2026)\"),MRpre2026,IF(AND(F761=\"Yes\",F762=\"Patented or Off Patent Exclusive (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F761=\"Yes\",F762=\"Off Patent Non-Exclusive 12.5% Rebate incorporated into Price to Wholesaler\"),\"None\",IF(AND(F761=\"Yes\",F762=\"Off Patent Non-Exclusive 12.5% Rebate\"),MRB,\"Error\")))))))))","v":""},{"$f":"IF(OR(F761=\"\",AND(F761=\"Yes\",F762=\"\"),AND(F761=\"No\",F763=\"\"),F756=\"\",ISBLANK(F757)),\"\",IF(E780=\"None\",0,(E780*F777)))","v":""},{"$f":"IF(OR(F761=\"\",AND(F761=\"Yes\",F762=\"\"),AND(F761=\"No\",F763=\"\"),G756=\"\",ISBLANK(G757)),\"\",IF(E780=\"None\",0,(E780*G777)))","v":""},{"$f":"IF(OR(F761=\"\",AND(F761=\"Yes\",F762=\"\"),AND(F761=\"No\",F763=\"\"),H756=\"\",ISBLANK(H757)),\"\",IF(E780=\"None\",0,(E780*H777)))","v":""},{"$f":"IF(OR(F761=\"\",AND(F761=\"Yes\",F762=\"\"),AND(F761=\"No\",F763=\"\"),I756=\"\",ISBLANK(I757)),\"\",IF(E780=\"None\",0,(E780*I777)))","v":""}]
["E","VAT on Drug Cost ",null,null,{"$f":"IF(F760=\"\",\"\",IF(F760=\"Yes\",0,VT))","v":""},{"$f":"IF(OR(F757=\"\",ISBLANK(F757)),\"\",($E781*F779))","v":""},{"$f":"IF(OR(G757=\"\",ISBLANK(G757)),\"\",($E781*G779))","v":""},"",""]
["F(i)","Total Drug Cost to the HSE per pack including VAT",null,null,null,{"$f":"IF(OR(F756=\"\",$F758=\"\",$F760=\"\",$F761=\"\"),\"\",SUM(F779:F781))","v":""},{"$f":"IF(OR(G756=\"\",$F758=\"\",$F760=\"\",$F761=\"\"),\"\",SUM(G779:G781))","v":""},{"$f":"IF(OR(H756=\"\",$F758=\"\",$F760=\"\",$F761=\"\"),\"\",SUM(H779:H781))","v":""},{"$f":"IF(OR(I756=\"\",$F758=\"\",$F760=\"\",$F761=\"\"),\"\",SUM(I779:I781))","v":""}]
["F(ii)","Total Drug Cost to the HSE per pack excluding VAT",null,null,null,{"$f":"IF(OR(F756=\"\",$F758=\"\",$F760=\"\",$F761=\"\"),\"\",SUM(F779:F780))","v":""},{"$f":"IF(OR(G756=\"\",$F758=\"\",$F760=\"\",$F761=\"\"),\"\",SUM(G779:G780))","v":""},{"$f":"IF(OR(H756=\"\",$F758=\"\",$F760=\"\",$F761=\"\"),\"\",SUM(H779:H780))","v":""},{"$f":"IF(OR(I756=\"\",$F758=\"\",$F760=\"\",$F761=\"\"),\"\",SUM(I779:I780))","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table D. Pharmacy Fees payable based on the type of product and reimbursement arrangements"]
[null,"For hospital drugs this table may be ignored."]
[null,"This table fills  automatically based on scheme and product information inputted above in Table A. "]
[]
[null,null,null,null,null,null,"Calculation ","Value"]
[null,"Pharmacy Fees excluding VAT",null,null,null,null,{"$f":"IF(F758=\"\",\"\",IF(F758=\"CDS\",\"per dispensing\",IF(F758=\"HT\",\"per month\",IF(F758=\"Hosp\",\"No Fee\", ERROR))))","v":""},{"$f":"IF(F758=\"\",\"\",IF(F758=\"CDS\",DF,IF(F758=\"HT\",PC,IF(F758=\"Hosp\",\"No Fee\",ERROR))))","v":""},"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         "]
[null,"VAT on Pharmacy Fees",null,null,null,null,{"$f":"IF(OR(F758=\"\",F760=\"\"),\"\",IF(F758=\"Hosp\",\"No Fee\",IF(F758=\"HT\",\"No VAT\",IF(AND(F758=\"CDS\",F760=\"No\"),VT,\"No VAT\"))))","v":""},{"$f":"IF(OR(F760=\"\",F758=\"Hosp\"),\"\",IF(OR(F760=\"Yes\",F758=\"HT\"),0,H790*G791))","v":""}]
[]
[]
["Table E Pharmacy Fees per product treatment cycle. \n",null,null,null,null,null,null,null,null,null," - Based on the drug's dispensing regimen and the NCPE drug cost guidelines, please input the pharmacy fees per treatment cycle. Use data presented in Table D to generate an appropriate formula for Column H of Table E. Notes may be added in column G. "]
["This section may be ommited for hospital drugs",null,null,null,null,null,"Notes","Value",null,null,{"$f":"IF(F758=\"HT\",\"For High tech, if a treatment cycle =28 days the corresponding pharmacy fee is =62.03*12/365.25*28.  The pharmacy fee remains the same regardless of the number of products dispensed that month.\",IF(F758=\"CDS\",\"For CDS, if 2 packets of the same pack presentation are required per treatment cycle, one dispensing fee applies (€5.48). If multiple pack presentations are required, multiple dispensing fees apply\",\"\"))","v":""}]
["G","Pharmacy Fees per treatment cycle excluding VAT"]
["H","Non dispensed patient care fee per treatment cycle (High Tech only)",null,null,null,null,null,null,null,null," - Enter here if relevant. See NCPE drug cost guidelines for more information on non-dispensed patient care fees (High Tech only). "]
["I","VAT on pharmacy Fees",null,null,null,null,null,null,null,null," - Please input VAT payable on pharmacy fees if applicable based on the information presented in Table D. "]
["J (i)","Total pharmacy Fees per treatment cycle including VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H796),\"\",SUM(H796:H798))","v":""}]
["J (ii)","Total pharmacy Fees per treatment cycle excluding VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H796),\"\",SUM(H796:H797))","v":""}]
[]
[]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time",null," - Calculate the cost for the budget impact model using  cost per number of cycles, per year or per unit time. Input the length of time required  into the blue boxes where applicable. Irrelevant columns may be left blank. Use the drop down boxes to select days or months when calculating the cost per unit time."]
[]
[null,null,null,null,null,null,"number of cycles"]
["A",{"$f":"B777","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F777:I777,F769:I769)","v":0},{"$f":"F808*G806","v":0},{"$f":"IF(H767=\"Days\",F808/F767*365.25,IF(H767=\"Months\",F808/F767*12,\"\"))","v":""},{"$f":"IF(AND(H767=\"Days\",I807=\"Days\"),F808/F767*I806,IF(AND(H767=\"Months\",I807=\"Months\"),F808/F767*I806,IF(AND(H767=\"Days\",I807=\"Months\"),F808/F767*30.4375*I806,IF(AND(H767=\"Months\",I807=\"Days\"),F808/F767/30.4375*I806,\"\"))))","v":""}]
["B",{"$f":"B778","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F778:I778,F769:I769)","v":0},{"$f":"F809*G806","v":0},{"$f":"IF(H767=\"Days\",F809/F767*365.25,IF(H767=\"Months\",F809/F767*12,\"\"))","v":""},{"$f":"IF(AND(H767=\"Days\",I807=\"Days\"),F809/F767*I806,IF(AND(H767=\"Months\",I807=\"Months\"),F809/F767*I806,IF(AND(H767=\"Days\",I807=\"Months\"),F809/F767*30.4375*I806,IF(AND(H767=\"Months\",I807=\"Days\"),F809/F767/30.4375*I806,\"\"))))","v":""}]
["C",{"$f":"B779","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F779:I779,F769:I769)","v":0},{"$f":"F810*G806","v":0},{"$f":"IF(H767=\"Days\",F810/F767*365.25,IF(H767=\"Months\",F810/F767*12,\"\"))","v":""},{"$f":"IF(AND(H767=\"Days\",I807=\"Days\"),F810/F767*I806,IF(AND(H767=\"Months\",I807=\"Months\"),F810/F767*I806,IF(AND(H767=\"Days\",I807=\"Months\"),F810/F767*30.4375*I806,IF(AND(H767=\"Months\",I807=\"Days\"),F810/F767/30.4375*I806,\"\"))))","v":""}]
["D",{"$f":"B780","v":"Framework Agreement Rebate"},null,null,null,{"$f":"SUMPRODUCT(F780:I780,F769:I769)","v":0},{"$f":"F811*G806","v":0},{"$f":"IF(H767=\"Days\",F811/F767*365.25,IF(H767=\"Months\",F811/F767*12,\"\"))","v":""},{"$f":"IF(AND(H767=\"Days\",I807=\"Days\"),F811/F767*I806,IF(AND(H767=\"Months\",I807=\"Months\"),F811/F767*I806,IF(AND(H767=\"Days\",I807=\"Months\"),F811/F767*30.4375*I806,IF(AND(H767=\"Months\",I807=\"Days\"),F811/F767/30.4375*I806,\"\"))))","v":""}]
["E",{"$f":"B781","v":"VAT on Drug Cost "},null,null,null,{"$f":"SUMPRODUCT(F781:I781,F769:I769)","v":0},{"$f":"F812*G806","v":0},{"$f":"IF(H767=\"Days\",F812/F767*365.25,IF(H767=\"Months\",F812/F767*12,\"\"))","v":""},{"$f":"IF(AND(H767=\"Days\",I807=\"Days\"),F812/F767*I806,IF(AND(H767=\"Months\",I807=\"Months\"),F812/F767*I806,IF(AND(H767=\"Days\",I807=\"Months\"),F812/F767*30.4375*I806,IF(AND(H767=\"Months\",I807=\"Days\"),F812/F767/30.4375*I806,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF(H799=\"\",\"\",H799)","v":""},{"$f":"IF(F813=\"\",\"\",F813*G806)","v":""},{"$f":"IF(F813=\"\",\"\",MIN(IF(H767=\"Days\",F813/F767*365.25,IF(H767=\"Months\",F813/F767*12,\"\")), 744.36))","v":""},{"$f":"IF(F813=\"\",\"\",IF(AND(H767=\"Days\",I807=\"Days\"),F813/F767*I806,IF(AND(H767=\"Months\",I807=\"Months\"),F813/F767*I806,IF(AND(H767=\"Days\",I807=\"Months\"),F813/F767*30.4375*I806,IF(AND(H767=\"Months\",I807=\"Days\"),F813/F767/30.4375*I806,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF(H800=\"\",\"\",H800)","v":""},{"$f":"IF(F814=\"\",\"\",F814*G806)","v":""},{"$f":"IF(F814=\"\",\"\",MIN(IF(H767=\"Days\",F814/F767*365.25,IF(H767=\"Months\",F814/F767*12,\"\")), 744.36))","v":""},{"$f":"IF(F814=\"\",\"\",IF(AND(H767=\"Days\",I807=\"Days\"),F814/F767*I806,IF(AND(H767=\"Months\",I807=\"Months\"),F814/F767*I806,IF(AND(H767=\"Days\",I807=\"Months\"),F814/F767*30.4375*I806,IF(AND(H767=\"Months\",I807=\"Days\"),F814/F767/30.4375*I806,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 8",null,null,null,{"$f":"SUM(F810:F813)","v":0},{"$f":"SUM(G810:G813)","v":0},{"$f":"SUM(H810:H813)","v":0},{"$f":"SUM(I810:I813)","v":0},null,"It is important to complete Table F as figures will automatically populate in Tables 1a and 1b based on selections in Table G"]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 8",null,null,null,{"$f":"IF(F814=\"\",SUM(F810+F811),F810+F811+F814)","v":0},{"$f":"IF(G814=\"\",SUM(G810+G811),G810+G811+G814)","v":0},{"$f":"IF(H814=\"\",SUM(H810:H811),H810+H811+H814)","v":0},{"$f":"IF(I814=\"\",SUM(I810:I811),I810+I811+I814)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"CONCATENATE(\"Comparator 8: \",NameComparator8)","v":"Comparator 8: "},null,null,null,{"$f":"IF($E820=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E820,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$113&\" Comparator 8\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E820=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E820,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$113&\" Comparator 8\"),$B:$B,0))","v":{"$error":"#N/A"}},null,null," - Figures will automatically populate in Tables 1a and 1b based on selections in Table G unless selected as \"Calculated elsewhere by Applicant\" in Table G. The corresponding cells will then be coloured blue in Tables 1a and 1b. Please manually overwrite the formula in the blue cells with the appropriate figure if using the manual option."]
[]
[null,"Notes"]
[]
[null,"Source used to inform the duration of treatment (e.g pivotal trial publication/ reference cell in CEM):",null,null,null,null,null,null,null,null,"•\tThe Applicant should provide any additional detail necessary to permit validation of drug cost calculations by the Review Group. \n•\tPlease note that where drug cost calculations are insufficiently described, this will lead to delays in the appraisal process. "]
[null,"Please specify whether the above refers to a particular subpopulation (if applicable):"]
[null,"Source for dosing regimen applied in BIM (e.g product SmPC): "]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 9: \",NameComparator9)","v":"Comparator 9: "}]
[]
[]
[null,"Table A: Applicant Input Selection Table to calculate the cost per pack",null,null,null,null,null,null,null,null," - Please input all information requested in this table to automatically calculate the cost per pack in Table C. Up to four type of packs  can be accomodated in this table across columns F to I. If there are less than four packs, please leave extra columns blank. If there are more than four products, please contact bim@ncpe.ie. "]
[null,"Details required to calculate the cost per pack and pharmacy fee information"]
[null,null,null,null,null,"Strength/Pack Size"]
[null,"Pack Identification",null,null,null,null,null,null,null,null," - Enter identifying information (e.g. strength, pack size) for each pack. For example, column F: 40mgx28; column G: 20mgx28. "]
[null,"Calculation Starting Point",null,null,null,null,null,null,null,"\u0080"," - Enter whether the calculation starting point is the Price to Wholesaler (PTW) or Reimbursement Price. PTW is listed on the pricing application form (PAF) submitted to the HSE. Reimbursement price is listed on the PCRS website. "]
[null,"Price per Pack",null,null,null,null,null,null,null,null," - Enter the relevant pack price here.  "]
[null,"Drug Funding Arrangement",null,null,null,null,null,null,null,"\u0080"," - Choose the funding arrangements. CDS = Community Drug Schemes, HT = High Tech Drug Arrangements, Hosp = Hospital. "]
[null,"Fridge",null,null,null,null,null,null,null,"\u0080"," - Optional: fridge item status only required for the CDS as wholesale mark-up varies here. May leave blank for other schemes."]
[null,"Oral product (including inhalers)",null,null,null,null,null,null,null,"\u0080"," - Required for VAT. Oral products including inhalers are exempt from VAT."]
[null,"Biologic",null,null,null,null,null,null,null,"\u0080"," - Required for Frameowrk Agreement rebate calculation."]
[null,"If Biologic =Yes: Select  Biologic and Patent Exclusivity Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =Yes, select the biologic and patent exclusivity status, pre- or post- 2026,  from the drop down list. If Biologic =No, select N/A. Required for Framework Agreement rebate calculation."]
[null,"If Biologic =No,  select Non Biologic Patent Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =No, select the non-biologic patent status, pre- or post- 2026.  If Biologic =Yes, select N/A. Required for Framework Agreement rebate calculation."]
[]
[null,"Table B: Applicant Input Table to calculate the cost per treatment cycle",null,null,null,null,null,null,null,null," - Treatment cycle is the length of time between product dispensings. For example, many oral tablet products have a treatment cycle of 28 days. If a drug is administered every six months, the treatment cycle is six months."]
[null,"Details required to calculate  the cost per treatment cycle"]
[null,"Length of Treatment Cycle",null,null,null,null,null,null,null,null," - Enter treatment cycle length in column F and select unit of measurement (Days/Months) in column H.  For treatment cycles measured in weeks, convert the number of weeks to days (e.g. 4 weeks = 28 days). One month is not equivalent to four weeks. If there is confusion over whether a dose is administered every four weeks or every month, refer to the SPC. "]
[null,{"$f":"B843","v":"Pack Identification"},null,null,null,{"$f":"IF(ISBLANK(F843),\"\",F843)","v":""},{"$f":"IF(ISBLANK(G843),\"\",G843)","v":""},{"$f":"IF(ISBLANK(H843),\"\",H843)","v":""},{"$f":"IF(ISBLANK(I843),\"\",I843)","v":""}]
[null,"Number of packs required per treatment cycle",null,null,null,null,null,null,null,null," - Enter the number of packs of each pack presentation required per treatment cycle. For example if the treatment cycle is 28 days, and there are 14 days supply in one pack, enter \"2\" into column F.  Where each patient requires multiple products every treatment cycle, enter the number of packs of each pack type into the relevant column. For example,  where a patient requires 2 x Pack (F) and 1 x Pack (G) every 28 day treatment cycle, please enter 2 in column F and 1 in column G. Alternatively, where only a single pack is required by a patient each cycle but multiple strengths are available, a weighted average can be calculated by entering the relevant weight for each pack in every column. Ensure weights sum to 1. Add details of how weights are derived in notes section. "]
[]
[]
[]
[null,"Table C. Total Cost to the HSE per pack"]
["This table will fill automatically based on the information inserted above. This information in this table is used to calculate the costs in Table F."]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF(F843=\"\",\"\",F843)","v":""},{"$f":"IF(G843=\"\",\"\",G843)","v":""},{"$f":"IF(H843=\"\",\"\",H843)","v":""},{"$f":"IF(I843=\"\",\"\",I843)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR(F844=\"\",F845=\"\",F846=\"\"),\"\",IF(F844=\"Price to Wholesaler\",F845,IF(F844=\"Reimbursement Price\",(F867/(1+E866)*1),\"Error\")))","v":""},{"$f":"IF(OR(G844=\"\",G845=\"\",F846=\"\"),\"\",IF(G844=\"Price to Wholesaler\",G845,IF(G844=\"Reimbursement Price\",(G867/(1+E866)*1),\"Error\")))","v":""},{"$f":"IF(OR(H844=\"\",H845=\"\",F846=\"\"),\"\",IF(H844=\"Price to Wholesaler\",H845,IF(H844=\"Reimbursement Price\",(H867/(1+E866)*1),\"Error\")))","v":""},{"$f":"IF(OR(I844=\"\",I845=\"\",F846=\"\"),\"\",IF(I844=\"Price to Wholesaler\",I845,IF(I844=\"Reimbursement Price\",(I867/(1+E866)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR(F846=\"\"),\"\",IF(AND(F846=\"CDS\",F847=\"Yes\"),CYF,IF(AND(F846=\"CDS\",F847=\"No\"),CNF,IF(F846=\"HT\",CHT,IF(F846=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR(F846=\"\",F845=\"\",F844=\"\"),\"\",F865*E866)","v":""},{"$f":"IF(OR(F846=\"\",G845=\"\",G844=\"\"),\"\",G865*E866)","v":""},{"$f":"IF(OR(F846=\"\",H845=\"\",H844=\"\"),\"\",H865*E866)","v":""},{"$f":"IF(OR(F846=\"\",I845=\"\",I844=\"\"),\"\",I865*E866)","v":""}]
["C",{"$f":"IF(F846=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF(F844=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF(F844=\"Reimbursement Price\",F845,IF(ISBLANK(E866),\"\",IF(F844=\"Price to Wholesaler\",(F865+F866),IF(F844=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(G844=\"Reimbursement Price\",G845,IF(ISBLANK(E866),\"\",IF(G844=\"Price to Wholesaler\",(G865+G866),IF(G844=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(H844=\"Reimbursement Price\",H845,IF(ISBLANK(E866),\"\",IF(H844=\"Price to Wholesaler\",(H865+H866),IF(H844=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(I844=\"Reimbursement Price\",I845,IF(ISBLANK(E866),\"\",IF(I844=\"Price to Wholesaler\",(I865+I866),IF(I844=\"\",\"\",\"Error\"))))","v":""}]
["D","Framework Agreement Rebate",null,null,{"$f":"IF(OR(F849=\"\",AND(F849=\"Yes\",F850=\"\"),AND(F849=\"No\",F851=\"\")),\"\",IF(AND(F849=\"No\",F851=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (pre-2026)\"),MRpre2026,IF(AND(F849=\"No\",F851=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F849=\"No\",F851=\"Off Patent Non-Exclusive or Generic\"),\"None\",IF(AND(F849=\"Yes\",F850=\"Biosimilar\"),\"None\",IF(AND(F849=\"Yes\",F850=\"Patented or Off Patent Exclusive (pre-2026)\"),MRpre2026,IF(AND(F849=\"Yes\",F850=\"Patented or Off Patent Exclusive (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F849=\"Yes\",F850=\"Off Patent Non-Exclusive 12.5% Rebate incorporated into Price to Wholesaler\"),\"None\",IF(AND(F849=\"Yes\",F850=\"Off Patent Non-Exclusive 12.5% Rebate\"),MRB,\"Error\")))))))))","v":""},{"$f":"IF(OR(F849=\"\",AND(F849=\"Yes\",F850=\"\"),AND(F849=\"No\",F851=\"\"),F844=\"\",ISBLANK(F845)),\"\",IF(E868=\"None\",0,(E868*F865)))","v":""},{"$f":"IF(OR(F849=\"\",AND(F849=\"Yes\",F850=\"\"),AND(F849=\"No\",F851=\"\"),G844=\"\",ISBLANK(G845)),\"\",IF(E868=\"None\",0,(E868*G865)))","v":""},{"$f":"IF(OR(F849=\"\",AND(F849=\"Yes\",F850=\"\"),AND(F849=\"No\",F851=\"\"),H844=\"\",ISBLANK(H845)),\"\",IF(E868=\"None\",0,(E868*H865)))","v":""},{"$f":"IF(OR(F849=\"\",AND(F849=\"Yes\",F850=\"\"),AND(F849=\"No\",F851=\"\"),I844=\"\",ISBLANK(I845)),\"\",IF(E868=\"None\",0,(E868*I865)))","v":""}]
["E","VAT on Drug Cost ",null,null,{"$f":"IF(F848=\"\",\"\",IF(F848=\"Yes\",0,VT))","v":""},{"$f":"IF(OR(F845=\"\",ISBLANK(F845)),\"\",($E869*F867))","v":""},{"$f":"IF(OR(G845=\"\",ISBLANK(G845)),\"\",($E869*G867))","v":""},"",""]
["F(i)","Total Drug Cost to the HSE per pack including VAT",null,null,null,{"$f":"IF(OR(F844=\"\",$F846=\"\",$F848=\"\",$F849=\"\"),\"\",SUM(F867:F869))","v":""},{"$f":"IF(OR(G844=\"\",$F846=\"\",$F848=\"\",$F849=\"\"),\"\",SUM(G867:G869))","v":""},{"$f":"IF(OR(H844=\"\",$F846=\"\",$F848=\"\",$F849=\"\"),\"\",SUM(H867:H869))","v":""},{"$f":"IF(OR(I844=\"\",$F846=\"\",$F848=\"\",$F849=\"\"),\"\",SUM(I867:I869))","v":""}]
["F(ii)","Total Drug Cost to the HSE per pack excluding VAT",null,null,null,{"$f":"IF(OR(F844=\"\",$F846=\"\",$F848=\"\",$F849=\"\"),\"\",SUM(F867:F868))","v":""},{"$f":"IF(OR(G844=\"\",$F846=\"\",$F848=\"\",$F849=\"\"),\"\",SUM(G867:G868))","v":""},{"$f":"IF(OR(H844=\"\",$F846=\"\",$F848=\"\",$F849=\"\"),\"\",SUM(H867:H868))","v":""},{"$f":"IF(OR(I844=\"\",$F846=\"\",$F848=\"\",$F849=\"\"),\"\",SUM(I867:I868))","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table D. Pharmacy Fees payable based on the type of product and reimbursement arrangements"]
[null,"For hospital drugs this table may be ignored."]
[null,"This table fills  automatically based on scheme and product information inputted above in Table A. "]
[]
[null,null,null,null,null,null,"Calculation ","Value"]
[null,"Pharmacy Fees excluding VAT",null,null,null,null,{"$f":"IF(F846=\"\",\"\",IF(F846=\"CDS\",\"per dispensing\",IF(F846=\"HT\",\"per month\",IF(F846=\"Hosp\",\"No Fee\", ERROR))))","v":""},{"$f":"IF(F846=\"\",\"\",IF(F846=\"CDS\",DF,IF(F846=\"HT\",PC,IF(F846=\"Hosp\",\"No Fee\",ERROR))))","v":""},"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         "]
[null,"VAT on Pharmacy Fees",null,null,null,null,{"$f":"IF(OR(F846=\"\",F848=\"\"),\"\",IF(F846=\"Hosp\",\"No Fee\",IF(F846=\"HT\",\"No VAT\",IF(AND(F846=\"CDS\",F848=\"No\"),VT,\"No VAT\"))))","v":""},{"$f":"IF(OR(F848=\"\",F846=\"Hosp\"),\"\",IF(OR(F848=\"Yes\",F846=\"HT\"),0,H878*G879))","v":""}]
[]
[]
["Table E Pharmacy Fees per product treatment cycle. \n",null,null,null,null,null,null,null,null,null," - Based on the drug's dispensing regimen and the NCPE drug cost guidelines, please input the pharmacy fees per treatment cycle. Use data presented in Table D to generate an appropriate formula for Column H of Table E. Notes may be added in column G. "]
["This section may be ommited for hospital drugs",null,null,null,null,null,"Notes","Value",null,null,{"$f":"IF(F846=\"HT\",\"For High tech, if a treatment cycle =28 days the corresponding pharmacy fee is =62.03*12/365.25*28.  The pharmacy fee remains the same regardless of the number of products dispensed that month.\",IF(F846=\"CDS\",\"For CDS, if 2 packets of the same pack presentation are required per treatment cycle, one dispensing fee applies (€5.48). If multiple pack presentations are required, multiple dispensing fees apply\",\"\"))","v":""}]
["G","Pharmacy Fees per treatment cycle excluding VAT"]
["H","Non dispensed patient care fee per treatment cycle (High Tech only)",null,null,null,null,null,null,null,null," - Enter here if relevant. See NCPE drug cost guidelines for more information on non-dispensed patient care fees (High Tech only). "]
["I","VAT on pharmacy Fees",null,null,null,null,null,null,null,null," - Please input VAT payable on pharmacy fees if applicable based on the information presented in Table D. "]
["J (i)","Total pharmacy Fees per treatment cycle including VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H884),\"\",SUM(H884:H886))","v":""}]
["J (ii)","Total pharmacy Fees per treatment cycle excluding VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H884),\"\",SUM(H884:H885))","v":""}]
[]
[]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time",null," - Calculate the cost for the budget impact model using  cost per number of cycles, per year or per unit time. Input the length of time required  into the blue boxes where applicable. Irrelevant columns may be left blank. Use the drop down boxes to select days or months when calculating the cost per unit time."]
[]
[null,null,null,null,null,null,"number of cycles"]
["A",{"$f":"B865","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F865:I865,F857:I857)","v":0},{"$f":"F896*G894","v":0},{"$f":"IF(H855=\"Days\",F896/F855*365.25,IF(H855=\"Months\",F896/F855*12,\"\"))","v":""},{"$f":"IF(AND(H855=\"Days\",I895=\"Days\"),F896/F855*I894,IF(AND(H855=\"Months\",I895=\"Months\"),F896/F855*I894,IF(AND(H855=\"Days\",I895=\"Months\"),F896/F855*30.4375*I894,IF(AND(H855=\"Months\",I895=\"Days\"),F896/F855/30.4375*I894,\"\"))))","v":""}]
["B",{"$f":"B866","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F866:I866,F857:I857)","v":0},{"$f":"F897*G894","v":0},{"$f":"IF(H855=\"Days\",F897/F855*365.25,IF(H855=\"Months\",F897/F855*12,\"\"))","v":""},{"$f":"IF(AND(H855=\"Days\",I895=\"Days\"),F897/F855*I894,IF(AND(H855=\"Months\",I895=\"Months\"),F897/F855*I894,IF(AND(H855=\"Days\",I895=\"Months\"),F897/F855*30.4375*I894,IF(AND(H855=\"Months\",I895=\"Days\"),F897/F855/30.4375*I894,\"\"))))","v":""}]
["C",{"$f":"B867","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F867:I867,F857:I857)","v":0},{"$f":"F898*G894","v":0},{"$f":"IF(H855=\"Days\",F898/F855*365.25,IF(H855=\"Months\",F898/F855*12,\"\"))","v":""},{"$f":"IF(AND(H855=\"Days\",I895=\"Days\"),F898/F855*I894,IF(AND(H855=\"Months\",I895=\"Months\"),F898/F855*I894,IF(AND(H855=\"Days\",I895=\"Months\"),F898/F855*30.4375*I894,IF(AND(H855=\"Months\",I895=\"Days\"),F898/F855/30.4375*I894,\"\"))))","v":""}]
["D",{"$f":"B868","v":"Framework Agreement Rebate"},null,null,null,{"$f":"SUMPRODUCT(F868:I868,F857:I857)","v":0},{"$f":"F899*G894","v":0},{"$f":"IF(H855=\"Days\",F899/F855*365.25,IF(H855=\"Months\",F899/F855*12,\"\"))","v":""},{"$f":"IF(AND(H855=\"Days\",I895=\"Days\"),F899/F855*I894,IF(AND(H855=\"Months\",I895=\"Months\"),F899/F855*I894,IF(AND(H855=\"Days\",I895=\"Months\"),F899/F855*30.4375*I894,IF(AND(H855=\"Months\",I895=\"Days\"),F899/F855/30.4375*I894,\"\"))))","v":""}]
["E",{"$f":"B869","v":"VAT on Drug Cost "},null,null,null,{"$f":"SUMPRODUCT(F869:I869,F857:I857)","v":0},{"$f":"F900*G894","v":0},{"$f":"IF(H855=\"Days\",F900/F855*365.25,IF(H855=\"Months\",F900/F855*12,\"\"))","v":""},{"$f":"IF(AND(H855=\"Days\",I895=\"Days\"),F900/F855*I894,IF(AND(H855=\"Months\",I895=\"Months\"),F900/F855*I894,IF(AND(H855=\"Days\",I895=\"Months\"),F900/F855*30.4375*I894,IF(AND(H855=\"Months\",I895=\"Days\"),F900/F855/30.4375*I894,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF(H887=\"\",\"\",H887)","v":""},{"$f":"IF(F901=\"\",\"\",F901*G894)","v":""},{"$f":"IF(F901=\"\",\"\",MIN(IF(H855=\"Days\",F901/F855*365.25,IF(H855=\"Months\",F901/F855*12,\"\")), 744.36))","v":""},{"$f":"IF(F901=\"\",\"\",IF(AND(H855=\"Days\",I895=\"Days\"),F901/F855*I894,IF(AND(H855=\"Months\",I895=\"Months\"),F901/F855*I894,IF(AND(H855=\"Days\",I895=\"Months\"),F901/F855*30.4375*I894,IF(AND(H855=\"Months\",I895=\"Days\"),F901/F855/30.4375*I894,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF(H888=\"\",\"\",H888)","v":""},{"$f":"IF(F902=\"\",\"\",F902*G894)","v":""},{"$f":"IF(F902=\"\",\"\",MIN(IF(H855=\"Days\",F902/F855*365.25,IF(H855=\"Months\",F902/F855*12,\"\")), 744.36))","v":""},{"$f":"IF(F902=\"\",\"\",IF(AND(H855=\"Days\",I895=\"Days\"),F902/F855*I894,IF(AND(H855=\"Months\",I895=\"Months\"),F902/F855*I894,IF(AND(H855=\"Days\",I895=\"Months\"),F902/F855*30.4375*I894,IF(AND(H855=\"Months\",I895=\"Days\"),F902/F855/30.4375*I894,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 9",null,null,null,{"$f":"SUM(F898:F901)","v":0},{"$f":"SUM(G898:G901)","v":0},{"$f":"SUM(H898:H901)","v":0},{"$f":"SUM(I898:I901)","v":0},null,"It is important to complete Table F as figures will automatically populate in Tables 1a and 1b based on selections in Table G"]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 9",null,null,null,{"$f":"IF(F902=\"\",SUM(F898+F899),F898+F899+F902)","v":0},{"$f":"IF(G902=\"\",SUM(G898+G899),G898+G899+G902)","v":0},{"$f":"IF(H902=\"\",SUM(H898:H899),H898+H899+H902)","v":0},{"$f":"IF(I902=\"\",SUM(I898:I899),I898+I899+I902)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"CONCATENATE(\"Comparator 9: \",NameComparator9)","v":"Comparator 9: "},null,null,null,{"$f":"IF($E908=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E908,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$113&\" Comparator 9\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E908=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E908,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$113&\" Comparator 9\"),$B:$B,0))","v":{"$error":"#N/A"}},null,null," - Figures will automatically populate in Tables 1a and 1b based on selections in Table G unless selected as \"Calculated elsewhere by Applicant\" in Table G. The corresponding cells will then be coloured blue in Tables 1a and 1b. Please manually overwrite the formula in the blue cells with the appropriate figure if using the manual option."]
[]
[null,"Notes"]
[]
[null,"Source used to inform the duration of treatment (e.g pivotal trial publication/ reference cell in CEM):",null,null,null,null,null,null,null,null,"•\tThe Applicant should provide any additional detail necessary to permit validation of drug cost calculations by the Review Group. \n•\tPlease note that where drug cost calculations are insufficiently described, this will lead to delays in the appraisal process. "]
[null,"Please specify whether the above refers to a particular subpopulation (if applicable):"]
[null,"Source for dosing regimen applied in BIM (e.g product SmPC): "]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 10: \",NameComparator10)","v":"Comparator 10: "}]
[]
[]
[null,"Table A: Applicant Input Selection Table to calculate the cost per pack",null,null,null,null,null,null,null,null," - Please input all information requested in this table to automatically calculate the cost per pack in Table C. Up to four type of packs  can be accomodated in this table across columns F to I. If there are less than four packs, please leave extra columns blank. If there are more than four products, please contact bim@ncpe.ie. "]
[null,"Details required to calculate the cost per pack and pharmacy fee information"]
[null,null,null,null,null,"Strength/Pack Size"]
[null,"Pack Identification",null,null,null,null,null,null,null,null," - Enter identifying information (e.g. strength, pack size) for each pack. For example, column F: 40mgx28; column G: 20mgx28. "]
[null,"Calculation Starting Point",null,null,null,null,null,null,null,"\u0080"," - Enter whether the calculation starting point is the Price to Wholesaler (PTW) or Reimbursement Price. PTW is listed on the pricing application form (PAF) submitted to the HSE. Reimbursement price is listed on the PCRS website. "]
[null,"Price per Pack",null,null,null,null,null,null,null,null," - Enter the relevant pack price here.  "]
[null,"Drug Funding Arrangement",null,null,null,null,null,null,null,"\u0080"," - Choose the funding arrangements. CDS = Community Drug Schemes, HT = High Tech Drug Arrangements, Hosp = Hospital. "]
[null,"Fridge",null,null,null,null,null,null,null,"\u0080"," - Optional: fridge item status only required for the CDS as wholesale mark-up varies here. May leave blank for other schemes."]
[null,"Oral product (including inhalers)",null,null,null,null,null,null,null,"\u0080"," - Required for VAT. Oral products including inhalers are exempt from VAT."]
[null,"Biologic",null,null,null,null,null,null,null,"\u0080"," - Required for Frameowrk Agreement rebate calculation."]
[null,"If Biologic =Yes: Select  Biologic and Patent Exclusivity Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =Yes, select the biologic and patent exclusivity status, pre- or post- 2026,  from the drop down list. If Biologic =No, select N/A. Required for Framework Agreement rebate calculation."]
[null,"If Biologic =No,  select Non Biologic Patent Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =No, select the non-biologic patent status, pre- or post- 2026.  If Biologic =Yes, select N/A. Required for Framework Agreement rebate calculation."]
[]
[null,"Table B: Applicant Input Table to calculate the cost per treatment cycle",null,null,null,null,null,null,null,null," - Treatment cycle is the length of time between product dispensings. For example, many oral tablet products have a treatment cycle of 28 days. If a drug is administered every six months, the treatment cycle is six months."]
[null,"Details required to calculate  the cost per treatment cycle"]
[null,"Length of Treatment Cycle",null,null,null,null,null,null,null,null," - Enter treatment cycle length in column F and select unit of measurement (Days/Months) in column H.  For treatment cycles measured in weeks, convert the number of weeks to days (e.g. 4 weeks = 28 days). One month is not equivalent to four weeks. If there is confusion over whether a dose is administered every four weeks or every month, refer to the SPC. "]
[null,{"$f":"B931","v":"Pack Identification"},null,null,null,{"$f":"IF(ISBLANK(F931),\"\",F931)","v":""},{"$f":"IF(ISBLANK(G931),\"\",G931)","v":""},{"$f":"IF(ISBLANK(H931),\"\",H931)","v":""},{"$f":"IF(ISBLANK(I931),\"\",I931)","v":""}]
[null,"Number of packs required per treatment cycle",null,null,null,null,null,null,null,null," - Enter the number of packs of each pack presentation required per treatment cycle. For example if the treatment cycle is 28 days, and there are 14 days supply in one pack, enter \"2\" into column F.  Where each patient requires multiple products every treatment cycle, enter the number of packs of each pack type into the relevant column. For example,  where a patient requires 2 x Pack (F) and 1 x Pack (G) every 28 day treatment cycle, please enter 2 in column F and 1 in column G. Alternatively, where only a single pack is required by a patient each cycle but multiple strengths are available, a weighted average can be calculated by entering the relevant weight for each pack in every column. Ensure weights sum to 1. Add details of how weights are derived in notes section. "]
[]
[]
[]
[null,"Table C. Total Cost to the HSE per pack"]
["This table will fill automatically based on the information inserted above. This information in this table is used to calculate the costs in Table F."]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF(F931=\"\",\"\",F931)","v":""},{"$f":"IF(G931=\"\",\"\",G931)","v":""},{"$f":"IF(H931=\"\",\"\",H931)","v":""},{"$f":"IF(I931=\"\",\"\",I931)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR(F932=\"\",F933=\"\",F934=\"\"),\"\",IF(F932=\"Price to Wholesaler\",F933,IF(F932=\"Reimbursement Price\",(F955/(1+E954)*1),\"Error\")))","v":""},{"$f":"IF(OR(G932=\"\",G933=\"\",F934=\"\"),\"\",IF(G932=\"Price to Wholesaler\",G933,IF(G932=\"Reimbursement Price\",(G955/(1+E954)*1),\"Error\")))","v":""},{"$f":"IF(OR(H932=\"\",H933=\"\",F934=\"\"),\"\",IF(H932=\"Price to Wholesaler\",H933,IF(H932=\"Reimbursement Price\",(H955/(1+E954)*1),\"Error\")))","v":""},{"$f":"IF(OR(I932=\"\",I933=\"\",F934=\"\"),\"\",IF(I932=\"Price to Wholesaler\",I933,IF(I932=\"Reimbursement Price\",(I955/(1+E954)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR(F934=\"\"),\"\",IF(AND(F934=\"CDS\",F935=\"Yes\"),CYF,IF(AND(F934=\"CDS\",F935=\"No\"),CNF,IF(F934=\"HT\",CHT,IF(F934=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR(F934=\"\",F933=\"\",F932=\"\"),\"\",F953*E954)","v":""},{"$f":"IF(OR(F934=\"\",G933=\"\",G932=\"\"),\"\",G953*E954)","v":""},{"$f":"IF(OR(F934=\"\",H933=\"\",H932=\"\"),\"\",H953*E954)","v":""},{"$f":"IF(OR(F934=\"\",I933=\"\",I932=\"\"),\"\",I953*E954)","v":""}]
["C",{"$f":"IF(F934=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF(F932=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF(F932=\"Reimbursement Price\",F933,IF(ISBLANK(E954),\"\",IF(F932=\"Price to Wholesaler\",(F953+F954),IF(F932=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(G932=\"Reimbursement Price\",G933,IF(ISBLANK(E954),\"\",IF(G932=\"Price to Wholesaler\",(G953+G954),IF(G932=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(H932=\"Reimbursement Price\",H933,IF(ISBLANK(E954),\"\",IF(H932=\"Price to Wholesaler\",(H953+H954),IF(H932=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(I932=\"Reimbursement Price\",I933,IF(ISBLANK(E954),\"\",IF(I932=\"Price to Wholesaler\",(I953+I954),IF(I932=\"\",\"\",\"Error\"))))","v":""}]
["D","Framework Agreement Rebate",null,null,{"$f":"IF(OR(F937=\"\",AND(F937=\"Yes\",F938=\"\"),AND(F937=\"No\",F939=\"\")),\"\",IF(AND(F937=\"No\",F939=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (pre-2026)\"),MRpre2026,IF(AND(F937=\"No\",F939=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F937=\"No\",F939=\"Off Patent Non-Exclusive or Generic\"),\"None\",IF(AND(F937=\"Yes\",F938=\"Biosimilar\"),\"None\",IF(AND(F937=\"Yes\",F938=\"Patented or Off Patent Exclusive (pre-2026)\"),MRpre2026,IF(AND(F937=\"Yes\",F938=\"Patented or Off Patent Exclusive (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F937=\"Yes\",F938=\"Off Patent Non-Exclusive 12.5% Rebate incorporated into Price to Wholesaler\"),\"None\",IF(AND(F937=\"Yes\",F938=\"Off Patent Non-Exclusive 12.5% Rebate\"),MRB,\"Error\")))))))))","v":""},{"$f":"IF(OR(F937=\"\",AND(F937=\"Yes\",F938=\"\"),AND(F937=\"No\",F939=\"\"),F932=\"\",ISBLANK(F933)),\"\",IF(E956=\"None\",0,(E956*F953)))","v":""},{"$f":"IF(OR(F937=\"\",AND(F937=\"Yes\",F938=\"\"),AND(F937=\"No\",F939=\"\"),G932=\"\",ISBLANK(G933)),\"\",IF(E956=\"None\",0,(E956*G953)))","v":""},{"$f":"IF(OR(F937=\"\",AND(F937=\"Yes\",F938=\"\"),AND(F937=\"No\",F939=\"\"),H932=\"\",ISBLANK(H933)),\"\",IF(E956=\"None\",0,(E956*H953)))","v":""},{"$f":"IF(OR(F937=\"\",AND(F937=\"Yes\",F938=\"\"),AND(F937=\"No\",F939=\"\"),I932=\"\",ISBLANK(I933)),\"\",IF(E956=\"None\",0,(E956*I953)))","v":""}]
["E","VAT on Drug Cost ",null,null,{"$f":"IF(F936=\"\",\"\",IF(F936=\"Yes\",0,VT))","v":""},{"$f":"IF(OR(F933=\"\",ISBLANK(F933)),\"\",($E957*F955))","v":""},{"$f":"IF(OR(G933=\"\",ISBLANK(G933)),\"\",($E957*G955))","v":""},"",""]
["F(i)","Total Drug Cost to the HSE per pack including VAT",null,null,null,{"$f":"IF(OR(F932=\"\",$F934=\"\",$F936=\"\",$F937=\"\"),\"\",SUM(F955:F957))","v":""},{"$f":"IF(OR(G932=\"\",$F934=\"\",$F936=\"\",$F937=\"\"),\"\",SUM(G955:G957))","v":""},{"$f":"IF(OR(H932=\"\",$F934=\"\",$F936=\"\",$F937=\"\"),\"\",SUM(H955:H957))","v":""},{"$f":"IF(OR(I932=\"\",$F934=\"\",$F936=\"\",$F937=\"\"),\"\",SUM(I955:I957))","v":""}]
["F(ii)","Total Drug Cost to the HSE per pack excluding VAT",null,null,null,{"$f":"IF(OR(F932=\"\",$F934=\"\",$F936=\"\",$F937=\"\"),\"\",SUM(F955:F956))","v":""},{"$f":"IF(OR(G932=\"\",$F934=\"\",$F936=\"\",$F937=\"\"),\"\",SUM(G955:G956))","v":""},{"$f":"IF(OR(H932=\"\",$F934=\"\",$F936=\"\",$F937=\"\"),\"\",SUM(H955:H956))","v":""},{"$f":"IF(OR(I932=\"\",$F934=\"\",$F936=\"\",$F937=\"\"),\"\",SUM(I955:I956))","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table D. Pharmacy Fees payable based on the type of product and reimbursement arrangements"]
[null,"For hospital drugs this table may be ignored."]
[null,"This table fills  automatically based on scheme and product information inputted above in Table A. "]
[]
[null,null,null,null,null,null,"Calculation ","Value"]
[null,"Pharmacy Fees excluding VAT",null,null,null,null,{"$f":"IF(F934=\"\",\"\",IF(F934=\"CDS\",\"per dispensing\",IF(F934=\"HT\",\"per month\",IF(F934=\"Hosp\",\"No Fee\", ERROR))))","v":""},{"$f":"IF(F934=\"\",\"\",IF(F934=\"CDS\",DF,IF(F934=\"HT\",PC,IF(F934=\"Hosp\",\"No Fee\",ERROR))))","v":""},"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         "]
[null,"VAT on Pharmacy Fees",null,null,null,null,{"$f":"IF(OR(F934=\"\",F936=\"\"),\"\",IF(F934=\"Hosp\",\"No Fee\",IF(F934=\"HT\",\"No VAT\",IF(AND(F934=\"CDS\",F936=\"No\"),VT,\"No VAT\"))))","v":""},{"$f":"IF(OR(F936=\"\",F934=\"Hosp\"),\"\",IF(OR(F936=\"Yes\",F934=\"HT\"),0,H966*G967))","v":""}]
[]
[]
["Table E Pharmacy Fees per product treatment cycle. \n",null,null,null,null,null,null,null,null,null," - Based on the drug's dispensing regimen and the NCPE drug cost guidelines, please input the pharmacy fees per treatment cycle. Use data presented in Table D to generate an appropriate formula for Column H of Table E. Notes may be added in column G. "]
["This section may be ommited for hospital drugs",null,null,null,null,null,"Notes","Value",null,null,{"$f":"IF(F934=\"HT\",\"For High tech, if a treatment cycle =28 days the corresponding pharmacy fee is =62.03*12/365.25*28.  The pharmacy fee remains the same regardless of the number of products dispensed that month.\",IF(F934=\"CDS\",\"For CDS, if 2 packets of the same pack presentation are required per treatment cycle, one dispensing fee applies (€5.48). If multiple pack presentations are required, multiple dispensing fees apply\",\"\"))","v":""}]
["G","Pharmacy Fees per treatment cycle excluding VAT"]
["H","Non dispensed patient care fee per treatment cycle (High Tech only)",null,null,null,null,null,null,null,null," - Enter here if relevant. See NCPE drug cost guidelines for more information on non-dispensed patient care fees (High Tech only). "]
["I","VAT on pharmacy Fees",null,null,null,null,null,null,null,null," - Please input VAT payable on pharmacy fees if applicable based on the information presented in Table D. "]
["J (i)","Total pharmacy Fees per treatment cycle including VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H972),\"\",SUM(H972:H974))","v":""}]
["J (ii)","Total pharmacy Fees per treatment cycle excluding VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H972),\"\",SUM(H972:H973))","v":""}]
[]
[]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time",null," - Calculate the cost for the budget impact model using  cost per number of cycles, per year or per unit time. Input the length of time required  into the blue boxes where applicable. Irrelevant columns may be left blank. Use the drop down boxes to select days or months when calculating the cost per unit time."]
[]
[null,null,null,null,null,null,"number of cycles"]
["A",{"$f":"B953","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F953:I953,F945:I945)","v":0},{"$f":"F984*G982","v":0},{"$f":"IF(H943=\"Days\",F984/F943*365.25,IF(H943=\"Months\",F984/F943*12,\"\"))","v":""},{"$f":"IF(AND(H943=\"Days\",I983=\"Days\"),F984/F943*I982,IF(AND(H943=\"Months\",I983=\"Months\"),F984/F943*I982,IF(AND(H943=\"Days\",I983=\"Months\"),F984/F943*30.4375*I982,IF(AND(H943=\"Months\",I983=\"Days\"),F984/F943/30.4375*I982,\"\"))))","v":""}]
["B",{"$f":"B954","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F954:I954,F945:I945)","v":0},{"$f":"F985*G982","v":0},{"$f":"IF(H943=\"Days\",F985/F943*365.25,IF(H943=\"Months\",F985/F943*12,\"\"))","v":""},{"$f":"IF(AND(H943=\"Days\",I983=\"Days\"),F985/F943*I982,IF(AND(H943=\"Months\",I983=\"Months\"),F985/F943*I982,IF(AND(H943=\"Days\",I983=\"Months\"),F985/F943*30.4375*I982,IF(AND(H943=\"Months\",I983=\"Days\"),F985/F943/30.4375*I982,\"\"))))","v":""}]
["C",{"$f":"B955","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F955:I955,F945:I945)","v":0},{"$f":"F986*G982","v":0},{"$f":"IF(H943=\"Days\",F986/F943*365.25,IF(H943=\"Months\",F986/F943*12,\"\"))","v":""},{"$f":"IF(AND(H943=\"Days\",I983=\"Days\"),F986/F943*I982,IF(AND(H943=\"Months\",I983=\"Months\"),F986/F943*I982,IF(AND(H943=\"Days\",I983=\"Months\"),F986/F943*30.4375*I982,IF(AND(H943=\"Months\",I983=\"Days\"),F986/F943/30.4375*I982,\"\"))))","v":""}]
["D",{"$f":"B956","v":"Framework Agreement Rebate"},null,null,null,{"$f":"SUMPRODUCT(F956:I956,F945:I945)","v":0},{"$f":"F987*G982","v":0},{"$f":"IF(H943=\"Days\",F987/F943*365.25,IF(H943=\"Months\",F987/F943*12,\"\"))","v":""},{"$f":"IF(AND(H943=\"Days\",I983=\"Days\"),F987/F943*I982,IF(AND(H943=\"Months\",I983=\"Months\"),F987/F943*I982,IF(AND(H943=\"Days\",I983=\"Months\"),F987/F943*30.4375*I982,IF(AND(H943=\"Months\",I983=\"Days\"),F987/F943/30.4375*I982,\"\"))))","v":""}]
["E",{"$f":"B957","v":"VAT on Drug Cost "},null,null,null,{"$f":"SUMPRODUCT(F957:I957,F945:I945)","v":0},{"$f":"F988*G982","v":0},{"$f":"IF(H943=\"Days\",F988/F943*365.25,IF(H943=\"Months\",F988/F943*12,\"\"))","v":""},{"$f":"IF(AND(H943=\"Days\",I983=\"Days\"),F988/F943*I982,IF(AND(H943=\"Months\",I983=\"Months\"),F988/F943*I982,IF(AND(H943=\"Days\",I983=\"Months\"),F988/F943*30.4375*I982,IF(AND(H943=\"Months\",I983=\"Days\"),F988/F943/30.4375*I982,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF(H975=\"\",\"\",H975)","v":""},{"$f":"IF(F989=\"\",\"\",F989*G982)","v":""},{"$f":"IF(F989=\"\",\"\",MIN(IF(H943=\"Days\",F989/F943*365.25,IF(H943=\"Months\",F989/F943*12,\"\")), 744.36))","v":""},{"$f":"IF(F989=\"\",\"\",IF(AND(H943=\"Days\",I983=\"Days\"),F989/F943*I982,IF(AND(H943=\"Months\",I983=\"Months\"),F989/F943*I982,IF(AND(H943=\"Days\",I983=\"Months\"),F989/F943*30.4375*I982,IF(AND(H943=\"Months\",I983=\"Days\"),F989/F943/30.4375*I982,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF(H976=\"\",\"\",H976)","v":""},{"$f":"IF(F990=\"\",\"\",F990*G982)","v":""},{"$f":"IF(F990=\"\",\"\",MIN(IF(H943=\"Days\",F990/F943*365.25,IF(H943=\"Months\",F990/F943*12,\"\")), 744.36))","v":""},{"$f":"IF(F990=\"\",\"\",IF(AND(H943=\"Days\",I983=\"Days\"),F990/F943*I982,IF(AND(H943=\"Months\",I983=\"Months\"),F990/F943*I982,IF(AND(H943=\"Days\",I983=\"Months\"),F990/F943*30.4375*I982,IF(AND(H943=\"Months\",I983=\"Days\"),F990/F943/30.4375*I982,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 10",null,null,null,{"$f":"SUM(F986:F989)","v":0},{"$f":"SUM(G986:G989)","v":0},{"$f":"SUM(H986:H989)","v":0},{"$f":"SUM(I986:I989)","v":0},null,"It is important to complete Table F as figures will automatically populate in Tables 1a and 1b based on selections in Table G"]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 10",null,null,null,{"$f":"IF(F990=\"\",SUM(F986+F987),F986+F987+F990)","v":0},{"$f":"IF(G990=\"\",SUM(G986+G987),G986+G987+G990)","v":0},{"$f":"IF(H990=\"\",SUM(H986:H987),H986+H987+H990)","v":0},{"$f":"IF(I990=\"\",SUM(I986:I987),I986+I987+I990)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"CONCATENATE(\"Comparator 10: \",NameComparator10)","v":"Comparator 10: "},null,null,null,{"$f":"IF($E996=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E996,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$113&\" Comparator 10\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E996=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E996,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$113&\" Comparator 10\"),$B:$B,0))","v":{"$error":"#N/A"}},null,null," - Figures will automatically populate in Tables 1a and 1b based on selections in Table G unless selected as \"Calculated elsewhere by Applicant\" in Table G. The corresponding cells will then be coloured blue in Tables 1a and 1b. Please manually overwrite the formula in the blue cells with the appropriate figure if using the manual option."]
[]
[null,"Notes"]
[]
[null,"Source used to inform the duration of treatment (e.g pivotal trial publication/ reference cell in CEM):",null,null,null,null,null,null,null,null,"•\tThe Applicant should provide any additional detail necessary to permit validation of drug cost calculations by the Review Group. \n•\tPlease note that where drug cost calculations are insufficiently described, this will lead to delays in the appraisal process. "]
[null,"Please specify whether the above refers to a particular subpopulation (if applicable):"]
[null,"Source for dosing regimen applied in BIM (e.g product SmPC): "]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 11: \",NameComparator11)","v":"Comparator 11: "}]
[]
[]
[null,"Table A: Applicant Input Selection Table to calculate the cost per pack",null,null,null,null,null,null,null,null," - Please input all information requested in this table to automatically calculate the cost per pack in Table C. Up to four type of packs  can be accomodated in this table across columns F to I. If there are less than four packs, please leave extra columns blank. If there are more than four products, please contact bim@ncpe.ie. "]
[null,"Details required to calculate the cost per pack and pharmacy fee information"]
[null,null,null,null,null,"Strength/Pack Size"]
[null,"Pack Identification",null,null,null,null,null,null,null,null," - Enter identifying information (e.g. strength, pack size) for each pack. For example, column F: 40mgx28; column G: 20mgx28. "]
[null,"Calculation Starting Point",null,null,null,null,null,null,null,"\u0080"," - Enter whether the calculation starting point is the Price to Wholesaler (PTW) or Reimbursement Price. PTW is listed on the pricing application form (PAF) submitted to the HSE. Reimbursement price is listed on the PCRS website. "]
[null,"Price per Pack",null,null,null,null,null,null,null,null," - Enter the relevant pack price here.  "]
[null,"Drug Funding Arrangement",null,null,null,null,null,null,null,"\u0080"," - Choose the funding arrangements. CDS = Community Drug Schemes, HT = High Tech Drug Arrangements, Hosp = Hospital. "]
[null,"Fridge",null,null,null,null,null,null,null,"\u0080"," - Optional: fridge item status only required for the CDS as wholesale mark-up varies here. May leave blank for other schemes."]
[null,"Oral product (including inhalers)",null,null,null,null,null,null,null,"\u0080"," - Required for VAT. Oral products including inhalers are exempt from VAT."]
[null,"Biologic",null,null,null,null,null,null,null,"\u0080"," - Required for Frameowrk Agreement rebate calculation."]
[null,"If Biologic =Yes: Select  Biologic and Patent Exclusivity Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =Yes, select the biologic and patent exclusivity status, pre- or post- 2026,  from the drop down list. If Biologic =No, select N/A. Required for Framework Agreement rebate calculation."]
[null,"If Biologic =No,  select Non Biologic Patent Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =No, select the non-biologic patent status, pre- or post- 2026.  If Biologic =Yes, select N/A. Required for Framework Agreement rebate calculation."]
[]
[null,"Table B: Applicant Input Table to calculate the cost per treatment cycle",null,null,null,null,null,null,null,null," - Treatment cycle is the length of time between product dispensings. For example, many oral tablet products have a treatment cycle of 28 days. If a drug is administered every six months, the treatment cycle is six months."]
[null,"Details required to calculate  the cost per treatment cycle"]
[null,"Length of Treatment Cycle",null,null,null,null,null,null,null,null," - Enter treatment cycle length in column F and select unit of measurement (Days/Months) in column H.  For treatment cycles measured in weeks, convert the number of weeks to days (e.g. 4 weeks = 28 days). One month is not equivalent to four weeks. If there is confusion over whether a dose is administered every four weeks or every month, refer to the SPC. "]
[null,{"$f":"B1019","v":"Pack Identification"},null,null,null,{"$f":"IF(ISBLANK(F1019),\"\",F1019)","v":""},{"$f":"IF(ISBLANK(G1019),\"\",G1019)","v":""},{"$f":"IF(ISBLANK(H1019),\"\",H1019)","v":""},{"$f":"IF(ISBLANK(I1019),\"\",I1019)","v":""}]
[null,"Number of packs required per treatment cycle",null,null,null,null,null,null,null,null," - Enter the number of packs of each pack presentation required per treatment cycle. For example if the treatment cycle is 28 days, and there are 14 days supply in one pack, enter \"2\" into column F.  Where each patient requires multiple products every treatment cycle, enter the number of packs of each pack type into the relevant column. For example,  where a patient requires 2 x Pack (F) and 1 x Pack (G) every 28 day treatment cycle, please enter 2 in column F and 1 in column G. Alternatively, where only a single pack is required by a patient each cycle but multiple strengths are available, a weighted average can be calculated by entering the relevant weight for each pack in every column. Ensure weights sum to 1. Add details of how weights are derived in notes section. "]
[]
[]
[]
[null,"Table C. Total Cost to the HSE per pack"]
["This table will fill automatically based on the information inserted above. This information in this table is used to calculate the costs in Table F."]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF(F1019=\"\",\"\",F1019)","v":""},{"$f":"IF(G1019=\"\",\"\",G1019)","v":""},{"$f":"IF(H1019=\"\",\"\",H1019)","v":""},{"$f":"IF(I1019=\"\",\"\",I1019)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR(F1020=\"\",F1021=\"\",F1022=\"\"),\"\",IF(F1020=\"Price to Wholesaler\",F1021,IF(F1020=\"Reimbursement Price\",(F1043/(1+E1042)*1),\"Error\")))","v":""},{"$f":"IF(OR(G1020=\"\",G1021=\"\",F1022=\"\"),\"\",IF(G1020=\"Price to Wholesaler\",G1021,IF(G1020=\"Reimbursement Price\",(G1043/(1+E1042)*1),\"Error\")))","v":""},{"$f":"IF(OR(H1020=\"\",H1021=\"\",F1022=\"\"),\"\",IF(H1020=\"Price to Wholesaler\",H1021,IF(H1020=\"Reimbursement Price\",(H1043/(1+E1042)*1),\"Error\")))","v":""},{"$f":"IF(OR(I1020=\"\",I1021=\"\",F1022=\"\"),\"\",IF(I1020=\"Price to Wholesaler\",I1021,IF(I1020=\"Reimbursement Price\",(I1043/(1+E1042)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR(F1022=\"\"),\"\",IF(AND(F1022=\"CDS\",F1023=\"Yes\"),CYF,IF(AND(F1022=\"CDS\",F1023=\"No\"),CNF,IF(F1022=\"HT\",CHT,IF(F1022=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR(F1022=\"\",F1021=\"\",F1020=\"\"),\"\",F1041*E1042)","v":""},{"$f":"IF(OR(F1022=\"\",G1021=\"\",G1020=\"\"),\"\",G1041*E1042)","v":""},{"$f":"IF(OR(F1022=\"\",H1021=\"\",H1020=\"\"),\"\",H1041*E1042)","v":""},{"$f":"IF(OR(F1022=\"\",I1021=\"\",I1020=\"\"),\"\",I1041*E1042)","v":""}]
["C",{"$f":"IF(F1022=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF(F1020=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF(F1020=\"Reimbursement Price\",F1021,IF(ISBLANK(E1042),\"\",IF(F1020=\"Price to Wholesaler\",(F1041+F1042),IF(F1020=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(G1020=\"Reimbursement Price\",G1021,IF(ISBLANK(E1042),\"\",IF(G1020=\"Price to Wholesaler\",(G1041+G1042),IF(G1020=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(H1020=\"Reimbursement Price\",H1021,IF(ISBLANK(E1042),\"\",IF(H1020=\"Price to Wholesaler\",(H1041+H1042),IF(H1020=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(I1020=\"Reimbursement Price\",I1021,IF(ISBLANK(E1042),\"\",IF(I1020=\"Price to Wholesaler\",(I1041+I1042),IF(I1020=\"\",\"\",\"Error\"))))","v":""}]
["D","Framework Agreement Rebate",null,null,{"$f":"IF(OR(F1025=\"\",AND(F1025=\"Yes\",F1026=\"\"),AND(F1025=\"No\",F1027=\"\")),\"\",IF(AND(F1025=\"No\",F1027=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (pre-2026)\"),MRpre2026,IF(AND(F1025=\"No\",F1027=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F1025=\"No\",F1027=\"Off Patent Non-Exclusive or Generic\"),\"None\",IF(AND(F1025=\"Yes\",F1026=\"Biosimilar\"),\"None\",IF(AND(F1025=\"Yes\",F1026=\"Patented or Off Patent Exclusive (pre-2026)\"),MRpre2026,IF(AND(F1025=\"Yes\",F1026=\"Patented or Off Patent Exclusive (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F1025=\"Yes\",F1026=\"Off Patent Non-Exclusive 12.5% Rebate incorporated into Price to Wholesaler\"),\"None\",IF(AND(F1025=\"Yes\",F1026=\"Off Patent Non-Exclusive 12.5% Rebate\"),MRB,\"Error\")))))))))","v":""},{"$f":"IF(OR(F1025=\"\",AND(F1025=\"Yes\",F1026=\"\"),AND(F1025=\"No\",F1027=\"\"),F1020=\"\",ISBLANK(F1021)),\"\",IF(E1044=\"None\",0,(E1044*F1041)))","v":""},{"$f":"IF(OR(F1025=\"\",AND(F1025=\"Yes\",F1026=\"\"),AND(F1025=\"No\",F1027=\"\"),G1020=\"\",ISBLANK(G1021)),\"\",IF(E1044=\"None\",0,(E1044*G1041)))","v":""},{"$f":"IF(OR(F1025=\"\",AND(F1025=\"Yes\",F1026=\"\"),AND(F1025=\"No\",F1027=\"\"),H1020=\"\",ISBLANK(H1021)),\"\",IF(E1044=\"None\",0,(E1044*H1041)))","v":""},{"$f":"IF(OR(F1025=\"\",AND(F1025=\"Yes\",F1026=\"\"),AND(F1025=\"No\",F1027=\"\"),I1020=\"\",ISBLANK(I1021)),\"\",IF(E1044=\"None\",0,(E1044*I1041)))","v":""}]
["E","VAT on Drug Cost ",null,null,{"$f":"IF(F1024=\"\",\"\",IF(F1024=\"Yes\",0,VT))","v":""},{"$f":"IF(OR(F1021=\"\",ISBLANK(F1021)),\"\",($E1045*F1043))","v":""},{"$f":"IF(OR(G1021=\"\",ISBLANK(G1021)),\"\",($E1045*G1043))","v":""},"",""]
["F(i)","Total Drug Cost to the HSE per pack including VAT",null,null,null,{"$f":"IF(OR(F1020=\"\",$F1022=\"\",$F1024=\"\",$F1025=\"\"),\"\",SUM(F1043:F1045))","v":""},{"$f":"IF(OR(G1020=\"\",$F1022=\"\",$F1024=\"\",$F1025=\"\"),\"\",SUM(G1043:G1045))","v":""},{"$f":"IF(OR(H1020=\"\",$F1022=\"\",$F1024=\"\",$F1025=\"\"),\"\",SUM(H1043:H1045))","v":""},{"$f":"IF(OR(I1020=\"\",$F1022=\"\",$F1024=\"\",$F1025=\"\"),\"\",SUM(I1043:I1045))","v":""}]
["F(ii)","Total Drug Cost to the HSE per pack excluding VAT",null,null,null,{"$f":"IF(OR(F1020=\"\",$F1022=\"\",$F1024=\"\",$F1025=\"\"),\"\",SUM(F1043:F1044))","v":""},{"$f":"IF(OR(G1020=\"\",$F1022=\"\",$F1024=\"\",$F1025=\"\"),\"\",SUM(G1043:G1044))","v":""},{"$f":"IF(OR(H1020=\"\",$F1022=\"\",$F1024=\"\",$F1025=\"\"),\"\",SUM(H1043:H1044))","v":""},{"$f":"IF(OR(I1020=\"\",$F1022=\"\",$F1024=\"\",$F1025=\"\"),\"\",SUM(I1043:I1044))","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table D. Pharmacy Fees payable based on the type of product and reimbursement arrangements"]
[null,"For hospital drugs this table may be ignored."]
[null,"This table fills  automatically based on scheme and product information inputted above in Table A. "]
[]
[null,null,null,null,null,null,"Calculation ","Value"]
[null,"Pharmacy Fees excluding VAT",null,null,null,null,{"$f":"IF(F1022=\"\",\"\",IF(F1022=\"CDS\",\"per dispensing\",IF(F1022=\"HT\",\"per month\",IF(F1022=\"Hosp\",\"No Fee\", ERROR))))","v":""},{"$f":"IF(F1022=\"\",\"\",IF(F1022=\"CDS\",DF,IF(F1022=\"HT\",PC,IF(F1022=\"Hosp\",\"No Fee\",ERROR))))","v":""},"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         "]
[null,"VAT on Pharmacy Fees",null,null,null,null,{"$f":"IF(OR(F1022=\"\",F1024=\"\"),\"\",IF(F1022=\"Hosp\",\"No Fee\",IF(F1022=\"HT\",\"No VAT\",IF(AND(F1022=\"CDS\",F1024=\"No\"),VT,\"No VAT\"))))","v":""},{"$f":"IF(OR(F1024=\"\",F1022=\"Hosp\"),\"\",IF(OR(F1024=\"Yes\",F1022=\"HT\"),0,H1054*G1055))","v":""}]
[]
[]
["Table E Pharmacy Fees per product treatment cycle. \n",null,null,null,null,null,null,null,null,null," - Based on the drug's dispensing regimen and the NCPE drug cost guidelines, please input the pharmacy fees per treatment cycle. Use data presented in Table D to generate an appropriate formula for Column H of Table E. Notes may be added in column G. "]
["This section may be ommited for hospital drugs",null,null,null,null,null,"Notes","Value",null,null,{"$f":"IF(F1022=\"HT\",\"For High tech, if a treatment cycle =28 days the corresponding pharmacy fee is =62.03*12/365.25*28.  The pharmacy fee remains the same regardless of the number of products dispensed that month.\",IF(F1022=\"CDS\",\"For CDS, if 2 packets of the same pack presentation are required per treatment cycle, one dispensing fee applies (€5.48). If multiple pack presentations are required, multiple dispensing fees apply\",\"\"))","v":""}]
["G","Pharmacy Fees per treatment cycle excluding VAT"]
["H","Non dispensed patient care fee per treatment cycle (High Tech only)",null,null,null,null,null,null,null,null," - Enter here if relevant. See NCPE drug cost guidelines for more information on non-dispensed patient care fees (High Tech only). "]
["I","VAT on pharmacy Fees",null,null,null,null,null,null,null,null," - Please input VAT payable on pharmacy fees if applicable based on the information presented in Table D. "]
["J (i)","Total pharmacy Fees per treatment cycle including VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H1060),\"\",SUM(H1060:H1062))","v":""}]
["J (ii)","Total pharmacy Fees per treatment cycle excluding VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H1060),\"\",SUM(H1060:H1061))","v":""}]
[]
[]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time",null," - Calculate the cost for the budget impact model using  cost per number of cycles, per year or per unit time. Input the length of time required  into the blue boxes where applicable. Irrelevant columns may be left blank. Use the drop down boxes to select days or months when calculating the cost per unit time."]
[]
[null,null,null,null,null,null,"number of cycles"]
["A",{"$f":"B1041","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F1041:I1041,F1033:I1033)","v":0},{"$f":"F1072*G1070","v":0},{"$f":"IF(H1031=\"Days\",F1072/F1031*365.25,IF(H1031=\"Months\",F1072/F1031*12,\"\"))","v":""},{"$f":"IF(AND(H1031=\"Days\",I1071=\"Days\"),F1072/F1031*I1070,IF(AND(H1031=\"Months\",I1071=\"Months\"),F1072/F1031*I1070,IF(AND(H1031=\"Days\",I1071=\"Months\"),F1072/F1031*30.4375*I1070,IF(AND(H1031=\"Months\",I1071=\"Days\"),F1072/F1031/30.4375*I1070,\"\"))))","v":""}]
["B",{"$f":"B1042","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F1042:I1042,F1033:I1033)","v":0},{"$f":"F1073*G1070","v":0},{"$f":"IF(H1031=\"Days\",F1073/F1031*365.25,IF(H1031=\"Months\",F1073/F1031*12,\"\"))","v":""},{"$f":"IF(AND(H1031=\"Days\",I1071=\"Days\"),F1073/F1031*I1070,IF(AND(H1031=\"Months\",I1071=\"Months\"),F1073/F1031*I1070,IF(AND(H1031=\"Days\",I1071=\"Months\"),F1073/F1031*30.4375*I1070,IF(AND(H1031=\"Months\",I1071=\"Days\"),F1073/F1031/30.4375*I1070,\"\"))))","v":""}]
["C",{"$f":"B1043","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F1043:I1043,F1033:I1033)","v":0},{"$f":"F1074*G1070","v":0},{"$f":"IF(H1031=\"Days\",F1074/F1031*365.25,IF(H1031=\"Months\",F1074/F1031*12,\"\"))","v":""},{"$f":"IF(AND(H1031=\"Days\",I1071=\"Days\"),F1074/F1031*I1070,IF(AND(H1031=\"Months\",I1071=\"Months\"),F1074/F1031*I1070,IF(AND(H1031=\"Days\",I1071=\"Months\"),F1074/F1031*30.4375*I1070,IF(AND(H1031=\"Months\",I1071=\"Days\"),F1074/F1031/30.4375*I1070,\"\"))))","v":""}]
["D",{"$f":"B1044","v":"Framework Agreement Rebate"},null,null,null,{"$f":"SUMPRODUCT(F1044:I1044,F1033:I1033)","v":0},{"$f":"F1075*G1070","v":0},{"$f":"IF(H1031=\"Days\",F1075/F1031*365.25,IF(H1031=\"Months\",F1075/F1031*12,\"\"))","v":""},{"$f":"IF(AND(H1031=\"Days\",I1071=\"Days\"),F1075/F1031*I1070,IF(AND(H1031=\"Months\",I1071=\"Months\"),F1075/F1031*I1070,IF(AND(H1031=\"Days\",I1071=\"Months\"),F1075/F1031*30.4375*I1070,IF(AND(H1031=\"Months\",I1071=\"Days\"),F1075/F1031/30.4375*I1070,\"\"))))","v":""}]
["E",{"$f":"B1045","v":"VAT on Drug Cost "},null,null,null,{"$f":"SUMPRODUCT(F1045:I1045,F1033:I1033)","v":0},{"$f":"F1076*G1070","v":0},{"$f":"IF(H1031=\"Days\",F1076/F1031*365.25,IF(H1031=\"Months\",F1076/F1031*12,\"\"))","v":""},{"$f":"IF(AND(H1031=\"Days\",I1071=\"Days\"),F1076/F1031*I1070,IF(AND(H1031=\"Months\",I1071=\"Months\"),F1076/F1031*I1070,IF(AND(H1031=\"Days\",I1071=\"Months\"),F1076/F1031*30.4375*I1070,IF(AND(H1031=\"Months\",I1071=\"Days\"),F1076/F1031/30.4375*I1070,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF(H1063=\"\",\"\",H1063)","v":""},{"$f":"IF(F1077=\"\",\"\",F1077*G1070)","v":""},{"$f":"IF(F1077=\"\",\"\",MIN(IF(H1031=\"Days\",F1077/F1031*365.25,IF(H1031=\"Months\",F1077/F1031*12,\"\")), 744.36))","v":""},{"$f":"IF(F1077=\"\",\"\",IF(AND(H1031=\"Days\",I1071=\"Days\"),F1077/F1031*I1070,IF(AND(H1031=\"Months\",I1071=\"Months\"),F1077/F1031*I1070,IF(AND(H1031=\"Days\",I1071=\"Months\"),F1077/F1031*30.4375*I1070,IF(AND(H1031=\"Months\",I1071=\"Days\"),F1077/F1031/30.4375*I1070,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF(H1064=\"\",\"\",H1064)","v":""},{"$f":"IF(F1078=\"\",\"\",F1078*G1070)","v":""},{"$f":"IF(F1078=\"\",\"\",MIN(IF(H1031=\"Days\",F1078/F1031*365.25,IF(H1031=\"Months\",F1078/F1031*12,\"\")), 744.36))","v":""},{"$f":"IF(F1078=\"\",\"\",IF(AND(H1031=\"Days\",I1071=\"Days\"),F1078/F1031*I1070,IF(AND(H1031=\"Months\",I1071=\"Months\"),F1078/F1031*I1070,IF(AND(H1031=\"Days\",I1071=\"Months\"),F1078/F1031*30.4375*I1070,IF(AND(H1031=\"Months\",I1071=\"Days\"),F1078/F1031/30.4375*I1070,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 11",null,null,null,{"$f":"SUM(F1074:F1077)","v":0},{"$f":"SUM(G1074:G1077)","v":0},{"$f":"SUM(H1074:H1077)","v":0},{"$f":"SUM(I1074:I1077)","v":0},null,"It is important to complete Table F as figures will automatically populate in Tables 1a and 1b based on selections in Table G"]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 11",null,null,null,{"$f":"IF(F1078=\"\",SUM(F1074+F1075),F1074+F1075+F1078)","v":0},{"$f":"IF(G1078=\"\",SUM(G1074+G1075),G1074+G1075+G1078)","v":0},{"$f":"IF(H1078=\"\",SUM(H1074:H1075),H1074+H1075+H1078)","v":0},{"$f":"IF(I1078=\"\",SUM(I1074:I1075),I1074+I1075+I1078)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"CONCATENATE(\"Comparator 11: \",NameComparator11)","v":"Comparator 11: "},null,null,null,{"$f":"IF($E1084=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E1084,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$113&\" Comparator 11\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E1084=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E1084,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$113&\" Comparator 11\"),$B:$B,0))","v":{"$error":"#N/A"}},null,null," - Figures will automatically populate in Tables 1a and 1b based on selections in Table G unless selected as \"Calculated elsewhere by Applicant\" in Table G. The corresponding cells will then be coloured blue in Tables 1a and 1b. Please manually overwrite the formula in the blue cells with the appropriate figure if using the manual option."]
[]
[null,"Notes"]
[]
[null,"Source used to inform the duration of treatment (e.g pivotal trial publication/ reference cell in CEM):",null,null,null,null,null,null,null,null,"•\tThe Applicant should provide any additional detail necessary to permit validation of drug cost calculations by the Review Group. \n•\tPlease note that where drug cost calculations are insufficiently described, this will lead to delays in the appraisal process. "]
[null,"Please specify whether the above refers to a particular subpopulation (if applicable):"]
[null,"Source for dosing regimen applied in BIM (e.g product SmPC): "]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 12: \",NameComparator12)","v":"Comparator 12: "}]
[]
[]
[null,"Table A: Applicant Input Selection Table to calculate the cost per pack",null,null,null,null,null,null,null,null," - Please input all information requested in this table to automatically calculate the cost per pack in Table C. Up to four type of packs  can be accomodated in this table across columns F to I. If there are less than four packs, please leave extra columns blank. If there are more than four products, please contact bim@ncpe.ie. "]
[null,"Details required to calculate the cost per pack and pharmacy fee information"]
[null,null,null,null,null,"Strength/Pack Size"]
[null,"Pack Identification",null,null,null,null,null,null,null,null," - Enter identifying information (e.g. strength, pack size) for each pack. For example, column F: 40mgx28; column G: 20mgx28. "]
[null,"Calculation Starting Point",null,null,null,null,null,null,null,"\u0080"," - Enter whether the calculation starting point is the Price to Wholesaler (PTW) or Reimbursement Price. PTW is listed on the pricing application form (PAF) submitted to the HSE. Reimbursement price is listed on the PCRS website. "]
[null,"Price per Pack",null,null,null,null,null,null,null,null," - Enter the relevant pack price here.  "]
[null,"Drug Funding Arrangement",null,null,null,null,null,null,null,"\u0080"," - Choose the funding arrangements. CDS = Community Drug Schemes, HT = High Tech Drug Arrangements, Hosp = Hospital. "]
[null,"Fridge",null,null,null,null,null,null,null,"\u0080"," - Optional: fridge item status only required for the CDS as wholesale mark-up varies here. May leave blank for other schemes."]
[null,"Oral product (including inhalers)",null,null,null,null,null,null,null,"\u0080"," - Required for VAT. Oral products including inhalers are exempt from VAT."]
[null,"Biologic",null,null,null,null,null,null,null,"\u0080"," - Required for Frameowrk Agreement rebate calculation."]
[null,"If Biologic =Yes: Select  Biologic and Patent Exclusivity Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =Yes, select the biologic and patent exclusivity status, pre- or post- 2026,  from the drop down list. If Biologic =No, select N/A. Required for Framework Agreement rebate calculation."]
[null,"If Biologic =No,  select Non Biologic Patent Status",null,null,null,null,null,null,null,"\u0080"," - If Biologic =No, select the non-biologic patent status, pre- or post- 2026.  If Biologic =Yes, select N/A. Required for Framework Agreement rebate calculation."]
[]
[null,"Table B: Applicant Input Table to calculate the cost per treatment cycle",null,null,null,null,null,null,null,null," - Treatment cycle is the length of time between product dispensings. For example, many oral tablet products have a treatment cycle of 28 days. If a drug is administered every six months, the treatment cycle is six months."]
[null,"Details required to calculate  the cost per treatment cycle"]
[null,"Length of Treatment Cycle",null,null,null,null,null,null,null,null," - Enter treatment cycle length in column F and select unit of measurement (Days/Months) in column H.  For treatment cycles measured in weeks, convert the number of weeks to days (e.g. 4 weeks = 28 days). One month is not equivalent to four weeks. If there is confusion over whether a dose is administered every four weeks or every month, refer to the SPC. "]
[null,{"$f":"B1107","v":"Pack Identification"},null,null,null,{"$f":"IF(ISBLANK(F1107),\"\",F1107)","v":""},{"$f":"IF(ISBLANK(G1107),\"\",G1107)","v":""},{"$f":"IF(ISBLANK(H1107),\"\",H1107)","v":""},{"$f":"IF(ISBLANK(I1107),\"\",I1107)","v":""}]
[null,"Number of packs required per treatment cycle",null,null,null,null,null,null,null,null," - Enter the number of packs of each pack presentation required per treatment cycle. For example if the treatment cycle is 28 days, and there are 14 days supply in one pack, enter \"2\" into column F.  Where each patient requires multiple products every treatment cycle, enter the number of packs of each pack type into the relevant column. For example,  where a patient requires 2 x Pack (F) and 1 x Pack (G) every 28 day treatment cycle, please enter 2 in column F and 1 in column G. Alternatively, where only a single pack is required by a patient each cycle but multiple strengths are available, a weighted average can be calculated by entering the relevant weight for each pack in every column. Ensure weights sum to 1. Add details of how weights are derived in notes section. "]
[]
[]
[]
[null,"Table C. Total Cost to the HSE per pack"]
["This table will fill automatically based on the information inserted above. This information in this table is used to calculate the costs in Table F."]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF(F1107=\"\",\"\",F1107)","v":""},{"$f":"IF(G1107=\"\",\"\",G1107)","v":""},{"$f":"IF(H1107=\"\",\"\",H1107)","v":""},{"$f":"IF(I1107=\"\",\"\",I1107)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR(F1108=\"\",F1109=\"\",F1110=\"\"),\"\",IF(F1108=\"Price to Wholesaler\",F1109,IF(F1108=\"Reimbursement Price\",(F1131/(1+E1130)*1),\"Error\")))","v":""},{"$f":"IF(OR(G1108=\"\",G1109=\"\",F1110=\"\"),\"\",IF(G1108=\"Price to Wholesaler\",G1109,IF(G1108=\"Reimbursement Price\",(G1131/(1+E1130)*1),\"Error\")))","v":""},{"$f":"IF(OR(H1108=\"\",H1109=\"\",F1110=\"\"),\"\",IF(H1108=\"Price to Wholesaler\",H1109,IF(H1108=\"Reimbursement Price\",(H1131/(1+E1130)*1),\"Error\")))","v":""},{"$f":"IF(OR(I1108=\"\",I1109=\"\",F1110=\"\"),\"\",IF(I1108=\"Price to Wholesaler\",I1109,IF(I1108=\"Reimbursement Price\",(I1131/(1+E1130)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR(F1110=\"\"),\"\",IF(AND(F1110=\"CDS\",F1111=\"Yes\"),CYF,IF(AND(F1110=\"CDS\",F1111=\"No\"),CNF,IF(F1110=\"HT\",CHT,IF(F1110=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR(F1110=\"\",F1109=\"\",F1108=\"\"),\"\",F1129*E1130)","v":""},{"$f":"IF(OR(F1110=\"\",G1109=\"\",G1108=\"\"),\"\",G1129*E1130)","v":""},{"$f":"IF(OR(F1110=\"\",H1109=\"\",H1108=\"\"),\"\",H1129*E1130)","v":""},{"$f":"IF(OR(F1110=\"\",I1109=\"\",I1108=\"\"),\"\",I1129*E1130)","v":""}]
["C",{"$f":"IF(F1110=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF(F1108=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF(F1108=\"Reimbursement Price\",F1109,IF(ISBLANK(E1130),\"\",IF(F1108=\"Price to Wholesaler\",(F1129+F1130),IF(F1108=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(G1108=\"Reimbursement Price\",G1109,IF(ISBLANK(E1130),\"\",IF(G1108=\"Price to Wholesaler\",(G1129+G1130),IF(G1108=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(H1108=\"Reimbursement Price\",H1109,IF(ISBLANK(E1130),\"\",IF(H1108=\"Price to Wholesaler\",(H1129+H1130),IF(H1108=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF(I1108=\"Reimbursement Price\",I1109,IF(ISBLANK(E1130),\"\",IF(I1108=\"Price to Wholesaler\",(I1129+I1130),IF(I1108=\"\",\"\",\"Error\"))))","v":""}]
["D","Framework Agreement Rebate",null,null,{"$f":"IF(OR(F1113=\"\",AND(F1113=\"Yes\",F1114=\"\"),AND(F1113=\"No\",F1115=\"\")),\"\",IF(AND(F1113=\"No\",F1115=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (pre-2026)\"),MRpre2026,IF(AND(F1113=\"No\",F1115=\"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F1113=\"No\",F1115=\"Off Patent Non-Exclusive or Generic\"),\"None\",IF(AND(F1113=\"Yes\",F1114=\"Biosimilar\"),\"None\",IF(AND(F1113=\"Yes\",F1114=\"Patented or Off Patent Exclusive (pre-2026)\"),MRpre2026,IF(AND(F1113=\"Yes\",F1114=\"Patented or Off Patent Exclusive (post-2026)\"),IF(Scenario_of_5__rebate=\"Yes\",-0.05,MRpost2026),IF(AND(F1113=\"Yes\",F1114=\"Off Patent Non-Exclusive 12.5% Rebate incorporated into Price to Wholesaler\"),\"None\",IF(AND(F1113=\"Yes\",F1114=\"Off Patent Non-Exclusive 12.5% Rebate\"),MRB,\"Error\")))))))))","v":""},{"$f":"IF(OR(F1113=\"\",AND(F1113=\"Yes\",F1114=\"\"),AND(F1113=\"No\",F1115=\"\"),F1108=\"\",ISBLANK(F1109)),\"\",IF(E1132=\"None\",0,(E1132*F1129)))","v":""},{"$f":"IF(OR(F1113=\"\",AND(F1113=\"Yes\",F1114=\"\"),AND(F1113=\"No\",F1115=\"\"),G1108=\"\",ISBLANK(G1109)),\"\",IF(E1132=\"None\",0,(E1132*G1129)))","v":""},{"$f":"IF(OR(F1113=\"\",AND(F1113=\"Yes\",F1114=\"\"),AND(F1113=\"No\",F1115=\"\"),H1108=\"\",ISBLANK(H1109)),\"\",IF(E1132=\"None\",0,(E1132*H1129)))","v":""},{"$f":"IF(OR(F1113=\"\",AND(F1113=\"Yes\",F1114=\"\"),AND(F1113=\"No\",F1115=\"\"),I1108=\"\",ISBLANK(I1109)),\"\",IF(E1132=\"None\",0,(E1132*I1129)))","v":""}]
["E","VAT on Drug Cost ",null,null,{"$f":"IF(F1112=\"\",\"\",IF(F1112=\"Yes\",0,VT))","v":""},{"$f":"IF(OR(F1109=\"\",ISBLANK(F1109)),\"\",($E1133*F1131))","v":""},{"$f":"IF(OR(G1109=\"\",ISBLANK(G1109)),\"\",($E1133*G1131))","v":""},"",""]
["F(i)","Total Drug Cost to the HSE per pack including VAT",null,null,null,{"$f":"IF(OR(F1108=\"\",$F1110=\"\",$F1112=\"\",$F1113=\"\"),\"\",SUM(F1131:F1133))","v":""},{"$f":"IF(OR(G1108=\"\",$F1110=\"\",$F1112=\"\",$F1113=\"\"),\"\",SUM(G1131:G1133))","v":""},{"$f":"IF(OR(H1108=\"\",$F1110=\"\",$F1112=\"\",$F1113=\"\"),\"\",SUM(H1131:H1133))","v":""},{"$f":"IF(OR(I1108=\"\",$F1110=\"\",$F1112=\"\",$F1113=\"\"),\"\",SUM(I1131:I1133))","v":""}]
["F(ii)","Total Drug Cost to the HSE per pack excluding VAT",null,null,null,{"$f":"IF(OR(F1108=\"\",$F1110=\"\",$F1112=\"\",$F1113=\"\"),\"\",SUM(F1131:F1132))","v":""},{"$f":"IF(OR(G1108=\"\",$F1110=\"\",$F1112=\"\",$F1113=\"\"),\"\",SUM(G1131:G1132))","v":""},{"$f":"IF(OR(H1108=\"\",$F1110=\"\",$F1112=\"\",$F1113=\"\"),\"\",SUM(H1131:H1132))","v":""},{"$f":"IF(OR(I1108=\"\",$F1110=\"\",$F1112=\"\",$F1113=\"\"),\"\",SUM(I1131:I1132))","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table D. Pharmacy Fees payable based on the type of product and reimbursement arrangements"]
[null,"For hospital drugs this table may be ignored."]
[null,"This table fills  automatically based on scheme and product information inputted above in Table A. "]
[]
[null,null,null,null,null,null,"Calculation ","Value"]
[null,"Pharmacy Fees excluding VAT",null,null,null,null,{"$f":"IF(F1110=\"\",\"\",IF(F1110=\"CDS\",\"per dispensing\",IF(F1110=\"HT\",\"per month\",IF(F1110=\"Hosp\",\"No Fee\", ERROR))))","v":""},{"$f":"IF(F1110=\"\",\"\",IF(F1110=\"CDS\",DF,IF(F1110=\"HT\",PC,IF(F1110=\"Hosp\",\"No Fee\",ERROR))))","v":""},"                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         "]
[null,"VAT on Pharmacy Fees",null,null,null,null,{"$f":"IF(OR(F1110=\"\",F1112=\"\"),\"\",IF(F1110=\"Hosp\",\"No Fee\",IF(F1110=\"HT\",\"No VAT\",IF(AND(F1110=\"CDS\",F1112=\"No\"),VT,\"No VAT\"))))","v":""},{"$f":"IF(OR(F1112=\"\",F1110=\"Hosp\"),\"\",IF(OR(F1112=\"Yes\",F1110=\"HT\"),0,H1142*G1143))","v":""}]
[]
[]
["Table E Pharmacy Fees per product treatment cycle. \n",null,null,null,null,null,null,null,null,null," - Based on the drug's dispensing regimen and the NCPE drug cost guidelines, please input the pharmacy fees per treatment cycle. Use data presented in Table D to generate an appropriate formula for Column H of Table E. Notes may be added in column G. "]
["This section may be ommited for hospital drugs",null,null,null,null,null,"Notes","Value",null,null,{"$f":"IF(F1110=\"HT\",\"For High tech, if a treatment cycle =28 days the corresponding pharmacy fee is =62.03*12/365.25*28.  The pharmacy fee remains the same regardless of the number of products dispensed that month.\",IF(F1110=\"CDS\",\"For CDS, if 2 packets of the same pack presentation are required per treatment cycle, one dispensing fee applies (€5.48). If multiple pack presentations are required, multiple dispensing fees apply\",\"\"))","v":""}]
["G","Pharmacy Fees per treatment cycle excluding VAT"]
["H","Non dispensed patient care fee per treatment cycle (High Tech only)",null,null,null,null,null,null,null,null," - Enter here if relevant. See NCPE drug cost guidelines for more information on non-dispensed patient care fees (High Tech only). "]
["I","VAT on pharmacy Fees",null,null,null,null,null,null,null,null," - Please input VAT payable on pharmacy fees if applicable based on the information presented in Table D. "]
["J (i)","Total pharmacy Fees per treatment cycle including VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H1148),\"\",SUM(H1148:H1150))","v":""}]
["J (ii)","Total pharmacy Fees per treatment cycle excluding VAT",null,null,null,null,null,{"$f":"IF(ISBLANK(H1148),\"\",SUM(H1148:H1149))","v":""}]
[]
[]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time",null," - Calculate the cost for the budget impact model using  cost per number of cycles, per year or per unit time. Input the length of time required  into the blue boxes where applicable. Irrelevant columns may be left blank. Use the drop down boxes to select days or months when calculating the cost per unit time."]
[]
[null,null,null,null,null,null,"number of cycles"]
["A",{"$f":"B1129","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F1129:I1129,F1121:I1121)","v":0},{"$f":"F1160*G1158","v":0},{"$f":"IF(H1119=\"Days\",F1160/F1119*365.25,IF(H1119=\"Months\",F1160/F1119*12,\"\"))","v":""},{"$f":"IF(AND(H1119=\"Days\",I1159=\"Days\"),F1160/F1119*I1158,IF(AND(H1119=\"Months\",I1159=\"Months\"),F1160/F1119*I1158,IF(AND(H1119=\"Days\",I1159=\"Months\"),F1160/F1119*30.4375*I1158,IF(AND(H1119=\"Months\",I1159=\"Days\"),F1160/F1119/30.4375*I1158,\"\"))))","v":""}]
["B",{"$f":"B1130","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F1130:I1130,F1121:I1121)","v":0},{"$f":"F1161*G1158","v":0},{"$f":"IF(H1119=\"Days\",F1161/F1119*365.25,IF(H1119=\"Months\",F1161/F1119*12,\"\"))","v":""},{"$f":"IF(AND(H1119=\"Days\",I1159=\"Days\"),F1161/F1119*I1158,IF(AND(H1119=\"Months\",I1159=\"Months\"),F1161/F1119*I1158,IF(AND(H1119=\"Days\",I1159=\"Months\"),F1161/F1119*30.4375*I1158,IF(AND(H1119=\"Months\",I1159=\"Days\"),F1161/F1119/30.4375*I1158,\"\"))))","v":""}]
["C",{"$f":"B1131","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F1131:I1131,F1121:I1121)","v":0},{"$f":"F1162*G1158","v":0},{"$f":"IF(H1119=\"Days\",F1162/F1119*365.25,IF(H1119=\"Months\",F1162/F1119*12,\"\"))","v":""},{"$f":"IF(AND(H1119=\"Days\",I1159=\"Days\"),F1162/F1119*I1158,IF(AND(H1119=\"Months\",I1159=\"Months\"),F1162/F1119*I1158,IF(AND(H1119=\"Days\",I1159=\"Months\"),F1162/F1119*30.4375*I1158,IF(AND(H1119=\"Months\",I1159=\"Days\"),F1162/F1119/30.4375*I1158,\"\"))))","v":""}]
["D",{"$f":"B1132","v":"Framework Agreement Rebate"},null,null,null,{"$f":"SUMPRODUCT(F1132:I1132,F1121:I1121)","v":0},{"$f":"F1163*G1158","v":0},{"$f":"IF(H1119=\"Days\",F1163/F1119*365.25,IF(H1119=\"Months\",F1163/F1119*12,\"\"))","v":""},{"$f":"IF(AND(H1119=\"Days\",I1159=\"Days\"),F1163/F1119*I1158,IF(AND(H1119=\"Months\",I1159=\"Months\"),F1163/F1119*I1158,IF(AND(H1119=\"Days\",I1159=\"Months\"),F1163/F1119*30.4375*I1158,IF(AND(H1119=\"Months\",I1159=\"Days\"),F1163/F1119/30.4375*I1158,\"\"))))","v":""}]
["E",{"$f":"B1133","v":"VAT on Drug Cost "},null,null,null,{"$f":"SUMPRODUCT(F1133:I1133,F1121:I1121)","v":0},{"$f":"F1164*G1158","v":0},{"$f":"IF(H1119=\"Days\",F1164/F1119*365.25,IF(H1119=\"Months\",F1164/F1119*12,\"\"))","v":""},{"$f":"IF(AND(H1119=\"Days\",I1159=\"Days\"),F1164/F1119*I1158,IF(AND(H1119=\"Months\",I1159=\"Months\"),F1164/F1119*I1158,IF(AND(H1119=\"Days\",I1159=\"Months\"),F1164/F1119*30.4375*I1158,IF(AND(H1119=\"Months\",I1159=\"Days\"),F1164/F1119/30.4375*I1158,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF(H1151=\"\",\"\",H1151)","v":""},{"$f":"IF(F1165=\"\",\"\",F1165*G1158)","v":""},{"$f":"IF(F1165=\"\",\"\",MIN(IF(H1119=\"Days\",F1165/F1119*365.25,IF(H1119=\"Months\",F1165/F1119*12,\"\")), 744.36))","v":""},{"$f":"IF(F1165=\"\",\"\",IF(AND(H1119=\"Days\",I1159=\"Days\"),F1165/F1119*I1158,IF(AND(H1119=\"Months\",I1159=\"Months\"),F1165/F1119*I1158,IF(AND(H1119=\"Days\",I1159=\"Months\"),F1165/F1119*30.4375*I1158,IF(AND(H1119=\"Months\",I1159=\"Days\"),F1165/F1119/30.4375*I1158,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF(H1152=\"\",\"\",H1152)","v":""},{"$f":"IF(F1166=\"\",\"\",F1166*G1158)","v":""},{"$f":"IF(F1166=\"\",\"\",MIN(IF(H1119=\"Days\",F1166/F1119*365.25,IF(H1119=\"Months\",F1166/F1119*12,\"\")), 744.36))","v":""},{"$f":"IF(F1166=\"\",\"\",IF(AND(H1119=\"Days\",I1159=\"Days\"),F1166/F1119*I1158,IF(AND(H1119=\"Months\",I1159=\"Months\"),F1166/F1119*I1158,IF(AND(H1119=\"Days\",I1159=\"Months\"),F1166/F1119*30.4375*I1158,IF(AND(H1119=\"Months\",I1159=\"Days\"),F1166/F1119/30.4375*I1158,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 12",null,null,null,{"$f":"SUM(F1162:F1165)","v":0},{"$f":"SUM(G1162:G1165)","v":0},{"$f":"SUM(H1162:H1165)","v":0},{"$f":"SUM(I1162:I1165)","v":0},null,"It is important to complete Table F as figures will automatically populate in Tables 1a and 1b based on selections in Table G"]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 12",null,null,null,{"$f":"IF(F1166=\"\",SUM(F1162+F1163),F1162+F1163+F1166)","v":0},{"$f":"IF(G1166=\"\",SUM(G1162+G1163),G1162+G1163+G1166)","v":0},{"$f":"IF(H1166=\"\",SUM(H1162:H1163),H1162+H1163+H1166)","v":0},{"$f":"IF(I1166=\"\",SUM(I1162:I1163),I1162+I1163+I1166)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"CONCATENATE(\"Comparator 12: \",NameComparator12)","v":"Comparator 12: "},null,null,null,{"$f":"IF($E1172=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E1172,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$113&\" Comparator 12\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E1172=References!$B$52,\"Please overwrite formula in Tables 1a and 1b (cells coloured blue)\",\"$\"&VLOOKUP($E1172,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$113&\" Comparator 12\"),$B:$B,0))","v":{"$error":"#N/A"}},null,null," - Figures will automatically populate in Tables 1a and 1b based on selections in Table G unless selected as \"Calculated elsewhere by Applicant\" in Table G. The corresponding cells will then be coloured blue in Tables 1a and 1b. Please manually overwrite the formula in the blue cells with the appropriate figure if using the manual option."]
[]
[null,"Notes"]
[]
[null,"Source used to inform the duration of treatment (e.g pivotal trial publication/ reference cell in CEM):",null,null,null,null,null,null,null,null,"•\tThe Applicant should provide any additional detail necessary to permit validation of drug cost calculations by the Review Group. \n•\tPlease note that where drug cost calculations are insufficiently described, this will lead to delays in the appraisal process. "]
[null,"Please specify whether the above refers to a particular subpopulation (if applicable):"]
[null,"Source for dosing regimen applied in BIM (e.g product SmPC): "]

{"sheet":"Drug Acquisition Costs (PAS)","index":5,"n_rows":657,"n_cols":18,"rows_kept":657,"cut":false,"hidden":false,"merged":[[118,1,118,4],[119,1,119,4],[120,1,120,4],[121,1,121,4],[122,1,122,4],[126,1,126,3],[124,5,124,8],[125,5,125,6],[125,7,125,8],[126,5,126,6],[126,7,126,8],[98,5,98,8],[100,1,100,3],[101,1,101,3],[102,1,102,3],[94,1,94,3],[114,1,114,4],[111,5,113,5],[111,7,113,7],[115,1,115,4],[103,1,103,3],[104,1,104,3],[105,1,105,3],[106,1,106,3],[107,1,107,3],[92,1,92,6],[74,5,74,8],[75,5,75,6],[75,7,75,8],[76,1,76,3],[76,5,76,6],[76,7,76,8],[68,1,68,4],[69,1,69,4],[70,1,70,4],[71,1,71,4],[72,1,72,4],[61,5,63,5],[61,7,63,7],[61,10,63,14],[64,1,64,4],[65,1,65,4],[37,1,37,3],[38,1,38,3],[39,1,39,3],[42,1,42,6],[55,1,55,3],[44,1,44,3],[56,1,56,3],[57,1,57,3],[46,5,46,8],[48,5,48,8],[50,1,50,3],[51,1,51,3],[52,1,52,3],[53,1,53,3],[54,1,54,3],[37,10,37,12],[38,10,38,12],[39,10,39,12],[36,1,36,3],[16,1,22,8],[18,10,18,13],[27,1,27,3],[28,1,28,3],[29,1,29,3],[30,1,30,3],[25,1,25,3],[31,1,31,3],[32,1,32,3],[33,1,33,3],[34,1,34,3],[35,1,35,3],[27,10,27,12],[28,10,28,12],[29,10,29,12],[35,10,35,12],[36,10,36,12],[30,10,30,12],[31,10,31,12],[32,10,32,12],[33,10,33,12],[34,10,34,12],[150,1,150,3],[151,1,151,3],[152,1,152,3],[153,1,153,3],[154,1,154,3],[140,1,140,6],[142,1,142,3],[146,5,146,8],[148,1,148,3],[149,1,149,3],[166,1,166,4],[167,1,167,4],[168,1,168,4],[169,1,169,4],[170,1,170,4],[155,1,155,3],[159,5,161,5],[159,7,161,7],[162,1,162,4],[163,1,163,4],[196,1,196,3],[188,1,188,6],[190,1,190,3],[194,5,194,8],[172,5,172,8],[173,5,173,6],[173,7,173,8],[174,1,174,3],[174,5,174,6],[174,7,174,8],[202,1,202,3],[210,1,210,4],[203,1,203,3],[207,5,209,5],[207,7,209,7],[197,1,197,3],[198,1,198,3],[199,1,199,3],[200,1,200,3],[201,1,201,3],[211,1,211,4],[218,1,218,4],[220,5,220,8],[222,1,222,3],[222,5,222,6],[222,7,222,8],[221,5,221,6],[221,7,221,8],[214,1,214,4],[215,1,215,4],[216,1,216,4],[217,1,217,4],[246,1,246,3],[247,1,247,3],[248,1,248,3],[249,1,249,3],[250,1,250,3],[236,1,236,6],[238,1,238,3],[242,5,242,8],[244,1,244,3],[245,1,245,3],[262,1,262,4],[263,1,263,4],[264,1,264,4],[265,1,265,4],[266,1,266,4],[251,1,251,3],[255,5,257,5],[255,7,257,7],[258,1,258,4],[259,1,259,4],[292,1,292,3],[284,1,284,6],[286,1,286,3],[290,5,290,8],[268,5,268,8],[269,5,269,6],[269,7,269,8],[270,1,270,3],[270,5,270,6],[270,7,270,8],[298,1,298,3],[306,1,306,4],[299,1,299,3],[303,5,305,5],[303,7,305,7],[293,1,293,3],[294,1,294,3],[295,1,295,3],[296,1,296,3],[297,1,297,3],[307,1,307,4],[314,1,314,4],[316,5,316,8],[318,1,318,3],[318,5,318,6],[318,7,318,8],[317,5,317,6],[317,7,317,8],[310,1,310,4],[311,1,311,4],[312,1,312,4],[313,1,313,4],[390,1,390,3],[366,5,366,6],[366,7,366,8],[366,1,366,3],[365,7,365,8],[365,5,365,6],[359,1,359,4],[360,1,360,4],[361,1,361,4],[362,1,362,4],[406,1,406,4],[403,1,403,4],[399,5,401,5],[399,7,401,7],[402,1,402,4],[393,1,393,3],[394,1,394,3],[395,1,395,3],[391,1,391,3],[392,1,392,3],[332,1,332,6],[389,1,389,3],[380,1,380,6],[382,1,382,3],[386,5,386,8],[388,1,388,3],[364,5,364,8],[358,1,358,4],[354,1,354,4],[351,7,353,7],[351,5,353,5],[355,1,355,4],[343,1,343,3],[344,1,344,3],[345,1,345,3],[346,1,346,3],[347,1,347,3],[341,1,341,3],[342,1,342,3],[340,1,340,3],[338,5,338,8],[334,1,334,3],[428,1,428,6],[430,1,430,3],[434,5,434,8],[436,1,436,3],[437,1,437,3],[407,1,407,4],[408,1,408,4],[414,5,414,6],[414,7,414,8],[412,5,412,8],[413,5,413,6],[413,7,413,8],[414,1,414,3],[409,1,409,4],[410,1,410,4],[443,1,443,3],[447,5,449,5],[447,7,449,7],[450,1,450,4],[451,1,451,4],[438,1,438,3],[439,1,439,3],[440,1,440,3],[441,1,441,3],[442,1,442,3],[460,5,460,8],[461,5,461,6],[461,7,461,8],[462,1,462,3],[462,5,462,6],[462,7,462,8],[454,1,454,4],[455,1,455,4],[456,1,456,4],[457,1,457,4],[458,1,458,4],[486,1,486,3],[487,1,487,3],[488,1,488,3],[489,1,489,3],[490,1,490,3],[476,1,476,6],[478,1,478,3],[482,5,482,8],[484,1,484,3],[485,1,485,3],[502,1,502,4],[503,1,503,4],[504,1,504,4],[505,1,505,4],[506,1,506,4],[491,1,491,3],[495,5,497,5],[495,7,497,7],[498,1,498,4],[499,1,499,4],[524,1,524,6],[526,1,526,3],[530,5,530,8],[532,1,532,3],[533,1,533,3],[508,5,508,8],[509,5,509,6],[509,7,509,8],[510,1,510,3],[510,5,510,6],[510,7,510,8],[539,1,539,3],[543,5,545,5],[543,7,545,7],[546,1,546,4],[547,1,547,4],[534,1,534,3],[535,1,535,3],[536,1,536,3],[537,1,537,3],[538,1,538,3],[556,5,556,8],[557,5,557,6],[557,7,557,8],[558,1,558,3],[558,5,558,6],[558,7,558,8],[550,1,550,4],[551,1,551,4],[552,1,552,4],[553,1,553,4],[554,1,554,4],[582,1,582,3],[583,1,583,3],[584,1,584,3],[585,1,585,3],[586,1,586,3],[572,1,572,6],[574,1,574,3],[578,5,578,8],[580,1,580,3],[581,1,581,3],[598,1,598,4],[599,1,599,4],[600,1,600,4],[601,1,601,4],[602,1,602,4],[587,1,587,3],[591,5,593,5],[591,7,593,7],[594,1,594,4],[595,1,595,4],[620,1,620,6],[622,1,622,3],[626,5,626,8],[628,1,628,3],[629,1,629,3],[604,5,604,8],[605,5,605,6],[605,7,605,8],[606,1,606,3],[606,5,606,6],[606,7,606,8],[635,1,635,3],[639,5,641,5],[639,7,641,7],[642,1,642,4],[643,1,643,4],[630,1,630,3],[631,1,631,3],[632,1,632,3],[633,1,633,3],[634,1,634,3],[652,5,652,8],[653,5,653,6],[653,7,653,8],[654,1,654,3],[654,5,654,6],[654,7,654,8],[646,1,646,4],[647,1,647,4],[648,1,648,4],[649,1,649,4],[650,1,650,4]]}
[]
[]
[]
[]
[]
[]
[]
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[null,"• Table 1 on this tab will automatically populate from the 'Drug Acquisition Costs' tab for the comparators.\n• If the Applicant chooses to submit a commercial in confidence (CIC) patient access scheme (PAS)  at this stage,please input the cost of the intervention including the CIC PAS using Cell E45 below. Please note that it is not a requirement to submit a CIC PAS at this stage but this tab should be used if a CIC PAS is included as part of the submission.\n"]
[]
[null,null,null,null,null,null,null,null,null,null,"NCPE Drug Cost Guidelines"]
[]
[]
[]
[]
[]
[null,"Figures will automatically populate in Tables 1a and 1b based on selections in Table G."]
[null,"Table 1a: Price including VAT",null,null,null,null,null,null,null,null,"Table 1b: Price excluding VAT"]
[null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5",null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5"]
[null,{"$f":"CONCATENATE(\"Intervention: \",InterventionINN)","v":"Intervention: "},null,null,{"$f":"IFERROR(INDIRECT($F77),0)","v":0},{"$f":"IFERROR(INDIRECT($F77),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Intervention: \",InterventionINN)","v":"Intervention: "},null,null,{"$f":"IFERROR(INDIRECT($H77),0)","v":0},{"$f":"IFERROR(INDIRECT($H77),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 1: \",NameComparator1)","v":"Comparator 1: "},null,null,{"$f":"IFERROR(INDIRECT($F127),0)","v":0},{"$f":"IFERROR(INDIRECT($F127),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 1: \",NameComparator1)","v":"Comparator 1: "},null,null,{"$f":"IFERROR(INDIRECT($H127),0)","v":0},{"$f":"IFERROR(INDIRECT($H127),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 2: \",NameComparator2)","v":"Comparator 2: "},null,null,{"$f":"IFERROR(INDIRECT($F175),0)","v":0},{"$f":"IFERROR(INDIRECT($F175),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 2: \",NameComparator2)","v":"Comparator 2: "},null,null,{"$f":"IFERROR(INDIRECT($H175),0)","v":0},{"$f":"IFERROR(INDIRECT($H175),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 3: \",NameComparator3)","v":"Comparator 3: "},null,null,{"$f":"IFERROR(INDIRECT($F223),0)","v":0},{"$f":"IFERROR(INDIRECT($F223),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 3: \",NameComparator3)","v":"Comparator 3: "},null,null,{"$f":"IFERROR(INDIRECT($H223),0)","v":0},{"$f":"IFERROR(INDIRECT($H223),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 4: \",NameComparator4)","v":"Comparator 4: "},null,null,{"$f":"IFERROR(INDIRECT($F271),0)","v":0},{"$f":"IFERROR(INDIRECT($F271),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 4: \",NameComparator4)","v":"Comparator 4: "},null,null,{"$f":"IFERROR(INDIRECT($H271),0)","v":0},{"$f":"IFERROR(INDIRECT($H271),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 5: \",NameComparator5)","v":"Comparator 5: "},null,null,{"$f":"IFERROR(INDIRECT($F319),0)","v":0},{"$f":"IFERROR(INDIRECT($F319),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 5: \",NameComparator5)","v":"Comparator 5: "},null,null,{"$f":"IFERROR(INDIRECT($H319),0)","v":0},{"$f":"IFERROR(INDIRECT($H319),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 6: \",NameComparator6)","v":"Comparator 6: "},null,null,{"$f":"IFERROR(INDIRECT($F367),0)","v":0},{"$f":"IFERROR(INDIRECT($F367),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 6: \",NameComparator6)","v":"Comparator 6: "},null,null,{"$f":"IFERROR(INDIRECT($H367),0)","v":0},{"$f":"IFERROR(INDIRECT($H367),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 7: \",NameComparator7)","v":"Comparator 7: "},null,null,{"$f":"IFERROR(INDIRECT($F415),0)","v":0},{"$f":"IFERROR(INDIRECT($F415),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 7: \",NameComparator7)","v":"Comparator 7: "},null,null,{"$f":"IFERROR(INDIRECT($H415),0)","v":0},{"$f":"IFERROR(INDIRECT($H415),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 8: \",NameComparator8)","v":"Comparator 8: "},null,null,{"$f":"IFERROR(INDIRECT($F463),0)","v":0},{"$f":"IFERROR(INDIRECT($F463),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 8: \",NameComparator8)","v":"Comparator 8: "},null,null,{"$f":"IFERROR(INDIRECT($H463),0)","v":0},{"$f":"IFERROR(INDIRECT($H463),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 9: \",NameComparator9)","v":"Comparator 9: "},null,null,{"$f":"IFERROR(INDIRECT($F511),0)","v":0},{"$f":"IFERROR(INDIRECT($F511),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 9: \",NameComparator9)","v":"Comparator 9: "},null,null,{"$f":"IFERROR(INDIRECT($H511),0)","v":0},{"$f":"IFERROR(INDIRECT($H511),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 10: \",NameComparator10)","v":"Comparator 10: "},null,null,{"$f":"IFERROR(INDIRECT($F559),0)","v":0},{"$f":"IFERROR(INDIRECT($F559),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 10: \",NameComparator10)","v":"Comparator 10: "},null,null,{"$f":"IFERROR(INDIRECT($H559),0)","v":0},{"$f":"IFERROR(INDIRECT($H559),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 11: \",NameComparator11)","v":"Comparator 11: "},null,null,{"$f":"IFERROR(INDIRECT($F607),0)","v":0},{"$f":"IFERROR(INDIRECT($F607),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 11: \",NameComparator11)","v":"Comparator 11: "},null,null,{"$f":"IFERROR(INDIRECT($H607),0)","v":0},{"$f":"IFERROR(INDIRECT($H607),0)","v":0},0,0,0]
[null,{"$f":"CONCATENATE(\"Comparator 12: \",NameComparator12)","v":"Comparator 12: "},null,null,{"$f":"IFERROR(INDIRECT($F655),0)","v":0},{"$f":"IFERROR(INDIRECT($F655),0)","v":0},0,0,0,null,{"$f":"CONCATENATE(\"Comparator 12: \",NameComparator12)","v":"Comparator 12: "},null,null,{"$f":"IFERROR(INDIRECT($H655),0)","v":0},{"$f":"IFERROR(INDIRECT($H655),0)","v":0},0,0,0]
[]
[]
[null,{"$f":"CONCATENATE(\"Intervention: \",InterventionINN)","v":"Intervention: "}]
[]
[null,"Total Rebate (Including framework agreement and CIC) "]
[]
[null,"Table C. Total Cost to the HSE per pack"]
["This table will fill automatically based on the information inserted above. This information in this table is used to calculate the costs in Table F."]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!F49=\"\",\"\",'Drug Acquisition Costs'!F49)","v":""},{"$f":"IF('Drug Acquisition Costs'!G49=\"\",\"\",'Drug Acquisition Costs'!G49)","v":""},{"$f":"IF('Drug Acquisition Costs'!H49=\"\",\"\",'Drug Acquisition Costs'!H49)","v":""},{"$f":"IF('Drug Acquisition Costs'!I49=\"\",\"\",'Drug Acquisition Costs'!I49)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F50=\"\",'Drug Acquisition Costs'!F51=\"\",'Drug Acquisition Costs'!$F52=\"\"),\"\",IF('Drug Acquisition Costs'!F50=\"Price to Wholesaler\",'Drug Acquisition Costs'!F51,IF('Drug Acquisition Costs'!F50=\"Reimbursement Price\",(F53/(1+$E52)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G50=\"\",'Drug Acquisition Costs'!G51=\"\",'Drug Acquisition Costs'!$F52=\"\"),\"\",IF('Drug Acquisition Costs'!G50=\"Price to Wholesaler\",'Drug Acquisition Costs'!G51,IF('Drug Acquisition Costs'!G50=\"Reimbursement Price\",(G53/(1+$E52)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H50=\"\",'Drug Acquisition Costs'!H51=\"\",'Drug Acquisition Costs'!$F52=\"\"),\"\",IF('Drug Acquisition Costs'!H50=\"Price to Wholesaler\",'Drug Acquisition Costs'!H51,IF('Drug Acquisition Costs'!H50=\"Reimbursement Price\",(H53/(1+$E52)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I50=\"\",'Drug Acquisition Costs'!I51=\"\",'Drug Acquisition Costs'!$F52=\"\"),\"\",IF('Drug Acquisition Costs'!I50=\"Price to Wholesaler\",'Drug Acquisition Costs'!I51,IF('Drug Acquisition Costs'!I50=\"Reimbursement Price\",(I53/(1+$E52)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F52=\"\"),\"\",IF(AND('Drug Acquisition Costs'!F52=\"CDS\",'Drug Acquisition Costs'!F53=\"Yes\"),CYF,IF(AND('Drug Acquisition Costs'!F52=\"CDS\",'Drug Acquisition Costs'!F53=\"No\"),CNF,IF('Drug Acquisition Costs'!F52=\"HT\",CHT,IF('Drug Acquisition Costs'!F52=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F52=\"\",'Drug Acquisition Costs'!F51=\"\",'Drug Acquisition Costs'!F50=\"\"),\"\",F51*$E52)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F52=\"\",'Drug Acquisition Costs'!G51=\"\",'Drug Acquisition Costs'!G50=\"\"),\"\",G51*$E52)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F52=\"\",'Drug Acquisition Costs'!H51=\"\",'Drug Acquisition Costs'!H50=\"\"),\"\",H51*$E52)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F52=\"\",'Drug Acquisition Costs'!I51=\"\",'Drug Acquisition Costs'!I50=\"\"),\"\",I51*$E52)","v":""}]
["C",{"$f":"IF('Drug Acquisition Costs'!F52=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF('Drug Acquisition Costs'!F50=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF('Drug Acquisition Costs'!F50=\"Reimbursement Price\",'Drug Acquisition Costs'!F51,IF(ISBLANK($E52),\"\",IF('Drug Acquisition Costs'!F50=\"Price to Wholesaler\",(F51+F52),IF('Drug Acquisition Costs'!F50=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!G50=\"Reimbursement Price\",'Drug Acquisition Costs'!G51,IF(ISBLANK($E52),\"\",IF('Drug Acquisition Costs'!G50=\"Price to Wholesaler\",(G51+G52),IF('Drug Acquisition Costs'!G50=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!H50=\"Reimbursement Price\",'Drug Acquisition Costs'!H51,IF(ISBLANK($E52),\"\",IF('Drug Acquisition Costs'!H50=\"Price to Wholesaler\",(H51+H52),IF('Drug Acquisition Costs'!H50=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!I50=\"Reimbursement Price\",'Drug Acquisition Costs'!I51,IF(ISBLANK($E52),\"\",IF('Drug Acquisition Costs'!I50=\"Price to Wholesaler\",(I51+I52),IF('Drug Acquisition Costs'!I50=\"\",\"\",\"Error\"))))","v":""}]
["D","Total Rebate (Including framework agreement and CIC) ",null,null,null,{"$f":"IF('Drug Acquisition Costs'!F51=\"\", \"\", F51*IF($E45=\"\", \"\", -$E45))","v":""},{"$f":"IF('Drug Acquisition Costs'!G51=\"\", \"\", G51*IF($E45=\"\", \"\", -$E45))","v":""},{"$f":"IF('Drug Acquisition Costs'!H51=\"\", \"\", H51*IF($E45=\"\", \"\", -$E45))","v":""},{"$f":"IF('Drug Acquisition Costs'!I51=\"\", \"\", I51*IF($E45=\"\", \"\", -$E45))","v":""}]
["E","Net price (PtW less total rebate)",null,null,null,{"$f":"IFERROR(F51+F54,\"\")","v":""},{"$f":"IFERROR(G51+G54,\"\")","v":""},{"$f":"IFERROR(H51+H54,\"\")","v":""},{"$f":"IFERROR(I51+I54,\"\")","v":""}]
["F","VAT on Reimbursement Price",null,null,{"$f":"IF('Drug Acquisition Costs'!F54=\"\",\"\",IF('Drug Acquisition Costs'!F54=\"Yes\",0,VT))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!F51=\"\",ISBLANK('Drug Acquisition Costs'!F51)),\"\",($E56*F53))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G51=\"\",ISBLANK('Drug Acquisition Costs'!G51)),\"\",($E56*G53))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H51=\"\",ISBLANK('Drug Acquisition Costs'!H51)),\"\",($E56*H53))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I51=\"\",ISBLANK('Drug Acquisition Costs'!I51)),\"\",($E56*I53))","v":""}]
["G(i)","Total Drug Cost to the HSE per pack with CIC PAS including VAT (B+E+F)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F50=\"\",'Drug Acquisition Costs'!$F52=\"\",'Drug Acquisition Costs'!$F54=\"\",'Drug Acquisition Costs'!$F55=\"\"),\"\",F52+F55+F56)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G50=\"\",'Drug Acquisition Costs'!$F52=\"\",'Drug Acquisition Costs'!$F54=\"\",'Drug Acquisition Costs'!$F55=\"\"),\"\",G52+G55+G56)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H50=\"\",'Drug Acquisition Costs'!$F52=\"\",'Drug Acquisition Costs'!$F54=\"\",'Drug Acquisition Costs'!$F55=\"\"),\"\",H52+H55+H56)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I50=\"\",'Drug Acquisition Costs'!$F52=\"\",'Drug Acquisition Costs'!$F54=\"\",'Drug Acquisition Costs'!$F55=\"\"),\"\",I52+I55+I56)","v":""}]
["G(ii)","Total Drug Cost to the HSE per pack with CIC PAS excluding VAT (B+E)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F50=\"\",'Drug Acquisition Costs'!$F52=\"\",'Drug Acquisition Costs'!$F54=\"\",'Drug Acquisition Costs'!$F55=\"\"),\"\",F52+F55)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G50=\"\",'Drug Acquisition Costs'!$F52=\"\",'Drug Acquisition Costs'!$F54=\"\",'Drug Acquisition Costs'!$F55=\"\"),\"\",G52+G55)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H50=\"\",'Drug Acquisition Costs'!$F52=\"\",'Drug Acquisition Costs'!$F54=\"\",'Drug Acquisition Costs'!$F55=\"\"),\"\",H52+H55)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I50=\"\",'Drug Acquisition Costs'!$F52=\"\",'Drug Acquisition Costs'!$F54=\"\",'Drug Acquisition Costs'!$F55=\"\"),\"\",I52+I55)","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time"]
[null,null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!G100=\"\",0,'Drug Acquisition Costs'!G100)","v":0},null,{"$f":"IF('Drug Acquisition Costs'!I100=\"\",\"\",'Drug Acquisition Costs'!I100)","v":""}]
[null,null,null,null,null,null,"number of cycles",null,{"$f":"IF('Drug Acquisition Costs'!I101=\"\",\"\",'Drug Acquisition Costs'!I101)","v":""}]
["A",{"$f":"B51","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F51:I51,'Drug Acquisition Costs'!F63:'Drug Acquisition Costs'!I63)","v":0},{"$f":"F65*G63","v":0},{"$f":"IF('Drug Acquisition Costs'!H61=\"Days\",F65/'Drug Acquisition Costs'!F61*365.25,IF('Drug Acquisition Costs'!H61=\"Months\",F65/'Drug Acquisition Costs'!F61*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H61=\"Days\",I64=\"Days\"),F65/'Drug Acquisition Costs'!F61*I63,IF(AND('Drug Acquisition Costs'!H61=\"Months\",I64=\"Months\"),F65/'Drug Acquisition Costs'!F61*I63,IF(AND('Drug Acquisition Costs'!H61=\"Days\",I64=\"Months\"),F65/'Drug Acquisition Costs'!F61*30.4375*I63,IF(AND('Drug Acquisition Costs'!H61=\"Months\",I64=\"Days\"),F65/'Drug Acquisition Costs'!F61/30.4375*I63,\"\"))))","v":""}]
["B",{"$f":"B52","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F52:I52,'Drug Acquisition Costs'!F63:'Drug Acquisition Costs'!I63)","v":0},{"$f":"F66*G63","v":0},{"$f":"IF('Drug Acquisition Costs'!H61=\"Days\",F66/'Drug Acquisition Costs'!F61*365.25,IF('Drug Acquisition Costs'!H61=\"Months\",F66/'Drug Acquisition Costs'!F61*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H61=\"Days\",I64=\"Days\"),F66/'Drug Acquisition Costs'!F61*I63,IF(AND('Drug Acquisition Costs'!H61=\"Months\",I64=\"Months\"),F66/'Drug Acquisition Costs'!F61*I63,IF(AND('Drug Acquisition Costs'!H61=\"Days\",I64=\"Months\"),F66/'Drug Acquisition Costs'!F61*30.4375*I63,IF(AND('Drug Acquisition Costs'!H61=\"Months\",I64=\"Days\"),F66/'Drug Acquisition Costs'!F61/30.4375*I63,\"\"))))","v":""}]
["C",{"$f":"B53","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F53:I53,'Drug Acquisition Costs'!F63:'Drug Acquisition Costs'!I63)","v":0},{"$f":"F67*G63","v":0},{"$f":"IF('Drug Acquisition Costs'!H61=\"Days\",F67/'Drug Acquisition Costs'!F61*365.25,IF('Drug Acquisition Costs'!H61=\"Months\",F67/'Drug Acquisition Costs'!F61*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H61=\"Days\",I64=\"Days\"),F67/'Drug Acquisition Costs'!F61*I63,IF(AND('Drug Acquisition Costs'!H61=\"Months\",I64=\"Months\"),F67/'Drug Acquisition Costs'!F61*I63,IF(AND('Drug Acquisition Costs'!H61=\"Days\",I64=\"Months\"),F67/'Drug Acquisition Costs'!F61*30.4375*I63,IF(AND('Drug Acquisition Costs'!H61=\"Months\",I64=\"Days\"),F67/'Drug Acquisition Costs'!F61/30.4375*I63,\"\"))))","v":""}]
["D","CIC PAS (inclusive of framework agreement rebate)",null,null,null,{"$f":"SUMPRODUCT(F54:I54,'Drug Acquisition Costs'!F63:'Drug Acquisition Costs'!I63)","v":0},{"$f":" F68*G63","v":0},{"$f":"IF('Drug Acquisition Costs'!H61=\"Days\",F68/'Drug Acquisition Costs'!F61*365.25,IF('Drug Acquisition Costs'!H61=\"Months\",F68/'Drug Acquisition Costs'!F61*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H61=\"Days\",I64=\"Days\"),F68/'Drug Acquisition Costs'!F61*I63,IF(AND('Drug Acquisition Costs'!H61=\"Months\",I64=\"Months\"),F68/'Drug Acquisition Costs'!F61*I63,IF(AND('Drug Acquisition Costs'!H61=\"Days\",I64=\"Months\"),F68/'Drug Acquisition Costs'!F61*30.4375*I63,IF(AND('Drug Acquisition Costs'!H61=\"Months\",I64=\"Days\"),F68/'Drug Acquisition Costs'!F61/30.4375*I63,\"\"))))","v":""}]
["E",{"$f":"B56","v":"VAT on Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F56:I56,'Drug Acquisition Costs'!F63:'Drug Acquisition Costs'!I63)","v":0},{"$f":"F69*G63","v":0},{"$f":"IF('Drug Acquisition Costs'!H61=\"Days\",F69/'Drug Acquisition Costs'!F61*365.25,IF('Drug Acquisition Costs'!H61=\"Months\",F69/'Drug Acquisition Costs'!F61*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H61=\"Days\",I64=\"Days\"),F69/'Drug Acquisition Costs'!F61*I63,IF(AND('Drug Acquisition Costs'!H61=\"Months\",I64=\"Months\"),F69/'Drug Acquisition Costs'!F61*I63,IF(AND('Drug Acquisition Costs'!H62=\"Days\",I64=\"Months\"),F69/'Drug Acquisition Costs'!F61*30.4375*I63,IF(AND('Drug Acquisition Costs'!H61=\"Months\",I64=\"Days\"),F69/'Drug Acquisition Costs'!F61/30.4375*I63,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H93=\"\",\"\",'Drug Acquisition Costs'!H93)","v":""},{"$f":"IF(F70=\"\",\"\",F70*G63)","v":""},{"$f":"IF(F70=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H61=\"Days\",F70/'Drug Acquisition Costs'!F61*365.25,IF('Drug Acquisition Costs'!H61=\"Months\",F70/'Drug Acquisition Costs'!F61*12,\"\")), 744.36))","v":""},{"$f":"IF(F70=\"\",\"\",IF(AND('Drug Acquisition Costs'!H61=\"Days\",I64=\"Days\"),F70/'Drug Acquisition Costs'!F61*I63,IF(AND('Drug Acquisition Costs'!H61=\"Months\",I64=\"Months\"),F70/'Drug Acquisition Costs'!F61*I63,IF(AND('Drug Acquisition Costs'!H61=\"Days\",I64=\"Months\"),F70/'Drug Acquisition Costs'!F61*30.4375*I63,IF(AND('Drug Acquisition Costs'!H61=\"Months\",I64=\"Days\"),F70/'Drug Acquisition Costs'!F61/30.4375*I63,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H94=\"\",\"\",'Drug Acquisition Costs'!H94)","v":""},{"$f":"IF(F71=\"\",\"\",F71*G63)","v":""},{"$f":"IF(F71=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H61=\"Days\",F71/'Drug Acquisition Costs'!F61*365.25,IF('Drug Acquisition Costs'!H61=\"Months\",F71/'Drug Acquisition Costs'!F61*12,\"\")), 744.36))","v":""},{"$f":"IF(F71=\"\",\"\",IF(AND('Drug Acquisition Costs'!H61=\"Days\",I64=\"Days\"),F71/'Drug Acquisition Costs'!F61*I63,IF(AND('Drug Acquisition Costs'!H61=\"Months\",I64=\"Months\"),F71/'Drug Acquisition Costs'!F61*I63,IF(AND('Drug Acquisition Costs'!H61=\"Days\",I64=\"Months\"),F71/'Drug Acquisition Costs'!F61*30.4375*I63,IF(AND('Drug Acquisition Costs'!H61=\"Months\",I64=\"Days\"),F71/'Drug Acquisition Costs'!F61/30.4375*I63,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Intervention",null,null,null,{"$f":"SUM(F67:F70)","v":0},{"$f":"SUM(G67:G70)","v":0},{"$f":"SUM(H67:H70)","v":0},{"$f":"SUM(I67:I70)","v":0}]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Intervention",null,null,null,{"$f":"IF(F71=\"\",SUM(F67:F68),F67+F68+F71)","v":0},{"$f":"IF(G71=\"\",SUM(G67:G68),G67+G68+G71)","v":0},{"$f":"IF(H71=\"\",SUM(H67:H68),H67+H68+H71)","v":0},{"$f":"IF(I71=\"\",SUM(I67:I68),I67+I68+I71)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"CONCATENATE(\"Intervention: \",InterventionINN)","v":"Intervention: "},null,null,{"$f":"'Drug Acquisition Costs'!E114","v":0},{"$f":"IF($E77=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E77,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$76&\" Intervention\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E77=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E77,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$76&\" Intervention\"),$B:$B,0))","v":{"$error":"#N/A"}}]
[]
[null,"Notes"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
["For NCPE use only below here"]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 1: \",NameComparator1)","v":"Comparator 1: "}]
[]
[null,"Total Rebate (Including framework agreement and CIC) ",null,null,{"$f":"IF(ISNUMBER('Drug Acquisition Costs'!E162),ABS('Drug Acquisition Costs'!E162),0)","v":0}]
[]
[null,"Table C. Total Cost to the HSE per pack"]
[]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!F158=\"\",\"\",'Drug Acquisition Costs'!F158)","v":""},{"$f":"IF('Drug Acquisition Costs'!G158=\"\",\"\",'Drug Acquisition Costs'!G158)","v":""},{"$f":"IF('Drug Acquisition Costs'!H158=\"\",\"\",'Drug Acquisition Costs'!H158)","v":""},{"$f":"IF('Drug Acquisition Costs'!I158=\"\",\"\",'Drug Acquisition Costs'!I158)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F138=\"\",'Drug Acquisition Costs'!F139=\"\",'Drug Acquisition Costs'!$F140=\"\"),\"\",IF('Drug Acquisition Costs'!F138=\"Price to Wholesaler\",'Drug Acquisition Costs'!F139,IF('Drug Acquisition Costs'!F138=\"Reimbursement Price\",(F103/(1+$E102)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G138=\"\",'Drug Acquisition Costs'!G139=\"\",'Drug Acquisition Costs'!$F140=\"\"),\"\",IF('Drug Acquisition Costs'!G138=\"Price to Wholesaler\",'Drug Acquisition Costs'!G139,IF('Drug Acquisition Costs'!G138=\"Reimbursement Price\",(G103/(1+$E102)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H138=\"\",'Drug Acquisition Costs'!H139=\"\",'Drug Acquisition Costs'!$F140=\"\"),\"\",IF('Drug Acquisition Costs'!H138=\"Price to Wholesaler\",'Drug Acquisition Costs'!H139,IF('Drug Acquisition Costs'!H138=\"Reimbursement Price\",(H103/(1+$E102)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I138=\"\",'Drug Acquisition Costs'!I139=\"\",'Drug Acquisition Costs'!$F140=\"\"),\"\",IF('Drug Acquisition Costs'!I138=\"Price to Wholesaler\",'Drug Acquisition Costs'!I139,IF('Drug Acquisition Costs'!I138=\"Reimbursement Price\",(I103/(1+$E102)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F140=\"\"),\"\",IF(AND('Drug Acquisition Costs'!F140=\"CDS\",'Drug Acquisition Costs'!F141=\"Yes\"),CYF,IF(AND('Drug Acquisition Costs'!F140=\"CDS\",'Drug Acquisition Costs'!F141=\"No\"),CNF,IF('Drug Acquisition Costs'!F140=\"HT\",CHT,IF('Drug Acquisition Costs'!F140=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F140=\"\",'Drug Acquisition Costs'!F139=\"\",'Drug Acquisition Costs'!F138=\"\"),\"\",F101*$E102)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F140=\"\",'Drug Acquisition Costs'!G139=\"\",'Drug Acquisition Costs'!G138=\"\"),\"\",G101*$E102)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F140=\"\",'Drug Acquisition Costs'!H139=\"\",'Drug Acquisition Costs'!H138=\"\"),\"\",H101*$E102)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F140=\"\",'Drug Acquisition Costs'!I139=\"\",'Drug Acquisition Costs'!I138=\"\"),\"\",I101*$E102)","v":""}]
["C",{"$f":"IF('Drug Acquisition Costs'!F100=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF('Drug Acquisition Costs'!F138=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF('Drug Acquisition Costs'!F138=\"Reimbursement Price\",'Drug Acquisition Costs'!F139,IF(ISBLANK($E102),\"\",IF('Drug Acquisition Costs'!F138=\"Price to Wholesaler\",(F101+F102),IF('Drug Acquisition Costs'!F138=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!G138=\"Reimbursement Price\",'Drug Acquisition Costs'!G139,IF(ISBLANK($E102),\"\",IF('Drug Acquisition Costs'!G138=\"Price to Wholesaler\",(G101+G102),IF('Drug Acquisition Costs'!G138=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!H138=\"Reimbursement Price\",'Drug Acquisition Costs'!H139,IF(ISBLANK($E102),\"\",IF('Drug Acquisition Costs'!H138=\"Price to Wholesaler\",(H101+H102),IF('Drug Acquisition Costs'!H138=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!I138=\"Reimbursement Price\",'Drug Acquisition Costs'!I139,IF(ISBLANK($E102),\"\",IF('Drug Acquisition Costs'!I138=\"Price to Wholesaler\",(I101+I102),IF('Drug Acquisition Costs'!I138=\"\",\"\",\"Error\"))))","v":""}]
["D","Total Rebate (Including framework agreement and CIC) ",null,null,null,{"$f":"IF('Drug Acquisition Costs'!F139=\"\", \"\", F101*IF($E95=\"\", \"\", -$E95))","v":""},{"$f":"IF('Drug Acquisition Costs'!G139=\"\", \"\", G101*IF($E95=\"\", \"\", -$E95))","v":""},{"$f":"IF('Drug Acquisition Costs'!H139=\"\", \"\", H101*IF($E95=\"\", \"\", -$E95))","v":""},{"$f":"IF('Drug Acquisition Costs'!I139=\"\", \"\", I101*IF($E95=\"\", \"\", -$E95))","v":""}]
["E","Net price (PtW less total rebate)",null,null,null,{"$f":"IFERROR(F101+F104,\"\")","v":""},{"$f":"IFERROR(G101+G104,\"\")","v":""},{"$f":"IFERROR(H101+H104,\"\")","v":""},{"$f":"IFERROR(I101+I104,\"\")","v":""}]
["F","VAT on Reimbursement Price",null,null,{"$f":"IF('Drug Acquisition Costs'!F142=\"\",\"\",IF('Drug Acquisition Costs'!F142=\"Yes\",0,VT))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!F139=\"\",ISBLANK('Drug Acquisition Costs'!F139)),\"\",($E106*F103))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G139=\"\",ISBLANK('Drug Acquisition Costs'!G139)),\"\",($E106*G103))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H139=\"\",ISBLANK('Drug Acquisition Costs'!H139)),\"\",($E106*H103))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I139=\"\",ISBLANK('Drug Acquisition Costs'!I139)),\"\",($E106*I103))","v":""}]
["G(i)","Total Drug Cost to the HSE per pack with CIC PAS including VAT (B+E+F)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F138=\"\",'Drug Acquisition Costs'!$F140=\"\",'Drug Acquisition Costs'!$F142=\"\",'Drug Acquisition Costs'!$F143=\"\"),\"\",F102+F105+F106)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G138=\"\",'Drug Acquisition Costs'!$F140=\"\",'Drug Acquisition Costs'!$F142=\"\",'Drug Acquisition Costs'!$F143=\"\"),\"\",G102+G105+G106)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H138=\"\",'Drug Acquisition Costs'!$F140=\"\",'Drug Acquisition Costs'!$F142=\"\",'Drug Acquisition Costs'!$F143=\"\"),\"\",H102+H105+H106)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I138=\"\",'Drug Acquisition Costs'!$F140=\"\",'Drug Acquisition Costs'!$F142=\"\",'Drug Acquisition Costs'!$F143=\"\"),\"\",I102+I105+I106)","v":""}]
["G(ii)","Total Drug Cost to the HSE per pack with CIC PAS excluding VAT (B+E)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F138=\"\",'Drug Acquisition Costs'!$F140=\"\",'Drug Acquisition Costs'!$F142=\"\",'Drug Acquisition Costs'!$F143=\"\"),\"\",F102+F105)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G138=\"\",'Drug Acquisition Costs'!$F140=\"\",'Drug Acquisition Costs'!$F142=\"\",'Drug Acquisition Costs'!$F143=\"\"),\"\",G102+G105)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H138=\"\",'Drug Acquisition Costs'!$F140=\"\",'Drug Acquisition Costs'!$F142=\"\",'Drug Acquisition Costs'!$F143=\"\"),\"\",H102+H105)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I138=\"\",'Drug Acquisition Costs'!$F140=\"\",'Drug Acquisition Costs'!$F142=\"\",'Drug Acquisition Costs'!$F143=\"\"),\"\",I102+I105)","v":""}]
[]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time"]
[null,null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!G188=\"\",0,'Drug Acquisition Costs'!G188)","v":0},null,{"$f":"IF('Drug Acquisition Costs'!I188=\"\",\"\",'Drug Acquisition Costs'!I188)","v":""}]
[null,null,null,null,null,null,"number of cycles",null,{"$f":"IF('Drug Acquisition Costs'!I189=\"\",\"\",'Drug Acquisition Costs'!I189)","v":""}]
["A",{"$f":"B101","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F101:I101,'Drug Acquisition Costs'!F151:'Drug Acquisition Costs'!I151)","v":0},{"$f":"F115*G113","v":0},{"$f":"IF('Drug Acquisition Costs'!H149=\"Days\",F115/'Drug Acquisition Costs'!F149*365.25,IF('Drug Acquisition Costs'!H149=\"Months\",F115/'Drug Acquisition Costs'!F149*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H149=\"Days\",I114=\"Days\"),F115/'Drug Acquisition Costs'!F149*I113,IF(AND('Drug Acquisition Costs'!H149=\"Months\",I114=\"Months\"),F115/'Drug Acquisition Costs'!F149*I113,IF(AND('Drug Acquisition Costs'!H149=\"Days\",I114=\"Months\"),F115/'Drug Acquisition Costs'!F149*30.4375*I113,IF(AND('Drug Acquisition Costs'!H149=\"Months\",I114=\"Days\"),F115/'Drug Acquisition Costs'!F149/30.4375*I113,\"\"))))","v":""}]
["B",{"$f":"B102","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F102:I102,'Drug Acquisition Costs'!F151:'Drug Acquisition Costs'!I151)","v":0},{"$f":"F116*G113","v":0},{"$f":"IF('Drug Acquisition Costs'!H149=\"Days\",F116/'Drug Acquisition Costs'!F149*365.25,IF('Drug Acquisition Costs'!H149=\"Months\",F116/'Drug Acquisition Costs'!F149*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H149=\"Days\",I114=\"Days\"),F116/'Drug Acquisition Costs'!F149*I113,IF(AND('Drug Acquisition Costs'!H149=\"Months\",I114=\"Months\"),F116/'Drug Acquisition Costs'!F149*I113,IF(AND('Drug Acquisition Costs'!H149=\"Days\",I114=\"Months\"),F116/'Drug Acquisition Costs'!F149*30.4375*I113,IF(AND('Drug Acquisition Costs'!H149=\"Months\",I114=\"Days\"),F116/'Drug Acquisition Costs'!F149/30.4375*I113,\"\"))))","v":""}]
["C",{"$f":"B103","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F103:I103,'Drug Acquisition Costs'!F151:'Drug Acquisition Costs'!I151)","v":0},{"$f":"F117*G113","v":0},{"$f":"IF('Drug Acquisition Costs'!H149=\"Days\",F117/'Drug Acquisition Costs'!F149*365.25,IF('Drug Acquisition Costs'!H149=\"Months\",F117/'Drug Acquisition Costs'!F149*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H149=\"Days\",I114=\"Days\"),F117/'Drug Acquisition Costs'!F149*I113,IF(AND('Drug Acquisition Costs'!H149=\"Months\",I114=\"Months\"),F117/'Drug Acquisition Costs'!F149*I113,IF(AND('Drug Acquisition Costs'!H149=\"Days\",I114=\"Months\"),F117/'Drug Acquisition Costs'!F149*30.4375*I113,IF(AND('Drug Acquisition Costs'!H149=\"Months\",I114=\"Days\"),F117/'Drug Acquisition Costs'!F149/30.4375*I113,\"\"))))","v":""}]
["D","CIC PAS (inclusive of framework agreement rebate)",null,null,null,{"$f":"SUMPRODUCT(F104:I104,'Drug Acquisition Costs'!F151:'Drug Acquisition Costs'!I151)","v":0},{"$f":" F118*G113","v":0},{"$f":"IF('Drug Acquisition Costs'!H149=\"Days\",F118/'Drug Acquisition Costs'!F149*365.25,IF('Drug Acquisition Costs'!H149=\"Months\",F118/'Drug Acquisition Costs'!F149*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H149=\"Days\",I114=\"Days\"),F118/'Drug Acquisition Costs'!F149*I113,IF(AND('Drug Acquisition Costs'!H149=\"Months\",I114=\"Months\"),F118/'Drug Acquisition Costs'!F149*I113,IF(AND('Drug Acquisition Costs'!H149=\"Days\",I114=\"Months\"),F118/'Drug Acquisition Costs'!F149*30.4375*I113,IF(AND('Drug Acquisition Costs'!H149=\"Months\",I114=\"Days\"),F118/'Drug Acquisition Costs'!F149/30.4375*I113,\"\"))))","v":""}]
["E",{"$f":"B106","v":"VAT on Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F106:I106,'Drug Acquisition Costs'!F151:'Drug Acquisition Costs'!I151)","v":0},{"$f":"F119*G113","v":0},{"$f":"IF('Drug Acquisition Costs'!H149=\"Days\",F119/'Drug Acquisition Costs'!F149*365.25,IF('Drug Acquisition Costs'!H149=\"Months\",F119/'Drug Acquisition Costs'!F149*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H149=\"Days\",I114=\"Days\"),F119/'Drug Acquisition Costs'!F149*I113,IF(AND('Drug Acquisition Costs'!H149=\"Months\",I114=\"Months\"),F119/'Drug Acquisition Costs'!F149*I113,IF(AND('Drug Acquisition Costs'!H150=\"Days\",I114=\"Months\"),F119/'Drug Acquisition Costs'!F149*30.4375*I113,IF(AND('Drug Acquisition Costs'!H149=\"Months\",I114=\"Days\"),F119/'Drug Acquisition Costs'!F149/30.4375*I113,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H181=\"\",\"\",'Drug Acquisition Costs'!H181)","v":""},{"$f":"IF(F120=\"\",\"\",F120*G113)","v":""},{"$f":"IF(F120=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H149=\"Days\",F120/'Drug Acquisition Costs'!F149*365.25,IF('Drug Acquisition Costs'!H149=\"Months\",F120/'Drug Acquisition Costs'!F149*12,\"\")), 744.36))","v":""},{"$f":"IF(F120=\"\",\"\",IF(AND('Drug Acquisition Costs'!H149=\"Days\",I114=\"Days\"),F120/'Drug Acquisition Costs'!F149*I113,IF(AND('Drug Acquisition Costs'!H149=\"Months\",I114=\"Months\"),F120/'Drug Acquisition Costs'!F149*I113,IF(AND('Drug Acquisition Costs'!H149=\"Days\",I114=\"Months\"),F120/'Drug Acquisition Costs'!F149*30.4375*I113,IF(AND('Drug Acquisition Costs'!H149=\"Months\",I114=\"Days\"),F120/'Drug Acquisition Costs'!F149/30.4375*I113,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H182=\"\",\"\",'Drug Acquisition Costs'!H182)","v":""},{"$f":"IF(F121=\"\",\"\",F121*G113)","v":""},{"$f":"IF(F121=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H149=\"Days\",F121/'Drug Acquisition Costs'!F149*365.25,IF('Drug Acquisition Costs'!H149=\"Months\",F121/'Drug Acquisition Costs'!F149*12,\"\")), 744.36))","v":""},{"$f":"IF(F121=\"\",\"\",IF(AND('Drug Acquisition Costs'!H149=\"Days\",I114=\"Days\"),F121/'Drug Acquisition Costs'!F149*I113,IF(AND('Drug Acquisition Costs'!H149=\"Months\",I114=\"Months\"),F121/'Drug Acquisition Costs'!F149*I113,IF(AND('Drug Acquisition Costs'!H149=\"Days\",I114=\"Months\"),F121/'Drug Acquisition Costs'!F149*30.4375*I113,IF(AND('Drug Acquisition Costs'!H149=\"Months\",I114=\"Days\"),F121/'Drug Acquisition Costs'!F149/30.4375*I113,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 1",null,null,null,{"$f":"SUM(F117:F120)","v":0},{"$f":"SUM(G117:G120)","v":0},{"$f":"SUM(H117:H120)","v":0},{"$f":"SUM(I117:I120)","v":0}]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 1",null,null,null,{"$f":"IF(F121=\"\",SUM(F117:F118),F117+F118+F121)","v":0},{"$f":"IF(G121=\"\",SUM(G117:G118),G117+G118+G121)","v":0},{"$f":"IF(H121=\"\",SUM(H117:H118),H117+H118+H121)","v":0},{"$f":"IF(I121=\"\",SUM(I117:I118),I117+I118+I121)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"'Drug Acquisition Costs'!B202:D202","v":"Comparator 1: "},null,null,{"$f":"'Drug Acquisition Costs'!E202","v":0},{"$f":"IF($E127=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E127,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$126&\" Comparator 1\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E127=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E127,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$126&\" Comparator 1\"),$B:$B,0))","v":{"$error":"#N/A"}}]
[]
[null,"Notes"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 2: \",NameComparator2)","v":"Comparator 2: "}]
[]
[null,"Total Rebate (Including framework agreement and CIC) ",null,null,{"$f":"IF(ISNUMBER('Drug Acquisition Costs'!E250),ABS('Drug Acquisition Costs'!E250),0)","v":0}]
[]
[null,"Table C. Total Cost to the HSE per pack"]
[]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!F246=\"\",\"\",'Drug Acquisition Costs'!F246)","v":""},{"$f":"IF('Drug Acquisition Costs'!G246=\"\",\"\",'Drug Acquisition Costs'!G246)","v":""},{"$f":"IF('Drug Acquisition Costs'!H246=\"\",\"\",'Drug Acquisition Costs'!H246)","v":""},{"$f":"IF('Drug Acquisition Costs'!I246=\"\",\"\",'Drug Acquisition Costs'!I246)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F226=\"\",'Drug Acquisition Costs'!F227=\"\",'Drug Acquisition Costs'!$F228=\"\"),\"\",IF('Drug Acquisition Costs'!F226=\"Price to Wholesaler\",'Drug Acquisition Costs'!F227,IF('Drug Acquisition Costs'!F226=\"Reimbursement Price\",(F151/(1+$E150)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G226=\"\",'Drug Acquisition Costs'!G227=\"\",'Drug Acquisition Costs'!$F228=\"\"),\"\",IF('Drug Acquisition Costs'!G226=\"Price to Wholesaler\",'Drug Acquisition Costs'!G227,IF('Drug Acquisition Costs'!G226=\"Reimbursement Price\",(G151/(1+$E150)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H226=\"\",'Drug Acquisition Costs'!H227=\"\",'Drug Acquisition Costs'!$F228=\"\"),\"\",IF('Drug Acquisition Costs'!H226=\"Price to Wholesaler\",'Drug Acquisition Costs'!H227,IF('Drug Acquisition Costs'!H226=\"Reimbursement Price\",(H151/(1+$E150)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I226=\"\",'Drug Acquisition Costs'!I227=\"\",'Drug Acquisition Costs'!$F228=\"\"),\"\",IF('Drug Acquisition Costs'!I226=\"Price to Wholesaler\",'Drug Acquisition Costs'!I227,IF('Drug Acquisition Costs'!I226=\"Reimbursement Price\",(I151/(1+$E150)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F228=\"\"),\"\",IF(AND('Drug Acquisition Costs'!F228=\"CDS\",'Drug Acquisition Costs'!F229=\"Yes\"),CYF,IF(AND('Drug Acquisition Costs'!F228=\"CDS\",'Drug Acquisition Costs'!F229=\"No\"),CNF,IF('Drug Acquisition Costs'!F228=\"HT\",CHT,IF('Drug Acquisition Costs'!F228=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F228=\"\",'Drug Acquisition Costs'!F227=\"\",'Drug Acquisition Costs'!F226=\"\"),\"\",F149*$E150)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F228=\"\",'Drug Acquisition Costs'!G227=\"\",'Drug Acquisition Costs'!G226=\"\"),\"\",G149*$E150)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F228=\"\",'Drug Acquisition Costs'!H227=\"\",'Drug Acquisition Costs'!H226=\"\"),\"\",H149*$E150)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F228=\"\",'Drug Acquisition Costs'!I227=\"\",'Drug Acquisition Costs'!I226=\"\"),\"\",I149*$E150)","v":""}]
["C",{"$f":"IF('Drug Acquisition Costs'!F148=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF('Drug Acquisition Costs'!F226=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF('Drug Acquisition Costs'!F226=\"Reimbursement Price\",'Drug Acquisition Costs'!F227,IF(ISBLANK($E150),\"\",IF('Drug Acquisition Costs'!F226=\"Price to Wholesaler\",(F149+F150),IF('Drug Acquisition Costs'!F226=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!G226=\"Reimbursement Price\",'Drug Acquisition Costs'!G227,IF(ISBLANK($E150),\"\",IF('Drug Acquisition Costs'!G226=\"Price to Wholesaler\",(G149+G150),IF('Drug Acquisition Costs'!G226=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!H226=\"Reimbursement Price\",'Drug Acquisition Costs'!H227,IF(ISBLANK($E150),\"\",IF('Drug Acquisition Costs'!H226=\"Price to Wholesaler\",(H149+H150),IF('Drug Acquisition Costs'!H226=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!I226=\"Reimbursement Price\",'Drug Acquisition Costs'!I227,IF(ISBLANK($E150),\"\",IF('Drug Acquisition Costs'!I226=\"Price to Wholesaler\",(I149+I150),IF('Drug Acquisition Costs'!I226=\"\",\"\",\"Error\"))))","v":""}]
["D","Total Rebate (Including framework agreement and CIC) ",null,null,null,{"$f":"IF('Drug Acquisition Costs'!F227=\"\", \"\", F149*IF($E143=\"\", \"\", -$E143))","v":""},{"$f":"IF('Drug Acquisition Costs'!G227=\"\", \"\", G149*IF($E143=\"\", \"\", -$E143))","v":""},{"$f":"IF('Drug Acquisition Costs'!H227=\"\", \"\", H149*IF($E143=\"\", \"\", -$E143))","v":""},{"$f":"IF('Drug Acquisition Costs'!I227=\"\", \"\", I149*IF($E143=\"\", \"\", -$E143))","v":""}]
["E","Net price (PtW less total rebate)",null,null,null,{"$f":"IFERROR(F149+F152,\"\")","v":""},{"$f":"IFERROR(G149+G152,\"\")","v":""},{"$f":"IFERROR(H149+H152,\"\")","v":""},{"$f":"IFERROR(I149+I152,\"\")","v":""}]
["F","VAT on Reimbursement Price",null,null,{"$f":"IF('Drug Acquisition Costs'!F230=\"\",\"\",IF('Drug Acquisition Costs'!F230=\"Yes\",0,VT))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!F227=\"\",ISBLANK('Drug Acquisition Costs'!F227)),\"\",($E154*F151))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G227=\"\",ISBLANK('Drug Acquisition Costs'!G227)),\"\",($E154*G151))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H227=\"\",ISBLANK('Drug Acquisition Costs'!H227)),\"\",($E154*H151))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I227=\"\",ISBLANK('Drug Acquisition Costs'!I227)),\"\",($E154*I151))","v":""}]
["G(i)","Total Drug Cost to the HSE per pack with CIC PAS including VAT (B+E+F)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F226=\"\",'Drug Acquisition Costs'!$F228=\"\",'Drug Acquisition Costs'!$F230=\"\",'Drug Acquisition Costs'!$F231=\"\"),\"\",F150+F153+F154)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G226=\"\",'Drug Acquisition Costs'!$F228=\"\",'Drug Acquisition Costs'!$F230=\"\",'Drug Acquisition Costs'!$F231=\"\"),\"\",G150+G153+G154)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H226=\"\",'Drug Acquisition Costs'!$F228=\"\",'Drug Acquisition Costs'!$F230=\"\",'Drug Acquisition Costs'!$F231=\"\"),\"\",H150+H153+H154)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I226=\"\",'Drug Acquisition Costs'!$F228=\"\",'Drug Acquisition Costs'!$F230=\"\",'Drug Acquisition Costs'!$F231=\"\"),\"\",I150+I153+I154)","v":""}]
["G(ii)","Total Drug Cost to the HSE per pack with CIC PAS excluding VAT (B+E)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F226=\"\",'Drug Acquisition Costs'!$F228=\"\",'Drug Acquisition Costs'!$F230=\"\",'Drug Acquisition Costs'!$F231=\"\"),\"\",F150+F153)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G226=\"\",'Drug Acquisition Costs'!$F228=\"\",'Drug Acquisition Costs'!$F230=\"\",'Drug Acquisition Costs'!$F231=\"\"),\"\",G150+G153)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H226=\"\",'Drug Acquisition Costs'!$F228=\"\",'Drug Acquisition Costs'!$F230=\"\",'Drug Acquisition Costs'!$F231=\"\"),\"\",H150+H153)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I226=\"\",'Drug Acquisition Costs'!$F228=\"\",'Drug Acquisition Costs'!$F230=\"\",'Drug Acquisition Costs'!$F231=\"\"),\"\",I150+I153)","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time"]
[null,null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!G276=\"\",0,'Drug Acquisition Costs'!G276)","v":0},null,{"$f":"IF('Drug Acquisition Costs'!I276=\"\",\"\",'Drug Acquisition Costs'!I276)","v":""}]
[null,null,null,null,null,null,"number of cycles",null,{"$f":"IF('Drug Acquisition Costs'!I277=\"\",\"\",'Drug Acquisition Costs'!I277)","v":""}]
["A",{"$f":"B149","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F149:I149,'Drug Acquisition Costs'!F239:'Drug Acquisition Costs'!I239)","v":0},{"$f":"F163*G161","v":0},{"$f":"IF('Drug Acquisition Costs'!H237=\"Days\",F163/'Drug Acquisition Costs'!F237*365.25,IF('Drug Acquisition Costs'!H237=\"Months\",F163/'Drug Acquisition Costs'!F237*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H237=\"Days\",I162=\"Days\"),F163/'Drug Acquisition Costs'!F237*I161,IF(AND('Drug Acquisition Costs'!H237=\"Months\",I162=\"Months\"),F163/'Drug Acquisition Costs'!F237*I161,IF(AND('Drug Acquisition Costs'!H237=\"Days\",I162=\"Months\"),F163/'Drug Acquisition Costs'!F237*30.4375*I161,IF(AND('Drug Acquisition Costs'!H237=\"Months\",I162=\"Days\"),F163/'Drug Acquisition Costs'!F237/30.4375*I161,\"\"))))","v":""}]
["B",{"$f":"B150","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F150:I150,'Drug Acquisition Costs'!F239:'Drug Acquisition Costs'!I239)","v":0},{"$f":"F164*G161","v":0},{"$f":"IF('Drug Acquisition Costs'!H237=\"Days\",F164/'Drug Acquisition Costs'!F237*365.25,IF('Drug Acquisition Costs'!H237=\"Months\",F164/'Drug Acquisition Costs'!F237*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H237=\"Days\",I162=\"Days\"),F164/'Drug Acquisition Costs'!F237*I161,IF(AND('Drug Acquisition Costs'!H237=\"Months\",I162=\"Months\"),F164/'Drug Acquisition Costs'!F237*I161,IF(AND('Drug Acquisition Costs'!H237=\"Days\",I162=\"Months\"),F164/'Drug Acquisition Costs'!F237*30.4375*I161,IF(AND('Drug Acquisition Costs'!H237=\"Months\",I162=\"Days\"),F164/'Drug Acquisition Costs'!F237/30.4375*I161,\"\"))))","v":""}]
["C",{"$f":"B151","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F151:I151,'Drug Acquisition Costs'!F239:'Drug Acquisition Costs'!I239)","v":0},{"$f":"F165*G161","v":0},{"$f":"IF('Drug Acquisition Costs'!H237=\"Days\",F165/'Drug Acquisition Costs'!F237*365.25,IF('Drug Acquisition Costs'!H237=\"Months\",F165/'Drug Acquisition Costs'!F237*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H237=\"Days\",I162=\"Days\"),F165/'Drug Acquisition Costs'!F237*I161,IF(AND('Drug Acquisition Costs'!H237=\"Months\",I162=\"Months\"),F165/'Drug Acquisition Costs'!F237*I161,IF(AND('Drug Acquisition Costs'!H237=\"Days\",I162=\"Months\"),F165/'Drug Acquisition Costs'!F237*30.4375*I161,IF(AND('Drug Acquisition Costs'!H237=\"Months\",I162=\"Days\"),F165/'Drug Acquisition Costs'!F237/30.4375*I161,\"\"))))","v":""}]
["D","CIC PAS (inclusive of framework agreement rebate)",null,null,null,{"$f":"SUMPRODUCT(F152:I152,'Drug Acquisition Costs'!F239:'Drug Acquisition Costs'!I239)","v":0},{"$f":" F166*G161","v":0},{"$f":"IF('Drug Acquisition Costs'!H237=\"Days\",F166/'Drug Acquisition Costs'!F237*365.25,IF('Drug Acquisition Costs'!H237=\"Months\",F166/'Drug Acquisition Costs'!F237*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H237=\"Days\",I162=\"Days\"),F166/'Drug Acquisition Costs'!F237*I161,IF(AND('Drug Acquisition Costs'!H237=\"Months\",I162=\"Months\"),F166/'Drug Acquisition Costs'!F237*I161,IF(AND('Drug Acquisition Costs'!H237=\"Days\",I162=\"Months\"),F166/'Drug Acquisition Costs'!F237*30.4375*I161,IF(AND('Drug Acquisition Costs'!H237=\"Months\",I162=\"Days\"),F166/'Drug Acquisition Costs'!F237/30.4375*I161,\"\"))))","v":""}]
["E",{"$f":"B154","v":"VAT on Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F154:I154,'Drug Acquisition Costs'!F239:'Drug Acquisition Costs'!I239)","v":0},{"$f":"F167*G161","v":0},{"$f":"IF('Drug Acquisition Costs'!H237=\"Days\",F167/'Drug Acquisition Costs'!F237*365.25,IF('Drug Acquisition Costs'!H237=\"Months\",F167/'Drug Acquisition Costs'!F237*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H237=\"Days\",I162=\"Days\"),F167/'Drug Acquisition Costs'!F237*I161,IF(AND('Drug Acquisition Costs'!H237=\"Months\",I162=\"Months\"),F167/'Drug Acquisition Costs'!F237*I161,IF(AND('Drug Acquisition Costs'!H238=\"Days\",I162=\"Months\"),F167/'Drug Acquisition Costs'!F237*30.4375*I161,IF(AND('Drug Acquisition Costs'!H237=\"Months\",I162=\"Days\"),F167/'Drug Acquisition Costs'!F237/30.4375*I161,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H269=\"\",\"\",'Drug Acquisition Costs'!H269)","v":""},{"$f":"IF(F168=\"\",\"\",F168*G161)","v":""},{"$f":"IF(F168=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H237=\"Days\",F168/'Drug Acquisition Costs'!F237*365.25,IF('Drug Acquisition Costs'!H237=\"Months\",F168/'Drug Acquisition Costs'!F237*12,\"\")), 744.36))","v":""},{"$f":"IF(F168=\"\",\"\",IF(AND('Drug Acquisition Costs'!H237=\"Days\",I162=\"Days\"),F168/'Drug Acquisition Costs'!F237*I161,IF(AND('Drug Acquisition Costs'!H237=\"Months\",I162=\"Months\"),F168/'Drug Acquisition Costs'!F237*I161,IF(AND('Drug Acquisition Costs'!H237=\"Days\",I162=\"Months\"),F168/'Drug Acquisition Costs'!F237*30.4375*I161,IF(AND('Drug Acquisition Costs'!H237=\"Months\",I162=\"Days\"),F168/'Drug Acquisition Costs'!F237/30.4375*I161,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H270=\"\",\"\",'Drug Acquisition Costs'!H270)","v":""},{"$f":"IF(F169=\"\",\"\",F169*G161)","v":""},{"$f":"IF(F169=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H237=\"Days\",F169/'Drug Acquisition Costs'!F237*365.25,IF('Drug Acquisition Costs'!H237=\"Months\",F169/'Drug Acquisition Costs'!F237*12,\"\")), 744.36))","v":""},{"$f":"IF(F169=\"\",\"\",IF(AND('Drug Acquisition Costs'!H237=\"Days\",I162=\"Days\"),F169/'Drug Acquisition Costs'!F237*I161,IF(AND('Drug Acquisition Costs'!H237=\"Months\",I162=\"Months\"),F169/'Drug Acquisition Costs'!F237*I161,IF(AND('Drug Acquisition Costs'!H237=\"Days\",I162=\"Months\"),F169/'Drug Acquisition Costs'!F237*30.4375*I161,IF(AND('Drug Acquisition Costs'!H237=\"Months\",I162=\"Days\"),F169/'Drug Acquisition Costs'!F237/30.4375*I161,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 2",null,null,null,{"$f":"SUM(F165:F168)","v":0},{"$f":"SUM(G165:G168)","v":0},{"$f":"SUM(H165:H168)","v":0},{"$f":"SUM(I165:I168)","v":0}]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 2",null,null,null,{"$f":"IF(F169=\"\",SUM(F165:F166),F165+F166+F169)","v":0},{"$f":"IF(G169=\"\",SUM(G165:G166),G165+G166+G169)","v":0},{"$f":"IF(H169=\"\",SUM(H165:H166),H165+H166+H169)","v":0},{"$f":"IF(I169=\"\",SUM(I165:I166),I165+I166+I169)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"'Drug Acquisition Costs'!B290:D290","v":"Comparator 2: "},null,null,{"$f":"'Drug Acquisition Costs'!E290","v":0},{"$f":"IF($E175=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E175,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$174&\" Comparator 2\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E175=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E175,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$174&\" Comparator 2\"),$B:$B,0))","v":{"$error":"#N/A"}}]
[]
[null,"Notes"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 3: \",NameComparator3)","v":"Comparator 3: "}]
[]
[null,"Total Rebate (Including framework agreement and CIC) ",null,null,{"$f":"IF(ISNUMBER('Drug Acquisition Costs'!E339),ABS('Drug Acquisition Costs'!E339),0)","v":0}]
[]
[null,"Table C. Total Cost to the HSE per pack"]
[]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!F345=\"\",\"\",'Drug Acquisition Costs'!F345)","v":""},{"$f":"IF('Drug Acquisition Costs'!G345=\"\",\"\",'Drug Acquisition Costs'!G345)","v":""},{"$f":"IF('Drug Acquisition Costs'!H345=\"\",\"\",'Drug Acquisition Costs'!H345)","v":""},{"$f":"IF('Drug Acquisition Costs'!I345=\"\",\"\",'Drug Acquisition Costs'!I345)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F315=\"\",'Drug Acquisition Costs'!F316=\"\",'Drug Acquisition Costs'!$F317=\"\"),\"\",IF('Drug Acquisition Costs'!F315=\"Price to Wholesaler\",'Drug Acquisition Costs'!F316,IF('Drug Acquisition Costs'!F315=\"Reimbursement Price\",(F199/(1+$E198)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G315=\"\",'Drug Acquisition Costs'!G316=\"\",'Drug Acquisition Costs'!$F317=\"\"),\"\",IF('Drug Acquisition Costs'!G315=\"Price to Wholesaler\",'Drug Acquisition Costs'!G316,IF('Drug Acquisition Costs'!G315=\"Reimbursement Price\",(G199/(1+$E198)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H315=\"\",'Drug Acquisition Costs'!H316=\"\",'Drug Acquisition Costs'!$F317=\"\"),\"\",IF('Drug Acquisition Costs'!H315=\"Price to Wholesaler\",'Drug Acquisition Costs'!H316,IF('Drug Acquisition Costs'!H315=\"Reimbursement Price\",(H199/(1+$E198)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I315=\"\",'Drug Acquisition Costs'!I316=\"\",'Drug Acquisition Costs'!$F317=\"\"),\"\",IF('Drug Acquisition Costs'!I315=\"Price to Wholesaler\",'Drug Acquisition Costs'!I316,IF('Drug Acquisition Costs'!I315=\"Reimbursement Price\",(I199/(1+$E198)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F317=\"\"),\"\",IF(AND('Drug Acquisition Costs'!F317=\"CDS\",'Drug Acquisition Costs'!F318=\"Yes\"),CYF,IF(AND('Drug Acquisition Costs'!F317=\"CDS\",'Drug Acquisition Costs'!F318=\"No\"),CNF,IF('Drug Acquisition Costs'!F317=\"HT\",CHT,IF('Drug Acquisition Costs'!F317=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F317=\"\",'Drug Acquisition Costs'!F316=\"\",'Drug Acquisition Costs'!F315=\"\"),\"\",F197*$E198)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F317=\"\",'Drug Acquisition Costs'!G316=\"\",'Drug Acquisition Costs'!G315=\"\"),\"\",G197*$E198)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F317=\"\",'Drug Acquisition Costs'!H316=\"\",'Drug Acquisition Costs'!H315=\"\"),\"\",H197*$E198)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F317=\"\",'Drug Acquisition Costs'!I316=\"\",'Drug Acquisition Costs'!I315=\"\"),\"\",I197*$E198)","v":""}]
["C",{"$f":"IF('Drug Acquisition Costs'!F197=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF('Drug Acquisition Costs'!F315=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF('Drug Acquisition Costs'!F315=\"Reimbursement Price\",'Drug Acquisition Costs'!F316,IF(ISBLANK($E198),\"\",IF('Drug Acquisition Costs'!F315=\"Price to Wholesaler\",(F197+F198),IF('Drug Acquisition Costs'!F315=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!G315=\"Reimbursement Price\",'Drug Acquisition Costs'!G316,IF(ISBLANK($E198),\"\",IF('Drug Acquisition Costs'!G315=\"Price to Wholesaler\",(G197+G198),IF('Drug Acquisition Costs'!G315=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!H315=\"Reimbursement Price\",'Drug Acquisition Costs'!H316,IF(ISBLANK($E198),\"\",IF('Drug Acquisition Costs'!H315=\"Price to Wholesaler\",(H197+H198),IF('Drug Acquisition Costs'!H315=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!I315=\"Reimbursement Price\",'Drug Acquisition Costs'!I316,IF(ISBLANK($E198),\"\",IF('Drug Acquisition Costs'!I315=\"Price to Wholesaler\",(I197+I198),IF('Drug Acquisition Costs'!I315=\"\",\"\",\"Error\"))))","v":""}]
["D","Total Rebate (Including framework agreement and CIC) ",null,null,null,{"$f":"IF('Drug Acquisition Costs'!F316=\"\", \"\", F197*IF($E191=\"\", \"\", -$E191))","v":""},{"$f":"IF('Drug Acquisition Costs'!G316=\"\", \"\", G197*IF($E191=\"\", \"\", -$E191))","v":""},{"$f":"IF('Drug Acquisition Costs'!H316=\"\", \"\", H197*IF($E191=\"\", \"\", -$E191))","v":""},{"$f":"IF('Drug Acquisition Costs'!I316=\"\", \"\", I197*IF($E191=\"\", \"\", -$E191))","v":""}]
["E","Net price (PtW less total rebate)",null,null,null,{"$f":"IFERROR(F197+F200,\"\")","v":""},{"$f":"IFERROR(G197+G200,\"\")","v":""},{"$f":"IFERROR(H197+H200,\"\")","v":""},{"$f":"IFERROR(I197+I200,\"\")","v":""}]
["F","VAT on Reimbursement Price",null,null,{"$f":"IF('Drug Acquisition Costs'!F319=\"\",\"\",IF('Drug Acquisition Costs'!F319=\"Yes\",0,VT))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!F316=\"\",ISBLANK('Drug Acquisition Costs'!F316)),\"\",($E202*F199))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G316=\"\",ISBLANK('Drug Acquisition Costs'!G316)),\"\",($E202*G199))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H316=\"\",ISBLANK('Drug Acquisition Costs'!H316)),\"\",($E202*H199))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I316=\"\",ISBLANK('Drug Acquisition Costs'!I316)),\"\",($E202*I199))","v":""}]
["G(i)","Total Drug Cost to the HSE per pack with CIC PAS including VAT (B+E+F)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F315=\"\",'Drug Acquisition Costs'!$F317=\"\",'Drug Acquisition Costs'!$F319=\"\",'Drug Acquisition Costs'!$F320=\"\"),\"\",F198+F201+F202)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G315=\"\",'Drug Acquisition Costs'!$F317=\"\",'Drug Acquisition Costs'!$F319=\"\",'Drug Acquisition Costs'!$F320=\"\"),\"\",G198+G201+G202)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H315=\"\",'Drug Acquisition Costs'!$F317=\"\",'Drug Acquisition Costs'!$F319=\"\",'Drug Acquisition Costs'!$F320=\"\"),\"\",H198+H201+H202)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I315=\"\",'Drug Acquisition Costs'!$F317=\"\",'Drug Acquisition Costs'!$F319=\"\",'Drug Acquisition Costs'!$F320=\"\"),\"\",I198+I201+I202)","v":""}]
["G(ii)","Total Drug Cost to the HSE per pack with CIC PAS excluding VAT (B+E)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F315=\"\",'Drug Acquisition Costs'!$F317=\"\",'Drug Acquisition Costs'!$F319=\"\",'Drug Acquisition Costs'!$F320=\"\"),\"\",F198+F201)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G315=\"\",'Drug Acquisition Costs'!$F317=\"\",'Drug Acquisition Costs'!$F319=\"\",'Drug Acquisition Costs'!$F320=\"\"),\"\",G198+G201)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H315=\"\",'Drug Acquisition Costs'!$F317=\"\",'Drug Acquisition Costs'!$F319=\"\",'Drug Acquisition Costs'!$F320=\"\"),\"\",H198+H201)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I315=\"\",'Drug Acquisition Costs'!$F317=\"\",'Drug Acquisition Costs'!$F319=\"\",'Drug Acquisition Costs'!$F320=\"\"),\"\",I198+I201)","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time"]
[null,null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!G365=\"\",0,'Drug Acquisition Costs'!G365)","v":0},null,{"$f":"IF('Drug Acquisition Costs'!I365=\"\",\"\",'Drug Acquisition Costs'!I365)","v":""}]
[null,null,null,null,null,null,"number of cycles",null,{"$f":"IF('Drug Acquisition Costs'!I366=\"\",\"\",'Drug Acquisition Costs'!I366)","v":""}]
["A",{"$f":"B197","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F197:I197,'Drug Acquisition Costs'!F328:'Drug Acquisition Costs'!I328)","v":0},{"$f":"F211*G209","v":0},{"$f":"IF('Drug Acquisition Costs'!H326=\"Days\",F211/'Drug Acquisition Costs'!F326*365.25,IF('Drug Acquisition Costs'!H326=\"Months\",F211/'Drug Acquisition Costs'!F326*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H326=\"Days\",I210=\"Days\"),F211/'Drug Acquisition Costs'!F326*I209,IF(AND('Drug Acquisition Costs'!H326=\"Months\",I210=\"Months\"),F211/'Drug Acquisition Costs'!F326*I209,IF(AND('Drug Acquisition Costs'!H326=\"Days\",I210=\"Months\"),F211/'Drug Acquisition Costs'!F326*30.4375*I209,IF(AND('Drug Acquisition Costs'!H326=\"Months\",I210=\"Days\"),F211/'Drug Acquisition Costs'!F326/30.4375*I209,\"\"))))","v":""}]
["B",{"$f":"B198","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F198:I198,'Drug Acquisition Costs'!F328:'Drug Acquisition Costs'!I328)","v":0},{"$f":"F212*G209","v":0},{"$f":"IF('Drug Acquisition Costs'!H326=\"Days\",F212/'Drug Acquisition Costs'!F326*365.25,IF('Drug Acquisition Costs'!H326=\"Months\",F212/'Drug Acquisition Costs'!F326*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H326=\"Days\",I210=\"Days\"),F212/'Drug Acquisition Costs'!F326*I209,IF(AND('Drug Acquisition Costs'!H326=\"Months\",I210=\"Months\"),F212/'Drug Acquisition Costs'!F326*I209,IF(AND('Drug Acquisition Costs'!H326=\"Days\",I210=\"Months\"),F212/'Drug Acquisition Costs'!F326*30.4375*I209,IF(AND('Drug Acquisition Costs'!H326=\"Months\",I210=\"Days\"),F212/'Drug Acquisition Costs'!F326/30.4375*I209,\"\"))))","v":""}]
["C",{"$f":"B199","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F199:I199,'Drug Acquisition Costs'!F328:'Drug Acquisition Costs'!I328)","v":0},{"$f":"F213*G209","v":0},{"$f":"IF('Drug Acquisition Costs'!H326=\"Days\",F213/'Drug Acquisition Costs'!F326*365.25,IF('Drug Acquisition Costs'!H326=\"Months\",F213/'Drug Acquisition Costs'!F326*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H326=\"Days\",I210=\"Days\"),F213/'Drug Acquisition Costs'!F326*I209,IF(AND('Drug Acquisition Costs'!H326=\"Months\",I210=\"Months\"),F213/'Drug Acquisition Costs'!F326*I209,IF(AND('Drug Acquisition Costs'!H326=\"Days\",I210=\"Months\"),F213/'Drug Acquisition Costs'!F326*30.4375*I209,IF(AND('Drug Acquisition Costs'!H296=\"Months\",I210=\"Days\"),F213/'Drug Acquisition Costs'!F326/30.4375*I209,\"\"))))","v":""}]
["D","CIC PAS (inclusive of framework agreement rebate)",null,null,null,{"$f":"SUMPRODUCT(F200:I200,'Drug Acquisition Costs'!F328:'Drug Acquisition Costs'!I328)","v":0},{"$f":" F214*G209","v":0},{"$f":"IF('Drug Acquisition Costs'!H326=\"Days\",F214/'Drug Acquisition Costs'!F326*365.25,IF('Drug Acquisition Costs'!H326=\"Months\",F214/'Drug Acquisition Costs'!F326*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H326=\"Days\",I210=\"Days\"),F214/'Drug Acquisition Costs'!F326*I209,IF(AND('Drug Acquisition Costs'!H326=\"Months\",I210=\"Months\"),F214/'Drug Acquisition Costs'!F326*I209,IF(AND('Drug Acquisition Costs'!H326=\"Days\",I210=\"Months\"),F214/'Drug Acquisition Costs'!F326*30.4375*I209,IF(AND('Drug Acquisition Costs'!H326=\"Months\",I210=\"Days\"),F214/'Drug Acquisition Costs'!F326/30.4375*I209,\"\"))))","v":""}]
["E",{"$f":"B202","v":"VAT on Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F202:I202,'Drug Acquisition Costs'!F328:'Drug Acquisition Costs'!I328)","v":0},{"$f":"F215*G209","v":0},{"$f":"IF('Drug Acquisition Costs'!H326=\"Days\",F215/'Drug Acquisition Costs'!F326*365.25,IF('Drug Acquisition Costs'!H326=\"Months\",F215/'Drug Acquisition Costs'!F326*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H2326=\"Days\",I210=\"Days\"),F215/'Drug Acquisition Costs'!F326*I209,IF(AND('Drug Acquisition Costs'!H326=\"Months\",I210=\"Months\"),F215/'Drug Acquisition Costs'!F326*I209,IF(AND('Drug Acquisition Costs'!H327=\"Days\",I210=\"Months\"),F215/'Drug Acquisition Costs'!F326*30.4375*I209,IF(AND('Drug Acquisition Costs'!H326=\"Months\",I210=\"Days\"),F215/'Drug Acquisition Costs'!F326/30.4375*I209,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H358=\"\",\"\",'Drug Acquisition Costs'!H358)","v":""},{"$f":"IF(F216=\"\",\"\",F216*G209)","v":""},{"$f":"IF(F216=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H326=\"Days\",F216/'Drug Acquisition Costs'!F326*365.25,IF('Drug Acquisition Costs'!H326=\"Months\",F216/'Drug Acquisition Costs'!F326*12,\"\")), 744.36))","v":""},{"$f":"IF(F216=\"\",\"\",IF(AND('Drug Acquisition Costs'!H326=\"Days\",I210=\"Days\"),F216/'Drug Acquisition Costs'!F326*I209,IF(AND('Drug Acquisition Costs'!H326=\"Months\",I210=\"Months\"),F216/'Drug Acquisition Costs'!F326*I209,IF(AND('Drug Acquisition Costs'!H326=\"Days\",I210=\"Months\"),F216/'Drug Acquisition Costs'!F326*30.4375*I209,IF(AND('Drug Acquisition Costs'!H326=\"Months\",I210=\"Days\"),F216/'Drug Acquisition Costs'!F326/30.4375*I209,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H359=\"\",\"\",'Drug Acquisition Costs'!H359)","v":""},{"$f":"IF(F217=\"\",\"\",F217*G209)","v":""},{"$f":"IF(F217=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H326=\"Days\",F217/'Drug Acquisition Costs'!F326*365.25,IF('Drug Acquisition Costs'!H326=\"Months\",F217/'Drug Acquisition Costs'!F326*12,\"\")), 744.36))","v":""},{"$f":"IF(F217=\"\",\"\",IF(AND('Drug Acquisition Costs'!H326=\"Days\",I210=\"Days\"),F217/'Drug Acquisition Costs'!F326*I209,IF(AND('Drug Acquisition Costs'!H326=\"Months\",I210=\"Months\"),F217/'Drug Acquisition Costs'!F326*I209,IF(AND('Drug Acquisition Costs'!H326=\"Days\",I210=\"Months\"),F217/'Drug Acquisition Costs'!F326*30.4375*I209,IF(AND('Drug Acquisition Costs'!H326=\"Months\",I210=\"Days\"),F217/'Drug Acquisition Costs'!F326/30.4375*I209,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 3",null,null,null,{"$f":"SUM(F213:F216)","v":0},{"$f":"SUM(G213:G216)","v":0},{"$f":"SUM(H213:H216)","v":0},{"$f":"SUM(I213:I216)","v":0}]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 3",null,null,null,{"$f":"IF(F217=\"\",SUM(F213:F214),F213+F214+F217)","v":0},{"$f":"IF(G217=\"\",SUM(G213:G214),G213+G214+G217)","v":0},{"$f":"IF(H217=\"\",SUM(H213:H214),H213+H214+H217)","v":0},{"$f":"IF(I217=\"\",SUM(I213:I214),I213+I214+I217)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"'Drug Acquisition Costs'!B379:D379","v":"Comparator 3: "},null,null,{"$f":"'Drug Acquisition Costs'!E379","v":0},{"$f":"IF($E223=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E223,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$222&\" Comparator 3\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E223=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E223,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$222&\" Comparator 3\"),$B:$B,0))","v":{"$error":"#N/A"}}]
[]
[null,"Notes"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 4: \",NameComparator4)","v":"Comparator 4: "}]
[]
[null,"Total Rebate (Including framework agreement and CIC) ",null,null,{"$f":"IF(ISNUMBER('Drug Acquisition Costs'!E427),ABS('Drug Acquisition Costs'!E427),0)","v":0}]
[]
[null,"Table C. Total Cost to the HSE per pack"]
[]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!F423=\"\",\"\",'Drug Acquisition Costs'!F423)","v":""},{"$f":"IF('Drug Acquisition Costs'!G423=\"\",\"\",'Drug Acquisition Costs'!G423)","v":""},{"$f":"IF('Drug Acquisition Costs'!H423=\"\",\"\",'Drug Acquisition Costs'!H423)","v":""},{"$f":"IF('Drug Acquisition Costs'!I423=\"\",\"\",'Drug Acquisition Costs'!I423)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F403=\"\",'Drug Acquisition Costs'!F404=\"\",'Drug Acquisition Costs'!$F405=\"\"),\"\",IF('Drug Acquisition Costs'!F403=\"Price to Wholesaler\",'Drug Acquisition Costs'!F404,IF('Drug Acquisition Costs'!F403=\"Reimbursement Price\",(F247/(1+$E246)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G403=\"\",'Drug Acquisition Costs'!G404=\"\",'Drug Acquisition Costs'!$F405=\"\"),\"\",IF('Drug Acquisition Costs'!G403=\"Price to Wholesaler\",'Drug Acquisition Costs'!G404,IF('Drug Acquisition Costs'!G403=\"Reimbursement Price\",(G247/(1+$E246)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H403=\"\",'Drug Acquisition Costs'!H404=\"\",'Drug Acquisition Costs'!$F405=\"\"),\"\",IF('Drug Acquisition Costs'!H403=\"Price to Wholesaler\",'Drug Acquisition Costs'!H404,IF('Drug Acquisition Costs'!H403=\"Reimbursement Price\",(H247/(1+$E246)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I403=\"\",'Drug Acquisition Costs'!I404=\"\",'Drug Acquisition Costs'!$F405=\"\"),\"\",IF('Drug Acquisition Costs'!I403=\"Price to Wholesaler\",'Drug Acquisition Costs'!I404,IF('Drug Acquisition Costs'!I403=\"Reimbursement Price\",(I247/(1+$E246)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F405=\"\"),\"\",IF(AND('Drug Acquisition Costs'!F405=\"CDS\",'Drug Acquisition Costs'!F406=\"Yes\"),CYF,IF(AND('Drug Acquisition Costs'!F405=\"CDS\",'Drug Acquisition Costs'!F406=\"No\"),CNF,IF('Drug Acquisition Costs'!F405=\"HT\",CHT,IF('Drug Acquisition Costs'!F405=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F405=\"\",'Drug Acquisition Costs'!F404=\"\",'Drug Acquisition Costs'!F403=\"\"),\"\",F245*$E246)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F405=\"\",'Drug Acquisition Costs'!G404=\"\",'Drug Acquisition Costs'!G403=\"\"),\"\",G245*$E246)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F405=\"\",'Drug Acquisition Costs'!H404=\"\",'Drug Acquisition Costs'!H403=\"\"),\"\",H245*$E246)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F405=\"\",'Drug Acquisition Costs'!I404=\"\",'Drug Acquisition Costs'!I403=\"\"),\"\",I245*$E246)","v":""}]
["C",{"$f":"IF('Drug Acquisition Costs'!F245=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF('Drug Acquisition Costs'!F403=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF('Drug Acquisition Costs'!F403=\"Reimbursement Price\",'Drug Acquisition Costs'!F404,IF(ISBLANK($E246),\"\",IF('Drug Acquisition Costs'!F403=\"Price to Wholesaler\",(F245+F246),IF('Drug Acquisition Costs'!F403=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!G403=\"Reimbursement Price\",'Drug Acquisition Costs'!G404,IF(ISBLANK($E246),\"\",IF('Drug Acquisition Costs'!G403=\"Price to Wholesaler\",(G245+G246),IF('Drug Acquisition Costs'!G403=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!H403=\"Reimbursement Price\",'Drug Acquisition Costs'!H404,IF(ISBLANK($E246),\"\",IF('Drug Acquisition Costs'!H403=\"Price to Wholesaler\",(H245+H246),IF('Drug Acquisition Costs'!H403=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!I403=\"Reimbursement Price\",'Drug Acquisition Costs'!I404,IF(ISBLANK($E246),\"\",IF('Drug Acquisition Costs'!I403=\"Price to Wholesaler\",(I245+I246),IF('Drug Acquisition Costs'!I403=\"\",\"\",\"Error\"))))","v":""}]
["D","Total Rebate (Including framework agreement and CIC) ",null,null,null,{"$f":"IF('Drug Acquisition Costs'!F404=\"\", \"\", F245*IF($E239=\"\", \"\", -$E239))","v":""},{"$f":"IF('Drug Acquisition Costs'!G404=\"\", \"\", G245*IF($E239=\"\", \"\", -$E239))","v":""},{"$f":"IF('Drug Acquisition Costs'!H404=\"\", \"\", H245*IF($E239=\"\", \"\", -$E239))","v":""},{"$f":"IF('Drug Acquisition Costs'!I404=\"\", \"\", I245*IF($E239=\"\", \"\", -$E239))","v":""}]
["E","Net price (PtW less total rebate)",null,null,null,{"$f":"IFERROR(F245+F248,\"\")","v":""},{"$f":"IFERROR(G245+G248,\"\")","v":""},{"$f":"IFERROR(H245+H248,\"\")","v":""},{"$f":"IFERROR(I245+I248,\"\")","v":""}]
["F","VAT on Reimbursement Price",null,null,{"$f":"IF('Drug Acquisition Costs'!F407=\"\",\"\",IF('Drug Acquisition Costs'!F407=\"Yes\",0,VT))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!F404=\"\",ISBLANK('Drug Acquisition Costs'!F404)),\"\",($E250*F247))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G404=\"\",ISBLANK('Drug Acquisition Costs'!G404)),\"\",($E250*G247))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H404=\"\",ISBLANK('Drug Acquisition Costs'!H404)),\"\",($E250*H247))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I404=\"\",ISBLANK('Drug Acquisition Costs'!I404)),\"\",($E250*I247))","v":""}]
["G(i)","Total Drug Cost to the HSE per pack with CIC PAS including VAT (B+E+F)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F403=\"\",'Drug Acquisition Costs'!$F405=\"\",'Drug Acquisition Costs'!$F407=\"\",'Drug Acquisition Costs'!$F408=\"\"),\"\",F246+F249+F250)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G403=\"\",'Drug Acquisition Costs'!$F405=\"\",'Drug Acquisition Costs'!$F407=\"\",'Drug Acquisition Costs'!$F408=\"\"),\"\",G246+G249+G250)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H403=\"\",'Drug Acquisition Costs'!$F405=\"\",'Drug Acquisition Costs'!$F407=\"\",'Drug Acquisition Costs'!$F408=\"\"),\"\",H246+H249+H250)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I403=\"\",'Drug Acquisition Costs'!$F405=\"\",'Drug Acquisition Costs'!$F407=\"\",'Drug Acquisition Costs'!$F408=\"\"),\"\",I246+I249+I250)","v":""}]
["G(ii)","Total Drug Cost to the HSE per pack with CIC PAS excluding VAT (B+E)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F403=\"\",'Drug Acquisition Costs'!$F405=\"\",'Drug Acquisition Costs'!$F407=\"\",'Drug Acquisition Costs'!$F408=\"\"),\"\",F246+F249)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G403=\"\",'Drug Acquisition Costs'!$F405=\"\",'Drug Acquisition Costs'!$F407=\"\",'Drug Acquisition Costs'!$F408=\"\"),\"\",G246+G249)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H403=\"\",'Drug Acquisition Costs'!$F405=\"\",'Drug Acquisition Costs'!$F407=\"\",'Drug Acquisition Costs'!$F408=\"\"),\"\",H246+H249)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I403=\"\",'Drug Acquisition Costs'!$F405=\"\",'Drug Acquisition Costs'!$F407=\"\",'Drug Acquisition Costs'!$F408=\"\"),\"\",I246+I249)","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time"]
[null,null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!G453=\"\",0,'Drug Acquisition Costs'!G453)","v":0},null,{"$f":"IF('Drug Acquisition Costs'!I453=\"\",\"\",'Drug Acquisition Costs'!I453)","v":""}]
[null,null,null,null,null,null,"number of cycles",null,{"$f":"IF('Drug Acquisition Costs'!I454=\"\",\"\",'Drug Acquisition Costs'!I454)","v":""}]
["A",{"$f":"B245","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F245:I245,'Drug Acquisition Costs'!F416:'Drug Acquisition Costs'!I416)","v":0},{"$f":"F259*G257","v":0},{"$f":"IF('Drug Acquisition Costs'!H414=\"Days\",F259/'Drug Acquisition Costs'!F414*365.25,IF('Drug Acquisition Costs'!H414=\"Months\",F259/'Drug Acquisition Costs'!F414*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H414=\"Days\",I258=\"Days\"),F259/'Drug Acquisition Costs'!F414*I257,IF(AND('Drug Acquisition Costs'!H414=\"Months\",I258=\"Months\"),F259/'Drug Acquisition Costs'!F414*I257,IF(AND('Drug Acquisition Costs'!H414=\"Days\",I258=\"Months\"),F259/'Drug Acquisition Costs'!F414*30.4375*I257,IF(AND('Drug Acquisition Costs'!H414=\"Months\",I258=\"Days\"),F259/'Drug Acquisition Costs'!F414/30.4375*I257,\"\"))))","v":""}]
["B",{"$f":"B246","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F246:I246,'Drug Acquisition Costs'!F416:'Drug Acquisition Costs'!I416)","v":0},{"$f":"F260*G257","v":0},{"$f":"IF('Drug Acquisition Costs'!H414=\"Days\",F260/'Drug Acquisition Costs'!F414*365.25,IF('Drug Acquisition Costs'!H414=\"Months\",F260/'Drug Acquisition Costs'!F414*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H414=\"Days\",I258=\"Days\"),F260/'Drug Acquisition Costs'!F414*I257,IF(AND('Drug Acquisition Costs'!H414=\"Months\",I258=\"Months\"),F260/'Drug Acquisition Costs'!F414*I257,IF(AND('Drug Acquisition Costs'!H414=\"Days\",I258=\"Months\"),F260/'Drug Acquisition Costs'!F414*30.4375*I257,IF(AND('Drug Acquisition Costs'!H414=\"Months\",I258=\"Days\"),F260/'Drug Acquisition Costs'!F414/30.4375*I257,\"\"))))","v":""}]
["C",{"$f":"B247","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F247:I247,'Drug Acquisition Costs'!F416:'Drug Acquisition Costs'!I416)","v":0},{"$f":"F261*G257","v":0},{"$f":"IF('Drug Acquisition Costs'!H414=\"Days\",F261/'Drug Acquisition Costs'!F414*365.25,IF('Drug Acquisition Costs'!H414=\"Months\",F261/'Drug Acquisition Costs'!F414*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H414=\"Days\",I258=\"Days\"),F261/'Drug Acquisition Costs'!F414*I257,IF(AND('Drug Acquisition Costs'!H414=\"Months\",I258=\"Months\"),F261/'Drug Acquisition Costs'!F414*I257,IF(AND('Drug Acquisition Costs'!H414=\"Days\",I258=\"Months\"),F261/'Drug Acquisition Costs'!F414*30.4375*I257,IF(AND('Drug Acquisition Costs'!H414=\"Months\",I258=\"Days\"),F261/'Drug Acquisition Costs'!F414/30.4375*I257,\"\"))))","v":""}]
["D","CIC PAS (inclusive of framework agreement rebate)",null,null,null,{"$f":"SUMPRODUCT(F248:I248,'Drug Acquisition Costs'!F416:'Drug Acquisition Costs'!I416)","v":0},{"$f":" F262*G257","v":0},{"$f":"IF('Drug Acquisition Costs'!H414=\"Days\",F262/'Drug Acquisition Costs'!F414*365.25,IF('Drug Acquisition Costs'!H414=\"Months\",F262/'Drug Acquisition Costs'!F414*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H414=\"Days\",I258=\"Days\"),F262/'Drug Acquisition Costs'!F414*I257,IF(AND('Drug Acquisition Costs'!H414=\"Months\",I258=\"Months\"),F262/'Drug Acquisition Costs'!F414*I257,IF(AND('Drug Acquisition Costs'!H414=\"Days\",I258=\"Months\"),F262/'Drug Acquisition Costs'!F414*30.4375*I257,IF(AND('Drug Acquisition Costs'!H414=\"Months\",I258=\"Days\"),F262/'Drug Acquisition Costs'!F414/30.4375*I257,\"\"))))","v":""}]
["E",{"$f":"B250","v":"VAT on Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F250:I250,'Drug Acquisition Costs'!F416:'Drug Acquisition Costs'!I416)","v":0},{"$f":"F263*G257","v":0},{"$f":"IF('Drug Acquisition Costs'!H414=\"Days\",F263/'Drug Acquisition Costs'!F414*365.25,IF('Drug Acquisition Costs'!H414=\"Months\",F263/'Drug Acquisition Costs'!F414*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H414=\"Days\",I258=\"Days\"),F263/'Drug Acquisition Costs'!F414*I257,IF(AND('Drug Acquisition Costs'!H414=\"Months\",I258=\"Months\"),F263/'Drug Acquisition Costs'!F414*I257,IF(AND('Drug Acquisition Costs'!H415=\"Days\",I258=\"Months\"),F263/'Drug Acquisition Costs'!F414*30.4375*I257,IF(AND('Drug Acquisition Costs'!H414=\"Months\",I258=\"Days\"),F263/'Drug Acquisition Costs'!F414/30.4375*I257,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H446=\"\",\"\",'Drug Acquisition Costs'!H446)","v":""},{"$f":"IF(F264=\"\",\"\",F264*G257)","v":""},{"$f":"IF(F264=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H414=\"Days\",F264/'Drug Acquisition Costs'!F414*365.25,IF('Drug Acquisition Costs'!H414=\"Months\",F264/'Drug Acquisition Costs'!F414*12,\"\")), 744.36))","v":""},{"$f":"IF(F264=\"\",\"\",IF(AND('Drug Acquisition Costs'!H414=\"Days\",I258=\"Days\"),F264/'Drug Acquisition Costs'!F414*I257,IF(AND('Drug Acquisition Costs'!H414=\"Months\",I258=\"Months\"),F264/'Drug Acquisition Costs'!F414*I257,IF(AND('Drug Acquisition Costs'!H414=\"Days\",I258=\"Months\"),F264/'Drug Acquisition Costs'!F414*30.4375*I257,IF(AND('Drug Acquisition Costs'!H414=\"Months\",I258=\"Days\"),F264/'Drug Acquisition Costs'!F414/30.4375*I257,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H447=\"\",\"\",'Drug Acquisition Costs'!H447)","v":""},{"$f":"IF(F265=\"\",\"\",F265*G257)","v":""},{"$f":"IF(F265=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H414=\"Days\",F265/'Drug Acquisition Costs'!F414*365.25,IF('Drug Acquisition Costs'!H414=\"Months\",F265/'Drug Acquisition Costs'!F414*12,\"\")), 744.36))","v":""},{"$f":"IF(F265=\"\",\"\",IF(AND('Drug Acquisition Costs'!H414=\"Days\",I258=\"Days\"),F265/'Drug Acquisition Costs'!F414*I257,IF(AND('Drug Acquisition Costs'!H414=\"Months\",I258=\"Months\"),F265/'Drug Acquisition Costs'!F414*I257,IF(AND('Drug Acquisition Costs'!H414=\"Days\",I258=\"Months\"),F265/'Drug Acquisition Costs'!F414*30.4375*I257,IF(AND('Drug Acquisition Costs'!H414=\"Months\",I258=\"Days\"),F265/'Drug Acquisition Costs'!F414/30.4375*I257,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 4",null,null,null,{"$f":"SUM(F261:F264)","v":0},{"$f":"SUM(G261:G264)","v":0},{"$f":"SUM(H261:H264)","v":0},{"$f":"SUM(I261:I264)","v":0}]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 4",null,null,null,{"$f":"IF(F265=\"\",SUM(F261:F262),F261+F262+F265)","v":0},{"$f":"IF(G265=\"\",SUM(G261:G262),G261+G262+G265)","v":0},{"$f":"IF(H265=\"\",SUM(H261:H262),H261+H262+H265)","v":0},{"$f":"IF(I265=\"\",SUM(I261:I262),I261+I262+I265)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"'Drug Acquisition Costs'!B467","v":"Comparator 4: "},null,null,{"$f":"'Drug Acquisition Costs'!E467","v":0},{"$f":"IF($E271=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E271,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$270&\" Comparator 4\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E271=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E271,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$270&\" Comparator 4\"),$B:$B,0))","v":{"$error":"#N/A"}}]
[]
[null,"Notes"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 5: \",NameComparator5)","v":"Comparator 5: "}]
[]
[null,"Total Rebate (Including framework agreement and CIC) ",null,null,{"$f":"IF(ISNUMBER('Drug Acquisition Costs'!E516),ABS('Drug Acquisition Costs'!E516),0)","v":0}]
[]
[null,"Table C. Total Cost to the HSE per pack"]
[]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!F512=\"\",\"\",'Drug Acquisition Costs'!F512)","v":""},{"$f":"IF('Drug Acquisition Costs'!G512=\"\",\"\",'Drug Acquisition Costs'!G512)","v":""},{"$f":"IF('Drug Acquisition Costs'!H512=\"\",\"\",'Drug Acquisition Costs'!H512)","v":""},{"$f":"IF('Drug Acquisition Costs'!I512=\"\",\"\",'Drug Acquisition Costs'!I512)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F492=\"\",'Drug Acquisition Costs'!F493=\"\",'Drug Acquisition Costs'!$F494=\"\"),\"\",IF('Drug Acquisition Costs'!F492=\"Price to Wholesaler\",'Drug Acquisition Costs'!F493,IF('Drug Acquisition Costs'!F492=\"Reimbursement Price\",(F295/(1+$E294)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G492=\"\",'Drug Acquisition Costs'!G493=\"\",'Drug Acquisition Costs'!$F494=\"\"),\"\",IF('Drug Acquisition Costs'!G492=\"Price to Wholesaler\",'Drug Acquisition Costs'!G493,IF('Drug Acquisition Costs'!G492=\"Reimbursement Price\",(G295/(1+$E294)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H492=\"\",'Drug Acquisition Costs'!H493=\"\",'Drug Acquisition Costs'!$F494=\"\"),\"\",IF('Drug Acquisition Costs'!H492=\"Price to Wholesaler\",'Drug Acquisition Costs'!H493,IF('Drug Acquisition Costs'!H492=\"Reimbursement Price\",(H295/(1+$E294)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I492=\"\",'Drug Acquisition Costs'!I493=\"\",'Drug Acquisition Costs'!$F494=\"\"),\"\",IF('Drug Acquisition Costs'!I492=\"Price to Wholesaler\",'Drug Acquisition Costs'!I493,IF('Drug Acquisition Costs'!I492=\"Reimbursement Price\",(I295/(1+$E294)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F494=\"\"),\"\",IF(AND('Drug Acquisition Costs'!F494=\"CDS\",'Drug Acquisition Costs'!F495=\"Yes\"),CYF,IF(AND('Drug Acquisition Costs'!F494=\"CDS\",'Drug Acquisition Costs'!F495=\"No\"),CNF,IF('Drug Acquisition Costs'!F494=\"HT\",CHT,IF('Drug Acquisition Costs'!F494=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F494=\"\",'Drug Acquisition Costs'!F493=\"\",'Drug Acquisition Costs'!F492=\"\"),\"\",F293*$E294)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F494=\"\",'Drug Acquisition Costs'!G493=\"\",'Drug Acquisition Costs'!G492=\"\"),\"\",G293*$E294)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F494=\"\",'Drug Acquisition Costs'!H493=\"\",'Drug Acquisition Costs'!H492=\"\"),\"\",H293*$E294)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F494=\"\",'Drug Acquisition Costs'!I493=\"\",'Drug Acquisition Costs'!I492=\"\"),\"\",I293*$E294)","v":""}]
["C",{"$f":"IF('Drug Acquisition Costs'!F294=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF('Drug Acquisition Costs'!F492=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF('Drug Acquisition Costs'!F492=\"Reimbursement Price\",'Drug Acquisition Costs'!F493,IF(ISBLANK($E294),\"\",IF('Drug Acquisition Costs'!F492=\"Price to Wholesaler\",(F293+F294),IF('Drug Acquisition Costs'!F492=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!G492=\"Reimbursement Price\",'Drug Acquisition Costs'!G493,IF(ISBLANK($E294),\"\",IF('Drug Acquisition Costs'!G492=\"Price to Wholesaler\",(G293+G294),IF('Drug Acquisition Costs'!G492=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!H492=\"Reimbursement Price\",'Drug Acquisition Costs'!H493,IF(ISBLANK($E294),\"\",IF('Drug Acquisition Costs'!H492=\"Price to Wholesaler\",(H293+H294),IF('Drug Acquisition Costs'!H492=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!I492=\"Reimbursement Price\",'Drug Acquisition Costs'!I493,IF(ISBLANK($E294),\"\",IF('Drug Acquisition Costs'!I492=\"Price to Wholesaler\",(I293+I294),IF('Drug Acquisition Costs'!I492=\"\",\"\",\"Error\"))))","v":""}]
["D","Total Rebate (Including framework agreement and CIC) ",null,null,null,{"$f":"IF('Drug Acquisition Costs'!F493=\"\", \"\", F293*IF($E287=\"\", \"\", -$E287))","v":""},{"$f":"IF('Drug Acquisition Costs'!G493=\"\", \"\", G293*IF($E287=\"\", \"\", -$E287))","v":""},{"$f":"IF('Drug Acquisition Costs'!H493=\"\", \"\", H293*IF($E287=\"\", \"\", -$E287))","v":""},{"$f":"IF('Drug Acquisition Costs'!I493=\"\", \"\", I293*IF($E287=\"\", \"\", -$E287))","v":""}]
["E","Net price (PtW less total rebate)",null,null,null,{"$f":"IFERROR(F293+F296,\"\")","v":""},{"$f":"IFERROR(G293+G296,\"\")","v":""},{"$f":"IFERROR(H293+H296,\"\")","v":""},{"$f":"IFERROR(I293+I296,\"\")","v":""}]
["F","VAT on Reimbursement Price",null,null,{"$f":"IF('Drug Acquisition Costs'!F496=\"\",\"\",IF('Drug Acquisition Costs'!F496=\"Yes\",0,VT))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!F493=\"\",ISBLANK('Drug Acquisition Costs'!F493)),\"\",($E298*F295))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G493=\"\",ISBLANK('Drug Acquisition Costs'!G493)),\"\",($E298*G295))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H493=\"\",ISBLANK('Drug Acquisition Costs'!H493)),\"\",($E298*H295))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I493=\"\",ISBLANK('Drug Acquisition Costs'!I493)),\"\",($E298*I295))","v":""}]
["G(i)","Total Drug Cost to the HSE per pack with CIC PAS including VAT (B+E+F)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F492=\"\",'Drug Acquisition Costs'!$F494=\"\",'Drug Acquisition Costs'!$F496=\"\",'Drug Acquisition Costs'!$F497=\"\"),\"\",F294+F297+F298)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G492=\"\",'Drug Acquisition Costs'!$F494=\"\",'Drug Acquisition Costs'!$F496=\"\",'Drug Acquisition Costs'!$F497=\"\"),\"\",G294+G297+G298)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H492=\"\",'Drug Acquisition Costs'!$F494=\"\",'Drug Acquisition Costs'!$F496=\"\",'Drug Acquisition Costs'!$F497=\"\"),\"\",H294+H297+H298)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I492=\"\",'Drug Acquisition Costs'!$F494=\"\",'Drug Acquisition Costs'!$F496=\"\",'Drug Acquisition Costs'!$F497=\"\"),\"\",I294+I297+I298)","v":""}]
["G(ii)","Total Drug Cost to the HSE per pack with CIC PAS excluding VAT (B+E)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F492=\"\",'Drug Acquisition Costs'!$F494=\"\",'Drug Acquisition Costs'!$F496=\"\",'Drug Acquisition Costs'!$F497=\"\"),\"\",F294+F297)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G492=\"\",'Drug Acquisition Costs'!$F494=\"\",'Drug Acquisition Costs'!$F496=\"\",'Drug Acquisition Costs'!$F497=\"\"),\"\",G294+G297)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H492=\"\",'Drug Acquisition Costs'!$F494=\"\",'Drug Acquisition Costs'!$F496=\"\",'Drug Acquisition Costs'!$F497=\"\"),\"\",H294+H297)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I492=\"\",'Drug Acquisition Costs'!$F494=\"\",'Drug Acquisition Costs'!$F496=\"\",'Drug Acquisition Costs'!$F497=\"\"),\"\",I294+I297)","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time"]
[null,null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!G542=\"\",0,'Drug Acquisition Costs'!G542)","v":0},null,{"$f":"IF('Drug Acquisition Costs'!I542=\"\",\"\",'Drug Acquisition Costs'!I542)","v":""}]
[null,null,null,null,null,null,"number of cycles",null,{"$f":"IF('Drug Acquisition Costs'!I543=\"\",\"\",'Drug Acquisition Costs'!I543)","v":""}]
["A",{"$f":"B293","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F293:I293,'Drug Acquisition Costs'!F505:'Drug Acquisition Costs'!I505)","v":0},{"$f":"F307*G305","v":0},{"$f":"IF('Drug Acquisition Costs'!H503=\"Days\",F307/'Drug Acquisition Costs'!F503*365.25,IF('Drug Acquisition Costs'!H503=\"Months\",F307/'Drug Acquisition Costs'!F503*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H503=\"Days\",I306=\"Days\"),F307/'Drug Acquisition Costs'!F503*I305,IF(AND('Drug Acquisition Costs'!H503=\"Months\",I306=\"Months\"),F307/'Drug Acquisition Costs'!F503*I305,IF(AND('Drug Acquisition Costs'!H503=\"Days\",I306=\"Months\"),F307/'Drug Acquisition Costs'!F503*30.4375*I305,IF(AND('Drug Acquisition Costs'!H503=\"Months\",I306=\"Days\"),F307/'Drug Acquisition Costs'!F503/30.4375*I305,\"\"))))","v":""}]
["B",{"$f":"B294","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F294:I294,'Drug Acquisition Costs'!F505:'Drug Acquisition Costs'!I505)","v":0},{"$f":"F308*G305","v":0},{"$f":"IF('Drug Acquisition Costs'!H503=\"Days\",F308/'Drug Acquisition Costs'!F503*365.25,IF('Drug Acquisition Costs'!H503=\"Months\",F308/'Drug Acquisition Costs'!F503*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H503=\"Days\",I306=\"Days\"),F308/'Drug Acquisition Costs'!F503*I305,IF(AND('Drug Acquisition Costs'!H503=\"Months\",I306=\"Months\"),F308/'Drug Acquisition Costs'!F503*I305,IF(AND('Drug Acquisition Costs'!H503=\"Days\",I306=\"Months\"),F308/'Drug Acquisition Costs'!F503*30.4375*I305,IF(AND('Drug Acquisition Costs'!H503=\"Months\",I306=\"Days\"),F308/'Drug Acquisition Costs'!F503/30.4375*I305,\"\"))))","v":""}]
["C",{"$f":"B295","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F295:I295,'Drug Acquisition Costs'!F505:'Drug Acquisition Costs'!I505)","v":0},{"$f":"F309*G305","v":0},{"$f":"IF('Drug Acquisition Costs'!H503=\"Days\",F309/'Drug Acquisition Costs'!F503*365.25,IF('Drug Acquisition Costs'!H503=\"Months\",F309/'Drug Acquisition Costs'!F503*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H503=\"Days\",I306=\"Days\"),F309/'Drug Acquisition Costs'!F503*I305,IF(AND('Drug Acquisition Costs'!H503=\"Months\",I306=\"Months\"),F309/'Drug Acquisition Costs'!F503*I305,IF(AND('Drug Acquisition Costs'!H503=\"Days\",I306=\"Months\"),F309/'Drug Acquisition Costs'!F503*30.4375*I305,IF(AND('Drug Acquisition Costs'!H503=\"Months\",I306=\"Days\"),F309/'Drug Acquisition Costs'!F503/30.4375*I305,\"\"))))","v":""}]
["D","CIC PAS (inclusive of framework agreement rebate)",null,null,null,{"$f":"SUMPRODUCT(F296:I296,'Drug Acquisition Costs'!F505:'Drug Acquisition Costs'!I505)","v":0},{"$f":" F310*G305","v":0},{"$f":"IF('Drug Acquisition Costs'!H503=\"Days\",F310/'Drug Acquisition Costs'!F503*365.25,IF('Drug Acquisition Costs'!H503=\"Months\",F310/'Drug Acquisition Costs'!F503*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H503=\"Days\",I306=\"Days\"),F310/'Drug Acquisition Costs'!F503*I305,IF(AND('Drug Acquisition Costs'!H503=\"Months\",I306=\"Months\"),F310/'Drug Acquisition Costs'!F503*I305,IF(AND('Drug Acquisition Costs'!H503=\"Days\",I306=\"Months\"),F310/'Drug Acquisition Costs'!F503*30.4375*I305,IF(AND('Drug Acquisition Costs'!H503=\"Months\",I306=\"Days\"),F310/'Drug Acquisition Costs'!F503/30.4375*I305,\"\"))))","v":""}]
["E",{"$f":"B298","v":"VAT on Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F298:I298,'Drug Acquisition Costs'!F505:'Drug Acquisition Costs'!I505)","v":0},{"$f":"F311*G305","v":0},{"$f":"IF('Drug Acquisition Costs'!H503=\"Days\",F311/'Drug Acquisition Costs'!F503*365.25,IF('Drug Acquisition Costs'!H503=\"Months\",F311/'Drug Acquisition Costs'!F503*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H503=\"Days\",I306=\"Days\"),F311/'Drug Acquisition Costs'!F503*I305,IF(AND('Drug Acquisition Costs'!H503=\"Months\",I306=\"Months\"),F311/'Drug Acquisition Costs'!F503*I305,IF(AND('Drug Acquisition Costs'!H504=\"Days\",I306=\"Months\"),F311/'Drug Acquisition Costs'!F503*30.4375*I305,IF(AND('Drug Acquisition Costs'!H503=\"Months\",I306=\"Days\"),F311/'Drug Acquisition Costs'!F503/30.4375*I305,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H535=\"\",\"\",'Drug Acquisition Costs'!H535)","v":""},{"$f":"IF(F312=\"\",\"\",F312*G305)","v":""},{"$f":"IF(F312=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H503=\"Days\",F312/'Drug Acquisition Costs'!F503*365.25,IF('Drug Acquisition Costs'!H503=\"Months\",F312/'Drug Acquisition Costs'!F503*12,\"\")), 744.36))","v":""},{"$f":"IF(F312=\"\",\"\",IF(AND('Drug Acquisition Costs'!H503=\"Days\",I306=\"Days\"),F312/'Drug Acquisition Costs'!F503*I305,IF(AND('Drug Acquisition Costs'!H503=\"Months\",I306=\"Months\"),F312/'Drug Acquisition Costs'!F503*I305,IF(AND('Drug Acquisition Costs'!H503=\"Days\",I306=\"Months\"),F312/'Drug Acquisition Costs'!F503*30.4375*I305,IF(AND('Drug Acquisition Costs'!H503=\"Months\",I306=\"Days\"),F312/'Drug Acquisition Costs'!F503/30.4375*I305,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H536=\"\",\"\",'Drug Acquisition Costs'!H536)","v":""},{"$f":"IF(F313=\"\",\"\",F313*G305)","v":""},{"$f":"IF(F313=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H503=\"Days\",F313/'Drug Acquisition Costs'!F503*365.25,IF('Drug Acquisition Costs'!H503=\"Months\",F313/'Drug Acquisition Costs'!F503*12,\"\")), 744.36))","v":""},{"$f":"IF(F313=\"\",\"\",IF(AND('Drug Acquisition Costs'!H503=\"Days\",I306=\"Days\"),F313/'Drug Acquisition Costs'!F503*I305,IF(AND('Drug Acquisition Costs'!H503=\"Months\",I306=\"Months\"),F313/'Drug Acquisition Costs'!F503*I305,IF(AND('Drug Acquisition Costs'!H503=\"Days\",I306=\"Months\"),F313/'Drug Acquisition Costs'!F503*30.4375*I305,IF(AND('Drug Acquisition Costs'!H503=\"Months\",I306=\"Days\"),F313/'Drug Acquisition Costs'!F503/30.4375*I305,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 5",null,null,null,{"$f":"SUM(F309:F312)","v":0},{"$f":"SUM(G309:G312)","v":0},{"$f":"SUM(H309:H312)","v":0},{"$f":"SUM(I309:I312)","v":0}]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 5",null,null,null,{"$f":"IF(F313=\"\",SUM(F309:F310),F309+F310+F313)","v":0},{"$f":"IF(G313=\"\",SUM(G309:G310),G309+G310+G313)","v":0},{"$f":"IF(H313=\"\",SUM(H309:H310),H309+H310+H313)","v":0},{"$f":"IF(I313=\"\",SUM(I309:I310),I309+I310+I313)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"'Drug Acquisition Costs'!B556","v":"Comparator 5: "},null,null,{"$f":"'Drug Acquisition Costs'!E556","v":0},{"$f":"IF($E319=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E319,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$318&\" Comparator 5\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E319=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E319,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$318&\" Comparator 5\"),$B:$B,0))","v":{"$error":"#N/A"}}]
[]
[null,"Notes"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 6: \",NameComparator6)","v":"Comparator 6: "}]
[]
[null,"Total Rebate (Including framework agreement and CIC) ",null,null,{"$f":"IF(ISNUMBER('Drug Acquisition Costs'!E604),ABS('Drug Acquisition Costs'!E604),0)","v":0}]
[]
[null,"Table C. Total Cost to the HSE per pack"]
[]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!F600=\"\",\"\",'Drug Acquisition Costs'!F600)","v":""},{"$f":"IF('Drug Acquisition Costs'!G600=\"\",\"\",'Drug Acquisition Costs'!G600)","v":""},{"$f":"IF('Drug Acquisition Costs'!H600=\"\",\"\",'Drug Acquisition Costs'!H600)","v":""},{"$f":"IF('Drug Acquisition Costs'!I600=\"\",\"\",'Drug Acquisition Costs'!I600)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F580=\"\",'Drug Acquisition Costs'!F581=\"\",'Drug Acquisition Costs'!$F582=\"\"),\"\",IF('Drug Acquisition Costs'!F580=\"Price to Wholesaler\",'Drug Acquisition Costs'!F581,IF('Drug Acquisition Costs'!F580=\"Reimbursement Price\",(F343/(1+$E342)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G580=\"\",'Drug Acquisition Costs'!G581=\"\",'Drug Acquisition Costs'!$F582=\"\"),\"\",IF('Drug Acquisition Costs'!G580=\"Price to Wholesaler\",'Drug Acquisition Costs'!G581,IF('Drug Acquisition Costs'!G580=\"Reimbursement Price\",(G343/(1+$E342)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H580=\"\",'Drug Acquisition Costs'!H581=\"\",'Drug Acquisition Costs'!$F582=\"\"),\"\",IF('Drug Acquisition Costs'!H580=\"Price to Wholesaler\",'Drug Acquisition Costs'!H581,IF('Drug Acquisition Costs'!H580=\"Reimbursement Price\",(H343/(1+$E342)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I580=\"\",'Drug Acquisition Costs'!I581=\"\",'Drug Acquisition Costs'!$F582=\"\"),\"\",IF('Drug Acquisition Costs'!I580=\"Price to Wholesaler\",'Drug Acquisition Costs'!I581,IF('Drug Acquisition Costs'!I580=\"Reimbursement Price\",(I343/(1+$E342)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F582=\"\"),\"\",IF(AND('Drug Acquisition Costs'!F582=\"CDS\",'Drug Acquisition Costs'!F583=\"Yes\"),CYF,IF(AND('Drug Acquisition Costs'!F582=\"CDS\",'Drug Acquisition Costs'!F583=\"No\"),CNF,IF('Drug Acquisition Costs'!F582=\"HT\",CHT,IF('Drug Acquisition Costs'!F582=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F582=\"\",'Drug Acquisition Costs'!F581=\"\",'Drug Acquisition Costs'!F580=\"\"),\"\",F341*$E342)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F582=\"\",'Drug Acquisition Costs'!G581=\"\",'Drug Acquisition Costs'!G580=\"\"),\"\",G341*$E342)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F582=\"\",'Drug Acquisition Costs'!H581=\"\",'Drug Acquisition Costs'!H580=\"\"),\"\",H341*$E342)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F582=\"\",'Drug Acquisition Costs'!I581=\"\",'Drug Acquisition Costs'!I580=\"\"),\"\",I341*$E342)","v":""}]
["C",{"$f":"IF('Drug Acquisition Costs'!F342=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF('Drug Acquisition Costs'!F580=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF('Drug Acquisition Costs'!F580=\"Reimbursement Price\",'Drug Acquisition Costs'!F581,IF(ISBLANK($E342),\"\",IF('Drug Acquisition Costs'!F580=\"Price to Wholesaler\",(F341+F342),IF('Drug Acquisition Costs'!F580=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!G580=\"Reimbursement Price\",'Drug Acquisition Costs'!G581,IF(ISBLANK($E342),\"\",IF('Drug Acquisition Costs'!G580=\"Price to Wholesaler\",(G341+G342),IF('Drug Acquisition Costs'!G580=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!H580=\"Reimbursement Price\",'Drug Acquisition Costs'!H581,IF(ISBLANK($E342),\"\",IF('Drug Acquisition Costs'!H580=\"Price to Wholesaler\",(H341+H342),IF('Drug Acquisition Costs'!H580=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!I580=\"Reimbursement Price\",'Drug Acquisition Costs'!I581,IF(ISBLANK($E342),\"\",IF('Drug Acquisition Costs'!I580=\"Price to Wholesaler\",(I341+I342),IF('Drug Acquisition Costs'!I580=\"\",\"\",\"Error\"))))","v":""}]
["D","Total Rebate (Including framework agreement and CIC) ",null,null,null,{"$f":"IF('Drug Acquisition Costs'!F581=\"\", \"\", F341*IF($E335=\"\", \"\", -$E335))","v":""},{"$f":"IF('Drug Acquisition Costs'!G581=\"\", \"\", G341*IF($E335=\"\", \"\", -$E335))","v":""},{"$f":"IF('Drug Acquisition Costs'!H581=\"\", \"\", H341*IF($E335=\"\", \"\", -$E335))","v":""},{"$f":"IF('Drug Acquisition Costs'!I581=\"\", \"\", I341*IF($E335=\"\", \"\", -$E335))","v":""}]
["E","Net price (PtW less total rebate)",null,null,null,{"$f":"IFERROR(F341+F344,\"\")","v":""},{"$f":"IFERROR(G341+G344,\"\")","v":""},{"$f":"IFERROR(H341+H344,\"\")","v":""},{"$f":"IFERROR(I341+I344,\"\")","v":""}]
["F","VAT on Reimbursement Price",null,null,{"$f":"IF('Drug Acquisition Costs'!F584=\"\",\"\",IF('Drug Acquisition Costs'!F584=\"Yes\",0,VT))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!F581=\"\",ISBLANK('Drug Acquisition Costs'!F581)),\"\",($E346*F343))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G581=\"\",ISBLANK('Drug Acquisition Costs'!G581)),\"\",($E346*G343))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H581=\"\",ISBLANK('Drug Acquisition Costs'!H581)),\"\",($E346*H343))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I581=\"\",ISBLANK('Drug Acquisition Costs'!I581)),\"\",($E346*I343))","v":""}]
["G(i)","Total Drug Cost to the HSE per pack with CIC PAS including VAT (B+E+F)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F580=\"\",'Drug Acquisition Costs'!$F582=\"\",'Drug Acquisition Costs'!$F584=\"\",'Drug Acquisition Costs'!$F585=\"\"),\"\",F342+F345+F346)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G580=\"\",'Drug Acquisition Costs'!$F582=\"\",'Drug Acquisition Costs'!$F584=\"\",'Drug Acquisition Costs'!$F585=\"\"),\"\",G342+G345+G346)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H580=\"\",'Drug Acquisition Costs'!$F582=\"\",'Drug Acquisition Costs'!$F584=\"\",'Drug Acquisition Costs'!$F585=\"\"),\"\",H342+H345+H346)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I580=\"\",'Drug Acquisition Costs'!$F582=\"\",'Drug Acquisition Costs'!$F584=\"\",'Drug Acquisition Costs'!$F585=\"\"),\"\",I342+I345+I346)","v":""}]
["G(ii)","Total Drug Cost to the HSE per pack with CIC PAS excluding VAT (B+E)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F580=\"\",'Drug Acquisition Costs'!$F582=\"\",'Drug Acquisition Costs'!$F584=\"\",'Drug Acquisition Costs'!$F585=\"\"),\"\",F342+F345)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G580=\"\",'Drug Acquisition Costs'!$F582=\"\",'Drug Acquisition Costs'!$F584=\"\",'Drug Acquisition Costs'!$F585=\"\"),\"\",G342+G345)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H580=\"\",'Drug Acquisition Costs'!$F582=\"\",'Drug Acquisition Costs'!$F584=\"\",'Drug Acquisition Costs'!$F585=\"\"),\"\",H342+H345)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I580=\"\",'Drug Acquisition Costs'!$F582=\"\",'Drug Acquisition Costs'!$F584=\"\",'Drug Acquisition Costs'!$F585=\"\"),\"\",I342+I345)","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time"]
[null,null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!G630=\"\",0,'Drug Acquisition Costs'!G630)","v":0},null,{"$f":"IF('Drug Acquisition Costs'!I630=\"\",\"\",'Drug Acquisition Costs'!I630)","v":""}]
[null,null,null,null,null,null,"number of cycles",null,{"$f":"IF('Drug Acquisition Costs'!I631=\"\",\"\",'Drug Acquisition Costs'!I631)","v":""}]
["A",{"$f":"B341","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F341:I341,'Drug Acquisition Costs'!F593:'Drug Acquisition Costs'!I593)","v":0},{"$f":"F355*G353","v":0},{"$f":"IF('Drug Acquisition Costs'!H591=\"Days\",F355/'Drug Acquisition Costs'!F591*365.25,IF('Drug Acquisition Costs'!H591=\"Months\",F355/'Drug Acquisition Costs'!F591*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H591=\"Days\",I354=\"Days\"),F355/'Drug Acquisition Costs'!F591*I353,IF(AND('Drug Acquisition Costs'!H591=\"Months\",I354=\"Months\"),F355/'Drug Acquisition Costs'!F591*I353,IF(AND('Drug Acquisition Costs'!H591=\"Days\",I354=\"Months\"),F355/'Drug Acquisition Costs'!F591*30.4375*I353,IF(AND('Drug Acquisition Costs'!H591=\"Months\",I354=\"Days\"),F355/'Drug Acquisition Costs'!F591/30.4375*I353,\"\"))))","v":""}]
["B",{"$f":"B342","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F342:I342,'Drug Acquisition Costs'!F593:'Drug Acquisition Costs'!I593)","v":0},{"$f":"F356*G353","v":0},{"$f":"IF('Drug Acquisition Costs'!H591=\"Days\",F356/'Drug Acquisition Costs'!F591*365.25,IF('Drug Acquisition Costs'!H591=\"Months\",F356/'Drug Acquisition Costs'!F591*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H591=\"Days\",I354=\"Days\"),F356/'Drug Acquisition Costs'!F591*I353,IF(AND('Drug Acquisition Costs'!H591=\"Months\",I354=\"Months\"),F356/'Drug Acquisition Costs'!F591*I353,IF(AND('Drug Acquisition Costs'!H591=\"Days\",I354=\"Months\"),F356/'Drug Acquisition Costs'!F591*30.4375*I353,IF(AND('Drug Acquisition Costs'!H591=\"Months\",I354=\"Days\"),F356/'Drug Acquisition Costs'!F591/30.4375*I353,\"\"))))","v":""}]
["C",{"$f":"B343","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F343:I343,'Drug Acquisition Costs'!F593:'Drug Acquisition Costs'!I593)","v":0},{"$f":"F357*G353","v":0},{"$f":"IF('Drug Acquisition Costs'!H591=\"Days\",F357/'Drug Acquisition Costs'!F591*365.25,IF('Drug Acquisition Costs'!H591=\"Months\",F357/'Drug Acquisition Costs'!F591*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H591=\"Days\",I354=\"Days\"),F357/'Drug Acquisition Costs'!F591*I353,IF(AND('Drug Acquisition Costs'!H591=\"Months\",I354=\"Months\"),F357/'Drug Acquisition Costs'!F591*I353,IF(AND('Drug Acquisition Costs'!H591=\"Days\",I354=\"Months\"),F357/'Drug Acquisition Costs'!F591*30.4375*I353,IF(AND('Drug Acquisition Costs'!H591=\"Months\",I354=\"Days\"),F357/'Drug Acquisition Costs'!F591/30.4375*I353,\"\"))))","v":""}]
["D","CIC PAS (inclusive of framework agreement rebate)",null,null,null,{"$f":"SUMPRODUCT(F344:I344,'Drug Acquisition Costs'!F593:'Drug Acquisition Costs'!I593)","v":0},{"$f":" F358*G353","v":0},{"$f":"IF('Drug Acquisition Costs'!H591=\"Days\",F358/'Drug Acquisition Costs'!F591*365.25,IF('Drug Acquisition Costs'!H591=\"Months\",F358/'Drug Acquisition Costs'!F591*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H591=\"Days\",I354=\"Days\"),F358/'Drug Acquisition Costs'!F591*I353,IF(AND('Drug Acquisition Costs'!H591=\"Months\",I354=\"Months\"),F358/'Drug Acquisition Costs'!F591*I353,IF(AND('Drug Acquisition Costs'!H591=\"Days\",I354=\"Months\"),F358/'Drug Acquisition Costs'!F591*30.4375*I353,IF(AND('Drug Acquisition Costs'!H591=\"Months\",I354=\"Days\"),F358/'Drug Acquisition Costs'!F591/30.4375*I353,\"\"))))","v":""}]
["E",{"$f":"B346","v":"VAT on Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F346:I346,'Drug Acquisition Costs'!F593:'Drug Acquisition Costs'!I593)","v":0},{"$f":"F359*G353","v":0},{"$f":"IF('Drug Acquisition Costs'!H591=\"Days\",F359/'Drug Acquisition Costs'!F591*365.25,IF('Drug Acquisition Costs'!H591=\"Months\",F359/'Drug Acquisition Costs'!F591*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H591=\"Days\",I354=\"Days\"),F359/'Drug Acquisition Costs'!F591*I353,IF(AND('Drug Acquisition Costs'!H591=\"Months\",I354=\"Months\"),F359/'Drug Acquisition Costs'!F591*I353,IF(AND('Drug Acquisition Costs'!H592=\"Days\",I354=\"Months\"),F359/'Drug Acquisition Costs'!F591*30.4375*I353,IF(AND('Drug Acquisition Costs'!H591=\"Months\",I354=\"Days\"),F359/'Drug Acquisition Costs'!F591/30.4375*I353,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H623=\"\",\"\",'Drug Acquisition Costs'!H623)","v":""},{"$f":"IF(F360=\"\",\"\",F360*G353)","v":""},{"$f":"IF(F360=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H591=\"Days\",F360/'Drug Acquisition Costs'!F591*365.25,IF('Drug Acquisition Costs'!H591=\"Months\",F360/'Drug Acquisition Costs'!F591*12,\"\")), 744.36))","v":""},{"$f":"IF(F360=\"\",\"\",IF(AND('Drug Acquisition Costs'!H591=\"Days\",I354=\"Days\"),F360/'Drug Acquisition Costs'!F591*I353,IF(AND('Drug Acquisition Costs'!H591=\"Months\",I354=\"Months\"),F360/'Drug Acquisition Costs'!F591*I353,IF(AND('Drug Acquisition Costs'!H591=\"Days\",I354=\"Months\"),F360/'Drug Acquisition Costs'!F591*30.4375*I353,IF(AND('Drug Acquisition Costs'!H591=\"Months\",I354=\"Days\"),F360/'Drug Acquisition Costs'!F591/30.4375*I353,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H624=\"\",\"\",'Drug Acquisition Costs'!H624)","v":""},{"$f":"IF(F361=\"\",\"\",F361*G353)","v":""},{"$f":"IF(F361=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H591=\"Days\",F361/'Drug Acquisition Costs'!F591*365.25,IF('Drug Acquisition Costs'!H591=\"Months\",F361/'Drug Acquisition Costs'!F591*12,\"\")), 744.36))","v":""},{"$f":"IF(F361=\"\",\"\",IF(AND('Drug Acquisition Costs'!H591=\"Days\",I354=\"Days\"),F361/'Drug Acquisition Costs'!F591*I353,IF(AND('Drug Acquisition Costs'!H591=\"Months\",I354=\"Months\"),F361/'Drug Acquisition Costs'!F591*I353,IF(AND('Drug Acquisition Costs'!H591=\"Days\",I354=\"Months\"),F361/'Drug Acquisition Costs'!F591*30.4375*I353,IF(AND('Drug Acquisition Costs'!H591=\"Months\",I354=\"Days\"),F361/'Drug Acquisition Costs'!F591/30.4375*I353,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 6",null,null,null,{"$f":"SUM(F357:F360)","v":0},{"$f":"SUM(G357:G360)","v":0},{"$f":"SUM(H357:H360)","v":0},{"$f":"SUM(I357:I360)","v":0}]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 6",null,null,null,{"$f":"IF(F361=\"\",SUM(F357:F358),F357+F358+F361)","v":0},{"$f":"IF(G361=\"\",SUM(G357:G358),G357+G358+G361)","v":0},{"$f":"IF(H361=\"\",SUM(H357:H358),H357+H358+H361)","v":0},{"$f":"IF(I361=\"\",SUM(I357:I358),I357+I358+I361)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"'Drug Acquisition Costs'!B644","v":"Comparator 6: "},null,null,{"$f":"'Drug Acquisition Costs'!E644","v":0},{"$f":"IF($E367=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E367,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$366&\" Comparator 6\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E367=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E367,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$76&\" Comparator 6\"),$B:$B,0))","v":{"$error":"#N/A"}}]
[]
[null,"Notes"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 7: \",NameComparator7)","v":"Comparator 7: "}]
[]
[null,"Total Rebate (Including framework agreement and CIC) ",null,null,{"$f":"IF(ISNUMBER('Drug Acquisition Costs'!E692),ABS('Drug Acquisition Costs'!E692),0)","v":0}]
[]
[null,"Table C. Total Cost to the HSE per pack"]
[]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!F688=\"\",\"\",'Drug Acquisition Costs'!F688)","v":""},{"$f":"IF('Drug Acquisition Costs'!G688=\"\",\"\",'Drug Acquisition Costs'!G688)","v":""},{"$f":"IF('Drug Acquisition Costs'!H688=\"\",\"\",'Drug Acquisition Costs'!H688)","v":""},{"$f":"IF('Drug Acquisition Costs'!I688=\"\",\"\",'Drug Acquisition Costs'!I688)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F668=\"\",'Drug Acquisition Costs'!F669=\"\",'Drug Acquisition Costs'!$F670=\"\"),\"\",IF('Drug Acquisition Costs'!F668=\"Price to Wholesaler\",'Drug Acquisition Costs'!F669,IF('Drug Acquisition Costs'!F668=\"Reimbursement Price\",(F391/(1+$E390)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G668=\"\",'Drug Acquisition Costs'!G669=\"\",'Drug Acquisition Costs'!$F670=\"\"),\"\",IF('Drug Acquisition Costs'!G668=\"Price to Wholesaler\",'Drug Acquisition Costs'!G669,IF('Drug Acquisition Costs'!G668=\"Reimbursement Price\",(G391/(1+$E390)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H668=\"\",'Drug Acquisition Costs'!H669=\"\",'Drug Acquisition Costs'!$F670=\"\"),\"\",IF('Drug Acquisition Costs'!H668=\"Price to Wholesaler\",'Drug Acquisition Costs'!H669,IF('Drug Acquisition Costs'!H668=\"Reimbursement Price\",(H391/(1+$E390)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I668=\"\",'Drug Acquisition Costs'!I669=\"\",'Drug Acquisition Costs'!$F670=\"\"),\"\",IF('Drug Acquisition Costs'!I668=\"Price to Wholesaler\",'Drug Acquisition Costs'!I669,IF('Drug Acquisition Costs'!I668=\"Reimbursement Price\",(I391/(1+$E390)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F670=\"\"),\"\",IF(AND('Drug Acquisition Costs'!F670=\"CDS\",'Drug Acquisition Costs'!F671=\"Yes\"),CYF,IF(AND('Drug Acquisition Costs'!F670=\"CDS\",'Drug Acquisition Costs'!F671=\"No\"),CNF,IF('Drug Acquisition Costs'!F670=\"HT\",CHT,IF('Drug Acquisition Costs'!F670=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F670=\"\",'Drug Acquisition Costs'!F669=\"\",'Drug Acquisition Costs'!F668=\"\"),\"\",F389*$E390)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F670=\"\",'Drug Acquisition Costs'!G669=\"\",'Drug Acquisition Costs'!G668=\"\"),\"\",G389*$E390)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F670=\"\",'Drug Acquisition Costs'!H669=\"\",'Drug Acquisition Costs'!H668=\"\"),\"\",H389*$E390)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F670=\"\",'Drug Acquisition Costs'!I669=\"\",'Drug Acquisition Costs'!I668=\"\"),\"\",I389*$E390)","v":""}]
["C",{"$f":"IF('Drug Acquisition Costs'!F390=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF('Drug Acquisition Costs'!F668=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF('Drug Acquisition Costs'!F668=\"Reimbursement Price\",'Drug Acquisition Costs'!F669,IF(ISBLANK($E390),\"\",IF('Drug Acquisition Costs'!F668=\"Price to Wholesaler\",(F389+F390),IF('Drug Acquisition Costs'!F668=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!G668=\"Reimbursement Price\",'Drug Acquisition Costs'!G669,IF(ISBLANK($E390),\"\",IF('Drug Acquisition Costs'!G668=\"Price to Wholesaler\",(G389+G390),IF('Drug Acquisition Costs'!G668=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!H668=\"Reimbursement Price\",'Drug Acquisition Costs'!H669,IF(ISBLANK($E390),\"\",IF('Drug Acquisition Costs'!H668=\"Price to Wholesaler\",(H389+H390),IF('Drug Acquisition Costs'!H668=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!I668=\"Reimbursement Price\",'Drug Acquisition Costs'!I669,IF(ISBLANK($E390),\"\",IF('Drug Acquisition Costs'!I668=\"Price to Wholesaler\",(I389+I390),IF('Drug Acquisition Costs'!I668=\"\",\"\",\"Error\"))))","v":""}]
["D","Total Rebate (Including framework agreement and CIC) ",null,null,null,{"$f":"IF('Drug Acquisition Costs'!F669=\"\", \"\", F389*IF($E383=\"\", \"\", -$E383))","v":""},{"$f":"IF('Drug Acquisition Costs'!G669=\"\", \"\", G389*IF($E383=\"\", \"\", -$E383))","v":""},{"$f":"IF('Drug Acquisition Costs'!H669=\"\", \"\", H389*IF($E383=\"\", \"\", -$E383))","v":""},{"$f":"IF('Drug Acquisition Costs'!I669=\"\", \"\", I389*IF($E383=\"\", \"\", -$E383))","v":""}]
["E","Net price (PtW less total rebate)",null,null,null,{"$f":"IFERROR(F389+F392,\"\")","v":""},{"$f":"IFERROR(G389+G392,\"\")","v":""},{"$f":"IFERROR(H389+H392,\"\")","v":""},{"$f":"IFERROR(I389+I392,\"\")","v":""}]
["F","VAT on Reimbursement Price",null,null,{"$f":"IF('Drug Acquisition Costs'!F672=\"\",\"\",IF('Drug Acquisition Costs'!F672=\"Yes\",0,VT))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!F669=\"\",ISBLANK('Drug Acquisition Costs'!F669)),\"\",($E394*F391))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G669=\"\",ISBLANK('Drug Acquisition Costs'!G669)),\"\",($E394*G391))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H669=\"\",ISBLANK('Drug Acquisition Costs'!H669)),\"\",($E394*H391))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I669=\"\",ISBLANK('Drug Acquisition Costs'!I669)),\"\",($E394*I391))","v":""}]
["G(i)","Total Drug Cost to the HSE per pack with CIC PAS including VAT (B+E+F)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F668=\"\",'Drug Acquisition Costs'!$F670=\"\",'Drug Acquisition Costs'!$F672=\"\",'Drug Acquisition Costs'!$F673=\"\"),\"\",F390+F393+F394)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G668=\"\",'Drug Acquisition Costs'!$F670=\"\",'Drug Acquisition Costs'!$F672=\"\",'Drug Acquisition Costs'!$F673=\"\"),\"\",G390+G393+G394)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H668=\"\",'Drug Acquisition Costs'!$F670=\"\",'Drug Acquisition Costs'!$F672=\"\",'Drug Acquisition Costs'!$F673=\"\"),\"\",H390+H393+H394)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I668=\"\",'Drug Acquisition Costs'!$F670=\"\",'Drug Acquisition Costs'!$F672=\"\",'Drug Acquisition Costs'!$F673=\"\"),\"\",I390+I393+I394)","v":""}]
["G(ii)","Total Drug Cost to the HSE per pack with CIC PAS excluding VAT (B+E)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F668=\"\",'Drug Acquisition Costs'!$F670=\"\",'Drug Acquisition Costs'!$F672=\"\",'Drug Acquisition Costs'!$F673=\"\"),\"\",F390+F393)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G668=\"\",'Drug Acquisition Costs'!$F670=\"\",'Drug Acquisition Costs'!$F672=\"\",'Drug Acquisition Costs'!$F673=\"\"),\"\",G390+G393)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H668=\"\",'Drug Acquisition Costs'!$F670=\"\",'Drug Acquisition Costs'!$F672=\"\",'Drug Acquisition Costs'!$F673=\"\"),\"\",H390+H393)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I668=\"\",'Drug Acquisition Costs'!$F670=\"\",'Drug Acquisition Costs'!$F672=\"\",'Drug Acquisition Costs'!$F673=\"\"),\"\",I390+I393)","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time"]
[null,null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!G718=\"\",0,'Drug Acquisition Costs'!G718)","v":0},null,{"$f":"IF('Drug Acquisition Costs'!I718=\"\",\"\",'Drug Acquisition Costs'!I718)","v":""}]
[null,null,null,null,null,null,"number of cycles",null,{"$f":"IF('Drug Acquisition Costs'!I719=\"\",\"\",'Drug Acquisition Costs'!I719)","v":""}]
["A",{"$f":"B389","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F389:I389,'Drug Acquisition Costs'!F681:'Drug Acquisition Costs'!I681)","v":0},{"$f":"F403*G401","v":0},{"$f":"IF('Drug Acquisition Costs'!H679=\"Days\",F403/'Drug Acquisition Costs'!F679*365.25,IF('Drug Acquisition Costs'!H679=\"Months\",F403/'Drug Acquisition Costs'!F679*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H679=\"Days\",I402=\"Days\"),F403/'Drug Acquisition Costs'!F679*I401,IF(AND('Drug Acquisition Costs'!H679=\"Months\",I402=\"Months\"),F403/'Drug Acquisition Costs'!F679*I401,IF(AND('Drug Acquisition Costs'!H679=\"Days\",I402=\"Months\"),F403/'Drug Acquisition Costs'!F679*30.4375*I401,IF(AND('Drug Acquisition Costs'!H679=\"Months\",I402=\"Days\"),F403/'Drug Acquisition Costs'!F679/30.4375*I401,\"\"))))","v":""}]
["B",{"$f":"B390","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F390:I390,'Drug Acquisition Costs'!F681:'Drug Acquisition Costs'!I681)","v":0},{"$f":"F404*G401","v":0},{"$f":"IF('Drug Acquisition Costs'!H679=\"Days\",F404/'Drug Acquisition Costs'!F679*365.25,IF('Drug Acquisition Costs'!H679=\"Months\",F404/'Drug Acquisition Costs'!F679*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H679=\"Days\",I402=\"Days\"),F404/'Drug Acquisition Costs'!F679*I401,IF(AND('Drug Acquisition Costs'!H679=\"Months\",I402=\"Months\"),F404/'Drug Acquisition Costs'!F679*I401,IF(AND('Drug Acquisition Costs'!H679=\"Days\",I402=\"Months\"),F404/'Drug Acquisition Costs'!F679*30.4375*I401,IF(AND('Drug Acquisition Costs'!H679=\"Months\",I402=\"Days\"),F404/'Drug Acquisition Costs'!F679/30.4375*I401,\"\"))))","v":""}]
["C",{"$f":"B391","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F391:I391,'Drug Acquisition Costs'!F681:'Drug Acquisition Costs'!I681)","v":0},{"$f":"F405*G401","v":0},{"$f":"IF('Drug Acquisition Costs'!H679=\"Days\",F405/'Drug Acquisition Costs'!F679*365.25,IF('Drug Acquisition Costs'!H679=\"Months\",F405/'Drug Acquisition Costs'!F679*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H679=\"Days\",I402=\"Days\"),F405/'Drug Acquisition Costs'!F679*I401,IF(AND('Drug Acquisition Costs'!H679=\"Months\",I402=\"Months\"),F405/'Drug Acquisition Costs'!F679*I401,IF(AND('Drug Acquisition Costs'!H679=\"Days\",I402=\"Months\"),F405/'Drug Acquisition Costs'!F679*30.4375*I401,IF(AND('Drug Acquisition Costs'!H679=\"Months\",I402=\"Days\"),F405/'Drug Acquisition Costs'!F679/30.4375*I401,\"\"))))","v":""}]
["D","CIC PAS (inclusive of framework agreement rebate)",null,null,null,{"$f":"SUMPRODUCT(F392:I392,'Drug Acquisition Costs'!F681:'Drug Acquisition Costs'!I681)","v":0},{"$f":" F406*G401","v":0},{"$f":"IF('Drug Acquisition Costs'!H679=\"Days\",F406/'Drug Acquisition Costs'!F679*365.25,IF('Drug Acquisition Costs'!H679=\"Months\",F406/'Drug Acquisition Costs'!F679*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H679=\"Days\",I402=\"Days\"),F406/'Drug Acquisition Costs'!F679*I401,IF(AND('Drug Acquisition Costs'!H679=\"Months\",I402=\"Months\"),F406/'Drug Acquisition Costs'!F679*I401,IF(AND('Drug Acquisition Costs'!H679=\"Days\",I402=\"Months\"),F406/'Drug Acquisition Costs'!F679*30.4375*I401,IF(AND('Drug Acquisition Costs'!H679=\"Months\",I402=\"Days\"),F406/'Drug Acquisition Costs'!F679/30.4375*I401,\"\"))))","v":""}]
["E",{"$f":"B394","v":"VAT on Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F394:I394,'Drug Acquisition Costs'!F681:'Drug Acquisition Costs'!I681)","v":0},{"$f":"F407*G401","v":0},{"$f":"IF('Drug Acquisition Costs'!H679=\"Days\",F407/'Drug Acquisition Costs'!F679*365.25,IF('Drug Acquisition Costs'!H679=\"Months\",F407/'Drug Acquisition Costs'!F679*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H679=\"Days\",I402=\"Days\"),F407/'Drug Acquisition Costs'!F679*I401,IF(AND('Drug Acquisition Costs'!H679=\"Months\",I402=\"Months\"),F407/'Drug Acquisition Costs'!F679*I401,IF(AND('Drug Acquisition Costs'!H680=\"Days\",I402=\"Months\"),F407/'Drug Acquisition Costs'!F679*30.4375*I401,IF(AND('Drug Acquisition Costs'!H679=\"Months\",I402=\"Days\"),F407/'Drug Acquisition Costs'!F679/30.4375*I401,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H711=\"\",\"\",'Drug Acquisition Costs'!H711)","v":""},{"$f":"IF(F408=\"\",\"\",F408*G401)","v":""},{"$f":"IF(F408=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H679=\"Days\",F408/'Drug Acquisition Costs'!F679*365.25,IF('Drug Acquisition Costs'!H679=\"Months\",F408/'Drug Acquisition Costs'!F679*12,\"\")), 744.36))","v":""},{"$f":"IF(F408=\"\",\"\",IF(AND('Drug Acquisition Costs'!H679=\"Days\",I402=\"Days\"),F408/'Drug Acquisition Costs'!F679*I401,IF(AND('Drug Acquisition Costs'!H679=\"Months\",I402=\"Months\"),F408/'Drug Acquisition Costs'!F679*I401,IF(AND('Drug Acquisition Costs'!H679=\"Days\",I402=\"Months\"),F408/'Drug Acquisition Costs'!F679*30.4375*I401,IF(AND('Drug Acquisition Costs'!H679=\"Months\",I402=\"Days\"),F408/'Drug Acquisition Costs'!F679/30.4375*I401,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H712=\"\",\"\",'Drug Acquisition Costs'!H712)","v":""},{"$f":"IF(F409=\"\",\"\",F409*G401)","v":""},{"$f":"IF(F409=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H679=\"Days\",F409/'Drug Acquisition Costs'!F679*365.25,IF('Drug Acquisition Costs'!H679=\"Months\",F409/'Drug Acquisition Costs'!F679*12,\"\")), 744.36))","v":""},{"$f":"IF(F409=\"\",\"\",IF(AND('Drug Acquisition Costs'!H679=\"Days\",I402=\"Days\"),F409/'Drug Acquisition Costs'!F679*I401,IF(AND('Drug Acquisition Costs'!H679=\"Months\",I402=\"Months\"),F409/'Drug Acquisition Costs'!F679*I401,IF(AND('Drug Acquisition Costs'!H679=\"Days\",I402=\"Months\"),F409/'Drug Acquisition Costs'!F679*30.4375*I401,IF(AND('Drug Acquisition Costs'!H679=\"Months\",I402=\"Days\"),F409/'Drug Acquisition Costs'!F679/30.4375*I401,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 7",null,null,null,{"$f":"SUM(F405:F408)","v":0},{"$f":"SUM(G405:G408)","v":0},{"$f":"SUM(H405:H408)","v":0},{"$f":"SUM(I405:I408)","v":0}]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 7",null,null,null,{"$f":"IF(F409=\"\",SUM(F405:F406),F405+F406+F409)","v":0},{"$f":"IF(G409=\"\",SUM(G405:G406),G405+G406+G409)","v":0},{"$f":"IF(H409=\"\",SUM(H405:H406),H405+H406+H409)","v":0},{"$f":"IF(I409=\"\",SUM(I405:I406),I405+I406+I409)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"'Drug Acquisition Costs'!B732","v":"Comparator 7: "},null,null,{"$f":"'Drug Acquisition Costs'!E732","v":0},{"$f":"IF($E415=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E415,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$414&\" Comparator 7\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E415=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E415,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$414&\" Comparator 7\"),$B:$B,0))","v":{"$error":"#N/A"}}]
[]
[null,"Notes"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 8: \",NameComparator8)","v":"Comparator 8: "}]
[]
[null,"Total Rebate (Including framework agreement and CIC) ",null,null,{"$f":"IF(ISNUMBER('Drug Acquisition Costs'!E780),ABS('Drug Acquisition Costs'!E780),0)","v":0}]
[]
[null,"Table C. Total Cost to the HSE per pack"]
[]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!F776=\"\",\"\",'Drug Acquisition Costs'!F776)","v":""},{"$f":"IF('Drug Acquisition Costs'!G776=\"\",\"\",'Drug Acquisition Costs'!G776)","v":""},{"$f":"IF('Drug Acquisition Costs'!H776=\"\",\"\",'Drug Acquisition Costs'!H776)","v":""},{"$f":"IF('Drug Acquisition Costs'!I776=\"\",\"\",'Drug Acquisition Costs'!I776)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F756=\"\",'Drug Acquisition Costs'!F757=\"\",'Drug Acquisition Costs'!$F758=\"\"),\"\",IF('Drug Acquisition Costs'!F756=\"Price to Wholesaler\",'Drug Acquisition Costs'!F757,IF('Drug Acquisition Costs'!F756=\"Reimbursement Price\",(F439/(1+$E438)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G756=\"\",'Drug Acquisition Costs'!G757=\"\",'Drug Acquisition Costs'!$F758=\"\"),\"\",IF('Drug Acquisition Costs'!G756=\"Price to Wholesaler\",'Drug Acquisition Costs'!G757,IF('Drug Acquisition Costs'!G756=\"Reimbursement Price\",(G439/(1+$E438)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H756=\"\",'Drug Acquisition Costs'!H757=\"\",'Drug Acquisition Costs'!$F758=\"\"),\"\",IF('Drug Acquisition Costs'!H756=\"Price to Wholesaler\",'Drug Acquisition Costs'!H757,IF('Drug Acquisition Costs'!H756=\"Reimbursement Price\",(H439/(1+$E438)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I756=\"\",'Drug Acquisition Costs'!I757=\"\",'Drug Acquisition Costs'!$F758=\"\"),\"\",IF('Drug Acquisition Costs'!I756=\"Price to Wholesaler\",'Drug Acquisition Costs'!I757,IF('Drug Acquisition Costs'!I756=\"Reimbursement Price\",(I439/(1+$E438)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F758=\"\"),\"\",IF(AND('Drug Acquisition Costs'!F758=\"CDS\",'Drug Acquisition Costs'!F759=\"Yes\"),CYF,IF(AND('Drug Acquisition Costs'!F758=\"CDS\",'Drug Acquisition Costs'!F759=\"No\"),CNF,IF('Drug Acquisition Costs'!F758=\"HT\",CHT,IF('Drug Acquisition Costs'!F758=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F758=\"\",'Drug Acquisition Costs'!F757=\"\",'Drug Acquisition Costs'!F756=\"\"),\"\",F437*$E438)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F758=\"\",'Drug Acquisition Costs'!G757=\"\",'Drug Acquisition Costs'!G756=\"\"),\"\",G437*$E438)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F758=\"\",'Drug Acquisition Costs'!H757=\"\",'Drug Acquisition Costs'!H756=\"\"),\"\",H437*$E438)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F758=\"\",'Drug Acquisition Costs'!I757=\"\",'Drug Acquisition Costs'!I756=\"\"),\"\",I437*$E438)","v":""}]
["C",{"$f":"IF('Drug Acquisition Costs'!F438=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF('Drug Acquisition Costs'!F756=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF('Drug Acquisition Costs'!F756=\"Reimbursement Price\",'Drug Acquisition Costs'!F757,IF(ISBLANK($E438),\"\",IF('Drug Acquisition Costs'!F756=\"Price to Wholesaler\",(F437+F438),IF('Drug Acquisition Costs'!F756=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!G756=\"Reimbursement Price\",'Drug Acquisition Costs'!G757,IF(ISBLANK($E438),\"\",IF('Drug Acquisition Costs'!G756=\"Price to Wholesaler\",(G437+G438),IF('Drug Acquisition Costs'!G756=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!H756=\"Reimbursement Price\",'Drug Acquisition Costs'!H757,IF(ISBLANK($E438),\"\",IF('Drug Acquisition Costs'!H756=\"Price to Wholesaler\",(H437+H438),IF('Drug Acquisition Costs'!H756=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!I756=\"Reimbursement Price\",'Drug Acquisition Costs'!I757,IF(ISBLANK($E438),\"\",IF('Drug Acquisition Costs'!I756=\"Price to Wholesaler\",(I437+I438),IF('Drug Acquisition Costs'!I756=\"\",\"\",\"Error\"))))","v":""}]
["D","Total Rebate (Including framework agreement and CIC) ",null,null,null,{"$f":"IF('Drug Acquisition Costs'!F757=\"\", \"\", F437*IF($E431=\"\", \"\", -$E431))","v":""},{"$f":"IF('Drug Acquisition Costs'!G757=\"\", \"\", G437*IF($E431=\"\", \"\", -$E431))","v":""},{"$f":"IF('Drug Acquisition Costs'!H757=\"\", \"\", H437*IF($E431=\"\", \"\", -$E431))","v":""},{"$f":"IF('Drug Acquisition Costs'!I757=\"\", \"\", I437*IF($E431=\"\", \"\", -$E431))","v":""}]
["E","Net price (PtW less total rebate)",null,null,null,{"$f":"IFERROR(F437+F440,\"\")","v":""},{"$f":"IFERROR(G437+G440,\"\")","v":""},{"$f":"IFERROR(H437+H440,\"\")","v":""},{"$f":"IFERROR(I437+I440,\"\")","v":""}]
["F","VAT on Reimbursement Price",null,null,{"$f":"IF('Drug Acquisition Costs'!F760=\"\",\"\",IF('Drug Acquisition Costs'!F760=\"Yes\",0,VT))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!F757=\"\",ISBLANK('Drug Acquisition Costs'!F757)),\"\",($E442*F439))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G757=\"\",ISBLANK('Drug Acquisition Costs'!G757)),\"\",($E442*G439))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H757=\"\",ISBLANK('Drug Acquisition Costs'!H757)),\"\",($E442*H439))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I757=\"\",ISBLANK('Drug Acquisition Costs'!I757)),\"\",($E442*I439))","v":""}]
["G(i)","Total Drug Cost to the HSE per pack with CIC PAS including VAT (B+E+F)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F756=\"\",'Drug Acquisition Costs'!$F758=\"\",'Drug Acquisition Costs'!$F760=\"\",'Drug Acquisition Costs'!$F761=\"\"),\"\",F438+F441+F442)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G756=\"\",'Drug Acquisition Costs'!$F758=\"\",'Drug Acquisition Costs'!$F760=\"\",'Drug Acquisition Costs'!$F761=\"\"),\"\",G438+G441+G442)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H756=\"\",'Drug Acquisition Costs'!$F758=\"\",'Drug Acquisition Costs'!$F760=\"\",'Drug Acquisition Costs'!$F761=\"\"),\"\",H438+H441+H442)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I756=\"\",'Drug Acquisition Costs'!$F758=\"\",'Drug Acquisition Costs'!$F760=\"\",'Drug Acquisition Costs'!$F761=\"\"),\"\",I438+I441+I442)","v":""}]
["G(ii)","Total Drug Cost to the HSE per pack with CIC PAS excluding VAT (B+E)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F756=\"\",'Drug Acquisition Costs'!$F758=\"\",'Drug Acquisition Costs'!$F760=\"\",'Drug Acquisition Costs'!$F761=\"\"),\"\",F438+F441)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G756=\"\",'Drug Acquisition Costs'!$F758=\"\",'Drug Acquisition Costs'!$F760=\"\",'Drug Acquisition Costs'!$F761=\"\"),\"\",G438+G441)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H756=\"\",'Drug Acquisition Costs'!$F758=\"\",'Drug Acquisition Costs'!$F760=\"\",'Drug Acquisition Costs'!$F761=\"\"),\"\",H438+H441)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I756=\"\",'Drug Acquisition Costs'!$F758=\"\",'Drug Acquisition Costs'!$F760=\"\",'Drug Acquisition Costs'!$F761=\"\"),\"\",I438+I441)","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time"]
[null,null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!G806=\"\",0,'Drug Acquisition Costs'!G806)","v":0},null,{"$f":"IF('Drug Acquisition Costs'!I806=\"\",\"\",'Drug Acquisition Costs'!I806)","v":""}]
[null,null,null,null,null,null,"number of cycles",null,{"$f":"IF('Drug Acquisition Costs'!I807=\"\",\"\",'Drug Acquisition Costs'!I807)","v":""}]
["A",{"$f":"B437","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F437:I437,'Drug Acquisition Costs'!F769:'Drug Acquisition Costs'!I769)","v":0},{"$f":"F451*G449","v":0},{"$f":"IF('Drug Acquisition Costs'!H767=\"Days\",F451/'Drug Acquisition Costs'!F767*365.25,IF('Drug Acquisition Costs'!H767=\"Months\",F451/'Drug Acquisition Costs'!F767*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H767=\"Days\",I450=\"Days\"),F451/'Drug Acquisition Costs'!F767*I449,IF(AND('Drug Acquisition Costs'!H767=\"Months\",I450=\"Months\"),F451/'Drug Acquisition Costs'!F767*I449,IF(AND('Drug Acquisition Costs'!H767=\"Days\",I450=\"Months\"),F451/'Drug Acquisition Costs'!F767*30.4375*I449,IF(AND('Drug Acquisition Costs'!H767=\"Months\",I450=\"Days\"),F451/'Drug Acquisition Costs'!F767/30.4375*I449,\"\"))))","v":""}]
["B",{"$f":"B438","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F438:I438,'Drug Acquisition Costs'!F769:'Drug Acquisition Costs'!I769)","v":0},{"$f":"F452*G449","v":0},{"$f":"IF('Drug Acquisition Costs'!H767=\"Days\",F452/'Drug Acquisition Costs'!F767*365.25,IF('Drug Acquisition Costs'!H767=\"Months\",F452/'Drug Acquisition Costs'!F767*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H767=\"Days\",I450=\"Days\"),F452/'Drug Acquisition Costs'!F767*I449,IF(AND('Drug Acquisition Costs'!H767=\"Months\",I450=\"Months\"),F452/'Drug Acquisition Costs'!F767*I449,IF(AND('Drug Acquisition Costs'!H767=\"Days\",I450=\"Months\"),F452/'Drug Acquisition Costs'!F767*30.4375*I449,IF(AND('Drug Acquisition Costs'!H767=\"Months\",I450=\"Days\"),F452/'Drug Acquisition Costs'!F767/30.4375*I449,\"\"))))","v":""}]
["C",{"$f":"B439","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F439:I439,'Drug Acquisition Costs'!F769:'Drug Acquisition Costs'!I769)","v":0},{"$f":"F453*G449","v":0},{"$f":"IF('Drug Acquisition Costs'!H767=\"Days\",F453/'Drug Acquisition Costs'!F767*365.25,IF('Drug Acquisition Costs'!H767=\"Months\",F453/'Drug Acquisition Costs'!F767*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H767=\"Days\",I450=\"Days\"),F453/'Drug Acquisition Costs'!F767*I449,IF(AND('Drug Acquisition Costs'!H767=\"Months\",I450=\"Months\"),F453/'Drug Acquisition Costs'!F767*I449,IF(AND('Drug Acquisition Costs'!H767=\"Days\",I450=\"Months\"),F453/'Drug Acquisition Costs'!F767*30.4375*I449,IF(AND('Drug Acquisition Costs'!H767=\"Months\",I450=\"Days\"),F453/'Drug Acquisition Costs'!F767/30.4375*I449,\"\"))))","v":""}]
["D","CIC PAS (inclusive of framework agreement rebate)",null,null,null,{"$f":"SUMPRODUCT(F440:I440,'Drug Acquisition Costs'!F769:'Drug Acquisition Costs'!I769)","v":0},{"$f":" F454*G449","v":0},{"$f":"IF('Drug Acquisition Costs'!H767=\"Days\",F454/'Drug Acquisition Costs'!F767*365.25,IF('Drug Acquisition Costs'!H767=\"Months\",F454/'Drug Acquisition Costs'!F767*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H767=\"Days\",I450=\"Days\"),F454/'Drug Acquisition Costs'!F767*I449,IF(AND('Drug Acquisition Costs'!H767=\"Months\",I450=\"Months\"),F454/'Drug Acquisition Costs'!F767*I449,IF(AND('Drug Acquisition Costs'!H767=\"Days\",I450=\"Months\"),F454/'Drug Acquisition Costs'!F767*30.4375*I449,IF(AND('Drug Acquisition Costs'!H767=\"Months\",I450=\"Days\"),F454/'Drug Acquisition Costs'!F767/30.4375*I449,\"\"))))","v":""}]
["E",{"$f":"B442","v":"VAT on Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F442:I442,'Drug Acquisition Costs'!F769:'Drug Acquisition Costs'!I769)","v":0},{"$f":"F455*G449","v":0},{"$f":"IF('Drug Acquisition Costs'!H767=\"Days\",F455/'Drug Acquisition Costs'!F767*365.25,IF('Drug Acquisition Costs'!H767=\"Months\",F455/'Drug Acquisition Costs'!F767*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H767=\"Days\",I450=\"Days\"),F455/'Drug Acquisition Costs'!F767*I449,IF(AND('Drug Acquisition Costs'!H767=\"Months\",I450=\"Months\"),F455/'Drug Acquisition Costs'!F767*I449,IF(AND('Drug Acquisition Costs'!H768=\"Days\",I450=\"Months\"),F455/'Drug Acquisition Costs'!F767*30.4375*I449,IF(AND('Drug Acquisition Costs'!H767=\"Months\",I450=\"Days\"),F455/'Drug Acquisition Costs'!F767/30.4375*I449,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H799=\"\",\"\",'Drug Acquisition Costs'!H799)","v":""},{"$f":"IF(F456=\"\",\"\",F456*G449)","v":""},{"$f":"IF(F456=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H767=\"Days\",F456/'Drug Acquisition Costs'!F767*365.25,IF('Drug Acquisition Costs'!H767=\"Months\",F456/'Drug Acquisition Costs'!F767*12,\"\")), 744.36))","v":""},{"$f":"IF(F456=\"\",\"\",IF(AND('Drug Acquisition Costs'!H767=\"Days\",I450=\"Days\"),F456/'Drug Acquisition Costs'!F767*I449,IF(AND('Drug Acquisition Costs'!H767=\"Months\",I450=\"Months\"),F456/'Drug Acquisition Costs'!F767*I449,IF(AND('Drug Acquisition Costs'!H767=\"Days\",I450=\"Months\"),F456/'Drug Acquisition Costs'!F767*30.4375*I449,IF(AND('Drug Acquisition Costs'!H767=\"Months\",I450=\"Days\"),F456/'Drug Acquisition Costs'!F767/30.4375*I449,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H800=\"\",\"\",'Drug Acquisition Costs'!H800)","v":""},{"$f":"IF(F457=\"\",\"\",F457*G449)","v":""},{"$f":"IF(F457=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H767=\"Days\",F457/'Drug Acquisition Costs'!F767*365.25,IF('Drug Acquisition Costs'!H767=\"Months\",F457/'Drug Acquisition Costs'!F767*12,\"\")), 744.36))","v":""},{"$f":"IF(F457=\"\",\"\",IF(AND('Drug Acquisition Costs'!H767=\"Days\",I450=\"Days\"),F457/'Drug Acquisition Costs'!F767*I449,IF(AND('Drug Acquisition Costs'!H767=\"Months\",I450=\"Months\"),F457/'Drug Acquisition Costs'!F767*I449,IF(AND('Drug Acquisition Costs'!H767=\"Days\",I450=\"Months\"),F457/'Drug Acquisition Costs'!F767*30.4375*I449,IF(AND('Drug Acquisition Costs'!H767=\"Months\",I450=\"Days\"),F457/'Drug Acquisition Costs'!F767/30.4375*I449,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 8",null,null,null,{"$f":"SUM(F453:F456)","v":0},{"$f":"SUM(G453:G456)","v":0},{"$f":"SUM(H453:H456)","v":0},{"$f":"SUM(I453:I456)","v":0}]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 8",null,null,null,{"$f":"IF(F457=\"\",SUM(F453:F454),F453+F454+F457)","v":0},{"$f":"IF(G457=\"\",SUM(G453:G454),G453+G454+G457)","v":0},{"$f":"IF(H457=\"\",SUM(H453:H454),H453+H454+H457)","v":0},{"$f":"IF(I457=\"\",SUM(I453:I454),I453+I454+I457)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"'Drug Acquisition Costs'!B820","v":"Comparator 8: "},null,null,{"$f":"'Drug Acquisition Costs'!E820","v":0},{"$f":"IF($E463=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E463,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$462&\" Comparator 8\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E463=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E463,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$462&\" Comparator 8\"),$B:$B,0))","v":{"$error":"#N/A"}}]
[]
[null,"Notes"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 9: \",NameComparator9)","v":"Comparator 9: "}]
[]
[null,"Total Rebate (Including framework agreement and CIC) ",null,null,{"$f":"IF(ISNUMBER('Drug Acquisition Costs'!E868),ABS('Drug Acquisition Costs'!E868),0)","v":0}]
[]
[null,"Table C. Total Cost to the HSE per pack"]
[]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!F864=\"\",\"\",'Drug Acquisition Costs'!F864)","v":""},{"$f":"IF('Drug Acquisition Costs'!G864=\"\",\"\",'Drug Acquisition Costs'!G864)","v":""},{"$f":"IF('Drug Acquisition Costs'!H864=\"\",\"\",'Drug Acquisition Costs'!H864)","v":""},{"$f":"IF('Drug Acquisition Costs'!I864=\"\",\"\",'Drug Acquisition Costs'!I864)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F844=\"\",'Drug Acquisition Costs'!F845=\"\",'Drug Acquisition Costs'!$F846=\"\"),\"\",IF('Drug Acquisition Costs'!F844=\"Price to Wholesaler\",'Drug Acquisition Costs'!F845,IF('Drug Acquisition Costs'!F844=\"Reimbursement Price\",(F487/(1+$E486)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G844=\"\",'Drug Acquisition Costs'!G845=\"\",'Drug Acquisition Costs'!$F846=\"\"),\"\",IF('Drug Acquisition Costs'!G844=\"Price to Wholesaler\",'Drug Acquisition Costs'!G845,IF('Drug Acquisition Costs'!G844=\"Reimbursement Price\",(G487/(1+$E486)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H844=\"\",'Drug Acquisition Costs'!H845=\"\",'Drug Acquisition Costs'!$F846=\"\"),\"\",IF('Drug Acquisition Costs'!H844=\"Price to Wholesaler\",'Drug Acquisition Costs'!H845,IF('Drug Acquisition Costs'!H844=\"Reimbursement Price\",(H487/(1+$E486)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I844=\"\",'Drug Acquisition Costs'!I845=\"\",'Drug Acquisition Costs'!$F846=\"\"),\"\",IF('Drug Acquisition Costs'!I844=\"Price to Wholesaler\",'Drug Acquisition Costs'!I845,IF('Drug Acquisition Costs'!I844=\"Reimbursement Price\",(I487/(1+$E486)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F846=\"\"),\"\",IF(AND('Drug Acquisition Costs'!F846=\"CDS\",'Drug Acquisition Costs'!F847=\"Yes\"),CYF,IF(AND('Drug Acquisition Costs'!F846=\"CDS\",'Drug Acquisition Costs'!F847=\"No\"),CNF,IF('Drug Acquisition Costs'!F846=\"HT\",CHT,IF('Drug Acquisition Costs'!F846=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F846=\"\",'Drug Acquisition Costs'!F845=\"\",'Drug Acquisition Costs'!F844=\"\"),\"\",F485*$E486)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F846=\"\",'Drug Acquisition Costs'!G845=\"\",'Drug Acquisition Costs'!G844=\"\"),\"\",G485*$E486)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F846=\"\",'Drug Acquisition Costs'!H845=\"\",'Drug Acquisition Costs'!H844=\"\"),\"\",H485*$E486)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F846=\"\",'Drug Acquisition Costs'!I845=\"\",'Drug Acquisition Costs'!I844=\"\"),\"\",I485*$E486)","v":""}]
["C",{"$f":"IF('Drug Acquisition Costs'!F486=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF('Drug Acquisition Costs'!F844=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF('Drug Acquisition Costs'!F844=\"Reimbursement Price\",'Drug Acquisition Costs'!F845,IF(ISBLANK($E486),\"\",IF('Drug Acquisition Costs'!F844=\"Price to Wholesaler\",(F485+F486),IF('Drug Acquisition Costs'!F844=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!G844=\"Reimbursement Price\",'Drug Acquisition Costs'!G845,IF(ISBLANK($E486),\"\",IF('Drug Acquisition Costs'!G844=\"Price to Wholesaler\",(G485+G486),IF('Drug Acquisition Costs'!G844=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!H844=\"Reimbursement Price\",'Drug Acquisition Costs'!H845,IF(ISBLANK($E486),\"\",IF('Drug Acquisition Costs'!H844=\"Price to Wholesaler\",(H485+H486),IF('Drug Acquisition Costs'!H844=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!I844=\"Reimbursement Price\",'Drug Acquisition Costs'!I845,IF(ISBLANK($E486),\"\",IF('Drug Acquisition Costs'!I844=\"Price to Wholesaler\",(I485+I486),IF('Drug Acquisition Costs'!I844=\"\",\"\",\"Error\"))))","v":""}]
["D","Total Rebate (Including framework agreement and CIC) ",null,null,null,{"$f":"IF('Drug Acquisition Costs'!F845=\"\", \"\", F485*IF($E479=\"\", \"\", -$E479))","v":""},{"$f":"IF('Drug Acquisition Costs'!G845=\"\", \"\", G485*IF($E479=\"\", \"\", -$E479))","v":""},{"$f":"IF('Drug Acquisition Costs'!H845=\"\", \"\", H485*IF($E479=\"\", \"\", -$E479))","v":""},{"$f":"IF('Drug Acquisition Costs'!I845=\"\", \"\", I485*IF($E479=\"\", \"\", -$E479))","v":""}]
["E","Net price (PtW less total rebate)",null,null,null,{"$f":"IFERROR(F485+F488,\"\")","v":""},{"$f":"IFERROR(G485+G488,\"\")","v":""},{"$f":"IFERROR(H485+H488,\"\")","v":""},{"$f":"IFERROR(I485+I488,\"\")","v":""}]
["F","VAT on Reimbursement Price",null,null,{"$f":"IF('Drug Acquisition Costs'!F848=\"\",\"\",IF('Drug Acquisition Costs'!F848=\"Yes\",0,VT))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!F845=\"\",ISBLANK('Drug Acquisition Costs'!F845)),\"\",($E490*F487))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G845=\"\",ISBLANK('Drug Acquisition Costs'!G845)),\"\",($E490*G487))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H845=\"\",ISBLANK('Drug Acquisition Costs'!H845)),\"\",($E490*H487))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I845=\"\",ISBLANK('Drug Acquisition Costs'!I845)),\"\",($E490*I487))","v":""}]
["G(i)","Total Drug Cost to the HSE per pack with CIC PAS including VAT (B+E+F)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F844=\"\",'Drug Acquisition Costs'!$F846=\"\",'Drug Acquisition Costs'!$F848=\"\",'Drug Acquisition Costs'!$F849=\"\"),\"\",F486+F489+F490)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G844=\"\",'Drug Acquisition Costs'!$F846=\"\",'Drug Acquisition Costs'!$F848=\"\",'Drug Acquisition Costs'!$F849=\"\"),\"\",G486+G489+G490)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H844=\"\",'Drug Acquisition Costs'!$F846=\"\",'Drug Acquisition Costs'!$F848=\"\",'Drug Acquisition Costs'!$F849=\"\"),\"\",H486+H489+H490)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I844=\"\",'Drug Acquisition Costs'!$F846=\"\",'Drug Acquisition Costs'!$F848=\"\",'Drug Acquisition Costs'!$F849=\"\"),\"\",I486+I489+I490)","v":""}]
["G(ii)","Total Drug Cost to the HSE per pack with CIC PAS excluding VAT (B+E)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F844=\"\",'Drug Acquisition Costs'!$F846=\"\",'Drug Acquisition Costs'!$F848=\"\",'Drug Acquisition Costs'!$F849=\"\"),\"\",F486+F489)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G844=\"\",'Drug Acquisition Costs'!$F846=\"\",'Drug Acquisition Costs'!$F848=\"\",'Drug Acquisition Costs'!$F849=\"\"),\"\",G486+G489)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H844=\"\",'Drug Acquisition Costs'!$F846=\"\",'Drug Acquisition Costs'!$F848=\"\",'Drug Acquisition Costs'!$F849=\"\"),\"\",H486+H489)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I844=\"\",'Drug Acquisition Costs'!$F846=\"\",'Drug Acquisition Costs'!$F848=\"\",'Drug Acquisition Costs'!$F849=\"\"),\"\",I486+I489)","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table F. Total Drug Costs to the HSE"]
[]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time"]
[null,null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!G894=\"\",0,'Drug Acquisition Costs'!G894)","v":0},null,{"$f":"IF('Drug Acquisition Costs'!I894=\"\",\"\",'Drug Acquisition Costs'!I894)","v":""}]
[null,null,null,null,null,null,"number of cycles",null,{"$f":"IF('Drug Acquisition Costs'!I895=\"\",\"\",'Drug Acquisition Costs'!I895)","v":""}]
["A",{"$f":"B485","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F485:I485,'Drug Acquisition Costs'!F857:'Drug Acquisition Costs'!I857)","v":0},{"$f":"F499*G497","v":0},{"$f":"IF('Drug Acquisition Costs'!H855=\"Days\",F499/'Drug Acquisition Costs'!F855*365.25,IF('Drug Acquisition Costs'!H855=\"Months\",F499/'Drug Acquisition Costs'!F855*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H855=\"Days\",I498=\"Days\"),F499/'Drug Acquisition Costs'!F855*I497,IF(AND('Drug Acquisition Costs'!H855=\"Months\",I498=\"Months\"),F499/'Drug Acquisition Costs'!F855*I497,IF(AND('Drug Acquisition Costs'!H855=\"Days\",I498=\"Months\"),F499/'Drug Acquisition Costs'!F855*30.4375*I497,IF(AND('Drug Acquisition Costs'!H855=\"Months\",I498=\"Days\"),F499/'Drug Acquisition Costs'!F855/30.4375*I497,\"\"))))","v":""}]
["B",{"$f":"B486","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F486:I486,'Drug Acquisition Costs'!F857:'Drug Acquisition Costs'!I857)","v":0},{"$f":"F500*G497","v":0},{"$f":"IF('Drug Acquisition Costs'!H855=\"Days\",F500/'Drug Acquisition Costs'!F855*365.25,IF('Drug Acquisition Costs'!H855=\"Months\",F500/'Drug Acquisition Costs'!F855*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H855=\"Days\",I498=\"Days\"),F500/'Drug Acquisition Costs'!F855*I497,IF(AND('Drug Acquisition Costs'!H855=\"Months\",I498=\"Months\"),F500/'Drug Acquisition Costs'!F855*I497,IF(AND('Drug Acquisition Costs'!H855=\"Days\",I498=\"Months\"),F500/'Drug Acquisition Costs'!F855*30.4375*I497,IF(AND('Drug Acquisition Costs'!H855=\"Months\",I498=\"Days\"),F500/'Drug Acquisition Costs'!F855/30.4375*I497,\"\"))))","v":""}]
["C",{"$f":"B487","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F487:I487,'Drug Acquisition Costs'!F857:'Drug Acquisition Costs'!I857)","v":0},{"$f":"F501*G497","v":0},{"$f":"IF('Drug Acquisition Costs'!H855=\"Days\",F501/'Drug Acquisition Costs'!F855*365.25,IF('Drug Acquisition Costs'!H855=\"Months\",F501/'Drug Acquisition Costs'!F855*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H855=\"Days\",I498=\"Days\"),F501/'Drug Acquisition Costs'!F855*I497,IF(AND('Drug Acquisition Costs'!H855=\"Months\",I498=\"Months\"),F501/'Drug Acquisition Costs'!F855*I497,IF(AND('Drug Acquisition Costs'!H855=\"Days\",I498=\"Months\"),F501/'Drug Acquisition Costs'!F855*30.4375*I497,IF(AND('Drug Acquisition Costs'!H855=\"Months\",I498=\"Days\"),F501/'Drug Acquisition Costs'!F855/30.4375*I497,\"\"))))","v":""}]
["D","CIC PAS (inclusive of framework agreement rebate)",null,null,null,{"$f":"SUMPRODUCT(F488:I488,'Drug Acquisition Costs'!F857:'Drug Acquisition Costs'!I857)","v":0},{"$f":" F502*G497","v":0},{"$f":"IF('Drug Acquisition Costs'!H855=\"Days\",F502/'Drug Acquisition Costs'!F855*365.25,IF('Drug Acquisition Costs'!H855=\"Months\",F502/'Drug Acquisition Costs'!F855*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H855=\"Days\",I498=\"Days\"),F502/'Drug Acquisition Costs'!F855*I497,IF(AND('Drug Acquisition Costs'!H855=\"Months\",I498=\"Months\"),F502/'Drug Acquisition Costs'!F855*I497,IF(AND('Drug Acquisition Costs'!H855=\"Days\",I498=\"Months\"),F502/'Drug Acquisition Costs'!F855*30.4375*I497,IF(AND('Drug Acquisition Costs'!H855=\"Months\",I498=\"Days\"),F502/'Drug Acquisition Costs'!F855/30.4375*I497,\"\"))))","v":""}]
["E",{"$f":"B490","v":"VAT on Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F490:I490,'Drug Acquisition Costs'!F857:'Drug Acquisition Costs'!I857)","v":0},{"$f":"F503*G497","v":0},{"$f":"IF('Drug Acquisition Costs'!H855=\"Days\",F503/'Drug Acquisition Costs'!F855*365.25,IF('Drug Acquisition Costs'!H855=\"Months\",F503/'Drug Acquisition Costs'!F855*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H855=\"Days\",I498=\"Days\"),F503/'Drug Acquisition Costs'!F855*I497,IF(AND('Drug Acquisition Costs'!H855=\"Months\",I498=\"Months\"),F503/'Drug Acquisition Costs'!F855*I497,IF(AND('Drug Acquisition Costs'!H856=\"Days\",I498=\"Months\"),F503/'Drug Acquisition Costs'!F855*30.4375*I497,IF(AND('Drug Acquisition Costs'!H855=\"Months\",I498=\"Days\"),F503/'Drug Acquisition Costs'!F855/30.4375*I497,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H887=\"\",\"\",'Drug Acquisition Costs'!H887)","v":""},{"$f":"IF(F504=\"\",\"\",F504*G497)","v":""},{"$f":"IF(F504=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H855=\"Days\",F504/'Drug Acquisition Costs'!F855*365.25,IF('Drug Acquisition Costs'!H855=\"Months\",F504/'Drug Acquisition Costs'!F855*12,\"\")), 744.36))","v":""},{"$f":"IF(F504=\"\",\"\",IF(AND('Drug Acquisition Costs'!H855=\"Days\",I498=\"Days\"),F504/'Drug Acquisition Costs'!F855*I497,IF(AND('Drug Acquisition Costs'!H855=\"Months\",I498=\"Months\"),F504/'Drug Acquisition Costs'!F855*I497,IF(AND('Drug Acquisition Costs'!H855=\"Days\",I498=\"Months\"),F504/'Drug Acquisition Costs'!F855*30.4375*I497,IF(AND('Drug Acquisition Costs'!H855=\"Months\",I498=\"Days\"),F504/'Drug Acquisition Costs'!F855/30.4375*I497,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H888=\"\",\"\",'Drug Acquisition Costs'!H888)","v":""},{"$f":"IF(F505=\"\",\"\",F505*G497)","v":""},{"$f":"IF(F505=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H855=\"Days\",F505/'Drug Acquisition Costs'!F855*365.25,IF('Drug Acquisition Costs'!H855=\"Months\",F505/'Drug Acquisition Costs'!F855*12,\"\")), 744.36))","v":""},{"$f":"IF(F505=\"\",\"\",IF(AND('Drug Acquisition Costs'!H855=\"Days\",I498=\"Days\"),F505/'Drug Acquisition Costs'!F855*I497,IF(AND('Drug Acquisition Costs'!H855=\"Months\",I498=\"Months\"),F505/'Drug Acquisition Costs'!F855*I497,IF(AND('Drug Acquisition Costs'!H855=\"Days\",I498=\"Months\"),F505/'Drug Acquisition Costs'!F855*30.4375*I497,IF(AND('Drug Acquisition Costs'!H855=\"Months\",I498=\"Days\"),F505/'Drug Acquisition Costs'!F855/30.4375*I497,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 9",null,null,null,{"$f":"SUM(F501:F504)","v":0},{"$f":"SUM(G501:G504)","v":0},{"$f":"SUM(H501:H504)","v":0},{"$f":"SUM(I501:I504)","v":0}]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 9",null,null,null,{"$f":"IF(F505=\"\",SUM(F501:F502),F501+F502+F505)","v":0},{"$f":"IF(G505=\"\",SUM(G501:G502),G501+G502+G505)","v":0},{"$f":"IF(H505=\"\",SUM(H501:H502),H501+H502+H505)","v":0},{"$f":"IF(I505=\"\",SUM(I501:I502),I501+I502+I505)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"'Drug Acquisition Costs'!B908","v":"Comparator 9: "},null,null,{"$f":"'Drug Acquisition Costs'!E908","v":0},{"$f":"IF($E511=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E511,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$510&\" Comparator 9\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E511=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E511,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$510&\" Comparator 9\"),$B:$B,0))","v":{"$error":"#N/A"}}]
[]
[null,"Notes"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 10: \",NameComparator10)","v":"Comparator 10: "}]
[]
[null,"Total Rebate (Including framework agreement and CIC) ",null,null,{"$f":"IF(ISNUMBER('Drug Acquisition Costs'!E956),ABS('Drug Acquisition Costs'!E956),0)","v":0}]
[]
[null,"Table C. Total Cost to the HSE per pack"]
[]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!F952=\"\",\"\",'Drug Acquisition Costs'!F952)","v":""},{"$f":"IF('Drug Acquisition Costs'!G952=\"\",\"\",'Drug Acquisition Costs'!G952)","v":""},{"$f":"IF('Drug Acquisition Costs'!H952=\"\",\"\",'Drug Acquisition Costs'!H952)","v":""},{"$f":"IF('Drug Acquisition Costs'!I952=\"\",\"\",'Drug Acquisition Costs'!I952)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F932=\"\",'Drug Acquisition Costs'!F933=\"\",'Drug Acquisition Costs'!$F934=\"\"),\"\",IF('Drug Acquisition Costs'!F932=\"Price to Wholesaler\",'Drug Acquisition Costs'!F933,IF('Drug Acquisition Costs'!F932=\"Reimbursement Price\",(F535/(1+$E534)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G932=\"\",'Drug Acquisition Costs'!G933=\"\",'Drug Acquisition Costs'!$F934=\"\"),\"\",IF('Drug Acquisition Costs'!G932=\"Price to Wholesaler\",'Drug Acquisition Costs'!G933,IF('Drug Acquisition Costs'!G932=\"Reimbursement Price\",(G535/(1+$E534)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H932=\"\",'Drug Acquisition Costs'!H933=\"\",'Drug Acquisition Costs'!$F934=\"\"),\"\",IF('Drug Acquisition Costs'!H932=\"Price to Wholesaler\",'Drug Acquisition Costs'!H933,IF('Drug Acquisition Costs'!H932=\"Reimbursement Price\",(H535/(1+$E534)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I932=\"\",'Drug Acquisition Costs'!I933=\"\",'Drug Acquisition Costs'!$F934=\"\"),\"\",IF('Drug Acquisition Costs'!I932=\"Price to Wholesaler\",'Drug Acquisition Costs'!I933,IF('Drug Acquisition Costs'!I932=\"Reimbursement Price\",(I535/(1+$E534)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F934=\"\"),\"\",IF(AND('Drug Acquisition Costs'!F934=\"CDS\",'Drug Acquisition Costs'!F935=\"Yes\"),CYF,IF(AND('Drug Acquisition Costs'!F934=\"CDS\",'Drug Acquisition Costs'!F935=\"No\"),CNF,IF('Drug Acquisition Costs'!F934=\"HT\",CHT,IF('Drug Acquisition Costs'!F934=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F934=\"\",'Drug Acquisition Costs'!F933=\"\",'Drug Acquisition Costs'!F932=\"\"),\"\",F533*$E534)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F934=\"\",'Drug Acquisition Costs'!G933=\"\",'Drug Acquisition Costs'!G932=\"\"),\"\",G533*$E534)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F934=\"\",'Drug Acquisition Costs'!H933=\"\",'Drug Acquisition Costs'!H932=\"\"),\"\",H533*$E534)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F934=\"\",'Drug Acquisition Costs'!I933=\"\",'Drug Acquisition Costs'!I932=\"\"),\"\",I533*$E534)","v":""}]
["C",{"$f":"IF('Drug Acquisition Costs'!F534=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF('Drug Acquisition Costs'!F932=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF('Drug Acquisition Costs'!F932=\"Reimbursement Price\",'Drug Acquisition Costs'!F933,IF(ISBLANK($E534),\"\",IF('Drug Acquisition Costs'!F932=\"Price to Wholesaler\",(F533+F534),IF('Drug Acquisition Costs'!F932=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!G932=\"Reimbursement Price\",'Drug Acquisition Costs'!G933,IF(ISBLANK($E534),\"\",IF('Drug Acquisition Costs'!G932=\"Price to Wholesaler\",(G533+G534),IF('Drug Acquisition Costs'!G932=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!H932=\"Reimbursement Price\",'Drug Acquisition Costs'!H933,IF(ISBLANK($E534),\"\",IF('Drug Acquisition Costs'!H932=\"Price to Wholesaler\",(H533+H534),IF('Drug Acquisition Costs'!H932=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!I932=\"Reimbursement Price\",'Drug Acquisition Costs'!I933,IF(ISBLANK($E534),\"\",IF('Drug Acquisition Costs'!I932=\"Price to Wholesaler\",(I533+I534),IF('Drug Acquisition Costs'!I932=\"\",\"\",\"Error\"))))","v":""}]
["D","Total Rebate (Including framework agreement and CIC) ",null,null,null,{"$f":"IF('Drug Acquisition Costs'!F933=\"\", \"\", F533*IF($E527=\"\", \"\", -$E527))","v":""},{"$f":"IF('Drug Acquisition Costs'!G933=\"\", \"\", G533*IF($E527=\"\", \"\", -$E527))","v":""},{"$f":"IF('Drug Acquisition Costs'!H933=\"\", \"\", H533*IF($E527=\"\", \"\", -$E527))","v":""},{"$f":"IF('Drug Acquisition Costs'!I933=\"\", \"\", I533*IF($E527=\"\", \"\", -$E527))","v":""}]
["E","Net price (PtW less total rebate)",null,null,null,{"$f":"IFERROR(F533+F536,\"\")","v":""},{"$f":"IFERROR(G533+G536,\"\")","v":""},{"$f":"IFERROR(H533+H536,\"\")","v":""},{"$f":"IFERROR(I533+I536,\"\")","v":""}]
["F","VAT on Reimbursement Price",null,null,{"$f":"IF('Drug Acquisition Costs'!F936=\"\",\"\",IF('Drug Acquisition Costs'!F936=\"Yes\",0,VT))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!F933=\"\",ISBLANK('Drug Acquisition Costs'!F933)),\"\",($E538*F535))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G933=\"\",ISBLANK('Drug Acquisition Costs'!G933)),\"\",($E538*G535))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H933=\"\",ISBLANK('Drug Acquisition Costs'!H933)),\"\",($E538*H535))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I933=\"\",ISBLANK('Drug Acquisition Costs'!I933)),\"\",($E538*I535))","v":""}]
["G(i)","Total Drug Cost to the HSE per pack with CIC PAS including VAT (B+E+F)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F932=\"\",'Drug Acquisition Costs'!$F934=\"\",'Drug Acquisition Costs'!$F936=\"\",'Drug Acquisition Costs'!$F937=\"\"),\"\",F534+F537+F538)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G932=\"\",'Drug Acquisition Costs'!$F934=\"\",'Drug Acquisition Costs'!$F936=\"\",'Drug Acquisition Costs'!$F937=\"\"),\"\",G534+G537+G538)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H932=\"\",'Drug Acquisition Costs'!$F934=\"\",'Drug Acquisition Costs'!$F936=\"\",'Drug Acquisition Costs'!$F937=\"\"),\"\",H534+H537+H538)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I932=\"\",'Drug Acquisition Costs'!$F934=\"\",'Drug Acquisition Costs'!$F936=\"\",'Drug Acquisition Costs'!$F937=\"\"),\"\",I534+I537+I538)","v":""}]
["G(ii)","Total Drug Cost to the HSE per pack with CIC PAS excluding VAT (B+E)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F932=\"\",'Drug Acquisition Costs'!$F934=\"\",'Drug Acquisition Costs'!$F936=\"\",'Drug Acquisition Costs'!$F937=\"\"),\"\",F534+F537)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G932=\"\",'Drug Acquisition Costs'!$F934=\"\",'Drug Acquisition Costs'!$F936=\"\",'Drug Acquisition Costs'!$F937=\"\"),\"\",G534+G537)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H932=\"\",'Drug Acquisition Costs'!$F934=\"\",'Drug Acquisition Costs'!$F936=\"\",'Drug Acquisition Costs'!$F937=\"\"),\"\",H534+H537)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I932=\"\",'Drug Acquisition Costs'!$F934=\"\",'Drug Acquisition Costs'!$F936=\"\",'Drug Acquisition Costs'!$F937=\"\"),\"\",I534+I537)","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table F. Total Drug Costs to the HSE"]
[null,null,null,null,null,null,null,null,"Need to do this column. Table below done."]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time"]
[null,null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!G982=\"\",0,'Drug Acquisition Costs'!G982)","v":0},null,{"$f":"IF('Drug Acquisition Costs'!I982=\"\",\"\",'Drug Acquisition Costs'!I982)","v":""}]
[null,null,null,null,null,null,"number of cycles",null,{"$f":"IF('Drug Acquisition Costs'!I983=\"\",\"\",'Drug Acquisition Costs'!I983)","v":""}]
["A",{"$f":"B533","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F533:I533,'Drug Acquisition Costs'!F945:'Drug Acquisition Costs'!I945)","v":0},{"$f":"F547*G545","v":0},{"$f":"IF('Drug Acquisition Costs'!H943=\"Days\",F547/'Drug Acquisition Costs'!F943*365.25,IF('Drug Acquisition Costs'!H943=\"Months\",F547/'Drug Acquisition Costs'!F943*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H943=\"Days\",I546=\"Days\"),F547/'Drug Acquisition Costs'!F943*I545,IF(AND('Drug Acquisition Costs'!H943=\"Months\",I546=\"Months\"),F547/'Drug Acquisition Costs'!F943*I545,IF(AND('Drug Acquisition Costs'!H943=\"Days\",I546=\"Months\"),F547/'Drug Acquisition Costs'!F943*30.4375*I545,IF(AND('Drug Acquisition Costs'!H943=\"Months\",I546=\"Days\"),F547/'Drug Acquisition Costs'!F943/30.4375*I545,\"\"))))","v":""}]
["B",{"$f":"B534","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F534:I534,'Drug Acquisition Costs'!F945:'Drug Acquisition Costs'!I945)","v":0},{"$f":"F548*G545","v":0},{"$f":"IF('Drug Acquisition Costs'!H943=\"Days\",F548/'Drug Acquisition Costs'!F943*365.25,IF('Drug Acquisition Costs'!H943=\"Months\",F548/'Drug Acquisition Costs'!F943*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H943=\"Days\",I546=\"Days\"),F548/'Drug Acquisition Costs'!F943*I545,IF(AND('Drug Acquisition Costs'!H943=\"Months\",I546=\"Months\"),F548/'Drug Acquisition Costs'!F943*I545,IF(AND('Drug Acquisition Costs'!H943=\"Days\",I546=\"Months\"),F548/'Drug Acquisition Costs'!F943*30.4375*I545,IF(AND('Drug Acquisition Costs'!H943=\"Months\",I546=\"Days\"),F548/'Drug Acquisition Costs'!F943/30.4375*I545,\"\"))))","v":""}]
["C",{"$f":"B535","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F535:I535,'Drug Acquisition Costs'!F945:'Drug Acquisition Costs'!I945)","v":0},{"$f":"F549*G545","v":0},{"$f":"IF('Drug Acquisition Costs'!H943=\"Days\",F549/'Drug Acquisition Costs'!F943*365.25,IF('Drug Acquisition Costs'!H943=\"Months\",F549/'Drug Acquisition Costs'!F943*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H943=\"Days\",I546=\"Days\"),F549/'Drug Acquisition Costs'!F943*I545,IF(AND('Drug Acquisition Costs'!H943=\"Months\",I546=\"Months\"),F549/'Drug Acquisition Costs'!F943*I545,IF(AND('Drug Acquisition Costs'!H943=\"Days\",I546=\"Months\"),F549/'Drug Acquisition Costs'!F943*30.4375*I545,IF(AND('Drug Acquisition Costs'!H943=\"Months\",I546=\"Days\"),F549/'Drug Acquisition Costs'!F943/30.4375*I545,\"\"))))","v":""}]
["D","CIC PAS (inclusive of framework agreement rebate)",null,null,null,{"$f":"SUMPRODUCT(F536:I536,'Drug Acquisition Costs'!F945:'Drug Acquisition Costs'!I945)","v":0},{"$f":" F550*G545","v":0},{"$f":"IF('Drug Acquisition Costs'!H943=\"Days\",F550/'Drug Acquisition Costs'!F943*365.25,IF('Drug Acquisition Costs'!H943=\"Months\",F550/'Drug Acquisition Costs'!F943*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H943=\"Days\",I546=\"Days\"),F550/'Drug Acquisition Costs'!F943*I545,IF(AND('Drug Acquisition Costs'!H943=\"Months\",I546=\"Months\"),F550/'Drug Acquisition Costs'!F943*I545,IF(AND('Drug Acquisition Costs'!H943=\"Days\",I546=\"Months\"),F550/'Drug Acquisition Costs'!F943*30.4375*I545,IF(AND('Drug Acquisition Costs'!H943=\"Months\",I546=\"Days\"),F550/'Drug Acquisition Costs'!F943/30.4375*I545,\"\"))))","v":""}]
["E",{"$f":"B538","v":"VAT on Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F538:I538,'Drug Acquisition Costs'!F945:'Drug Acquisition Costs'!I945)","v":0},{"$f":"F551*G545","v":0},{"$f":"IF('Drug Acquisition Costs'!H943=\"Days\",F551/'Drug Acquisition Costs'!F943*365.25,IF('Drug Acquisition Costs'!H943=\"Months\",F551/'Drug Acquisition Costs'!F943*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H943=\"Days\",I546=\"Days\"),F551/'Drug Acquisition Costs'!F943*I545,IF(AND('Drug Acquisition Costs'!H943=\"Months\",I546=\"Months\"),F551/'Drug Acquisition Costs'!F943*I545,IF(AND('Drug Acquisition Costs'!H944=\"Days\",I546=\"Months\"),F551/'Drug Acquisition Costs'!F943*30.4375*I545,IF(AND('Drug Acquisition Costs'!H943=\"Months\",I546=\"Days\"),F551/'Drug Acquisition Costs'!F943/30.4375*I545,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H975=\"\",\"\",'Drug Acquisition Costs'!H975)","v":""},{"$f":"IF(F552=\"\",\"\",F552*G545)","v":""},{"$f":"IF(F552=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H943=\"Days\",F552/'Drug Acquisition Costs'!F943*365.25,IF('Drug Acquisition Costs'!H943=\"Months\",F552/'Drug Acquisition Costs'!F943*12,\"\")), 744.36))","v":""},{"$f":"IF(F552=\"\",\"\",IF(AND('Drug Acquisition Costs'!H943=\"Days\",I546=\"Days\"),F552/'Drug Acquisition Costs'!F943*I545,IF(AND('Drug Acquisition Costs'!H943=\"Months\",I546=\"Months\"),F552/'Drug Acquisition Costs'!F943*I545,IF(AND('Drug Acquisition Costs'!H943=\"Days\",I546=\"Months\"),F552/'Drug Acquisition Costs'!F943*30.4375*I545,IF(AND('Drug Acquisition Costs'!H943=\"Months\",I546=\"Days\"),F552/'Drug Acquisition Costs'!F943/30.4375*I545,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H976=\"\",\"\",'Drug Acquisition Costs'!H976)","v":""},{"$f":"IF(F553=\"\",\"\",F553*G545)","v":""},{"$f":"IF(F553=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H943=\"Days\",F553/'Drug Acquisition Costs'!F943*365.25,IF('Drug Acquisition Costs'!H943=\"Months\",F553/'Drug Acquisition Costs'!F943*12,\"\")), 744.36))","v":""},{"$f":"IF(F553=\"\",\"\",IF(AND('Drug Acquisition Costs'!H943=\"Days\",I546=\"Days\"),F553/'Drug Acquisition Costs'!F943*I545,IF(AND('Drug Acquisition Costs'!H943=\"Months\",I546=\"Months\"),F553/'Drug Acquisition Costs'!F943*I545,IF(AND('Drug Acquisition Costs'!H943=\"Days\",I546=\"Months\"),F553/'Drug Acquisition Costs'!F943*30.4375*I545,IF(AND('Drug Acquisition Costs'!H943=\"Months\",I546=\"Days\"),F553/'Drug Acquisition Costs'!F943/30.4375*I545,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 10",null,null,null,{"$f":"SUM(F549:F552)","v":0},{"$f":"SUM(G549:G552)","v":0},{"$f":"SUM(H549:H552)","v":0},{"$f":"SUM(I549:I552)","v":0}]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 10",null,null,null,{"$f":"IF(F553=\"\",SUM(F549:F550),F549+F550+F553)","v":0},{"$f":"IF(G553=\"\",SUM(G549:G550),G549+G550+G553)","v":0},{"$f":"IF(H553=\"\",SUM(H549:H550),H549+H550+H553)","v":0},{"$f":"IF(I553=\"\",SUM(I549:I550),I549+I550+I553)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"'Drug Acquisition Costs'!B996","v":"Comparator 10: "},null,null,{"$f":"'Drug Acquisition Costs'!E996","v":0},{"$f":"IF($E559=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E559,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$558&\" Comparator 10\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E559=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E559,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$558&\" Comparator 10\"),$B:$B,0))","v":{"$error":"#N/A"}}]
[]
[null,"Notes"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 11: \",NameComparator11)","v":"Comparator 11: "}]
[]
[null,"Total Rebate (Including framework agreement and CIC) ",null,null,{"$f":"IF(ISNUMBER('Drug Acquisition Costs'!E1044),ABS('Drug Acquisition Costs'!E1044),0)","v":0}]
[]
[null,"Table C. Total Cost to the HSE per pack"]
[]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!F1040=\"\",\"\",'Drug Acquisition Costs'!F1000)","v":""},{"$f":"IF('Drug Acquisition Costs'!G1040=\"\",\"\",'Drug Acquisition Costs'!G1000)","v":""},{"$f":"IF('Drug Acquisition Costs'!H1040=\"\",\"\",'Drug Acquisition Costs'!H1000)","v":""},{"$f":"IF('Drug Acquisition Costs'!I1040=\"\",\"\",'Drug Acquisition Costs'!I1000)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F1020=\"\",'Drug Acquisition Costs'!F1021=\"\",'Drug Acquisition Costs'!$F1022=\"\"),\"\",IF('Drug Acquisition Costs'!F1020=\"Price to Wholesaler\",'Drug Acquisition Costs'!F1021,IF('Drug Acquisition Costs'!F1020=\"Reimbursement Price\",(F583/(1+$E582)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G1020=\"\",'Drug Acquisition Costs'!G1021=\"\",'Drug Acquisition Costs'!$F1022=\"\"),\"\",IF('Drug Acquisition Costs'!G1020=\"Price to Wholesaler\",'Drug Acquisition Costs'!G1021,IF('Drug Acquisition Costs'!G1020=\"Reimbursement Price\",(G583/(1+$E582)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H1020=\"\",'Drug Acquisition Costs'!H1021=\"\",'Drug Acquisition Costs'!$F1022=\"\"),\"\",IF('Drug Acquisition Costs'!H1020=\"Price to Wholesaler\",'Drug Acquisition Costs'!H1021,IF('Drug Acquisition Costs'!H1020=\"Reimbursement Price\",(H583/(1+$E582)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I1020=\"\",'Drug Acquisition Costs'!I1021=\"\",'Drug Acquisition Costs'!$F1022=\"\"),\"\",IF('Drug Acquisition Costs'!I1020=\"Price to Wholesaler\",'Drug Acquisition Costs'!I1021,IF('Drug Acquisition Costs'!I1020=\"Reimbursement Price\",(I583/(1+$E582)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F1022=\"\"),\"\",IF(AND('Drug Acquisition Costs'!F1022=\"CDS\",'Drug Acquisition Costs'!F1023=\"Yes\"),CYF,IF(AND('Drug Acquisition Costs'!F1022=\"CDS\",'Drug Acquisition Costs'!F1023=\"No\"),CNF,IF('Drug Acquisition Costs'!F1022=\"HT\",CHT,IF('Drug Acquisition Costs'!F1022=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F1022=\"\",'Drug Acquisition Costs'!F1021=\"\",'Drug Acquisition Costs'!F1020=\"\"),\"\",F581*$E582)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F1022=\"\",'Drug Acquisition Costs'!G1021=\"\",'Drug Acquisition Costs'!G1020=\"\"),\"\",G581*$E582)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F1022=\"\",'Drug Acquisition Costs'!H1021=\"\",'Drug Acquisition Costs'!H1020=\"\"),\"\",H581*$E582)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F1022=\"\",'Drug Acquisition Costs'!I1021=\"\",'Drug Acquisition Costs'!I1020=\"\"),\"\",I581*$E582)","v":""}]
["C",{"$f":"IF('Drug Acquisition Costs'!F582=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF('Drug Acquisition Costs'!F1020=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF('Drug Acquisition Costs'!F1020=\"Reimbursement Price\",'Drug Acquisition Costs'!F1021,IF(ISBLANK($E582),\"\",IF('Drug Acquisition Costs'!F1020=\"Price to Wholesaler\",(F581+F582),IF('Drug Acquisition Costs'!F1020=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!G1020=\"Reimbursement Price\",'Drug Acquisition Costs'!G1021,IF(ISBLANK($E582),\"\",IF('Drug Acquisition Costs'!G1020=\"Price to Wholesaler\",(G581+G582),IF('Drug Acquisition Costs'!G1020=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!H1020=\"Reimbursement Price\",'Drug Acquisition Costs'!H1021,IF(ISBLANK($E582),\"\",IF('Drug Acquisition Costs'!H1020=\"Price to Wholesaler\",(H581+H582),IF('Drug Acquisition Costs'!H1020=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!I1020=\"Reimbursement Price\",'Drug Acquisition Costs'!I1021,IF(ISBLANK($E582),\"\",IF('Drug Acquisition Costs'!I1020=\"Price to Wholesaler\",(I581+I582),IF('Drug Acquisition Costs'!I1020=\"\",\"\",\"Error\"))))","v":""}]
["D","Total Rebate (Including framework agreement and CIC) ",null,null,null,{"$f":"IF('Drug Acquisition Costs'!F1021=\"\", \"\", F581*IF($E575=\"\", \"\", -$E575))","v":""},{"$f":"IF('Drug Acquisition Costs'!G1021=\"\", \"\", G581*IF($E575=\"\", \"\", -$E575))","v":""},{"$f":"IF('Drug Acquisition Costs'!H1021=\"\", \"\", H581*IF($E575=\"\", \"\", -$E575))","v":""},{"$f":"IF('Drug Acquisition Costs'!I1021=\"\", \"\", I581*IF($E575=\"\", \"\", -$E575))","v":""}]
["E","Net price (PtW less total rebate)",null,null,null,{"$f":"IFERROR(F581+F584,\"\")","v":""},{"$f":"IFERROR(G581+G584,\"\")","v":""},{"$f":"IFERROR(H581+H584,\"\")","v":""},{"$f":"IFERROR(I581+I584,\"\")","v":""}]
["F","VAT on Reimbursement Price",null,null,{"$f":"IF('Drug Acquisition Costs'!F1024=\"\",\"\",IF('Drug Acquisition Costs'!F1024=\"Yes\",0,VT))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!F1021=\"\",ISBLANK('Drug Acquisition Costs'!F1021)),\"\",($E586*F583))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G1021=\"\",ISBLANK('Drug Acquisition Costs'!G1021)),\"\",($E586*G583))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H1021=\"\",ISBLANK('Drug Acquisition Costs'!H1021)),\"\",($E586*H583))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I1021=\"\",ISBLANK('Drug Acquisition Costs'!I1021)),\"\",($E586*I583))","v":""}]
["G(i)","Total Drug Cost to the HSE per pack with CIC PAS including VAT (B+E+F)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F1020=\"\",'Drug Acquisition Costs'!$F1022=\"\",'Drug Acquisition Costs'!$F1024=\"\",'Drug Acquisition Costs'!$F1025=\"\"),\"\",F582+F585+F586)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G1020=\"\",'Drug Acquisition Costs'!$F1022=\"\",'Drug Acquisition Costs'!$F1024=\"\",'Drug Acquisition Costs'!$F1025=\"\"),\"\",G582+G585+G586)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H1020=\"\",'Drug Acquisition Costs'!$F1022=\"\",'Drug Acquisition Costs'!$F1024=\"\",'Drug Acquisition Costs'!$F1025=\"\"),\"\",H582+H585+H586)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I1020=\"\",'Drug Acquisition Costs'!$F1022=\"\",'Drug Acquisition Costs'!$F1024=\"\",'Drug Acquisition Costs'!$F1025=\"\"),\"\",I582+I585+I586)","v":""}]
["G(ii)","Total Drug Cost to the HSE per pack with CIC PAS excluding VAT (B+E)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F1020=\"\",'Drug Acquisition Costs'!$F1022=\"\",'Drug Acquisition Costs'!$F1024=\"\",'Drug Acquisition Costs'!$F1025=\"\"),\"\",F582+F585)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G1020=\"\",'Drug Acquisition Costs'!$F1022=\"\",'Drug Acquisition Costs'!$F1024=\"\",'Drug Acquisition Costs'!$F1025=\"\"),\"\",G582+G585)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H1020=\"\",'Drug Acquisition Costs'!$F1022=\"\",'Drug Acquisition Costs'!$F1024=\"\",'Drug Acquisition Costs'!$F1025=\"\"),\"\",H582+H585)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I1020=\"\",'Drug Acquisition Costs'!$F1022=\"\",'Drug Acquisition Costs'!$F1024=\"\",'Drug Acquisition Costs'!$F1025=\"\"),\"\",I582+I585)","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table F. Total Drug Costs to the HSE"]
[null,null,null,null,null,null,null,null,"Need to do this column. Table below done."]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time"]
[null,null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!G1070=\"\",0,'Drug Acquisition Costs'!G1070)","v":0},null,{"$f":"IF('Drug Acquisition Costs'!I1070=\"\",\"\",'Drug Acquisition Costs'!I1070)","v":""}]
[null,null,null,null,null,null,"number of cycles",null,{"$f":"IF('Drug Acquisition Costs'!I1071=\"\",\"\",'Drug Acquisition Costs'!I1071)","v":""}]
["A",{"$f":"B581","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F581:I581,'Drug Acquisition Costs'!F1033:'Drug Acquisition Costs'!I1033)","v":0},{"$f":"F595*G593","v":0},{"$f":"IF('Drug Acquisition Costs'!H1031=\"Days\",F595/'Drug Acquisition Costs'!F1031*365.25,IF('Drug Acquisition Costs'!H1031=\"Months\",F595/'Drug Acquisition Costs'!F1031*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H1031=\"Days\",I594=\"Days\"),F595/'Drug Acquisition Costs'!F1031*I593,IF(AND('Drug Acquisition Costs'!H1031=\"Months\",I594=\"Months\"),F595/'Drug Acquisition Costs'!F1031*I593,IF(AND('Drug Acquisition Costs'!H1031=\"Days\",I594=\"Months\"),F595/'Drug Acquisition Costs'!F1031*30.4375*I593,IF(AND('Drug Acquisition Costs'!H1031=\"Months\",I594=\"Days\"),F595/'Drug Acquisition Costs'!F1031/30.4375*I593,\"\"))))","v":""}]
["B",{"$f":"B582","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F582:I582,'Drug Acquisition Costs'!F1033:'Drug Acquisition Costs'!I1033)","v":0},{"$f":"F596*G593","v":0},{"$f":"IF('Drug Acquisition Costs'!H1031=\"Days\",F596/'Drug Acquisition Costs'!F1031*365.25,IF('Drug Acquisition Costs'!H1031=\"Months\",F596/'Drug Acquisition Costs'!F1031*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H1031=\"Days\",I594=\"Days\"),F596/'Drug Acquisition Costs'!F1031*I593,IF(AND('Drug Acquisition Costs'!H1031=\"Months\",I594=\"Months\"),F596/'Drug Acquisition Costs'!F1031*I593,IF(AND('Drug Acquisition Costs'!H1031=\"Days\",I594=\"Months\"),F596/'Drug Acquisition Costs'!F1031*30.4375*I593,IF(AND('Drug Acquisition Costs'!H1031=\"Months\",I594=\"Days\"),F596/'Drug Acquisition Costs'!F1031/30.4375*I593,\"\"))))","v":""}]
["C",{"$f":"B583","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F583:I583,'Drug Acquisition Costs'!F1033:'Drug Acquisition Costs'!I1033)","v":0},{"$f":"F597*G593","v":0},{"$f":"IF('Drug Acquisition Costs'!H1031=\"Days\",F597/'Drug Acquisition Costs'!F1031*365.25,IF('Drug Acquisition Costs'!H1031=\"Months\",F597/'Drug Acquisition Costs'!F1031*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H1031=\"Days\",I594=\"Days\"),F597/'Drug Acquisition Costs'!F1031*I593,IF(AND('Drug Acquisition Costs'!H1031=\"Months\",I594=\"Months\"),F597/'Drug Acquisition Costs'!F1031*I593,IF(AND('Drug Acquisition Costs'!H1031=\"Days\",I594=\"Months\"),F597/'Drug Acquisition Costs'!F1031*30.4375*I593,IF(AND('Drug Acquisition Costs'!H1031=\"Months\",I594=\"Days\"),F597/'Drug Acquisition Costs'!F1031/30.4375*I593,\"\"))))","v":""}]
["D","CIC PAS (inclusive of framework agreement rebate)",null,null,null,{"$f":"SUMPRODUCT(F584:I584,'Drug Acquisition Costs'!F1033:'Drug Acquisition Costs'!I1033)","v":0},{"$f":" F598*G593","v":0},{"$f":"IF('Drug Acquisition Costs'!H1031=\"Days\",F598/'Drug Acquisition Costs'!F1031*365.25,IF('Drug Acquisition Costs'!H1031=\"Months\",F598/'Drug Acquisition Costs'!F1031*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H1031=\"Days\",I594=\"Days\"),F598/'Drug Acquisition Costs'!F1031*I593,IF(AND('Drug Acquisition Costs'!H1031=\"Months\",I594=\"Months\"),F598/'Drug Acquisition Costs'!F1031*I593,IF(AND('Drug Acquisition Costs'!H1031=\"Days\",I594=\"Months\"),F598/'Drug Acquisition Costs'!F1031*30.4375*I593,IF(AND('Drug Acquisition Costs'!H1031=\"Months\",I594=\"Days\"),F598/'Drug Acquisition Costs'!F1031/30.4375*I593,\"\"))))","v":""}]
["E",{"$f":"B586","v":"VAT on Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F586:I586,'Drug Acquisition Costs'!F1033:'Drug Acquisition Costs'!I1033)","v":0},{"$f":"F599*G593","v":0},{"$f":"IF('Drug Acquisition Costs'!H1031=\"Days\",F599/'Drug Acquisition Costs'!F1031*365.25,IF('Drug Acquisition Costs'!H1031=\"Months\",F599/'Drug Acquisition Costs'!F1031*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H1031=\"Days\",I594=\"Days\"),F599/'Drug Acquisition Costs'!F1031*I593,IF(AND('Drug Acquisition Costs'!H1031=\"Months\",I594=\"Months\"),F599/'Drug Acquisition Costs'!F1031*I593,IF(AND('Drug Acquisition Costs'!H1032=\"Days\",I594=\"Months\"),F599/'Drug Acquisition Costs'!F1031*30.4375*I593,IF(AND('Drug Acquisition Costs'!H1031=\"Months\",I594=\"Days\"),F599/'Drug Acquisition Costs'!F1031/30.4375*I593,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H1063=\"\",\"\",'Drug Acquisition Costs'!H1063)","v":""},{"$f":"IF(F600=\"\",\"\",F600*G593)","v":""},{"$f":"IF(F600=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H1031=\"Days\",F600/'Drug Acquisition Costs'!F1031*365.25,IF('Drug Acquisition Costs'!H1031=\"Months\",F600/'Drug Acquisition Costs'!F1031*12,\"\")), 744.36))","v":""},{"$f":"IF(F600=\"\",\"\",IF(AND('Drug Acquisition Costs'!H1031=\"Days\",I594=\"Days\"),F600/'Drug Acquisition Costs'!F1031*I593,IF(AND('Drug Acquisition Costs'!H1031=\"Months\",I594=\"Months\"),F600/'Drug Acquisition Costs'!F1031*I593,IF(AND('Drug Acquisition Costs'!H1031=\"Days\",I594=\"Months\"),F600/'Drug Acquisition Costs'!F1031*30.4375*I593,IF(AND('Drug Acquisition Costs'!H1031=\"Months\",I594=\"Days\"),F600/'Drug Acquisition Costs'!F1031/30.4375*I593,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H1064=\"\",\"\",'Drug Acquisition Costs'!H1064)","v":""},{"$f":"IF(F601=\"\",\"\",F601*G593)","v":""},{"$f":"IF(F601=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H1031=\"Days\",F601/'Drug Acquisition Costs'!F1031*365.25,IF('Drug Acquisition Costs'!H1031=\"Months\",F601/'Drug Acquisition Costs'!F1031*12,\"\")), 744.36))","v":""},{"$f":"IF(F601=\"\",\"\",IF(AND('Drug Acquisition Costs'!H1031=\"Days\",I594=\"Days\"),F601/'Drug Acquisition Costs'!F1031*I593,IF(AND('Drug Acquisition Costs'!H1031=\"Months\",I594=\"Months\"),F601/'Drug Acquisition Costs'!F1031*I593,IF(AND('Drug Acquisition Costs'!H1031=\"Days\",I594=\"Months\"),F601/'Drug Acquisition Costs'!F1031*30.4375*I593,IF(AND('Drug Acquisition Costs'!H1031=\"Months\",I594=\"Days\"),F601/'Drug Acquisition Costs'!F1031/30.4375*I593,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 11",null,null,null,{"$f":"SUM(F597:F600)","v":0},{"$f":"SUM(G597:G600)","v":0},{"$f":"SUM(H597:H600)","v":0},{"$f":"SUM(I597:I600)","v":0}]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 11",null,null,null,{"$f":"IF(F601=\"\",SUM(F597:F598),F597+F598+F601)","v":0},{"$f":"IF(G601=\"\",SUM(G597:G598),G597+G598+G601)","v":0},{"$f":"IF(H601=\"\",SUM(H597:H598),H597+H598+H601)","v":0},{"$f":"IF(I601=\"\",SUM(I597:I598),I597+I598+I601)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"'Drug Acquisition Costs'!B1084","v":"Comparator 11: "},null,null,{"$f":"'Drug Acquisition Costs'!E1084","v":0},{"$f":"IF($E607=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E607,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$606&\" Comparator 11\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E607=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E607,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$606&\" Comparator 11\"),$B:$B,0))","v":{"$error":"#N/A"}}]
[]
[null,"Notes"]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,{"$f":"CONCATENATE(\"Comparator 12: \",NameComparator12)","v":"Comparator 12: "}]
[]
[null,"Total Rebate (Including framework agreement and CIC) ",null,null,{"$f":"IF(ISNUMBER('Drug Acquisition Costs'!E1132),ABS('Drug Acquisition Costs'!E1132),0)","v":0}]
[]
[null,"Table C. Total Cost to the HSE per pack"]
[]
[null,null,null,null,null,"Strength Pack Size"]
[null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!F1128=\"\",\"\",'Drug Acquisition Costs'!F1088)","v":""},{"$f":"IF('Drug Acquisition Costs'!G1128=\"\",\"\",'Drug Acquisition Costs'!G1088)","v":""},{"$f":"IF('Drug Acquisition Costs'!H1128=\"\",\"\",'Drug Acquisition Costs'!H1088)","v":""},{"$f":"IF('Drug Acquisition Costs'!I1128=\"\",\"\",'Drug Acquisition Costs'!I1088)","v":""}]
["A","Price to Wholesaler",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F1108=\"\",'Drug Acquisition Costs'!F1109=\"\",'Drug Acquisition Costs'!$F1110=\"\"),\"\",IF('Drug Acquisition Costs'!F1108=\"Price to Wholesaler\",'Drug Acquisition Costs'!F1109,IF('Drug Acquisition Costs'!F1108=\"Reimbursement Price\",(F631/(1+$E630)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G1108=\"\",'Drug Acquisition Costs'!G1109=\"\",'Drug Acquisition Costs'!$F1110=\"\"),\"\",IF('Drug Acquisition Costs'!G1108=\"Price to Wholesaler\",'Drug Acquisition Costs'!G1109,IF('Drug Acquisition Costs'!G1108=\"Reimbursement Price\",(G631/(1+$E630)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H1108=\"\",'Drug Acquisition Costs'!H1109=\"\",'Drug Acquisition Costs'!$F1110=\"\"),\"\",IF('Drug Acquisition Costs'!H1108=\"Price to Wholesaler\",'Drug Acquisition Costs'!H1109,IF('Drug Acquisition Costs'!H1108=\"Reimbursement Price\",(H631/(1+$E630)*1),\"Error\")))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I1108=\"\",'Drug Acquisition Costs'!I1109=\"\",'Drug Acquisition Costs'!$F1110=\"\"),\"\",IF('Drug Acquisition Costs'!I1108=\"Price to Wholesaler\",'Drug Acquisition Costs'!I1109,IF('Drug Acquisition Costs'!I1108=\"Reimbursement Price\",(I631/(1+$E630)*1),\"Error\")))","v":""}]
["B","Wholesale Mark-up",null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F1110=\"\"),\"\",IF(AND('Drug Acquisition Costs'!F1110=\"CDS\",'Drug Acquisition Costs'!F1111=\"Yes\"),CYF,IF(AND('Drug Acquisition Costs'!F1110=\"CDS\",'Drug Acquisition Costs'!F1111=\"No\"),CNF,IF('Drug Acquisition Costs'!F1110=\"HT\",CHT,IF('Drug Acquisition Costs'!F1110=\"Hosp\",CHO,\"Error\")))))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F1110=\"\",'Drug Acquisition Costs'!F1109=\"\",'Drug Acquisition Costs'!F1108=\"\"),\"\",F629*$E630)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F1110=\"\",'Drug Acquisition Costs'!G1109=\"\",'Drug Acquisition Costs'!G1108=\"\"),\"\",G629*$E630)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F1110=\"\",'Drug Acquisition Costs'!H1109=\"\",'Drug Acquisition Costs'!H1108=\"\"),\"\",H629*$E630)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!$F1110=\"\",'Drug Acquisition Costs'!I1109=\"\",'Drug Acquisition Costs'!I1108=\"\"),\"\",I629*$E630)","v":""}]
["C",{"$f":"IF('Drug Acquisition Costs'!F630=\"Hosp\",\"Hospital Price\", \"Reimbursement Price\")","v":"Reimbursement Price"},null,null,{"$f":"IF('Drug Acquisition Costs'!F1108=\"Price to Wholesaler\",\"A+B\",\"\")","v":""},{"$f":"IF('Drug Acquisition Costs'!F1108=\"Reimbursement Price\",'Drug Acquisition Costs'!F1109,IF(ISBLANK($E630),\"\",IF('Drug Acquisition Costs'!F1108=\"Price to Wholesaler\",(F629+F630),IF('Drug Acquisition Costs'!F1108=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!G1108=\"Reimbursement Price\",'Drug Acquisition Costs'!G1109,IF(ISBLANK($E630),\"\",IF('Drug Acquisition Costs'!G1108=\"Price to Wholesaler\",(G629+G630),IF('Drug Acquisition Costs'!G1108=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!H1108=\"Reimbursement Price\",'Drug Acquisition Costs'!H1109,IF(ISBLANK($E630),\"\",IF('Drug Acquisition Costs'!H1108=\"Price to Wholesaler\",(H629+H630),IF('Drug Acquisition Costs'!H1108=\"\",\"\",\"Error\"))))","v":""},{"$f":"IF('Drug Acquisition Costs'!I1108=\"Reimbursement Price\",'Drug Acquisition Costs'!I1109,IF(ISBLANK($E630),\"\",IF('Drug Acquisition Costs'!I1108=\"Price to Wholesaler\",(I629+I630),IF('Drug Acquisition Costs'!I1108=\"\",\"\",\"Error\"))))","v":""}]
["D","Total Rebate (Including framework agreement and CIC) ",null,null,null,{"$f":"IF('Drug Acquisition Costs'!F1109=\"\", \"\", F629*IF($E623=\"\", \"\", -$E623))","v":""},{"$f":"IF('Drug Acquisition Costs'!G1109=\"\", \"\", G629*IF($E623=\"\", \"\", -$E623))","v":""},{"$f":"IF('Drug Acquisition Costs'!H1109=\"\", \"\", H629*IF($E623=\"\", \"\", -$E623))","v":""},{"$f":"IF('Drug Acquisition Costs'!I1109=\"\", \"\", I629*IF($E623=\"\", \"\", -$E623))","v":""}]
["E","Net price (PtW less total rebate)",null,null,null,{"$f":"IFERROR(F629+F632,\"\")","v":""},{"$f":"IFERROR(G629+G632,\"\")","v":""},{"$f":"IFERROR(H629+H632,\"\")","v":""},{"$f":"IFERROR(I629+I632,\"\")","v":""}]
["F","VAT on Reimbursement Price",null,null,{"$f":"IF('Drug Acquisition Costs'!F1112=\"\",\"\",IF('Drug Acquisition Costs'!F1112=\"Yes\",0,VT))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!F1109=\"\",ISBLANK('Drug Acquisition Costs'!F1109)),\"\",($E634*F631))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G1109=\"\",ISBLANK('Drug Acquisition Costs'!G1109)),\"\",($E634*G631))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H1109=\"\",ISBLANK('Drug Acquisition Costs'!H1109)),\"\",($E634*H631))","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I1109=\"\",ISBLANK('Drug Acquisition Costs'!I1109)),\"\",($E634*I631))","v":""}]
["G(i)","Total Drug Cost to the HSE per pack with CIC PAS including VAT (B+E+F)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F1108=\"\",'Drug Acquisition Costs'!$F1110=\"\",'Drug Acquisition Costs'!$F1112=\"\",'Drug Acquisition Costs'!$F1113=\"\"),\"\",F630+F633+F634)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G1108=\"\",'Drug Acquisition Costs'!$F1110=\"\",'Drug Acquisition Costs'!$F1112=\"\",'Drug Acquisition Costs'!$F1113=\"\"),\"\",G630+G633+G634)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H1108=\"\",'Drug Acquisition Costs'!$F1110=\"\",'Drug Acquisition Costs'!$F1112=\"\",'Drug Acquisition Costs'!$F1113=\"\"),\"\",H630+H633+H634)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I1108=\"\",'Drug Acquisition Costs'!$F1110=\"\",'Drug Acquisition Costs'!$F1112=\"\",'Drug Acquisition Costs'!$F1113=\"\"),\"\",I630+I633+I634)","v":""}]
["G(ii)","Total Drug Cost to the HSE per pack with CIC PAS excluding VAT (B+E)",null,null,null,{"$f":"IF(OR('Drug Acquisition Costs'!F1108=\"\",'Drug Acquisition Costs'!$F1110=\"\",'Drug Acquisition Costs'!$F1112=\"\",'Drug Acquisition Costs'!$F1113=\"\"),\"\",F630+F633)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!G1108=\"\",'Drug Acquisition Costs'!$F1110=\"\",'Drug Acquisition Costs'!$F1112=\"\",'Drug Acquisition Costs'!$F1113=\"\"),\"\",G630+G633)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!H1108=\"\",'Drug Acquisition Costs'!$F1110=\"\",'Drug Acquisition Costs'!$F1112=\"\",'Drug Acquisition Costs'!$F1113=\"\"),\"\",H630+H633)","v":""},{"$f":"IF(OR('Drug Acquisition Costs'!I1108=\"\",'Drug Acquisition Costs'!$F1110=\"\",'Drug Acquisition Costs'!$F1112=\"\",'Drug Acquisition Costs'!$F1113=\"\"),\"\",I630+I633)","v":""}]
[null,null,null,null,null,null,null,null,null,null," "]
["Table F. Total Drug Costs to the HSE"]
[null,null,null,null,null,null,null,null,"Need to do this column. Table below done."]
[null,null,null,null,null,"Total Cost per treatment Cycle","Total Cost per ","Total Cost per Year","Total Cost per unit time"]
[null,null,null,null,null,null,{"$f":"IF('Drug Acquisition Costs'!G1158=\"\",0,'Drug Acquisition Costs'!G1158)","v":0},null,{"$f":"IF('Drug Acquisition Costs'!I1158=\"\",\"\",'Drug Acquisition Costs'!I1158)","v":""}]
[null,null,null,null,null,null,"number of cycles",null,{"$f":"IF('Drug Acquisition Costs'!I1159=\"\",\"\",'Drug Acquisition Costs'!I1159)","v":""}]
["A",{"$f":"B629","v":"Price to Wholesaler"},null,null,null,{"$f":"SUMPRODUCT(F629:I629,'Drug Acquisition Costs'!F1121:'Drug Acquisition Costs'!I1121)","v":0},{"$f":"F643*G641","v":0},{"$f":"IF('Drug Acquisition Costs'!H1119=\"Days\",F643/'Drug Acquisition Costs'!F1119*365.25,IF('Drug Acquisition Costs'!H1119=\"Months\",F643/'Drug Acquisition Costs'!F119*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H1119=\"Days\",I642=\"Days\"),F643/'Drug Acquisition Costs'!F1119*I641,IF(AND('Drug Acquisition Costs'!H1119=\"Months\",I642=\"Months\"),F643/'Drug Acquisition Costs'!F1119*I641,IF(AND('Drug Acquisition Costs'!H1119=\"Days\",I642=\"Months\"),F643/'Drug Acquisition Costs'!F1119*30.4375*I641,IF(AND('Drug Acquisition Costs'!H1119=\"Months\",I642=\"Days\"),F643/'Drug Acquisition Costs'!F1119/30.4375*I641,\"\"))))","v":""}]
["B",{"$f":"B630","v":"Wholesale Mark-up"},null,null,null,{"$f":"SUMPRODUCT(F630:I630,'Drug Acquisition Costs'!F1121:'Drug Acquisition Costs'!I1121)","v":0},{"$f":"F644*G641","v":0},{"$f":"IF('Drug Acquisition Costs'!H1119=\"Days\",F644/'Drug Acquisition Costs'!F1119*365.25,IF('Drug Acquisition Costs'!H1119=\"Months\",F644/'Drug Acquisition Costs'!F1119*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H1119=\"Days\",I642=\"Days\"),F644/'Drug Acquisition Costs'!F1119*I641,IF(AND('Drug Acquisition Costs'!H1119=\"Months\",I642=\"Months\"),F644/'Drug Acquisition Costs'!F1119*I641,IF(AND('Drug Acquisition Costs'!H1119=\"Days\",I642=\"Months\"),F644/'Drug Acquisition Costs'!F1119*30.4375*I641,IF(AND('Drug Acquisition Costs'!H1119=\"Months\",I642=\"Days\"),F644/'Drug Acquisition Costs'!F1119/30.4375*I641,\"\"))))","v":""}]
["C",{"$f":"B631","v":"Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F631:I631,'Drug Acquisition Costs'!F1121:'Drug Acquisition Costs'!I1121)","v":0},{"$f":"F645*G641","v":0},{"$f":"IF('Drug Acquisition Costs'!H1119=\"Days\",F645/'Drug Acquisition Costs'!F1119*365.25,IF('Drug Acquisition Costs'!H1119=\"Months\",F645/'Drug Acquisition Costs'!F1119*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H1119=\"Days\",I642=\"Days\"),F645/'Drug Acquisition Costs'!F1119*I641,IF(AND('Drug Acquisition Costs'!H1119=\"Months\",I642=\"Months\"),F645/'Drug Acquisition Costs'!F1119*I641,IF(AND('Drug Acquisition Costs'!H1119=\"Days\",I642=\"Months\"),F645/'Drug Acquisition Costs'!F1119*30.4375*I641,IF(AND('Drug Acquisition Costs'!H1119=\"Months\",I642=\"Days\"),F645/'Drug Acquisition Costs'!F1119/30.4375*I641,\"\"))))","v":""}]
["D","CIC PAS (inclusive of framework agreement rebate)",null,null,null,{"$f":"SUMPRODUCT(F632:I632,'Drug Acquisition Costs'!F1121:'Drug Acquisition Costs'!I1121)","v":0},{"$f":" F646*G641","v":0},{"$f":"IF('Drug Acquisition Costs'!H1119=\"Days\",F646/'Drug Acquisition Costs'!F1119*365.25,IF('Drug Acquisition Costs'!H1119=\"Months\",F646/'Drug Acquisition Costs'!F1119*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H1119=\"Days\",I642=\"Days\"),F646/'Drug Acquisition Costs'!F1119*I641,IF(AND('Drug Acquisition Costs'!H1119=\"Months\",I642=\"Months\"),F646/'Drug Acquisition Costs'!F1119*I641,IF(AND('Drug Acquisition Costs'!H1119=\"Days\",I642=\"Months\"),F646/'Drug Acquisition Costs'!F1119*30.4375*I641,IF(AND('Drug Acquisition Costs'!H1119=\"Months\",I642=\"Days\"),F646/'Drug Acquisition Costs'!F1119/30.4375*I641,\"\"))))","v":""}]
["E",{"$f":"B634","v":"VAT on Reimbursement Price"},null,null,null,{"$f":"SUMPRODUCT(F634:I634,'Drug Acquisition Costs'!F1121:'Drug Acquisition Costs'!I1121)","v":0},{"$f":"F647*G641","v":0},{"$f":"IF('Drug Acquisition Costs'!H1119=\"Days\",F647/'Drug Acquisition Costs'!F1119*365.25,IF('Drug Acquisition Costs'!H1119=\"Months\",F647/'Drug Acquisition Costs'!F1119*12,\"\"))","v":""},{"$f":"IF(AND('Drug Acquisition Costs'!H1119=\"Days\",I642=\"Days\"),F647/'Drug Acquisition Costs'!F1119*I641,IF(AND('Drug Acquisition Costs'!H1119=\"Months\",I642=\"Months\"),F647/'Drug Acquisition Costs'!F1119*I641,IF(AND('Drug Acquisition Costs'!H1120=\"Days\",I642=\"Months\"),F647/'Drug Acquisition Costs'!F1119*30.4375*I641,IF(AND('Drug Acquisition Costs'!H1119=\"Months\",I642=\"Days\"),F647/'Drug Acquisition Costs'!F1119/30.4375*I641,\"\"))))","v":""}]
["J(i)","Total Pharmacy Fee including VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H1151=\"\",\"\",'Drug Acquisition Costs'!H1151)","v":""},{"$f":"IF(F648=\"\",\"\",F648*G641)","v":""},{"$f":"IF(F648=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H1119=\"Days\",F648/'Drug Acquisition Costs'!F1119*365.25,IF('Drug Acquisition Costs'!H1119=\"Months\",F648/'Drug Acquisition Costs'!F1119*12,\"\")), 744.36))","v":""},{"$f":"IF(F648=\"\",\"\",IF(AND('Drug Acquisition Costs'!H1119=\"Days\",I642=\"Days\"),F648/'Drug Acquisition Costs'!F1119*I641,IF(AND('Drug Acquisition Costs'!H1119=\"Months\",I642=\"Months\"),F648/'Drug Acquisition Costs'!F1119*I641,IF(AND('Drug Acquisition Costs'!H1119=\"Days\",I642=\"Months\"),F648/'Drug Acquisition Costs'!F1119*30.4375*I641,IF(AND('Drug Acquisition Costs'!H1119=\"Months\",I642=\"Days\"),F648/'Drug Acquisition Costs'!F1119/30.4375*I641,\"\")))))","v":""}]
["J(ii)","Total Pharmacy Fee excluding VAT",null,null,null,{"$f":"IF('Drug Acquisition Costs'!H1152=\"\",\"\",'Drug Acquisition Costs'!H1152)","v":""},{"$f":"IF(F649=\"\",\"\",F649*G641)","v":""},{"$f":"IF(F649=\"\",\"\",MIN(IF('Drug Acquisition Costs'!H1119=\"Days\",F649/'Drug Acquisition Costs'!F1119*365.25,IF('Drug Acquisition Costs'!H1119=\"Months\",F649/'Drug Acquisition Costs'!F1119*12,\"\")), 744.36))","v":""},{"$f":"IF(F649=\"\",\"\",IF(AND('Drug Acquisition Costs'!H1119=\"Days\",I642=\"Days\"),F649/'Drug Acquisition Costs'!F1119*I641,IF(AND('Drug Acquisition Costs'!H1119=\"Months\",I642=\"Months\"),F649/'Drug Acquisition Costs'!F1119*I641,IF(AND('Drug Acquisition Costs'!H1119=\"Days\",I642=\"Months\"),F649/'Drug Acquisition Costs'!F1119*30.4375*I641,IF(AND('Drug Acquisition Costs'!H1119=\"Months\",I642=\"Days\"),F649/'Drug Acquisition Costs'!F1119/30.4375*I641,\"\")))))","v":""}]
["K(i)","Total Drug Cost including Pharmacy Fees and VAT (Pro Rata): Comparator 12",null,null,null,{"$f":"SUM(F645:F648)","v":0},{"$f":"SUM(G645:G648)","v":0},{"$f":"SUM(H645:H648)","v":0},{"$f":"SUM(I645:I648)","v":0}]
["K(ii)","Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata): Comparator 12",null,null,null,{"$f":"IF(F649=\"\",SUM(F645:F646),F645+F646+F649)","v":0},{"$f":"IF(G649=\"\",SUM(G645:G646),G645+G646+G649)","v":0},{"$f":"IF(H649=\"\",SUM(H645:H646),H645+H646+H649)","v":0},{"$f":"IF(I649=\"\",SUM(I645:I646),I645+I646+I649)","v":0}]
[]
[null,"Table G: Calculation method (from Table F)",null,null,null,"Cell Reference for cost"]
[null,null,null,null,null,"Total Drug Cost including Pharmacy Fees and VAT (Pro Rata):",null,"Total Drug Cost including pharmacy fees and excluding VAT (Pro Rata):"]
[null,{"$f":"'Drug Acquisition Costs'!B1172","v":"Comparator 12: "},null,null,{"$f":"'Drug Acquisition Costs'!E1172","v":0},{"$f":"IF($E655=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E655,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(F$654&\" Comparator 12\"),$B:$B,0))","v":{"$error":"#N/A"}},null,{"$f":"IF($E655=References!$B$52,\"Please overwrite formula in Tables 1a and 1b\",\"$\"&VLOOKUP($E655,References!$B$48:$F$51,5,0)&\"$\"&MATCH(CONCATENATE(H$654&\" Comparator 12\"),$B:$B,0))","v":{"$error":"#N/A"}}]
[]
[null,"Notes"]

{"sheet":"Additional Costs","index":6,"n_rows":40,"n_cols":10,"rows_kept":40,"cut":false,"hidden":false,"merged":[[24,1,24,4],[28,1,28,4],[16,1,21,11]]}
[]
[]
[]
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[]
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[]
[null,"Describe the potential for additional costs and cost-offsets which may impact the wider healthcare budget in this tab. Administration, monitoring, adverse event costs etc. can be included here. Please use the space below to show any working out, and insert the additional costs and cost-offsets in the cells below. If an additional worksheet is needed, please add into the excel file. If there is a cost offset, place a minus sign in front of the amount. Please note: it is beyond the scope of the Rapid Review process to appraise the impact of an intervention on wider health care budgets; the net budget impact is not required for Rapid Review submissions."]
[]
[]
[]
[]
[]
[]
[null,null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5"]
[null,"Cost/cost-offset per patient per year (including VAT)"]
[]
[]
[]
[null,"Notes"]
[]
[null,"Additional costs"]
[]
[]
[]
[]
[]
[]
[]
[]
[null,"Additional savings"]

{"sheet":"Results","index":7,"n_rows":182,"n_cols":13,"rows_kept":182,"cut":false,"hidden":false,"merged":[[124,1,128,2],[129,1,133,2],[134,1,138,2],[181,1,182,11],[169,1,169,6],[172,1,172,6],[175,1,175,6],[177,1,177,6],[179,1,179,6],[138,3,138,6],[127,3,127,6],[132,3,132,6],[137,3,137,6],[128,3,128,6],[133,3,133,6],[125,3,125,6],[129,3,129,6],[130,3,130,6],[134,3,134,6],[158,3,158,6],[149,1,153,2],[149,3,149,6],[150,3,150,6],[126,3,126,6],[24,1,24,6],[21,1,21,6],[16,1,19,9],[27,1,27,6],[43,1,47,2],[34,1,34,6],[40,1,40,6],[37,1,37,6],[135,3,135,6],[43,3,43,6],[44,3,44,6],[48,3,48,6],[49,3,49,6],[53,3,53,6],[54,3,54,6],[58,3,58,6],[59,3,59,6],[63,3,63,6],[112,3,112,6],[122,3,122,6],[69,3,69,6],[68,3,68,6],[61,3,61,6],[66,3,66,6],[89,3,89,6],[29,1,33,2],[29,3,29,6],[30,3,30,6],[32,3,32,6],[33,3,33,6],[91,3,91,6],[92,3,92,6],[56,3,56,6],[57,3,57,6],[62,3,62,6],[67,3,67,6],[72,3,72,6],[86,3,86,6],[87,3,87,6],[88,3,88,6],[71,3,71,6],[64,3,64,6],[109,3,109,6],[114,3,114,6],[47,3,47,6],[52,3,52,6],[31,3,31,6],[35,1,35,6],[38,1,38,6],[78,1,82,2],[78,3,78,6],[79,3,79,6],[81,3,81,6],[82,3,82,6],[73,1,77,2],[73,3,73,6],[74,3,74,6],[110,3,110,6],[109,1,113,2],[42,1,42,6],[103,1,103,6],[48,1,52,2],[53,1,57,2],[58,1,62,2],[63,1,67,2],[68,1,72,2],[131,3,131,6],[153,3,153,6],[76,3,76,6],[77,3,77,6],[164,1,168,2],[164,3,164,6],[165,3,165,6],[167,3,167,6],[168,3,168,6],[159,1,163,2],[159,3,159,6],[160,3,160,6],[162,3,162,6],[163,3,163,6],[154,1,158,2],[154,3,154,6],[155,3,155,6],[157,3,157,6],[83,1,87,2],[83,3,83,6],[113,3,113,6],[118,3,118,6],[123,3,123,6],[120,3,120,6],[115,3,115,6],[117,3,117,6],[108,1,108,6],[90,3,90,6],[95,3,95,6],[100,3,100,6],[111,3,111,6],[116,3,116,6],[121,3,121,6],[114,1,118,2],[119,1,123,2],[99,3,99,6],[101,3,101,6],[102,3,102,6],[98,1,102,2],[98,3,98,6],[119,3,119,6],[104,1,104,6],[93,1,97,2],[93,3,93,6],[94,3,94,6],[96,3,96,6],[97,3,97,6],[88,1,92,2],[173,1,173,6],[170,1,170,6],[140,3,140,6],[142,3,142,6],[143,3,143,6],[144,1,148,2],[144,3,144,6],[145,3,145,6],[147,3,147,6],[148,3,148,6],[25,1,25,6],[136,3,136,6],[141,3,141,6],[146,3,146,6],[151,3,151,6],[156,3,156,6],[161,3,161,6],[166,3,166,6],[139,1,143,2],[139,3,139,6],[152,3,152,6],[45,3,45,6],[50,3,50,6],[55,3,55,6],[60,3,60,6],[65,3,65,6],[70,3,70,6],[75,3,75,6],[80,3,80,6],[85,3,85,6],[84,3,84,6],[46,3,46,6],[51,3,51,6],[124,3,124,6]]}
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null,"The gross and net drug budget impacts are presented below, based on the inputs used throughout the rest of the model. Separately, a net budget impact accounting for costs and offsets outside of the drugs budget is presented.  Patients who died or stopped treatment are assumed to have received treatment for 6 months."]
[]
[]
[]
[null,"Estimates from the BIM including and excluding VAT should be copied and pasted directly into the Applicant template."]
[null,"Summary"]
[]
[null,null,null,null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5","Cumulative"]
[null,"Number of patients expected to receive treatment (i.e. treated population)",null,null,null,null,null,{"$f":"'Patient Population'!E36","v":0},{"$f":"'Patient Population'!F36","v":0},{"$f":"'Patient Population'!G36","v":0},{"$f":"'Patient Population'!H36","v":0},{"$f":"'Patient Population'!I36","v":0}]
[null,"Market share for the intervention",null,null,null,null,null,{"$f":"'Patient Population'!E68","v":0},{"$f":"'Patient Population'!F68","v":0},{"$f":"'Patient Population'!G68","v":0},{"$f":"'Patient Population'!H68","v":0},{"$f":"'Patient Population'!I68","v":0}]
[]
[null,"Gross Drug Budget Impact"]
[null,null,null,null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5"]
[null,{"$f":"CONCATENATE(\"Intervention: \",InterventionINN)","v":"Intervention: "},null,"Number of patients receiving intervention",null,null,null,{"$f":"'Patient Population'!E36*'Patient Population'!E68","v":0},{"$f":"'Patient Population'!F36*'Patient Population'!F68","v":0},{"$f":"'Patient Population'!G36*'Patient Population'!G68","v":0},{"$f":"'Patient Population'!H36*'Patient Population'!H68","v":0},{"$f":"'Patient Population'!I36*'Patient Population'!I68","v":0}]
[null,null,null,"Cost of intervention each year (including VAT)",null,null,null,{"$f":" 'Drug Acquisition Costs'!E28","v":0},{"$f":" 'Drug Acquisition Costs'!F28","v":0},{"$f":" 'Drug Acquisition Costs'!G28","v":0},{"$f":" 'Drug Acquisition Costs'!H28","v":0},{"$f":" 'Drug Acquisition Costs'!I28","v":0}]
[null,null,null,"Cost of intervention each year (excluding VAT)",null,null,null,{"$f":"'Drug Acquisition Costs'!N28","v":0},{"$f":"'Drug Acquisition Costs'!O28","v":0},{"$f":"'Drug Acquisition Costs'!P28","v":0},{"$f":"'Drug Acquisition Costs'!Q28","v":0},{"$f":"'Drug Acquisition Costs'!R28","v":0}]
[null,null,null,"Number of patients who discontinued",null,null,null,{"$f":"('Patient Population'!E36*'Patient Population'!E68*'Patient Population'!E88)","v":0},{"$f":"('Patient Population'!F36*'Patient Population'!F68*'Patient Population'!F88)","v":0},{"$f":"('Patient Population'!G36*'Patient Population'!G68*'Patient Population'!G88)","v":0},{"$f":"('Patient Population'!H36*'Patient Population'!H68*'Patient Population'!H88)","v":0},{"$f":"('Patient Population'!I36*'Patient Population'!I68*'Patient Population'!I88)","v":0}]
[null,null,null,"Number of patients who died",null,null,null,{"$f":"'Patient Population'!E30*'Patient Population'!E31*'Patient Population'!E33*'Patient Population'!E35*'Patient Population'!E68","v":0},{"$f":"'Patient Population'!F30*'Patient Population'!F31*'Patient Population'!F33*'Patient Population'!F35*'Patient Population'!F68","v":0},{"$f":"'Patient Population'!G30*'Patient Population'!G31*'Patient Population'!G33*'Patient Population'!G35*'Patient Population'!G68","v":0},{"$f":"'Patient Population'!H30*'Patient Population'!H31*'Patient Population'!H33*'Patient Population'!H35*'Patient Population'!H68","v":0},{"$f":"'Patient Population'!I30*'Patient Population'!I31*'Patient Population'!I33*'Patient Population'!I35*'Patient Population'!I68","v":0}]
[null,"Total cost of intervention (including VAT)",null,null,null,null,null,{"$f":"(H30*H31)-((0.5*H31)*(H33+H34))","v":0},{"$f":"(I30*I31)-((0.5*I31)*(I33+I34))","v":0},{"$f":"(J30*J31)-((0.5*J31)*(J33+J34))","v":0},{"$f":"(K30*K31)-((0.5*K31)*(K33+K34))","v":0},{"$f":"(L30*L31)-((0.5*L31)*(L33+L34))","v":0}]
[null,"Total cost of intervention (excluding VAT)",null,null,null,null,null,{"$f":"(H30*H32)-((0.5*H32)*(H33+H34))","v":0},{"$f":"(I30*I32)-((0.5*I32)*(I33+I34))","v":0},{"$f":"(J30*J32)-((0.5*J32)*(J33+J34))","v":0},{"$f":"(K30*K32)-((0.5*K32)*(K33+K34))","v":0},{"$f":"(L30*L32)-((0.5*L32)*(L33+L34))","v":0}]
[]
[null,"Gross Drug Budget Impact (including VAT)",null,null,null,null,null,{"$f":"H35","v":0},{"$f":"I35","v":0},{"$f":"J35","v":0},{"$f":"K35","v":0},{"$f":"L35","v":0},{"$f":"SUM(H38:L38)","v":0}]
[null,"Gross Drug Budget Impact (excluding VAT)",null,null,null,null,null,{"$f":"H36","v":0},{"$f":"I36","v":0},0,0,0,{"$f":"SUM(H39:L39)","v":0}]
[]
[null,"Net Drug Budget Impact"]
[]
[null,"Comparator costs with new intervention in market",null,null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5"]
[null,{"$f":"CONCATENATE(\"Comparator 1: \",NameComparator1)","v":"Comparator 1: "},null,"Number of patients receiving comparator 1",null,null,null,{"$f":"'Patient Population'!E36*'Patient Population'!E69","v":0},{"$f":"'Patient Population'!F36*'Patient Population'!F69","v":0},{"$f":"'Patient Population'!G36*'Patient Population'!G69","v":0},{"$f":"'Patient Population'!H36*'Patient Population'!H69","v":0},{"$f":"'Patient Population'!I36*'Patient Population'!I69","v":0}]
[null,null,null,"Cost of comparator 1 each year (including VAT)",null,null,null,{"$f":" 'Drug Acquisition Costs'!E29","v":0},{"$f":" 'Drug Acquisition Costs'!F29","v":0},{"$f":" 'Drug Acquisition Costs'!G29","v":0},{"$f":" 'Drug Acquisition Costs'!H29","v":0},{"$f":" 'Drug Acquisition Costs'!I29","v":0}]
[null,null,null,"Cost of comparator 1 each year (excluding VAT)",null,null,null,{"$f":" 'Drug Acquisition Costs'!N29","v":0},{"$f":" 'Drug Acquisition Costs'!O29","v":0},{"$f":" 'Drug Acquisition Costs'!P29","v":0},{"$f":" 'Drug Acquisition Costs'!Q29","v":0},{"$f":" 'Drug Acquisition Costs'!R29","v":0}]
[null,null,null,"Number of patients who discontinued",null,null,null,{"$f":"('Patient Population'!E36*'Patient Population'!E69*'Patient Population'!E89)","v":0},{"$f":"('Patient Population'!F36*'Patient Population'!F69*'Patient Population'!F89)","v":0},{"$f":"('Patient Population'!G36*'Patient Population'!G69*'Patient Population'!G89)","v":0},{"$f":"('Patient Population'!H36*'Patient Population'!H69*'Patient Population'!H89)","v":0},{"$f":"('Patient Population'!I36*'Patient Population'!I69*'Patient Population'!I89)","v":0}]
[null,null,null,"Number of patients who died",null,null,null,{"$f":"'Patient Population'!E30*'Patient Population'!E31*'Patient Population'!E33*'Patient Population'!E35*'Patient Population'!E69","v":0},{"$f":"'Patient Population'!F30*'Patient Population'!F31*'Patient Population'!F33*'Patient Population'!F35*'Patient Population'!F69","v":0},{"$f":"'Patient Population'!G30*'Patient Population'!G31*'Patient Population'!G33*'Patient Population'!G35*'Patient Population'!G69","v":0},{"$f":"'Patient Population'!H30*'Patient Population'!H31*'Patient Population'!H33*'Patient Population'!H35*'Patient Population'!H69","v":0},{"$f":"'Patient Population'!I30*'Patient Population'!I31*'Patient Population'!I33*'Patient Population'!I35*'Patient Population'!I69","v":0}]
[null,{"$f":"CONCATENATE(\"Comparator 2: \",NameComparator2)","v":"Comparator 2: "},null,"Number of patients receiving comparator 2",null,null,null,{"$f":"'Patient Population'!E36*'Patient Population'!E70","v":0},{"$f":"'Patient Population'!F36*'Patient Population'!F70","v":0},{"$f":"'Patient Population'!G36*'Patient Population'!G70","v":0},{"$f":"'Patient Population'!H36*'Patient Population'!H70","v":0},{"$f":"'Patient Population'!I36*'Patient Population'!I70","v":0}]
[null,null,null,"Cost of comparator 2 each year (including VAT)",null,null,null,{"$f":" 'Drug Acquisition Costs'!E30","v":0},{"$f":" 'Drug Acquisition Costs'!F30","v":0},{"$f":" 'Drug Acquisition Costs'!G30","v":0},{"$f":" 'Drug Acquisition Costs'!H30","v":0},{"$f":" 'Drug Acquisition Costs'!I30","v":0}]
[null,null,null,"Cost of comparator 2 each year (excluding VAT)",null,null,null,{"$f":" 'Drug Acquisition Costs'!N30","v":0},{"$f":" 'Drug Acquisition Costs'!O30","v":0},{"$f":" 'Drug Acquisition Costs'!P30","v":0},{"$f":" 'Drug Acquisition Costs'!Q30","v":0},{"$f":" 'Drug Acquisition Costs'!R30","v":0}]
[null,null,null,"Number of patients who discontinued",null,null,null,{"$f":"('Patient Population'!E36*'Patient Population'!E70*'Patient Population'!E90)","v":0},{"$f":"('Patient Population'!F36*'Patient Population'!F70*'Patient Population'!F90)","v":0},{"$f":"('Patient Population'!G36*'Patient Population'!G70*'Patient Population'!G90)","v":0},{"$f":"('Patient Population'!H36*'Patient Population'!H70*'Patient Population'!H90)","v":0},{"$f":"('Patient Population'!I36*'Patient Population'!I70*'Patient Population'!I90)","v":0}]
[null,null,null,"Number of patients who died",null,null,null,{"$f":"'Patient Population'!E30*'Patient Population'!E31*'Patient Population'!E33*'Patient Population'!E35*'Patient Population'!E70","v":0},{"$f":"'Patient Population'!F30*'Patient Population'!F31*'Patient Population'!F33*'Patient Population'!F35*'Patient Population'!F70","v":0},{"$f":"'Patient Population'!G30*'Patient Population'!G31*'Patient Population'!G33*'Patient Population'!G35*'Patient Population'!G70","v":0},{"$f":"'Patient Population'!H30*'Patient Population'!H31*'Patient Population'!H33*'Patient Population'!H35*'Patient Population'!H70","v":0},{"$f":"'Patient Population'!I30*'Patient Population'!I31*'Patient Population'!I33*'Patient Population'!I35*'Patient Population'!I70","v":0}]
[null,{"$f":"CONCATENATE(\"Comparator 3: \",NameComparator3)","v":"Comparator 3: "},null,"Number of patients receiving comparator 3",null,null,null,{"$f":"'Patient Population'!E36*'Patient Population'!E71","v":0},{"$f":"'Patient Population'!F36*'Patient Population'!F71","v":0},{"$f":"'Patient Population'!G36*'Patient Population'!G71","v":0},{"$f":"'Patient Population'!H36*'Patient Population'!H71","v":0},{"$f":"'Patient Population'!I36*'Patient Population'!I71","v":0}]
[null,null,null,"Cost of comparator 3 each year (including VAT)",null,null,null,{"$f":" 'Drug Acquisition Costs'!E31","v":0},{"$f":" 'Drug Acquisition Costs'!F31","v":0},{"$f":" 'Drug Acquisition Costs'!G31","v":0},{"$f":" 'Drug Acquisition Costs'!H31","v":0},{"$f":" 'Drug Acquisition Costs'!I31","v":0}]
[null,null,null,"Cost of comparator 3 each year (excluding VAT)",null,null,null,{"$f":" 'Drug Acquisition Costs'!N31","v":0},{"$f":" 'Drug Acquisition Costs'!O31","v":0},{"$f":" 'Drug Acquisition Costs'!P31","v":0},{"$f":" 'Drug Acquisition Costs'!Q31","v":0},{"$f":" 'Drug Acquisition Costs'!R31","v":0}]
[null,null,null,"Number of patients who discontinued",null,null,null,{"$f":"('Patient Population'!E36*'Patient Population'!E71*'Patient Population'!E91)","v":0},{"$f":"('Patient Population'!F36*'Patient Population'!F71*'Patient Population'!F91)","v":0},{"$f":"('Patient Population'!G36*'Patient Population'!G71*'Patient Population'!G91)","v":0},{"$f":"('Patient Population'!H36*'Patient Population'!H71*'Patient Population'!H91)","v":0},{"$f":"('Patient Population'!I36*'Patient Population'!I71*'Patient Population'!I91)","v":0}]
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[null,null,null,"Number of patients who died",null,null,null,{"$f":"'Patient Population'!E30*'Patient Population'!E31*'Patient Population'!E33*'Patient Population'!E35*'Patient Population'!E80","v":0},{"$f":"'Patient Population'!F30*'Patient Population'!F31*'Patient Population'!F33*'Patient Population'!F35*'Patient Population'!F80","v":0},{"$f":"'Patient Population'!G30*'Patient Population'!G31*'Patient Population'!G33*'Patient Population'!G35*'Patient Population'!G80","v":0},{"$f":"'Patient Population'!H30*'Patient Population'!H31*'Patient Population'!H33*'Patient Population'!H35*'Patient Population'!H80","v":0},{"$f":"'Patient Population'!I30*'Patient Population'!I31*'Patient Population'!I33*'Patient Population'!I35*'Patient Population'!I80","v":0}]
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[]
[]
[]
[null,"Comparator costs with no intervention in market",null,null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5"]
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[null,null,null,"Cost of comparator 1 each year (including VAT)",null,null,null,{"$f":" 'Drug Acquisition Costs'!E29","v":0},{"$f":" 'Drug Acquisition Costs'!F29","v":0},{"$f":" 'Drug Acquisition Costs'!G29","v":0},{"$f":" 'Drug Acquisition Costs'!H29","v":0},{"$f":" 'Drug Acquisition Costs'!I29","v":0}]
[null,null,null,"Cost of comparator 1 each year (excluding VAT)",null,null,null,{"$f":" 'Drug Acquisition Costs'!N29","v":0},{"$f":" 'Drug Acquisition Costs'!O29","v":0},{"$f":" 'Drug Acquisition Costs'!P29","v":0},{"$f":" 'Drug Acquisition Costs'!Q29","v":0},{"$f":" 'Drug Acquisition Costs'!R29","v":0}]
[null,null,null,"Number of patients who discontinued",null,null,null,{"$f":"('Patient Population'!E36*'Patient Population'!E49*'Patient Population'!E89)","v":0},{"$f":"('Patient Population'!F36*'Patient Population'!F49*'Patient Population'!F89)","v":0},{"$f":"('Patient Population'!G36*'Patient Population'!G49*'Patient Population'!G89)","v":0},{"$f":"('Patient Population'!H36*'Patient Population'!H49*'Patient Population'!H89)","v":0},{"$f":"('Patient Population'!I36*'Patient Population'!I49*'Patient Population'!I89)","v":0}]
[null,null,null,"Number of patients who died",null,null,null,{"$f":"'Patient Population'!E30*'Patient Population'!E31*'Patient Population'!E33*'Patient Population'!E35*'Patient Population'!E49","v":0},{"$f":"'Patient Population'!F30*'Patient Population'!F31*'Patient Population'!F33*'Patient Population'!F35*'Patient Population'!F49","v":0},{"$f":"'Patient Population'!G30*'Patient Population'!G31*'Patient Population'!G33*'Patient Population'!G35*'Patient Population'!G49","v":0},{"$f":"'Patient Population'!H30*'Patient Population'!H31*'Patient Population'!H33*'Patient Population'!H35*'Patient Population'!H49","v":0},{"$f":"'Patient Population'!I30*'Patient Population'!I31*'Patient Population'!I33*'Patient Population'!I35*'Patient Population'!I49","v":0}]
[null,{"$f":"CONCATENATE(\"Comparator 2: \",NameComparator2)","v":"Comparator 2: "},null,"Number of patients receiving comparator 2",null,null,null,{"$f":"'Patient Population'!E36*'Patient Population'!E50","v":0},{"$f":"'Patient Population'!F36*'Patient Population'!F50","v":0},{"$f":"'Patient Population'!G36*'Patient Population'!G50","v":0},{"$f":"'Patient Population'!H36*'Patient Population'!H50","v":0},{"$f":"'Patient Population'!I36*'Patient Population'!I50","v":0}]
[null,null,null,"Cost of comparator 2 each year (including VAT)",null,null,null,{"$f":" 'Drug Acquisition Costs'!E30","v":0},{"$f":" 'Drug Acquisition Costs'!F30","v":0},{"$f":" 'Drug Acquisition Costs'!G30","v":0},{"$f":" 'Drug Acquisition Costs'!H30","v":0},{"$f":" 'Drug Acquisition Costs'!I30","v":0}]
[null,null,null,"Cost of comparator 2 each year (excluding VAT)",null,null,null,{"$f":" 'Drug Acquisition Costs'!N30","v":0},{"$f":" 'Drug Acquisition Costs'!O30","v":0},{"$f":" 'Drug Acquisition Costs'!P30","v":0},{"$f":" 'Drug Acquisition Costs'!Q30","v":0},{"$f":" 'Drug Acquisition Costs'!R30","v":0}]
[null,null,null,"Number of patients who discontinued",null,null,null,{"$f":"('Patient Population'!E36*'Patient Population'!E50*'Patient Population'!E90)","v":0},{"$f":"('Patient Population'!F36*'Patient Population'!F50*'Patient Population'!F90)","v":0},{"$f":"('Patient Population'!G36*'Patient Population'!G50*'Patient Population'!G90)","v":0},{"$f":"('Patient Population'!H36*'Patient Population'!H50*'Patient Population'!H90)","v":0},{"$f":"('Patient Population'!I36*'Patient Population'!I50*'Patient Population'!I90)","v":0}]
[null,null,null,"Number of patients who died",null,null,null,{"$f":"'Patient Population'!E30*'Patient Population'!E31*'Patient Population'!E33*'Patient Population'!E35*'Patient Population'!E50","v":0},{"$f":"'Patient Population'!F30*'Patient Population'!F31*'Patient Population'!F33*'Patient Population'!F35*'Patient Population'!F50","v":0},{"$f":"'Patient Population'!G30*'Patient Population'!G31*'Patient Population'!G33*'Patient Population'!G35*'Patient Population'!G50","v":0},{"$f":"'Patient Population'!H30*'Patient Population'!H31*'Patient Population'!H33*'Patient Population'!H35*'Patient Population'!H50","v":0},{"$f":"'Patient Population'!I30*'Patient Population'!I31*'Patient Population'!I33*'Patient Population'!I35*'Patient Population'!I50","v":0}]
[null,{"$f":"CONCATENATE(\"Comparator 3: \",NameComparator3)","v":"Comparator 3: "},null,"Number of patients receiving comparator 3",null,null,null,{"$f":"'Patient Population'!E36*'Patient Population'!E51","v":0},{"$f":"'Patient Population'!F36*'Patient Population'!F51","v":0},{"$f":"'Patient Population'!G36*'Patient Population'!G51","v":0},{"$f":"'Patient Population'!H36*'Patient Population'!H51","v":0},{"$f":"'Patient Population'!I36*'Patient Population'!I51","v":0}]
[null,null,null,"Cost of comparator 3 each year (including VAT)",null,null,null,{"$f":" 'Drug Acquisition Costs'!E31","v":0},{"$f":" 'Drug Acquisition Costs'!F31","v":0},{"$f":" 'Drug Acquisition Costs'!G31","v":0},{"$f":" 'Drug Acquisition Costs'!H31","v":0},{"$f":" 'Drug Acquisition Costs'!I31","v":0}]
[null,null,null,"Cost of comparator 3 each year (excluding VAT)",null,null,null,{"$f":" 'Drug Acquisition Costs'!N31","v":0},{"$f":" 'Drug Acquisition Costs'!O31","v":0},{"$f":" 'Drug Acquisition Costs'!P31","v":0},{"$f":" 'Drug Acquisition Costs'!Q31","v":0},{"$f":" 'Drug Acquisition Costs'!R31","v":0}]
[null,null,null,"Number of patients who discontinued",null,null,null,{"$f":"('Patient Population'!E36*'Patient Population'!E51*'Patient Population'!E91)","v":0},{"$f":"('Patient Population'!F36*'Patient Population'!F51*'Patient Population'!F91)","v":0},{"$f":"('Patient Population'!G36*'Patient Population'!G51*'Patient Population'!G91)","v":0},{"$f":"('Patient Population'!H36*'Patient Population'!H51*'Patient Population'!H91)","v":0},{"$f":"('Patient Population'!I36*'Patient Population'!I51*'Patient Population'!I91)","v":0}]
[null,null,null,"Number of patients who died",null,null,null,{"$f":"'Patient Population'!E30*'Patient Population'!E31*'Patient Population'!E33*'Patient Population'!E35*'Patient Population'!E51","v":0},{"$f":"'Patient Population'!F30*'Patient Population'!F31*'Patient Population'!F33*'Patient Population'!F35*'Patient Population'!F51","v":0},{"$f":"'Patient Population'!G30*'Patient Population'!G31*'Patient Population'!G33*'Patient Population'!G35*'Patient Population'!G51","v":0},{"$f":"'Patient Population'!H30*'Patient Population'!H31*'Patient Population'!H33*'Patient Population'!H35*'Patient Population'!H51","v":0},{"$f":"'Patient Population'!I30*'Patient Population'!I31*'Patient Population'!I33*'Patient Population'!I35*'Patient Population'!I51","v":0}]
[null,{"$f":"CONCATENATE(\"Comparator 4: \",NameComparator4)","v":"Comparator 4: "},null,"Number of patients receiving comparator 4",null,null,null,{"$f":"'Patient Population'!E36*'Patient Population'!E52","v":0},{"$f":"'Patient Population'!F36*'Patient Population'!F52","v":0},{"$f":"'Patient Population'!G36*'Patient Population'!G52","v":0},{"$f":"'Patient Population'!H36*'Patient Population'!H52","v":0},{"$f":"'Patient Population'!I36*'Patient Population'!I52","v":0}]
[null,null,null,"Cost of comparator 4 each year (including VAT)",null,null,null,{"$f":" 'Drug Acquisition Costs'!E32","v":0},{"$f":" 'Drug Acquisition Costs'!F32","v":0},{"$f":" 'Drug Acquisition Costs'!G32","v":0},{"$f":" 'Drug Acquisition Costs'!H32","v":0},{"$f":" 'Drug Acquisition Costs'!I32","v":0}]
[null,null,null,"Cost of comparator 4 each year (excluding VAT)",null,null,null,{"$f":" 'Drug Acquisition Costs'!N32","v":0},{"$f":" 'Drug Acquisition Costs'!O32","v":0},{"$f":" 'Drug Acquisition Costs'!P32","v":0},{"$f":" 'Drug Acquisition Costs'!Q32","v":0},{"$f":" 'Drug Acquisition Costs'!R32","v":0}]
[null,null,null,"Number of patients who discontinued",null,null,null,{"$f":"('Patient Population'!E36*'Patient Population'!E52*'Patient Population'!E92)","v":0},{"$f":"('Patient Population'!F36*'Patient Population'!F52*'Patient Population'!F92)","v":0},{"$f":"('Patient Population'!G36*'Patient Population'!G52*'Patient Population'!G92)","v":0},{"$f":"('Patient Population'!H36*'Patient Population'!H52*'Patient Population'!H92)","v":0},{"$f":"('Patient Population'!I36*'Patient Population'!I52*'Patient Population'!I92)","v":0}]
[null,null,null,"Number of patients who died",null,null,null,{"$f":"'Patient Population'!E30*'Patient Population'!E31*'Patient Population'!E33*'Patient Population'!E35*'Patient Population'!E52","v":0},{"$f":"'Patient Population'!F30*'Patient Population'!F31*'Patient Population'!F33*'Patient Population'!F35*'Patient Population'!F52","v":0},{"$f":"'Patient Population'!G30*'Patient Population'!G31*'Patient Population'!G33*'Patient Population'!G35*'Patient Population'!G52","v":0},{"$f":"'Patient Population'!H30*'Patient Population'!H31*'Patient Population'!H33*'Patient Population'!H35*'Patient Population'!H52","v":0},{"$f":"'Patient Population'!I30*'Patient Population'!I31*'Patient Population'!I33*'Patient Population'!I35*'Patient Population'!I52","v":0}]
[null,{"$f":"CONCATENATE(\"Comparator 5: \",NameComparator5)","v":"Comparator 5: "},null,"Number of patients receiving comparator 5",null,null,null,{"$f":"'Patient Population'!E36*'Patient Population'!E53","v":0},{"$f":"'Patient Population'!F36*'Patient Population'!F53","v":0},{"$f":"'Patient Population'!G36*'Patient Population'!G53","v":0},{"$f":"'Patient Population'!H36*'Patient Population'!H53","v":0},{"$f":"'Patient Population'!I36*'Patient Population'!I53","v":0}]
[null,null,null,"Cost of comparator 5 each year (including VAT)",null,null,null,{"$f":" 'Drug Acquisition Costs'!E33","v":0},{"$f":" 'Drug Acquisition Costs'!F33","v":0},{"$f":" 'Drug Acquisition Costs'!G33","v":0},{"$f":" 'Drug Acquisition Costs'!H33","v":0},{"$f":" 'Drug Acquisition Costs'!I33","v":0}]
[null,null,null,"Cost of comparator 5 each year (excluding VAT)",null,null,null,{"$f":" 'Drug Acquisition Costs'!N33","v":0},{"$f":" 'Drug Acquisition Costs'!O33","v":0},{"$f":" 'Drug Acquisition Costs'!P33","v":0},{"$f":" 'Drug Acquisition Costs'!Q33","v":0},{"$f":" 'Drug Acquisition Costs'!R33","v":0}]
[null,null,null,"Number of patients who discontinued",null,null,null,{"$f":"('Patient Population'!E36*'Patient Population'!E53*'Patient Population'!E93)","v":0},{"$f":"('Patient Population'!F36*'Patient Population'!F53*'Patient Population'!F93)","v":0},{"$f":"('Patient Population'!G36*'Patient Population'!G53*'Patient Population'!G93)","v":0},{"$f":"('Patient Population'!H36*'Patient Population'!H53*'Patient Population'!H93)","v":0},{"$f":"('Patient Population'!I36*'Patient Population'!I53*'Patient Population'!I93)","v":0}]
[null,null,null,"Number of patients who died",null,null,null,{"$f":"'Patient Population'!E30*'Patient Population'!E31*'Patient Population'!E33*'Patient Population'!E35*'Patient Population'!E53","v":0},{"$f":"'Patient Population'!F30*'Patient Population'!F31*'Patient Population'!F33*'Patient Population'!F35*'Patient Population'!F53","v":0},{"$f":"'Patient Population'!G30*'Patient Population'!G31*'Patient Population'!G33*'Patient Population'!G35*'Patient Population'!G53","v":0},{"$f":"'Patient Population'!H30*'Patient Population'!H31*'Patient Population'!H33*'Patient Population'!H35*'Patient Population'!H53","v":0},{"$f":"'Patient Population'!I30*'Patient Population'!I31*'Patient Population'!I33*'Patient Population'!I35*'Patient Population'!I53","v":0}]
[null,{"$f":"CONCATENATE(\"Comparator 6: \",NameComparator6)","v":"Comparator 6: "},null,"Number of patients receiving comparator 6",null,null,null,{"$f":"'Patient Population'!E36*'Patient Population'!E54","v":0},{"$f":"'Patient Population'!F36*'Patient Population'!F54","v":0},{"$f":"'Patient Population'!G36*'Patient Population'!G54","v":0},{"$f":"'Patient Population'!H36*'Patient Population'!H54","v":0},{"$f":"'Patient Population'!I36*'Patient Population'!I54","v":0}]
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[null,null,null,"Number of patients who died",null,null,null,{"$f":"'Patient Population'!E30*'Patient Population'!E31*'Patient Population'!E33*'Patient Population'!E35*'Patient Population'!E60","v":0},{"$f":"'Patient Population'!F30*'Patient Population'!F31*'Patient Population'!F33*'Patient Population'!F35*'Patient Population'!F60","v":0},{"$f":"'Patient Population'!G30*'Patient Population'!G31*'Patient Population'!G33*'Patient Population'!G35*'Patient Population'!G60","v":0},{"$f":"'Patient Population'!H30*'Patient Population'!H31*'Patient Population'!H33*'Patient Population'!H35*'Patient Population'!H60","v":0},{"$f":"'Patient Population'!I30*'Patient Population'!I31*'Patient Population'!I33*'Patient Population'!I35*'Patient Population'!I60","v":0}]
[null,"Total cost of comparators (including VAT)",null,null,null,null,null,{"$f":"(H110*H111)-((H113+H114)*(0.5*H111))+(H115*H116)-((H118+H119)*(0.5*H116))+(H120*H121)-((H123+H124)*(0.5*H121))+(H125*H126)-((H128+H129)*(0.5*H126))+(H130*H131)-((H133+H134)*(0.5*H131))+(H135*H136)-((H138+H139)*(0.5*H136))+(H140*H141)-((H143+H144)*(0.5*H141))+(H145*H146)-((H148+H149)*(0.5*H146))+(H150*H151)-((H153+H154)*(0.5*H151))+(H155*H156)-((H158+H159)*(0.5*H156))+(H160*H161)-((H163+H164)*(0.5*H161))+(H165*H166)-((H168+H169)*(0.5*H166))","v":0},{"$f":"(I110*I111)-((I113+I114)*(0.5*I111))+(I115*I116)-((I118+I119)*(0.5*I116))+(I120*I121)-((I123+I124)*(0.5*I121))+(I125*I126)-((I128+I129)*(0.5*I126))+(I130*I131)-((I133+I134)*(0.5*I131))+(I135*I136)-((I138+I139)*(0.5*I136))+(I140*I141)-((I143+I144)*(0.5*I141))+(I145*I146)-((I148+I149)*(0.5*I146))+(I150*I151)-((I153+I154)*(0.5*I151))+(I155*I156)-((I158+I159)*(0.5*I156))+(I160*I161)-((I163+I164)*(0.5*I161))+(I165*I166)-((I168+I169)*(0.5*I166))","v":0},{"$f":"(J110*J111)-((J113+J114)*(0.5*J111))+(J115*J116)-((J118+J119)*(0.5*J116))+(J120*J121)-((J123+J124)*(0.5*J121))+(J125*J126)-((J128+J129)*(0.5*J126))+(J130*J131)-((J133+J134)*(0.5*J131))+(J135*J136)-((J138+J139)*(0.5*J136))+(J140*J141)-((J143+J144)*(0.5*J141))+(J145*J146)-((J148+J149)*(0.5*J146))+(J150*J151)-((J153+J154)*(0.5*J151))+(J155*J156)-((J158+J159)*(0.5*J156))+(J160*J161)-((J163+J164)*(0.5*J161))+(J165*J166)-((J168+J169)*(0.5*J166))","v":0},{"$f":"(K110*K111)-((K113+K114)*(0.5*K111))+(K115*K116)-((K118+K119)*(0.5*K116))+(K120*K121)-((K123+K124)*(0.5*K121))+(K125*K126)-((K128+K129)*(0.5*K126))+(K130*K131)-((K133+K134)*(0.5*K131))+(K135*K136)-((K138+K139)*(0.5*K136))+(K140*K141)-((K143+K144)*(0.5*K141))+(K145*K146)-((K148+K149)*(0.5*K146))+(K150*K151)-((K153+K154)*(0.5*K151))+(K155*K156)-((K158+K159)*(0.5*K156))+(K160*K161)-((K163+K164)*(0.5*K161))+(K165*K166)-((K168+K169)*(0.5*K166))","v":0},{"$f":"(L110*L111)-((L113+L114)*(0.5*L111))+(L115*L116)-((L118+L119)*(0.5*L116))+(L120*L121)-((L123+L124)*(0.5*L121))+(L125*L126)-((L128+L129)*(0.5*L126))+(L130*L131)-((L133+L134)*(0.5*L131))+(L135*L136)-((L138+L139)*(0.5*L136))+(L140*L141)-((L143+L144)*(0.5*L141))+(L145*L146)-((L148+L149)*(0.5*L146))+(L150*L151)-((L153+L154)*(0.5*L151))+(L155*L156)-((L158+L159)*(0.5*L156))+(L160*L161)-((L163+L164)*(0.5*L161))+(L165*L166)-((L168+L169)*(0.5*L166))","v":0},{"$f":"SUM(H170:L170)","v":0}]
[null,"Total cost of comparators (excluding VAT)",null,null,null,null,null,{"$f":"(H110*H112)-((H113+H114)*(0.5*H112))+(H115*H117)-((H118+H119)*(0.5*H117))+(H120*H122)-((H123+H124)*(0.5*H122))+(H125*H127)-((H128+H129)*(0.5*H127))+(H130*H132)-((H133+H134)*(0.5*H132))+(H135*H137)-((H138+H139)*(0.5*H137))+(H140*H142)-((H143+H144)*(0.5*H142))+(H145*H147)-((H148+H149)*(0.5*H147))+(H150*H152)-((H153+H154)*(0.5*H152))+(H155*H157)-((H158+H159)*(0.5*H157))+(H160*H162)-((H163+H164)*(0.5*H162))+(H165*H167)-((H168+H169)*(0.5*H167))","v":0},{"$f":"(I110*I112)-((I113+I114)*(0.5*I112))+(I115*I117)-((I118+I119)*(0.5*I117))+(I120*I122)-((I123+I124)*(0.5*I122))+(I125*I127)-((I128+I129)*(0.5*I127))+(I130*I132)-((I133+I134)*(0.5*I132))+(I135*I137)-((I138+I139)*(0.5*I137))+(I140*I142)-((I143+I144)*(0.5*I142))+(I145*I147)-((I148+I149)*(0.5*I147))+(I150*I152)-((I153+I154)*(0.5*I152))+(I155*I157)-((I158+I159)*(0.5*I157))+(I160*I162)-((I163+I164)*(0.5*I162))+(I165*I167)-((I168+I169)*(0.5*I167))","v":0},{"$f":"(J110*J112)-((J113+J114)*(0.5*J112))+(J115*J117)-((J118+J119)*(0.5*J117))+(J120*J122)-((J123+J124)*(0.5*J122))+(J125*J127)-((J128+J129)*(0.5*J127))+(J130*J132)-((J133+J134)*(0.5*J132))+(J135*J137)-((J138+J139)*(0.5*J137))+(J140*J142)-((J143+J144)*(0.5*J142))+(J145*J147)-((J148+J149)*(0.5*J147))+(J150*J152)-((J153+J154)*(0.5*J152))+(J155*J157)-((J158+J159)*(0.5*J157))+(J160*J162)-((J163+J164)*(0.5*J162))+(J165*J167)-((J168+J169)*(0.5*J167))","v":0},{"$f":"(K110*K112)-((K113+K114)*(0.5*K112))+(K115*K117)-((K118+K119)*(0.5*K117))+(K120*K122)-((K123+K124)*(0.5*K122))+(K125*K127)-((K128+K129)*(0.5*K127))+(K130*K132)-((K133+K134)*(0.5*K132))+(K135*K137)-((K138+K139)*(0.5*K137))+(K140*K142)-((K143+K144)*(0.5*K142))+(K145*K147)-((K148+K149)*(0.5*K147))+(K150*K152)-((K153+K154)*(0.5*K152))+(K155*K157)-((K158+K159)*(0.5*K157))+(K160*K162)-((K163+K164)*(0.5*K162))+(K165*K167)-((K168+K169)*(0.5*K167))","v":0},{"$f":"(L110*L112)-((L113+L114)*(0.5*L112))+(L115*L117)-((L118+L119)*(0.5*L117))+(L120*L122)-((L123+L124)*(0.5*L122))+(L125*L127)-((L128+L129)*(0.5*L127))+(L130*L132)-((L133+L134)*(0.5*L132))+(L135*L137)-((L138+L139)*(0.5*L137))+(L140*L142)-((L143+L144)*(0.5*L142))+(L145*L147)-((L148+L149)*(0.5*L147))+(L150*L152)-((L153+L154)*(0.5*L152))+(L155*L157)-((L158+L159)*(0.5*L157))+(L160*L162)-((L163+L164)*(0.5*L162))+(L165*L167)-((L168+L169)*(0.5*L167))","v":0},{"$f":"SUM(H171:L171)","v":0}]
[]
[null,"Net Drug Budget Impact (including VAT)",null,null,null,null,null,{"$f":"H38+H104-H170","v":0},{"$f":"I38+I104-I170","v":0},0,0,0,{"$f":"SUM(H173:L173)","v":0}]
[null,"Net Drug Budget Impact (excluding VAT)",null,null,null,null,null,0,0,0,0,0,{"$f":"SUM(H174:L174)","v":0}]
[]
[null,"Net Budget Impact"]
[null,null,null,null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5"]
[null,"Cost/cost-offset per year",null,null,null,null,null,{"$f":"'Additional Costs'!F25*(H30-(0.5*(H33+H34)))","v":0},{"$f":"'Additional Costs'!G25*(I30-(0.5*(I33+I34)))","v":0},{"$f":"'Additional Costs'!H25*(J30-(0.5*(J33+J34)))","v":0},{"$f":"'Additional Costs'!I25*(K30-(0.5*(K33+K34)))","v":0},{"$f":"'Additional Costs'!J25*(L30-(0.5*(L33+L34)))","v":0}]
[]
[null,"Net healthcare budget impact",null,null,null,null,null,{"$f":"H173+H178","v":0},{"$f":"I173+I178","v":0},{"$f":"J173+J178","v":0},{"$f":"K173+K178","v":0},{"$f":"L173+L178","v":0},{"$f":"SUM(H180:L180)","v":0}]
[]
[null,"Please note: it is beyond the scope of the Rapid Review process to appraise the impact of an intervention on wider health care budgets; the net healthcare budget impact is not required for Rapid Review submissions."]

{"sheet":"Results (PAS)","index":8,"n_rows":182,"n_cols":13,"rows_kept":182,"cut":false,"hidden":false,"merged":[[16,1,19,9],[21,1,21,6],[24,1,24,6],[27,1,27,6],[29,1,33,2],[29,3,29,6],[30,3,30,6],[32,3,32,6],[33,3,33,6],[25,1,25,6],[31,3,31,6],[35,1,35,6],[37,1,37,6],[40,1,40,6],[42,1,42,6],[43,1,47,2],[43,3,43,6],[44,3,44,6],[46,3,46,6],[47,3,47,6],[63,1,67,2],[63,3,63,6],[64,3,64,6],[66,3,66,6],[67,3,67,6],[48,1,52,2],[48,3,48,6],[49,3,49,6],[51,3,51,6],[52,3,52,6],[53,1,57,2],[53,3,53,6],[54,3,54,6],[56,3,56,6],[57,3,57,6],[78,1,82,2],[78,3,78,6],[79,3,79,6],[81,3,81,6],[82,3,82,6],[83,1,87,2],[83,3,83,6],[84,3,84,6],[86,3,86,6],[87,3,87,6],[80,3,80,6],[85,3,85,6],[88,1,92,2],[88,3,88,6],[89,3,89,6],[91,3,91,6],[92,3,92,6],[93,1,97,2],[93,3,93,6],[94,3,94,6],[96,3,96,6],[97,3,97,6],[90,3,90,6],[95,3,95,6],[108,1,108,6],[109,1,113,2],[109,3,109,6],[110,3,110,6],[112,3,112,6],[113,3,113,6],[98,1,102,2],[98,3,98,6],[99,3,99,6],[101,3,101,6],[102,3,102,6],[103,1,103,6],[100,3,100,6],[111,3,111,6],[104,1,104,6],[114,1,118,2],[114,3,114,6],[115,3,115,6],[117,3,117,6],[118,3,118,6],[119,1,123,2],[119,3,119,6],[120,3,120,6],[122,3,122,6],[123,3,123,6],[116,3,116,6],[121,3,121,6],[124,1,128,2],[124,3,124,6],[125,3,125,6],[127,3,127,6],[128,3,128,6],[129,1,133,2],[129,3,129,6],[130,3,130,6],[132,3,132,6],[133,3,133,6],[126,3,126,6],[131,3,131,6],[134,1,138,2],[134,3,134,6],[135,3,135,6],[137,3,137,6],[138,3,138,6],[139,1,143,2],[139,3,139,6],[140,3,140,6],[142,3,142,6],[143,3,143,6],[136,3,136,6],[141,3,141,6],[144,1,148,2],[144,3,144,6],[145,3,145,6],[147,3,147,6],[148,3,148,6],[149,1,153,2],[149,3,149,6],[150,3,150,6],[152,3,152,6],[153,3,153,6],[146,3,146,6],[151,3,151,6],[154,1,158,2],[154,3,154,6],[155,3,155,6],[157,3,157,6],[158,3,158,6],[159,1,163,2],[159,3,159,6],[160,3,160,6],[162,3,162,6],[163,3,163,6],[156,3,156,6],[161,3,161,6],[172,1,172,6],[181,1,182,11],[164,1,168,2],[164,3,164,6],[165,3,165,6],[167,3,167,6],[168,3,168,6],[169,1,169,6],[166,3,166,6],[170,1,170,6],[173,1,173,6],[175,1,175,6],[177,1,177,6],[179,1,179,6],[34,1,34,6],[38,1,38,6],[45,3,45,6],[50,3,50,6],[55,3,55,6],[60,3,60,6],[65,3,65,6],[70,3,70,6],[75,3,75,6],[68,1,72,2],[68,3,68,6],[69,3,69,6],[71,3,71,6],[72,3,72,6],[73,1,77,2],[73,3,73,6],[74,3,74,6],[76,3,76,6],[77,3,77,6],[58,1,62,2],[58,3,58,6],[59,3,59,6],[61,3,61,6],[62,3,62,6]]}
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[null," The gross and net drug budget impacts are presented below, based on the inputs used throughout the rest of the model. Separately, a net budget impact accounting for costs and offsets outside of the drugs budget is presented.  Patients who died or stopped treatment are assumed to have received treatment for 6 months.\nPlease note that it is not a requirement to submit a CIC PAS at this stage but this tab should be used if a CIC PAS is included as part of the submission."]
[]
[]
[]
[null,"Estimates from the BIM including and excluding VAT should be copied and pasted directly into the Applicant template"]
[null,"Summary"]
[]
[null,null,null,null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5","Cumulative"]
[null,"Number of patients expected to receive treatment (i.e. treated population)",null,null,null,null,null,{"$f":"Results!H25","v":0},{"$f":"Results!I25","v":0},{"$f":"Results!J25","v":0},{"$f":"Results!K25","v":0},{"$f":"Results!L25","v":0}]
[null,"Market share for the intervention",null,null,null,null,null,{"$f":"Results!H26","v":0},{"$f":"Results!I26","v":0},{"$f":"Results!J26","v":0},{"$f":"Results!K26","v":0},{"$f":"Results!L26","v":0}]
[]
[null,"Gross Drug Budget Impact"]
[null,null,null,null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5"]
[null,{"$f":"CONCATENATE(\"Intervention: \",InterventionINN)","v":"Intervention: "},null,"Number of patients receiving intervention",null,null,null,{"$f":"Results!H30","v":0},{"$f":"Results!I30","v":0},{"$f":"Results!J30","v":0},{"$f":"Results!K30","v":0},{"$f":"Results!L30","v":0}]
[null,null,null,"Cost of intervention each year (including VAT)",null,null,null,{"$f":"'Drug Acquisition Costs (PAS)'!E28","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!F28","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!G28","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!H28","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!I28","v":0}]
[null,null,null,"Cost of intervention each year (excluding VAT)",null,null,null,{"$f":"'Drug Acquisition Costs (PAS)'!N28","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!O28","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!P28","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!Q28","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!R28","v":0}]
[null,null,null,"Number of patients who discontinued",null,null,null,{"$f":"Results!H33","v":0},{"$f":"Results!I33","v":0},{"$f":"Results!J33","v":0},{"$f":"Results!K33","v":0},{"$f":"Results!L33","v":0}]
[null,null,null,"Number of patients who died",null,null,null,{"$f":"Results!H34","v":0},{"$f":"Results!I34","v":0},{"$f":"Results!J34","v":0},{"$f":"Results!K34","v":0},{"$f":"Results!L34","v":0}]
[null,"Total cost of intervention (including VAT)",null,null,null,null,null,{"$f":"(H30*H31)-((0.5*H31)*(H33+H34))","v":0},{"$f":"(I30*I31)-((0.5*I31)*(I33+I34))","v":0},0,0,0]
[null,"Total cost of intervention (excluding VAT)",null,null,null,null,null,{"$f":"(H30*H32)-((0.5*H32)*(H33+H34))","v":0},{"$f":"(I30*I32)-((0.5*I32)*(I33+I34))","v":0},0,0,0]
[]
[null,"Gross Drug Budget Impact",null,null,null,null,null,{"$f":"H35","v":0},{"$f":"I35","v":0},0,0,0,{"$f":"SUM(H38:L38)","v":0}]
[null,"Gross Drug Budget Impact (excluding VAT)",null,null,null,null,null,{"$f":"H36","v":0},{"$f":"I36","v":0},0,0,0,{"$f":"SUM(H39:L39)","v":0}]
[]
[null,"Net Drug Budget Impact"]
[]
[null,"Comparator costs with new intervention in market",null,null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5"]
[null,{"$f":"CONCATENATE(\"Comparator 1: \",NameComparator1)","v":"Comparator 1: "},null,"Number of patients receiving comparator 1",null,null,null,{"$f":"Results!H44","v":0},{"$f":"Results!I44","v":0},{"$f":"Results!J44","v":0},{"$f":"Results!K44","v":0},{"$f":"Results!L44","v":0}]
[null,null,null,"Cost of comparator 1 each year (including VAT)",null,null,null,{"$f":"'Drug Acquisition Costs (PAS)'!E29","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!F29","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!G29","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!H29","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!I29","v":0}]
[null,null,null,"Cost of comparator 1 each year (excluding VAT)",null,null,null,{"$f":"'Drug Acquisition Costs (PAS)'!N29","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!O29","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!P29","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!Q29","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!R29","v":0}]
[null,null,null,"Number of patients who discontinued",null,null,null,{"$f":"Results!H47","v":0},{"$f":"Results!I47","v":0},{"$f":"Results!J47","v":0},{"$f":"Results!K47","v":0},{"$f":"Results!L47","v":0}]
[null,null,null,"Number of patients who died",null,null,null,{"$f":"Results!H48","v":0},{"$f":"Results!I48","v":0},{"$f":"Results!J48","v":0},{"$f":"Results!K48","v":0},{"$f":"Results!L48","v":0}]
[null,{"$f":"CONCATENATE(\"Comparator 2: \",NameComparator2)","v":"Comparator 2: "},null,"Number of patients receiving comparator 2",null,null,null,{"$f":"Results!H49","v":0},{"$f":"Results!I49","v":0},{"$f":"Results!J49","v":0},{"$f":"Results!K49","v":0},{"$f":"Results!L49","v":0}]
[null,null,null,"Cost of comparator 2 each year (including VAT)",null,null,null,{"$f":"'Drug Acquisition Costs (PAS)'!E30","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!F30","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!G30","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!H30","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!I30","v":0}]
[null,null,null,"Cost of comparator 2 each year (excluding VAT)",null,null,null,{"$f":"'Drug Acquisition Costs (PAS)'!N30","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!O30","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!P30","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!Q30","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!R30","v":0}]
[null,null,null,"Number of patients who discontinued",null,null,null,{"$f":"Results!H52","v":0},{"$f":"Results!I52","v":0},{"$f":"Results!J52","v":0},{"$f":"Results!K52","v":0},{"$f":"Results!L52","v":0}]
[null,null,null,"Number of patients who died",null,null,null,{"$f":"Results!H53","v":0},{"$f":"Results!I53","v":0},{"$f":"Results!J53","v":0},{"$f":"Results!K53","v":0},{"$f":"Results!L53","v":0}]
[null,{"$f":"CONCATENATE(\"Comparator 3: \",NameComparator3)","v":"Comparator 3: "},null,"Number of patients receiving comparator 3",null,null,null,{"$f":"Results!H54","v":0},{"$f":"Results!I54","v":0},{"$f":"Results!J54","v":0},{"$f":"Results!K54","v":0},{"$f":"Results!L54","v":0}]
[null,null,null,"Cost of comparator 3 each year (including VAT)",null,null,null,{"$f":"'Drug Acquisition Costs (PAS)'!E31","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!F31","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!G31","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!H31","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!I31","v":0}]
[null,null,null,"Cost of comparator 3 each year (excluding VAT)",null,null,null,{"$f":"'Drug Acquisition Costs (PAS)'!N31","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!O31","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!P31","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!Q31","v":0},{"$f":"'Drug Acquisition Costs (PAS)'!R31","v":0}]
[null,null,null,"Number of patients who discontinued",null,null,null,{"$f":"Results!H57","v":0},{"$f":"Results!I57","v":0},{"$f":"Results!J57","v":0},{"$f":"Results!K57","v":0},{"$f":"Results!L57","v":0}]
[null,null,null,"Number of patients who died",null,null,null,{"$f":"Results!H58","v":0},{"$f":"Results!I58","v":0},{"$f":"Results!J58","v":0},{"$f":"Results!K58","v":0},{"$f":"Results!L58","v":0}]
[null,{"$f":"CONCATENATE(\"Comparator 4: \",NameComparator4)","v":"Comparator 4: "},null,"Number of patients receiving comparator 4",null,null,null,{"$f":"Results!H59","v":0},{"$f":"Results!I59","v":0},{"$f":"Results!J59","v":0},{"$f":"Results!K59","v":0},{"$f":"Results!L59","v":0}]
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[]
[]
[]
[null,"Comparator costs with no intervention in market",null,null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5"]
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[null,null,null,"Number of patients who died",null,null,null,{"$f":"Results!H169","v":0},{"$f":"Results!I169","v":0},{"$f":"Results!J169","v":0},{"$f":"Results!K169","v":0},{"$f":"Results!L169","v":0}]
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[null,"Total cost of comparators (excluding VAT)",null,null,null,null,null,{"$f":"(H110*H112)-((H113+H114)*(0.5*H112))+(H115*H117)-((H118+H119)*(0.5*H117))+(H120*H122)-((H123+H124)*(0.5*H122))+(H125*H127)-((H128+H129)*(0.5*H127))+(H130*H132)-((H133+H134)*(0.5*H132))+(H135*H137)-((H138+H139)*(0.5*H137))+(H140*H142)-((H143+H144)*(0.5*H142))+(H145*H147)-((H148+H149)*(0.5*H147))+(H150*H152)-((H153+H154)*(0.5*H152))+(H155*H157)-((H158+H159)*(0.5*H157))+(H160*H162)-((H163+H164)*(0.5*H162))+(H165*H167)-((H168+H169)*(0.5*H167))","v":0},{"$f":"(I110*I112)-((I113+I114)*(0.5*I112))+(I115*I117)-((I118+I119)*(0.5*I117))+(I120*I122)-((I123+I124)*(0.5*I122))+(I125*I127)-((I128+I129)*(0.5*I127))+(I130*I132)-((I133+I134)*(0.5*I132))+(I135*I137)-((I138+I139)*(0.5*I137))+(I140*I142)-((I143+I144)*(0.5*I142))+(I145*I147)-((I148+I149)*(0.5*I147))+(I150*I152)-((I153+I154)*(0.5*I152))+(I155*I157)-((I158+I159)*(0.5*I157))+(I160*I162)-((I163+I164)*(0.5*I162))+(I165*I167)-((I168+I169)*(0.5*I167))","v":0},{"$f":"(J110*J112)-((J113+J114)*(0.5*J112))+(J115*J117)-((J118+J119)*(0.5*J117))+(J120*J122)-((J123+J124)*(0.5*J122))+(J125*J127)-((J128+J129)*(0.5*J127))+(J130*J132)-((J133+J134)*(0.5*J132))+(J135*J137)-((J138+J139)*(0.5*J137))+(J140*J142)-((J143+J144)*(0.5*J142))+(J145*J147)-((J148+J149)*(0.5*J147))+(J150*J152)-((J153+J154)*(0.5*J152))+(J155*J157)-((J158+J159)*(0.5*J157))+(J160*J162)-((J163+J164)*(0.5*J162))+(J165*J167)-((J168+J169)*(0.5*J167))","v":0},{"$f":"(K110*K112)-((K113+K114)*(0.5*K112))+(K115*K117)-((K118+K119)*(0.5*K117))+(K120*K122)-((K123+K124)*(0.5*K122))+(K125*K127)-((K128+K129)*(0.5*K127))+(K130*K132)-((K133+K134)*(0.5*K132))+(K135*K137)-((K138+K139)*(0.5*K137))+(K140*K142)-((K143+K144)*(0.5*K142))+(K145*K147)-((K148+K149)*(0.5*K147))+(K150*K152)-((K153+K154)*(0.5*K152))+(K155*K157)-((K158+K159)*(0.5*K157))+(K160*K162)-((K163+K164)*(0.5*K162))+(K165*K167)-((K168+K169)*(0.5*K167))","v":0},{"$f":"(L110*L112)-((L113+L114)*(0.5*L112))+(L115*L117)-((L118+L119)*(0.5*L117))+(L120*L122)-((L123+L124)*(0.5*L122))+(L125*L127)-((L128+L129)*(0.5*L127))+(L130*L132)-((L133+L134)*(0.5*L132))+(L135*L137)-((L138+L139)*(0.5*L137))+(L140*L142)-((L143+L144)*(0.5*L142))+(L145*L147)-((L148+L149)*(0.5*L147))+(L150*L152)-((L153+L154)*(0.5*L152))+(L155*L157)-((L158+L159)*(0.5*L157))+(L160*L162)-((L163+L164)*(0.5*L162))+(L165*L167)-((L168+L169)*(0.5*L167))","v":0},{"$f":"SUM(H171:L171)","v":0}]
[]
[null,"Net Drug Budget Impact (including VAT)",null,null,null,null,null,{"$f":"H38+H104-H170","v":0},0,0,0,0,{"$f":"SUM(H173:L173)","v":0}]
[null,"Net Drug Budget Impact (excluding VAT)",null,null,null,null,null,0,0,0,0,0,{"$f":"SUM(H174:L174)","v":0}]
[]
[null,"Net Budget Impact"]
[null,null,null,null,null,null,null,"Year 1","Year 2","Year 3","Year 4","Year 5"]
[null,"Cost/cost-offset per year",null,null,null,null,null,{"$f":"'Additional Costs'!F25*(H30-(0.5*(H33+H34)))","v":0},{"$f":"'Additional Costs'!G25*(I30-(0.5*(I33+I34)))","v":0},{"$f":"'Additional Costs'!H25*(J30-(0.5*(J33+J34)))","v":0},{"$f":"'Additional Costs'!I25*(K30-(0.5*(K33+K34)))","v":0},{"$f":"'Additional Costs'!J25*(L30-(0.5*(L33+L34)))","v":0}]
[]
[null,"Net healthcare budget impact",null,null,null,null,null,{"$f":"H173+H178","v":0},{"$f":"I173+I178","v":0},{"$f":"J173+J178","v":0},{"$f":"K173+K178","v":0},{"$f":"L173+L178","v":0},{"$f":"SUM(H180:L180)","v":0}]
[]
[null,"Please note: it is beyond the scope of the Rapid Review process to appraise the impact of an intervention on wider health care budgets; the net healthcare budget impact is not required for Rapid Review submissions."]

{"sheet":"References","index":9,"n_rows":66,"n_cols":6,"rows_kept":66,"cut":false,"hidden":false,"merged":[[32,1,32,4],[33,1,33,4],[35,1,35,4],[34,1,34,4],[38,1,38,4],[36,1,36,4],[37,1,37,4],[42,1,42,4],[43,1,43,4],[39,1,39,4],[40,1,40,4],[41,1,41,4],[51,1,51,4],[50,1,50,4],[45,1,45,4],[49,1,49,4],[46,1,46,4]]}
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
[]
["NCPE"]
["Ref 1","Central Statistics Office. https://www.cso.ie/en/statistics/population/populationandlabourforceprojections/. Method M1 is used. https://data.cso.ie/table/PEC19"]
["Ref 2","NCPE Guidelines for Inclusion of Drug Costs in Pharmacoeconomic Evaluation. https://www.ncpe.ie/wp-content/uploads/2024/10/Guidelines-for-Inclusion-of-Drug-Costs-in-Pharmacoeconomic-Evaluations-v3.3.pdf"]
["Other","HIQA Guidelines for the Budget Impact Analysis of Health Technologies in Ireland. https://www.hiqa.ie/reports-and-publications/health-technology-assessment/guidelines-budget-impact-analysis-health"]
[]
["Applicant"]
[null,"Please include any additional references here"]
[]
[]
[]
[]
[]
[]
[]
[]
["Cost","Definitions used for the drug cost calculator (do not change)."]
[null,"Wholesale Mark-up for non-fridge items on the CDS",null,null,null,0.08]
[null,"Wholesale Mark-up for fridge items on the CDS",null,null,null,0.12]
[null,"Wholesale Mark-up for all tems on the HT",null,null,null,0.08]
[null,"Hospital Mark-up",null,null,null,0]
[null,"Framework Agreement Rebate (pre-2026)",null,null,null,-0.09]
[null,"Framework Agreement Rebate (post-2026)",null,null,null,-0.09]
[null,"Patent-Expired Non-Exclusive Biologic",null,null,null,-0.125]
[null,"VAT",null,null,null,0.23]
[null,"Dispensing Fee",null,null,null,4.97]
[null,"High Tech Patient Care Fee",null,null,null,62.03]
[null,"Non Dispensing High Tech Fee",null,null,null,31.01]
[null,"Number of days in year",null,null,null,365.25]
[]
[null,null,null,null,null,"Cell Reference"]
[null,null,null,null,null,"Incl VAT"]
[null,"Total Cost per treatment Cycle",null,null,null,"F"]
[null,"Total Cost per treatment X number of cycles",null,null,null,"G"]
[null,"Total Cost per Year",null,null,null,"H"]
[null,"Total Cost per unit time",null,null,null,"I"]
[null,"Manual input by Applicant",null,null,null,"Applicant to enter"]
[]
[null,"Options for Table A if biologic=Yes"]
[null,"Biosimilar"]
[null,"Patented or Off Patent Exclusive (pre-2026)"]
[null,"Patented or Off Patent Exclusive (post-2026)"]
[null,"Off Patent Non-Exclusive 12.5% Rebate incorporated into Price to Wholesaler"]
[null,"Off Patent Non-Exclusive 12.5% Rebate"]
[null,"N/A"]
[]
[null,"Options for Table A if biologic=No"]
[null,"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (pre-2026)"]
[null,"Patented Exclusive or Off Patent Exclusive and subject to clause 10 of Framework Agreement (post-2026)"]
[null,"Off Patent Non-Exclusive or Generic"]
[null,"N/A"]