| - |
Insulin Glargine |
Abasaglar® |
For the treatment of diabetes mellitus in adults, adolescents and children aged 2 years and above. |
Rapid Review Complete |
12th October 2015 |
 |
| - |
Insulin Glargine U300 |
Toujeo® |
for the treatment of diabetes mellitus in adults. |
Rapid Review Complete |
2nd July 2015 |
|
| - |
Ipilimumab |
Yervoy® |
For the treatment of advanced (unresectable or metastatic) melanoma in adult patients who have received prior therapy. |
Assessment process complete |
6th September 2011 |
|
| 24023 |
Iptacopan |
Fabhalta® |
Iptacopan is indicated as monotherapy in the treatment of adult patients with paroxysmal nocturnal haemoglobinuria (PNH) who have haemolytic anaemia. |
Rapid Review Complete |
16th July 2024 |
|
| - |
Iron (III) isomaltoside 1000 |
Diafer® |
For the treatment of iron deficiency in patients with chronic kidney disease on dialysis, when oral iron preparations are ineffective or cannot be used. |
Rapid Review Complete |
20th November 2015 |
|
| - |
Iron (III) isomaltoside 1000 |
Monover® |
For the treatment of Iron deficiency anaemia when oral iron preparations are ineffective or cannot be used or where there is a clinical need to deliver iron rapidly. |
Rapid Review Complete |
20th November 2015 |
|
| - |
Iron isomaltoside 1000 |
MonoVer® |
For the treatment of iron deficiency anaemia in the following circumstances: When oral iron preparations are ineffective or cannot be used and where there is a clinical need to deliver iron rapidly. |
Rapid Review Complete |
2nd February 2011 |
|
| 23024 |
Isatuximab |
Sarclisa® |
Isatuximab (Sarclisa®) in combination with carfilzomib and dexamethasone, is indicated for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. |
Rapid Review Complete |
25th May 2023 |
|
| - |
Isavuconazole |
Cresemba® |
For the treatment of invasive aspergillosis |
Rapid Review Complete |
11th May 2016 |
|
| - |
Isavuconazole |
Cresemba® |
For the treatment of mucormycosis in adult patients for whom amphotericin B is inappropriate. |
Rapid Review Complete |
11th May 2016 |
|
| 25016 |
Isavuconazole |
Cresemba® |
Isavuconazole (Cresemba®is indicated for patients from one year of age to < 18 years for the treatment of invasive aspergillosis, and mucormycosis in patients for whom amphotericin B is inappropriate. |
Rapid Review Complete |
25th March 2025 |
|
| 23031 |
Itopride Hydrochloride |
Progit® |
Treatment of gastrointestinal symptoms of functional dyspepsia caused by reduced gastrointestinal motility. |
Rapid Review Complete |
7th July 2023 |
|
| 20027 |
IUB™ Ballerine® |
IUB™ Ballerine® MIDI 15mm diameter SCU300B |
For intrauterine contraception for up to five years. |
Rapid Review Complete |
29th July 2020 |
|
| 20062 |
IUB™ Ballerine® |
IUB™ Ballerine® MIDI 15mm diameter SCU300B |
For intrauterine contraception for up to five years. |
Rapid Review Complete |
17th February 2021 |
|
| - |
Ivacaftor |
Kalydeco® |
For the treatment of cystic fibrosis in patients age 6 years and older who have the G551D mutation |
Assessment process complete |
1st February 2013 |
|
| - |
Ivacaftor |
Kalydeco® |
For the treatment of children with CF aged 2 years and older and weighing less than 25 kg who have one of the following gating (class III) mutations in the CFTR gene: G551D, G1244E, G1349D, G178R, G551S, S1251N, S1255P, S549N, or S549R. |
Assessment process complete |
12th October 2016 |
|
| - |
Ivacaftor |
Kalydeco® |
For the treatment of patients with cystic fibrosis aged 18 years and older who have the R117H mutation in the CFTR gene. |
Assessment process complete |
5th January 2017 |
|
| 22022 |
Ivacaftor/tezacaftor/elexacaftor |
Kaftrio® |
Ivacaftor/tezacaftor/elexacaftor (Kaftrio®) in combination with ivacaftor for the treatment of cystic fibrosis (CF) in patients aged 6 years and older who have at least one F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. |
NCPE Assessment Process Complete |
9th February 2023 |
|
| 23015 |
Ivosidenib |
Tibsovo® |
To be used in combination with azacitidine, as indicated for the treatment of adult patients with newly diagnosed acute myeloid leukaemia (AML) with an isocitrate dehydrogenase-1 (IDH1) R132 mutation who are not eligible to receive standard induction chemotherapy. |
Full HTA submission received from Applicant |
31st July 2025 |
|
| 23016 |
Ivosidenib |
Tibsovo® |
For the treatment of adult patients with locally advanced or metastatic cholangiocarcinoma with an IDH1 R 132 mutation who were previously treated by at least one prior line of systemic therapy |
NCPE Assessment Process Complete |
7th March 2025 |
|
| - |
Ixazomib |
Ninlaro® |
In combination with lenalidomide and dexamethasone for the treatment of adult patients with multiple myeloma who have received at least one prior therapy. |
Assessment process complete |
18th December 2017 |
|
| - |
Ixekizumab |
Taltz® |
For the treatment of adult patients with moderate-to-severe plaque psoriasis who are candidates for systemic therapy. |
Rapid Review Complete |
26th July 2016 |
|
| - |
Ixekizumab |
Taltz® |
For the treatment of active PsA in adult patients who have responded inadequately to, or who are intolerant to one or more disease-modifying anti-rheumatic drug (DMARD) therapies |
Rapid Review Complete |
20th November 2018 |
|
| 21046 |
Ketoconazole |
Ketoconazole HRA® |
For the treatment of endogenous Cushing’s syndrome in adults and adolescents above the age of 12 years. |
Rapid Review Complete |
13th December 2021 |
|
| - |
Lacosamide |
Vimpat® |
As monotherapy and adjunctive therapy in the treatment of partial-onset seizures with or without secondary generalisation in adults, adolescents and children from 4 years of age with epilepsy. The Applicant is seeking reimbursement for an extension to the product license to cover children (≥4 years of age) and adolescents (≤ 15 years of age). |
Rapid Review Complete |
31st October 2017 |
|
| __ |
Lanadelumab |
Takhzyro® |
For routine prevention of recurrent attacks of hereditary angioedema (HAE) in patients aged 12 years and older. |
Assessment process complete |
26th June 2020 |
|
| - |
Lapatinib |
Tyverb® |
For the treatment of women with previously treated advanced or metastatic HER2 positive breast cancer. |
Assessment process complete |
28th January 2008 |
|
| 19050 |
Larotrectinib |
Vitrakvi® |
For patients with solid tumours that display a Neurotrophic Tyrosine Receptor Kinase (NTRK) gene fusion. |
NCPE Assessment Process Complete |
6th July 2023 |
|
| 21053 |
Latanoprost/Timolol |
Fixapost® |
In adults (including the elderly) for the reduction of intraocular pressure in patients with open angle glaucoma and ocular hypertension who are insufficiently responsive to topical beta‐blockers or prostaglandin analogues. |
Rapid Review Complete |
6th December 2021 |
|
| 25008 |
Lebrikizumab |
Ebglyss® |
Lebrikizumab (Ebglyss®) is indicated for the treatment of moderate-to-severe atopic dermatitis in adults and adolescents 12 years and older with a body weight of at least 40kg who are candidates for systemic therapy. |
Rapid Review Complete |
19th February 2025 |
|
| 24052 |
Lecanemab |
Leqembi® |
Lecanemab (Leqembi®) is indicated for the treatment of adult patients with a clinical diagnosis of mild cognitive impairment and mild dementia due to Alzheimer’s disease (Early Alzheimer’s disease) who are apolipoprotein E ε4 (ApoE ε4) non-carriers or heterozygotes with confirmed amyloid pathology. |
Awaiting full HTA submission from Applicant |
2nd July 2025 |
|
| - |
Ledipasvir/sofosbuvir |
Harvoni® |
For the treatment of Chronic Hepatitis C (CHC) infection (Genotye 1, 3 and 4) in adults. |
Assessment process complete |
20th November 2015 |
|
| - |
Lenalidomide |
Revlimid® |
For the treatment of adult patients with previously untreated multiple myelomas (MM) who are not eligible for transplant (licence extension). |
Rapid Review Complete |
20th November 2015 |
|
| - |
Lenvatinib |
Kisplyx® |
In combination with everolimus for the treatment of adult patients with advanced renal cell carcinoma (RCC) following one prior vascular endothelial growth factor (VEGF)-targeted therapy. |
Rapid Review Complete |
18th May 2017 |
|
| 22057 |
Lenvatinib |
Kisplyx® |
For the treatment of adults with advanced renal cell carcinoma, in combination with pembrolizumab, as first-line treatment |
Rapid Review Complete |
22nd September 2022 |
|
| - |
Lenvatinib |
Lenvima® |
For the treatment of adult patients with progressive, locally advanced or metastatic, differentiated (papillary/follicular/Hürthle cell) thyroid carcinoma (DTC), refractory to radioactive iodine. |
Rapid Review Complete |
10th July 2015 |
|
| - |
Lenvatinib |
Lenvima® |
As monotherapy for the treatment of adult patients with advanced or unresectable HCC who have received no prior systemic therapy. |
Rapid Review Complete |
16th August 2018 |
|
| - |
Lesinurad |
Zurampic® |
For the treatment of hyperuricaemia in adult patients with gout who have not achieved target serum uric acid levels with an adequate dose of a xanthine oxidase inhibitor. |
Assessment process complete |
6th December 2018 |
|
| - |
Letermovir |
Prevymis® |
For the prophylaxis of cytomegalovirus (CMV) reactivation or disease in adult CMV-seropositive recipients [R+] of an allogeneic haematopoietic stem cell transplant (HSCT). |
Assessment process complete |
20th May 2020 |
|
| - |
Levodopa 20mg/ml + carbidopa monohydrate 5mg intestinal gel |
Duodopa® |
For the treatment of advanced levodopa-responsive Parkinson’s disease with severe motor fluctuations and hyper-/dyskinesia when available combinations of Parkinson medicinal products have not given satisfactory results. A positive test of the clinical response to Duodopa® administered via a temporary nasoduodenal tube is required before a permanent tube is inserted. |
Assessment process complete |
14th June 2019 |
|
| 21068 |
Levodopa/carbidopa/entacapone intestinal gel |
Lecigon® |
For the treatment of advanced Parkinson's disease with severe motor fluctuations and hyperkinesia or dyskinesia when available oral combinations of Parkinson’s medicinal products have not given satisfactory results. |
Rapid Review Complete |
17th February 2022 |
|
| - |
Levofloxacin |
Quinsair® |
For the management of chronic pulmonary infections due to Pseudomonas aeruginosa in adult patients with Cystic Fibrosis. |
Rapid Review Complete |
2nd March 2016 |
|
| - |
Levonorgestrel intrauterine delivery system LNG IUS 12 |
Kyleena® |
For contraception for up to 5 years. |
Rapid Review Complete |
16th March 2017 |
|
| - |
Levonorgestrel Intrauterine System |
Levosert® |
For contraception and for the treatment of heavy menstrual bleeding. |
Rapid Review Complete |
23rd October 2019 |
|
| - |
Levonorgestrel intrauterine system LNG-IUS |
Jaydess® |
For contraception for up to three years. |
Rapid Review Complete |
26th March 2013 |
|
| - |
Lidocaine 5% plasters |
Versatis® |
For the symptomatic relief of neuropathic pain associated with previous herpes zoster infection (post-herpetic neuralgia, PHN). |
Assessment process complete |
24th September 2015 |
|
| - |
Linaclotide |
Constella® |
For the treatment of symptomatic treatment of moderate to severe irritable bowel syndrome with constipation (IBS-C) in adults. |
Rapid Review Complete |
28th June 2013 |
|
| - |
Linagliptin |
Trajenta® |
For treatment of type 2 diabetes mellitus to improve glycaemic control in adults, as monotherapy in patients inadequately controlled by diet and exercise alone and for whom metformin is inappropriate due to intolerance, or contraindicated due to renal impairment, as combination therapy in combination with metformin when diet and exercise plus metformin alone do not provide adequate glycaemic control, in combination with a sulphonylurea and metformin when diet and exercise plus dual therapy with these medicinal products do not provide adequate glycaemic control. |
Rapid Review Complete |
6th September 2011 |
|
| 23068 |
Linzagolix |
Yselty® |
Linzagolix is indicated for the treatment of moderate to severe symptoms of uterine fibroids in adult women of reproductive age. |
Awaiting full HTA submission from Applicant |
16th April 2024 |
|
| - |
Lipegfilgrastim |
Lonquex® |
For reduction in the duration of neutropenia and the incidence of febrile neutropenia in adult patients treated with cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes). |
Rapid Review Complete |
24th September 2013 |
|
