| Assessment Status | NCPE Assessment Process Complete |
| HTA ID | 25037 |
| Drug | Glofitamab |
| Brand | Columvi® |
| Indication | Glofitamab in combination with gemcitabine and oxaliplatin is indicated for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma not otherwise specified (DLBCL NOS) who are ineligible for autologous stem cell transplant (ASCT). |
| Assessment Process | |
| Rapid review commissioned | 30/05/2025 |
| Rapid review completed | 02/07/2025 |
| Rapid review outcome | A full HTA is recommended to assess the clinical effectiveness and cost effectiveness of glofitamab in combination with gemcitabine and oxaliplatin compared with the current standard of care. |
| Full HTA commissioned by the HSE | 30/07/2025 |
| Pre-submission consultation with Applicant | 24/09/2025 |
| Full submission received from Applicant | 12/12/2025 |
| Preliminary review sent to Applicant | 01/04/2026 |
| NCPE assessment re-commenced | 29/04/2026 |
| Factual accuracy sent to Applicant | 29/06/2026 |
| NCPE assessment re-commenced | 06/07/2026 |
| NCPE assessment completed | 31/07/2026 |
| NCPE assessment outcome | The NCPE recommends that glofitamab (Columvi®) in combination with gemcitabine and oxaliplatin be considered for reimbursement, for the indication under assessment, if costeffectiveness can be improved relative to existing treatments. |
Next steps: The NCPE Assessment Report and recommendation will be considered by the HSE when making their decision on reimbursement, while also having regard to the criteria specified in the Health (Pricing and Supply of Medical Goods) Act 2013