| - |
Certolizumab pegol |
Cimzia® |
For the treatment of moderate to severe rheumatoid arthritis. |
NCPE Assessment Process complete |
2nd September 2010 |
 |
| 23049 |
Chlormethine gel |
Ledaga® |
Chlormethine gel (Ledaga®) is indicated for the topical treatment of mycosis fungoides-type cutaneous T-cell lymphoma (MF-type CTCL) in adult patients. |
Rapid Review Complete |
20th September 2023 |
|
| 22033 |
Cholecalciferol |
Egostar® |
Prevention of vitamin D deficiency in adult patients with an identified risk, initial treatment of clinically relevant vitamin D deficiency, and as an adjunct to specific therapy for osteoporosis in patients with vitamin D deficiency or at risk of vitamin D insufficiency. |
Rapid Review complete |
23rd June 2022 |
|
| 21062 |
Cholic acid |
Orphacol® |
For the treatment of inborn errors in primary bile acid synthesis due to 3β-Hydroxy-Δ5-C27-steroid oxidoreductase deficiency or Δ4-3-Oxosteroid-5β-reductase deficiency in infants, children and adolescents aged one month to 18 years, and adults. |
Rapid Review complete |
12th January 2022 |
|
| - |
Ciclosporin |
Ikervis® |
For the treatment of severe keratitis in adult patients with dry eye disease (DED), which has not improved despite treatment with tear substitutes. |
Rapid Review complete |
18th January 2016 |
|
| 22021 |
Ciltacabtagene autoleucel |
Carvykti® |
For the treatment of adult patients with relapsed or refractory multiple myeloma, who have received at least three prior therapies, including an immunomodulatory agent, a proteasome inhibitor and an anti-CD38 antibody and have demonstrated disease progression on the last therapy. |
NCPE assessment ongoing |
12th September 2023 |
|
| - |
Cladribine |
Mavenclad® |
For the treatment of adult patients with highly active relapsing multiple sclerosis (MS) as defined by clinical or imaging features |
NCPE Assessment process complete |
20th July 2018 |
|
| - |
Clindamycin 1% with tretinoin 0.025% |
Treclinac® |
For the topical treatment of acne vulgaris when comedones, papules and pustules are present in patients 12 years or older. |
Rapid Review complete |
7th May 2014 |
|
| 19045 |
Co-enzyme Q10 |
CoQun® eye drops |
As a complementary add-on treatment to antihypertensive glaucoma therapy. |
Rapid Review complete |
13th January 2020 |
|
| - |
Cobimetinib |
Cotellic® |
For use in combination with vemurafenib for the treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600 mutation. |
NCPE Assessment process complete |
5th January 2017 |
|
| - |
Colesevelam |
Cholestagel® |
Hypercholesterolaemia |
Rapid Review complete |
22nd October 2010 |
|
| - |
Colistimethate sodium |
Colobreathe® |
For the management of chronic pulmonary infections due to Pseudomonas aeruginosa in patients with cystic fibrosis (CF) aged 6 years and older. |
Rapid Review complete |
28th June 2013 |
|
| - |
Collagenase Clostridium Histolyticum |
Xiapex® |
Treatment of Dupuytren’s contracture in adult patients with a palpable cord. |
Rapid Review complete |
9th June 2011 |
|
| 21017 |
Conestat alfa |
Ruconest® |
For the treatment of acute angioedema attacks in adults, adolescents, and children (aged 2 years and above) with hereditary angioedema (HAE) due to C1 esterase inhibitor deficiency. |
Rapid Review complete |
2nd June 2021 |
|
| - |
Corifollitropin alfa |
Elonva® |
Controlled Ovarian Stimulation (COS) in combination with a Gonadotropin Releasing Hormone (GnRH) antagonist for the development of multiple follicles in women participating in an Assisted Reproductive Technology (ART) program. |
Rapid Review complete |
22nd October 2010 |
|
| - |
Crizotinib |
Xalkori® |
Treatment of adults with previously treated anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC) (i.e. in the 2nd / 3rd–line treatment setting) |
NCPE Assessment process complete |
27th August 2013 |
|
| - |
Crizotinib |
Xalkori® |
For the first-line treatment of adults with anaplastic lymphoma kinase (ALK)-positive advanced non-small cell lung cancer (NSCLC). |
Rapid Review complete |
25th April 2017 |
|
| - |
Crizotinib |
Xalkori® |
For the treatment of adults with ROS1-positive advanced non-small cell lung cancer (NSCLC). |
Rapid Review complete |
25th April 2017 |
|
| - |
Cysteamine bitartrate delayed-release |
Procysbi® |
For the treatment of proven nephropathic cystinosis. |
NCPE Assessment process complete |
15th November 2017 |
|
| - |
Dabigatran |
Pradaxa® |
For the prevention of stroke and systemic embolism in atrial fibrillation |
NCPE Assessment Process Complete |
3rd June 2011 |
|
| - |
Dabigatran |
Pradaxa® |
For the Primary Prevention of Venous Thromboembolic Events in Adult Patients who have undergone Total Hip Replacement or Total Knee Surgery. |
NCPE Assessment Process Complete |
1st September 2008 |
|
| - |
Dabigatran |
Pradaxa® |
For the treatment of deep vein thrombosis (DVT) and pulmonary embolism (PE), and prevention of recurrent DVT and PE in adults. |
NCPE Assessment Process Complete |
13th June 2014 |
|
| - |
Dabrafeib |
Tafinlar® |
For the treatment of adult patients with unresectable or Metastic Melanoma with a BRAF V600 mutation. |
NCPE Assessment Process Complete |
24th June 2014 |
|
| - |
Dabrafenib |
Tafinlar® plus Mekinist® |
In combination with trametinib, is indicated for the adjuvant treatment of adult patients with stage III melanoma with a BRAF V600 mutation, following complete resection. |
NCPE Assessment Process Complete |
19th August 2020 |
|
| - |
Daclatasvir |
Daklinza® |
In combination with other medicinal products for the treatment of chronic hepatitis C (genotype 1,3 and 4) |
NCPE Assessment Process Complete |
29th May 2015 |
|
| - |
Daclizumab |
Zinbryta® |
Indicated in adult patients for the treatment of relapsing forms of multiple sclerosis. |
Rapid review complete |
23rd November 2016 |
|
| - |
Dacomitinib |
Vizimpro® |
Indicated as monotherapy, for the first-line treatment of adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR)-activating mutations. |
Rapid review complete |
13th May 2019 |
|
| - |
Dalbavancin |
Xydalba® |
Indicated for the treatment of acute bacterial skin and skin structure infections (ABSSSI) in adults. |
Rapid review complete |
28th April 2017 |
|
| - |
Dapagliflozin |
Forxiga® |
Indicated in adults aged 18 years and older with Type 2 Diabetes Mellitus to improve glycaemic control as: Monotherapy: When diet and exercise alone do not provide adequate glycaemic control in patients for whom use of metformin is considered inappropriate due to intolerance. Add-on combination therapy: In combination with other glucose lowering drugs including insulin, when these, together with diet and exercise, do not provide adequate glycaemic control. |
Rapid review complete |
31st December 2013 |
|
| 22030 |
Dapagliflozin |
Forxiga® |
Indicated in adults for the treatment of symptomatic chronic heart failure with reduced ejection fraction. |
Rapid review complete |
3rd June 2022 |
|
| 22040 |
Dapagliflozin |
Forxiga® |
For the treatment of chronic kidney disease |
Rapid review complete |
14th July 2022 |
|
| - |
Daratumumab |
Darzalex® |
For the treatment of adult patients with relapsed and refractory multiple myeloma, whose prior therapy included a proteasome inhibitor and an immunomodulatory agent and who have demonstrated disease progression on the last therapy. |
NCPE Assessment Process Complete |
13th March 2017 |
|
| - |
Daratumumab |
Darzalex® in combination with bortezomib and dexamethasone |
For the treatment of adult patients with multiple myeloma who have received at least one prior therapy. |
NCPE Assessment Process Complete |
15th March 2019 |
|
| - |
Daratumumab in combination with lenalidomide and dexamethasone |
Darzalex® |
For the treatment of adult patients with multiple myeloma wo have received at least one prior therapy. |
Rapid review complete |
27th November 2017 |
|
| 20025 |
Daratumumab |
Darzalex® |
In combination with bortezomib, thalidomide and dexamethasone for the treatment of adult patients with newly diagnosed multiple myeloma who are eligible for autologous stem cell transplant. |
NCPE Assessment Process Complete |
16th November 2021 |
|
| 21041 |
Daratumumab |
Darzalex® in combination with cyclophosphamide, bortezomib and dexamethasone |
For the treatment of adult patients with newly diagnosed systemic light chain amyloidosis. |
NCPE Assessment Process Complete |
19th December 2022 |
|
| 22039 |
Daratumumab |
Darzalex® |
In combination with lenalidomide (Revlimid®) and dexamethasone for the treatment of adult patients with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplant |
NCPE Assessment Process Complete |
20th September 2023 |
|
| 20022 |
Darolutamide |
Nubeqa® |
For the treatment of adult men with non-metastatic castration resistant prostate cancer (nmCRPC) who are at high risk of developing metastatic disease. |
NCPE Assessment Process Complete |
10th September 2021 |
|
| - |
Darunavir & cobicistat |
Rezolsta® |
Indicated in combination with other antiretroviral medicinal products for the treatment of human immunodeficiency virus-1 (HIV-1) infection in adults aged 18 years or older. |
Rapid review complete |
8th January 2015 |
|
| - |
Darunavir/ cobicistat/ emtricitabine/ tenofovir alafenamide |
Symtuza® |
For the treatment of HIV-1 in adults and adolescents. |
Rapid review complete |
26th October 2017 |
|
| - |
Darvadstrocel |
Alofisel® |
For the treatment of complex perianal fistulae in adult patients with non-active/ mildly active luminal Crohn’s Disease when fistulae have shown an inadequate response to at least one conventional or biologic therapy and should be used after conditioning of fistula. |
NCPE Assessment Process Complete |
24th September 2019 |
|
| - |
Decitabine |
Dacogen® |
For AML in patients who are >65yrs who are not candidates for standard induction therapy |
Rapid review complete |
21st December 2012 |
|
| 22019 |
Defatted powder of Arachis hypogaea L., semen (peanuts) |
Palforzia® |
For the treatment of patients aged 4 to 17 years with a confirmed diagnosis of peanut allergy. Palforzia® may be continued in patients 18 years of age and older. Palforzia® should be used in conjunction with a peanut-avoidant diet. |
NCPE assessment ongoing |
29th June 2023 |
|
| - |
Defibrotide |
Defitelio® |
Indicated in adults, children and infants (>1month) for the treatment of severe hepatic veno-occlusive disease (VOD) also known as sinusoidal obstruction syndrome (SOS) in haematopoietic stem-cell transplantation (HSCT) therapy |
Rapid review complete |
15th July 2014 |
|
| - |
Degarelin |
Firmagon® |
For the treatment of prostate cancer |
Rapid review complete |
15th October 2009 |
|
| 20038 |
Delafloxacin |
Quofenix® |
For the treatment of acute bacterial skin and skin structure infections (ABSSSI) in adults when it is considered inappropriate to use other antibacterial agents that are commonly recommended for the initial treatment of these infections. Consideration should be given to official guidance on the appropriate use of antibacterial agents. |
Rapid review complete |
19th November 2020 |
|
| - |
Delta-9-tetrahydrocannabinol/Cannabidiol, THC/CBD |
Sativex® |
Indicated as treatment for symptom improvement in adult patients with moderate to severe spasticity due to multiple sclerosis (MS) who have not responded adequately to other anti-spasticity medication and who demonstrate clinically significant improvement in spasticity related symptoms during an initial trial of therapy. |
NCPE Assessment Process Complete |
15th July 2021 |
|
| - |
Denosumab |
Prolia® |
For the Prevention of Osteoporotic Fractures in Postmenopausal Women |
NCPE Assessment Process Complete |
1st July 2010 |
|
| - |
Denosumab |
Xgeva® |
For the prevention of skeletal related events in adults with bone metastases from solid tumours in Ireland |
NCPE Assessment Process Complete |
8th December 2011 |
|
| 23030 |
Deucravacitinib |
Sotyktu® |
Deucravacitinib is indicated for the treatment of moderate to severe plaque psoriasis in adults who are candidates for systemic therapy. |
Rapid Review Complete |
27th June 2023 |
|
