Olaparib monotherapy is indicated for the maintenance treatment of adult patients with advanced (FIGO stages III and IV) BRCA1/2-mutated (germline and/or somatic) high-grade epithelial ovarian, fallopian tube or primary peritoneal cancer who are in response (complete or partial) following completion of first-line platinum-based chemotherapy.
|NCPE Assessment Process||Complete|
|Rapid review commissioned||30/04/2019|
|Rapid review completed||09/05/2019|
|Rapid Review outcome||A full HTA is recommended to assess the clinical effectiveness and cost effectiveness of olaparib compared with the current standard of care.|
|Full pharmacoeconomic assessment commissioned by the HSE||15/05/2019|
|Pre-submission consultation with Applicant||15/07/2019|
|Submission received from Applicant||10/10/2019|
|Preliminary review sent to Applicant||08/01/2020|
|NCPE assessment re-commenced||24/01/2020|
|Factual accuracy sent to Applicant||09/03/2020|
|NCPE assessment re-commenced||13/03/2020|
|NCPE assessment completed||30/03/2020|
|NCPE assessment outcome||Following assessment of the Applicant’s submission, the NCPE recommends that olaparib (Lynparza®) for this indication not be considered for reimbursement unless cost-effectiveness can be improved relative to existing treatments*.|
*This recommendation should be considered while also having regard to the criteria specified in the Health (Pricing and Supply of Medical Goods) Act 2013.
The HSE has approved reimbursement following confidential price negotiations; November 2020