| Assessment Status | NCPE Assessment Process Complete |
| HTA ID | 24015 |
| Drug | Capivasertib |
| Brand | Truqap® |
| Indication | Capivasertib (Truqap®) is indicated in combination with fulvestrant for the treatment of adult patients with oestrogen receptor (ER)-positive, HER2-negative locally advanced or metastatic breast cancer with one or more PIK3CA/AKT1/PTEN-alterations following recurrence or progression on or after an endocrine-based regimen. |
| Assessment Process | |
| Rapid review commissioned | 30/04/2024 |
| Rapid review completed | 29/05/2024 |
| Rapid review outcome | A full HTA is recommended to assess the clinical effectiveness and cost effectiveness of capivasertib in combination with fulvestrant compared with the current standard of care. |
| Full HTA commissioned by the HSE | 31/07/2024 |
| Pre-submission consultation with Applicant | 03/09/2024 |
| Full submission received from Applicant | 24/06/2025 |
| Preliminary review sent to Applicant | 03/12/2025 |
| NCPE assessment re-commenced | 09/02/2026 |
| Follow-up to preliminary review sent to Applicant | 12/02/2026 |
| NCPE assessment re-commenced | 17/02/2026 |
| Factual accuracy sent to Applicant | 05/03/2026 |
| NCPE assessment re-commenced | 13/03/2026 |
| NCPE assessment completed | 27/03/2026 |
| NCPE assessment outcome | The NCPE recommends that capivasertib plus fulvestrant not be considered for reimbursement unless cost-effectiveness can be improved*. |
*Next steps: The NCPE Assessment Report and recommendation, will be considered by the HSE when making their decision on reimbursement, while also having regard to the criteria specified in the Health (Pricing and Supply of Medical Goods) Act 2013. Further information on this process may be found here.