Ocrelizumab (Ocrevus®) for PPMS

Assessment Status Assessment process complete
Drug Ocrelizumab
Brand Ocrevus®
Indication For the treatment of adult patients with early primary progressive multiple sclerosis (PPMS) in terms of disease duration and level of disability, and with imaging features characteristic of inflammatory activity.
Assessment Process
Rapid review commissioned 29/11/2017
Rapid review completed 14/12/2017
Rapid review outcome Full Pharmacoeconomic Assessment Recommended
Full pharmacoeconomic assessment commissioned by HSE 17/01/2018
Pre-submission consultation with Applicant 20/02/2018
Full submission received from Applicant 27/03/2018
Preliminary review sent to Applicant 08/06/2018
NCPE assessment re-commenced 06/07/2018
Factual accuracy sent to Applicant 30/08/2018
NCPE assessment re-commenced 07/09/2018
NCPE assessment completed 04/10/2018
NCPE assessment outcome The NCPE recommends that ocrelizumab (Ocrevus®) not be considered for reimbursement*.

*This recommendation should be considered while also having regard to the criteria specified in the Health (Pricing and Supply of Medical Goods) Act 2013.

Technical Summary

The HSE has approved reimbursement following confidential price negotiations; October 2020