National Centre for Pharmacoeconomics

National Centre for

NCPE Ireland

Sensitivity analysis

A means of exploring the robustness of a mathematical model or analysis to determine how and whether changes in uncertain model inputs affect main results and conclusions of analysis.

Statistical significance

A conclusion that an intervention has a true effect, based upon observed differences in outcomes between the treatment and control groups that are sufficiently large so that these differences are unlikely to have occurred due to chance, as determined by a statistical test. Statistical significance indicates the probability that the observed difference was due to chance if the null hypothesis is true; it does not provide information about the magnitude of a treatment effect.

Systematic review

A form of structure literature review that addresses a question that is formulated to be answered by analysis of evidence, and involves objective means of searching the literature, applying predetermined inclusion and exclusion criteria to this literature, critically appraising the relevant literature, and extraction and synthesis of data from evidence base to formulate findings.