National Centre for Pharmacoeconomics

National Centre for
Pharmacoeconomics

NCPE Ireland

Burosumab (Crysvita®) for the treatment of X-linked hypophosphataemia (XLH) with radiographic evidence of bone disease in children 1 year of age and older and adolescents with growing skeletons.

 

NCPE Assessment Process Complete
Rapid review commissioned 22/11/2018
Rapid review completed 21/12/2018
Rapid Review outcome A full HTA is recommended
Full pharmacoeconomic assessment commissioned by the HSE 08/01/2019
Pre-submission consultation with Applicant 12/02/2019
Submission received from Applicant 03/07/2019
Preliminary review sent to Applicant 23/10/2019
NCPE assessment re-commenced 19/11/2019
Factual accuracy sent to Applicant 14/02/2020
NCPE assessment re-commenced 06/03/2020*
NCPE assessment completed 12/03/2020
Current status The NCPE recommends that burosumab (Crysvita®) not be considered for reimbursement unless cost-effectiveness can be improved relative to existing treatments**

*The NCPE have revised the timeline for burosumab due to new information received after the FAC stage, which necessitated additional revisions to be made to the final appraisal document.

Technical summary

Plain English summary

 

**This recommendation should be considered while also having regard to the criteria specified in the Health (Pricing and Supply of Medical Goods) Act 2013.