The NCPE do not recommend reimbursement of PROCYSBI for the treatment of nephropathic cystinosis patients.

The NCPE do not recommend reimbursement of Obeticholic acid (Ocaliva®) at the submitted price.

The NCPE do not recommend reimbursement of Pembrolizumab (Keytruda®) for NSCLC (first line) at the submitted price.

Reimbursement not recommeded.

Following NCPE assessment of the applicant’s submission, cost effectiveness of palbociclib (Ibrance®) for this indication has not been demonstrated, and therefore is not recommended for reimbursement.

Following NCPE assessment of the company submission, alirocumab (Praluent®) is not considered cost effective for the treatment of primary hypercholesterolemia and mixed dyslipidemia and is therefore not recommended for reimbursement.

Following NCPE assessment Migalastat (Galafold®) is considered cost-effective and reimbursement is recommended subject to continuing availability of a patient access scheme.

Following NCPE assessment of the applicant’s submission, nivolumab is not considered cost effective as monotherapy for the treatment of advanced renal cell carcinoma after prior therapy in adults and therefore is not recommended for reimbursement in the total population and not recommended for reimbursement at the submitted price for the clear cell population.

Following NCPE assessment of Trametinib (Mekinist®) it is not considered cost-effective and therefore not recommended for reimbursement at the submitted price.

Following NCPE assessment of daratumumab (Darzalex®) monotherapy, it is not considered cost-effective and therefore is not recommended for reimbursement.