E

HTA ID	Drug	Brand	Indication	Assessment status	Date
-	Eculizumab	Soliris®	For the treatment of paroxysmal nocturnal haemoglobinuria (PNH) in the Irish healthcare setting.	Assessment process complete	14th October 2013
-	Edoxaban	Lixiana®	For the prevention of stroke/SE in adults with NVAF and for the treatment/secondary prevention of DVT and PE in adults.	Rapid review complete	10th July 2015
23026	Efgartigimod alfa	Vyvgart®	Efgartigimod alfa is indicated as an add-on to standard therapy for the treatment of adult patients with generalised Myasthenia Gravis who are anti-acetylcholine receptor antibody positive.	Pre submission consultation scheduled	12th July 2023
22072	Eladocagene exuparvovec	Upstaza®	For the treatment of patients aged 18 months and older with a clinical, molecular, and genetically confirmed diagnosis of aromatic L-amino acid decarboxylase (AADC) deficiency with a severe phenotype.	Awaiting full HTA submission from Applicant	23rd December 2022
-	Elbasvir 50mg/100mg grazoprevir	Zepatier®	For the treatment of genotypes 1 and 4 chronic HCV infection in patients with Child-Turcotte-Pugh score A (CTPA)	Rapid review complete	13th October 2016
-	Eliglustat	Cerdelga®	For the long-term treatment of adult patients with Gaucher disease type 1.	Assessment process complete	25th April 2018
-	Elosulfase alfa	Vimzim®	For the treatment of mucopolysaccharidosis, type IVA (Morquio A syndrome, MPS IVA) in patients of all ages.	Assessment process complete	8th December 2016
-	Eltrombopag	Revolade®	For the treatment of chronic immune thrombocytopenic purpura (ITP)	Assessment process complete	4th November 2010
-	Eltrombopag	Revolade®	For the treatment adult patients with acquired severe aplastic anaemia (SAA) who were either refractory to prior immunosuppressive therapy or heavily pre-treated and are unsuitable for haematopoietic stem cell transplantation.	Assessment process complete	2nd March 2016
-	Eltrombopag	Revolade®	For adult patients with chronic hepatitis C virus (HCV) infection for the treatment of thrombocytopenia, where the degree of thrombocytopenia is the main factor preventing the initiation or limiting the ability to maintain optimal interferon-based therapy	Rapid review complete	14th February 2014
-	Elvitegravir, Cobicistat, Emtricitabine, Tenofovir alafenamide	Genvoya®	For the treatment of adults and adolescents infected with human immunodeficiency virus – 1 (HIV-1).	Rapid review complete	6th January 2016
-	Elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil (as fumerate)	Stribild®	For the treatment of human immunodeficiency virus-1 (HIV-1) infection in adults aged 18 years and over who are antiretroviral treatment-naïve or are infected with HIV-1 without known mutations associated with resistance to the three antiretroviral agents in Stribild®.	Rapid review complete	20th May 2013
-	Empagliflozin	Jardiance®	Add-on combination therapy: In combination with other glucose-lowering medicinal products including insulin, when these, together with diet and exercise, do not provide adequate glycaemic control. Monotherapy: When diet and exercise alone do not provide adequate glycaemic control in patients for whom use of metformin is considered inappropriate due to intolerance.	Rapid review complete	17th June 2014
21030	Empagliflozin	Jardiance®	For the treatment of symptomatic chronic heart failure with reduced ejection fraction.	Assessment process complete	28th April 2022
22068	Empagliflozin	Jardiance®	For the treatment of symptomatic chronic heart failure with left ventricular ejection fraction >40%	Rapid review complete	2nd December 2022
-	Emtricitabine / tenofovir disoproxil fumarate	Truvada®	In combination with safer sex practices for pre‑exposure prophylaxis (PrEP) to reduce the risk of sexually acquired HIV-1 infection in adults at high risk.	Awaiting Applicant submission	18th July 2017
-	Emtricitabine/tenofovir alafenamide	Descovy®	In combination with other antiretroviral agents (ARVs) for the treatment of adults and adolescents (≥12 years; body weight ≥35 kg) infected with human immunodeficiency virus (HIV) type 1	Rapid review complete	26th April 2016
-	Emtricitabine/tenofovir disoproxil	TEVA®	For pre-exposure prophylaxis in combination with safer sex practices to reduce the risk of sexually acquired HIV-1 infection in adults in high risk	Rapid review complete	22nd December 2017
20037	Encorafenib	Braftovi®	In combination with cetuximab, for the treatment of adult patients with metastatic colorectal cancer with a BRAF V600E mutation, who have received prior systemic therapy	Assessment process complete	28th January 2022
-	Encorafenib, binimetinib	Braftovi®, Mektovi®	For the treatment of adult patients with advanced (unresectable or metastatic) melanoma with a BRAF V600 mutation.	Rapid review complete	23rd January 2019
22024	Enfortumab vedotin	Padcev®	As monotherapy for the treatment of adult patients with locally advanced or metastatic urothelial cancer (la/mUC) who have previously received a platinum-containing chemotherapy and a programmed death receptor-1 or programmed death-ligand 1 inhibitor	NCPE Assessment Process Complete	12th July 2023
21038	Entrectinib	Rozlytrek®	As monotherapy for the treatment of patients with ROS1-positive advanced non-small cell lung cancer (NSCLC) not previously treated with ROS1 inhibitors	Rapid review complete	28th September 2021
22055	Entrectinib	Rozlytrek®	As monotherapy is indicated for the treatment of adult and paediatric patients 12 years of age and older with solid tumours expressing a neurotrophic tyrosine receptor kinase (NTRK) gene fusion, who have a disease that is locally advanced, metastatic or where surgical resection is likely to result in severe morbidity, and who have not received a prior NTRK inhibitor and who have no satisfactory treatment options	Rapid review complete	29th September 2022
-	Enzalutamide	Xtandi®	First line treatment of adult men with mCRPC who are asymptomatic or mildly symptomatic after failure of androgen deprivation therapy in whom chemotherapy is not yet clinically indicated	Assessment process complete	22nd June 2015
21022	Enzalutamide	Xtandi®	For the treatment of adult men with metastatic hormone-sensitive prostate cancer (mHSPC) in combination with androgen deprivation therapy.	Rapid review complete	7th July 2021
18056	Enzalutamide	Xtandi®	For the treatment of adult men with high-risk non-metastatic castration-resistant prostate cancer (nmCRPC).	Assessment process complete	24th May 2022
-	Enzalutamide	Xtandi®	For the treatment of adult men with metastatic castration-resistant prostate cancer (mCRPC) whose disease has progressed on or after docetaxel therapy.	Assessment process complete	10th April 2014
-	Epoprostenol	Veletri®	For the treatment of pulmonary arterial hypertension (PAH) (idiopathic or heritable PAH and PAH associated with connective tissue diseases) in patients with WHO FC III–IV symptoms to improve exercise capacity	Rapid review complete	7th February 2017
22052	Eptinezumab	Vyepti®	For the prophylaxis of migraine in adults who have at least four migraine days per month	Rapid review complete	27th January 2023
-	Erenumab	Aimovig®	For the treatment of chronic and episodic migraine in adults who have at least 4 migraine days per month when initiating treatment with erenumab.	Assessment process complete	30th September 2019
-	Eribulin	Halaven®	For the treatment of patients with locally advanced or metastatic breast cancer who have progressed after at least two chemotherapeutic regimens for advanced disease. Prior therapy should have included an anthracycline and a taxane unless patients were not suitable for these treatments.	Assessment process complete	7th December 2012
-	Ertugliflozin	Steglatro®	For the treatment of the treatment 2 diabetes mellitus (T2DM) in individuals 18 years and over to improve glycaemic control.	Rapid review complete	21st May 2018
19055	Esketamine	Spravato®	In combination with a SSRI or SNRI is indicated for adults with treatment-resistant Major Depressive Disorder, who have not responded to at least two different treatments with antidepressants in the current depressive episode	Assessment process complete	9th March 2021
-	Eslicarbazepine	Zebinix®	For the treatment of Epilepsy	Rapid review complete	1st September 2009
20013	Estradiol	Oestrogel® Pump Gel	For: Hormone replacement therapy (HRT) for oestrogen deficiency symptoms in postmenopausal women; Prevention of osteoporosis in postmenopausal women at high risk of future fractures who are intolerant of, or contraindicated for, other medicinal products approved for the prevention of osteoporosis.	Rapid review complete	9th April 2020
22071	Estriol	Blissel®	Estriol (Blissel®) 50 micrograms per gram is indicated for local treatment of vaginal dryness in post- menopausal women with vaginal atrophy.	Rapid Review Complete	23rd January 2023
-	Etanercept	Benepali®	A biosimilar of the TNF-α inhibitor Etanercept (Enbrel®) for the treatment of patients with rheumatoid arthritis, psoriatic arthritis, axial spondylitis and plaque psoriasis.	Rapid review complete	30th May 2016
-	Etelcalcitide	Parsabiv®	For the treatment of secondary hyperparathyroidism (SHPT) in adult patients with chronic kidney disease (CKD) on haemodialysis.	Rapid review complete	1st September 2017
-	Everolimus	Afinitor®	Treatment of hormone receptor-positive (HR+), HER2/neu-negative (HER2-) advanced breast cancer (HR+ advanced breast cancer), in combination with exemestane, in postmenopausal women without symptomatic visceral disease after recurrence or progression following a non-steroidal aromatase inhibitor	Rapid review complete	15th October 2012
-	Everolimus	Votubia®	For the treatment of refractory seizures associated with tuberous sclerosis complex (TSC): adjunctive treatment of patients aged 2 years and older whose refractory partial-onset seizures, with or without secondary generalisation, are associated with TSC.	Rapid review complete	26th April 2017
-	Everolimus	Votubia®	For the treatment of patients aged 3 years and older with subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex (TSC) who require therapeutic intervention but are not amenable to surgery	Rapid review complete	14th October 2011
-	Evolocumab	Repatha®	For both primary hypercholesterolaemia and mixed dyslipidaemia and heterozygous familial hypercholesterolaemia.	Assessment process complete	16th May 2018
-	Exenatide	Bydureon®	For the treatment of type II diabetes mellitus combined with Metformin, Sulphonylurea, Thiazolidinedione, Metform and SU and Metformn and TZD in adults who have not acheived glycaemic control on maximally tolerated doses of these oral therapies.	Rapid review complete	9th June 2011