| - |
Tisagenlecleucel |
Kymriah® |
For the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) after two or more lines of systemic therapy. |
Assessment process complete |
20th September 2019 |
 |
| - |
Tisagenlecleucel |
Kymriah® |
For the treatment of paediatric and young adult patients up to 25 years of age with B-cell acute lymphoblastic leukaemia (ALL) that is refractory, in relapse post-transplant or in second or later relapse. |
Assessment process complete |
27th August 2019 |
|
| 22044 |
Tisagenlecleucel |
Kymriah® |
For the treatment of adult patients with relapsed or refractory follicular lymphoma (FL) after two or more lines of systemic therapy. |
Awaiting HTA submission from Applicant |
6th December 2022 |
|
| - |
Tivozanib |
Fotivda® |
For the first line treatment of adult patients with advanced renal cell carcinoma (RCC) and for adult patients who are VEGFR and mTOR pathway inhibitor-naïve following disease progression after one prior treatment with cytokine therapy for advanced RCC. |
Rapid Review Complete |
24th January 2019 |
|
| 22015 |
Tixagevimab /cilgavimab |
Evusheld® |
For the pre-exposure prophylaxis of COVID-19 in adults and adolescents aged 12 years and older weighing at least 40 kg. |
Assessment process complete |
22nd December 2022 |
|
| 22074 |
Tixagevimab/cilgavimab |
Evusheld® |
Is indicated for the treatment of adults and adolescents (aged 12 years and older weighing at least 40 kg) with COVID-19, who do not require supplemental oxygen and who are at increased risk of progressing to severe COVID-19. |
Rapid Review Complete |
25th January 2023 |
|
| - |
Tobramycin |
TOBI Podhaler® |
For the suppressive therapy of chronic pulmonary infection due to Ps aeruginosa in adults and children aged 6 years and older with CF. |
Rapid Review Complete |
29th November 2010 |
|
| - |
Tocilizumab SC |
RoActemra® |
For the treatment of moderate to severe active rheumatoid arthritis (RA) in adult patients who have either responded inadequately to, or who were intolerant to, previous therapy with one or more disease-modifying anti-rheumatic drugs (DMARDs) or tumour necrosis factor (TNF) antagonists. It is licensed in monotherapy in patients who are intolerant of methotrexate or in cases where methotrexate is inappropriate. |
Rapid Review Complete |
16th July 2014 |
|
| __ |
__ |
__ |
__ |
__ |
28th April 2017 |
|
| 21034 |
Tofacitinib |
Xeljanz® |
For the treatment of active polyarticular juvenile idiopathic arthritis (rheumatoid factor positive or negative polyarthritis and extended oligoarthritis), and juvenile psoriatic arthritis in patients 2 years of age and older, who have responded inadequately to previous therapy with DMARDs. Tofacitinib can be given in combination with methotrexate (MTX) or as monotherapy in case of intolerance to MTX or where continued treatment with MTX is inappropriate. |
Rapid Review Complete |
8th September 2021 |
|
| 22005 |
Tofacitinib |
Xeljanz® |
For the treatment of adult patients with active ankylosing spondylitis who have responded inadequately to conventional therapy. |
Rapid Review Complete |
8th March 2022 |
|
| - |
Tofacitinib |
Xeljanz® |
For the treatment of adult patients with moderately to severely active UC who have had an inadequate response, lost response, or were intolerant to either conventional therapy (i.e. corticosteroids, azathioprine, 6-mercaptopurine) or a biologic agent (i.e. TNF inhibitor). |
Rapid Review Complete |
18th September 2018 |
|
| - |
Tolvaptan |
Jinarc® |
To slow the progression of cyst development and renal insufficiency of autosomal dominant polycystic kidney disease (ADPKD) in adults with CKD stage 1-3 at initiation of treatment with evidence of rapidly progressing disease. |
Assessment process complete |
13th September 2018 |
|
| 21028 |
Tralokinumab |
Adtralza® |
For the treatment of moderate to severe atopic dermatitis in adults who are candidates for systemic therapy. |
Rapid Review Complete |
29th July 2021 |
|
| - |
Tramadol hydrochloride/dexketoprofen |
Skudexa® |
For the symptomatic short-term treatment of moderate to severe acute pain in adult patients whose pain is considered to require a combination of tramadol and dexketoprofen. |
Rapid Review Complete |
1st December 2017 |
|
| - |
Trametinib |
Mekinist® |
For the treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600 mutation. |
Assessment process complete |
15th March 2017 |
|
| 22050 |
Trastuzumab deruxtecan |
Enhertu® |
As monotherapy for the treatment of adult patients with unresectable or metastatic HER2-positive breast cancer who have received one or more prior anti-HER2-based regimens. |
Full submission received from Applicant |
9th March 2023 |
|
| 23011 |
Trastuzumab deruxtecan |
Enhertu® |
Trastuzumab deruxtecan as monotherapy is indicated for the treatment of adult patients with unresectable or metastatic HER2 low breast cancer who have received prior chemotherapy in the metastatic setting or developed disease recurrence during or within 6 months of completing adjuvant chemotherapy. |
Awaiting full HTA submission from Applicant |
30th May 2023 |
|
| - |
Trastuzumab emtansine |
Kadcyla® |
For the treatment of adult patients with HER2-positive, unresectable locally advanced or metastatic breast cancer who previously received trastuzumab and taxane, separately or in combination. |
Assessment process complete |
1st July 2014 |
|
| 20002 |
Trastuzumab emtansine |
Kadcyla® |
As a single agent, for the adjuvant treatment of adults with HER2-positive, early breast cancer who have residual invasive disease, in the breast and/or lymph nodes, after neoadjuvant taxane-based and HER2-targeted therapy. |
Assessment process complete |
12th March 2021 |
|
| - |
Trientine Tetrahydrochloride (TETA 4HCL) |
Cuprior® |
For the treatment of Wilson’s disease in adults and children ≥ five years intolerant to D-penicillamine therapy. |
Rapid Review Complete |
9th October 2019 |
|
| - |
Trifluridine/tipiracil |
Lonsurf® |
For the treatment of adult patients with metastatic colorectal cancer who have been previously treated with, or are not considered candidates for, available therapies including fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapies, anti-VEGF agents, and anti-EGFR agents. |
Rapid Review Complete |
13th July 2016 |
|
| 22011 |
Trifluridine/tipiracil |
Lonsurf® |
As monotherapy for the treatment of adult patients with metastatic gastric cancer including adenocarcinoma of the gastroesophageal junction, who have been previously treated with at least two prior systemic treatment regimens for advanced disease. |
Rapid Review Complete |
15th March 2022 |
|
| 22058 |
Tucatinib |
Tukysa® |
In combination with trastuzumab and capecitabine for the treatment of adult patients with HER2-positive locally advanced or metastatic breast cancer wo have received at least two prior anti-HER2 treatment regimens. |
Rapid Review Complete |
20th September 2022 |
|
| - |
Ulipristal acetate |
Esmya® |
For the intermittent treatment of moderate to severe symptoms of uterine fibroids in adult women of reproductive age. |
Rapid review complete |
1st June 2016 |
|
| - |
Ulipristal acetate |
Esmya® |
For the pre-operative treatment of moderate to severe symptoms of uterine fibroids in adult women of reproductive age. |
Rapid review complete |
22nd October 2013 |
|
| - |
Umeclidinium/vilanterol |
Anoro® |
As a maintenance bronchodilator treatment to relieve symptoms in adult patients with COPD. |
Rapid review complete |
10th July 2014 |
|
| 21039 |
Upadacitinib |
Rinvoq® |
For active ankylosing spondylitis (AS) in adult patients who have responded inadequately to conventional therapy. |
Rapid review complete |
11th October 2021 |
|
| 21029 |
Upadacitinib |
Rinvoq® |
For the treatment of moderate to severe atopic dermatitis in adults and adolescents 12 years and older, who are candidates for systemic therapy. |
Rapid review complete |
29th July 2021 |
|
| 21040 |
Upadacitinib |
Rinvoq® |
For adults with active psoriatic arthritis who have responded inadequately to, or who are intolerant to one or more disease-modifying anti-rheumatic drugs. |
Rapid review complete |
19th October 2021 |
|
| 19047 |
Upadacitinib |
Rinvoq® |
For the treatment of moderate-to-severe active rheumatoid arthritis in adult patients who have responded inadequately to, or who are intolerant to one or more disease-modifying anti-rheumatic drugs. Upadacitinib may be used as monotherapy or in combination with methotrexate. |
Rapid review complete |
10th December 2019 |
|
| 22047 |
Upadacitinib |
Rinvoq® |
For the treatment of adult patients with moderately to severely active ulcerative colitis who have had an inadequate response, lost response or were intolerant to either conventional therapy or a biologic agent. |
Rapid review complete |
27th January 2023 |
|
| 23013 |
Upadacitinib |
Rinvoq® |
Upadacitinib (Rinvoq®) is indicated for the treatment of adult patients with moderately to severely active Crohn’s Disease who have had an inadequate response, lost response or were intolerant to either conventional therapy or a biologic agent. |
Rapid Review Complete |
21st April 2023 |
|
| - |
Urea |
GlucoRx Allpresan® Diabetic Foam Cream |
For the treatment of dry and sensitive foot skin (Basic) and very dry to chapped foot skin (Intensive) in patients with Diabetes Mellitus. |
Rapid review complete |
25th July 2018 |
|
| - |
Ustekinumab |
Stelara® |
For the treatment of moderate to severe psoriasis. |
Assessment process complete |
8th December 2009 |
|
| - |
Ustekinumab |
Stelara® |
For the treatment of adult patients with moderately to severely active Crohn’s disease who have had an inadequate response with, lost response to, or were intolerant to either conventional therapy or a TNF-α antagonist or have medical contraindications to such therapies |
Rapid review complete |
11th January 2017 |
|
| 19048 |
Ustekinumab |
Stelara® |
For the treatment of adult patients with moderately to severely active ulcerative colitis (UC) who have had an inadequate response with, lost response to, or were intolerant to either conventional therapy or a biologic or have medical contraindications to such therapies. |
Rapid review complete |
17th December 2019 |
|
| - |
Vandetanib |
Caprelsa® |
For the treatment of aggressive and symptomatic medullary thyroid cancer (MTC) in patients with unresectable locally advanced or metastatic disease. |
Rapid review complete |
4th July 2013 |
|
| - |
Vedolizumab |
Entyvio® |
For the treatment of adult patients with moderately to severely active Crohn’s disease who have had an inadequate response with, lost response to, or were intolerant to either conventional therapy or a tumour necrosis factor-alpha (TNFα) antagonist. |
Assessment process complete |
13th November 2015 |
|
| - |
Vedolizumab |
Entyvio® |
For the treatment of adult patients with moderately to severely active ulcerative colitis who have had an inadequate response with, lost response to, or were intolerant to either conventional therapy or a tumour necrosis factor-alpha (TNFα) antagonist. |
Assessment process complete |
13th November 2015 |
|
| 20029 |
Vedolizumab |
Entyvio® |
For subcutaneous administration is indicated for the treatment of adult patients with moderately to severely active Crohn’s disease who have had an inadequate response with, lost response to, or were intolerant to either conventional therapy or an anti-TNFα. |
Rapid review complete |
12th August 2020 |
|
| 20030 |
Vedolizumab |
Entyvio® |
For subcutaneous administration is indicated for the treatment of adult patients with moderately to severely active ulcerative colitis who have had an inadequate response with, lost response to, or were intolerant to either conventional therapy or an anti-TNFα. |
Rapid review complete |
12th August 2020 |
|
| - |
Velaglucerase Alfa |
VPRIV® |
For long-term enzyme replacement therapy (ERT) in patients with type1 Gaucher disease. |
Rapid review complete |
20th June 2011 |
|
| - |
Vemurafenib |
Zelboraf® |
For the treatment of adult patients with BRAF V600 mutation-positive unresectable or metastatic melanoma. |
Assessment process complete |
3rd September 2012 |
|
| - |
Venetoclax |
Venclyxto® |
For the treatment of chronic lymphocytic leukaemia (CLL) |
Rapid review complete |
21st June 2018 |
|
| 22001 |
Venetoclax |
Venclyxto® |
In combination with a hypomethylating agent is indicated for the treatment of adult patients with newly diagnosed acute myeloid leukaemia (AML) who are ineligible for intensive chemotherapy. |
NCPE assessment ongoing |
25th May 2023 |
|
| 20046 |
Venetoclax in combination with obinutuzumab |
Venclyxto® / Gazyvaro® |
For the treatment of adult patients with previously untreated chronic lymphocytic leukaemia. |
Assessment process complete |
17th August 2021 |
|
| - |
Venetoclax |
Venclyxto® |
For the treatment of adult patients with CLL who have received at least one prior therapy. |
Assessment process complete |
8th November 2019 |
|
| 21027 |
Vericiguat |
Verquvo® |
For the treatment of symptomatic chronic heart failure in adult patients with reduced ejection fraction who are stabilised after a recent decompensation event requiring intravenous therapy. |
Assessment process complete |
15th July 2021 |
|
| - |
Vernakalant |
Brinavess® |
For haemodynamically stable, symptomatic patients with atrial fibrillation of less than 48 hours duration. |
Assessment process complete |
4th May 2011 |
|
