National Centre for Pharmacoeconomics

National Centre for

NCPE Ireland

Cotellic® is indicated for use in combination with vemurafenib for the treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600 mutation.


Rapid Review

Commenced Completed Outcome
19/04/2016 26/04/2016 Full Pharmacoeconomic Evaluation Recommended

Pharmacoeconomic Evaluation

Commenced Completed Outcome
18/07/2016  05/01/2017 Reimbursement Not Recommended at the Submitted Price.


The NCPE does not consider cobimetinib (Cotellic®) with vemurafenib (Zelboraf®) cost-effective for the treatment of advanced (unresectable or metastatic) melanoma with the BRAF V600 mutation and therefore it is not recommended for reimbursement at the submitted price.